Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 Cells

AAPS Journal

Volumn 15, Issue 2, 2013, Pages 367-376

  Park, Yoon Shin ^a,b   David, Allan E ^a,c   Park, Kyung Min ^d   Lin, Chia Ying ^e   Than, Khoi D ^e   Lee, Kyuri ^a   Park, Jun Beom ^a   Jo, Inho ^b   Park, Ki Dong ^d   Yang, Victor C ^a,f,g  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Ewha Womans University School of Medicine   (South Korea)

^c AUBURN UNIVERSITY   (United States)

^d Ajou University   (South Korea)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f Seoul National University   (South Korea)

^g TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

hydrogel; MC3T3 E1; MMP 3; osteocalcin; osteogenesis; simvastatin

Indexed keywords

BUFFER; CELL MARKER; COLLAGENASE 3; GELATIN; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; MACROGOL; OSTEOCALCIN; SIMVASTATIN; TYRAMINE;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BONE DEVELOPMENT; BONE MINERALIZATION; CANCER CELL CULTURE; CELL CULTURE; CELL DIFFERENTIATION; CELL STRAIN MC3T3 E1; CELL SWELLING; CONCENTRATION RESPONSE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSS LINKING; DEGRADATION; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; ENCAPSULATION; GENE EXPRESSION; HYDROGEL; IN VITRO STUDY; MMP 13 GENE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIGIDITY; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BONE DENSITY CONSERVATION AGENTS; BUFFERS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; GELATIN; HORSERADISH PEROXIDASE; HYDROGELS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; KINETICS; MATRIX METALLOPROTEINASE 13; MICE; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; POLYETHYLENE GLYCOLS; POLYMERASE CHAIN REACTION; SIMVASTATIN; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TYRAMINE;

EID: 84877011640     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9442-6     Document Type: Article

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