메뉴 건너뛰기




Volumn 6, Issue 2, 2014, Pages 1138-1156

Mechanisms of cancer induction by tobacco-specific NNK and NNN

Author keywords

Cancer; Nitrosamines; Tobacco

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CARCINOGEN; NITROSONORNICOTINE; TOBACCO SMOKE;

EID: 84901218529     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6021138     Document Type: Review
Times cited : (177)

References (115)
  • 1
    • 27844472511 scopus 로고    scopus 로고
    • Causes of cancer in the world: Comparative risk assessment of nine behavioral and environmental risk factors
    • Comparative Risk Assessment Collaborating Group
    • Danaei, G.; Vander Hoorn, S.; Lopez, A.D.; Murray, C.J.; Ezzati, M.; Comparative Risk Assessment Collaborating Group. Causes of cancer in the world: Comparative risk assessment of nine behavioral and environmental risk factors. Lancet 2005, 366, 1784-1793.
    • (2005) Lancet , vol.366 , pp. 1784-1793
    • Danaei, G.1    Vander, H.S.2    Lopez, A.D.3    Murray, C.J.4    Ezzati, M.5
  • 2
    • 0003731910 scopus 로고    scopus 로고
    • World Health Organization, In The World Health Report; WHO: Geneva, Switzerland
    • World Health Organization. Reducing risks, promoting healthy life. In The World Health Report; WHO: Geneva, Switzerland, 2002.
    • (2002) Reducing Risks, Promoting Healthy Life
  • 3
    • 0142228320 scopus 로고    scopus 로고
    • Tobacco carcinogens, their biomarkers and tobacco-induced cancer
    • Hecht, S.S. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat. Rev. Cancer 2003, 3, 733-744.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 733-744
    • Hecht, S.S.1
  • 4
    • 69849086108 scopus 로고    scopus 로고
    • Global tobacco problem getting worse, not better
    • Jatoi, I.; Cummings, K.M.; Cazap, E. Global tobacco problem getting worse, not better. J. Oncol. Pract. 2009, 5, 21-23.
    • (2009) J. Oncol. Pract , vol.5 , pp. 21-23
    • Jatoi, I.1    Cummings, K.M.2    Cazap, E.3
  • 6
    • 0038748968 scopus 로고    scopus 로고
    • World Health Organization, Available online, (accessed on 5 January 2014)
    • World Health Organization. Global Cancer Rates Could Increase by 50% to 15 Million by 2020. Available online: http://www.who.int/mediacentre/news/releases/2003/pr27/en/ (accessed on 5 January 2014).
    • Global Cancer Rates Could Increase By 50% to 15 Million By 2020
  • 7
    • 14144253640 scopus 로고    scopus 로고
    • Metabolism and disposition kinetics of nicotine
    • Hukkanen, J.; Jacob, P., 3rd; Benowitz, N.L. Metabolism and disposition kinetics of nicotine. Pharmacol. Rev. 2005, 57, 79-115.
    • (2005) Pharmacol. Rev , vol.57 , pp. 79-115
    • Hukkanen, J.1    Jacob III, P.2    Benowitz, N.L.3
  • 8
    • 84888204716 scopus 로고    scopus 로고
    • Nicotine and lung cancer
    • doi:10.4103/1477-3163.106680
    • Warren, G.W.; Singh, A.K. Nicotine and lung cancer. J. Carcinog. 2013, doi:10.4103/1477-3163.106680.
    • (2013) J. Carcinog
    • Warren, G.W.1    Singh, A.K.2
  • 9
    • 0004012958 scopus 로고
    • Oxford Press: New York, NY, USA
    • Doll, R.; Peto, R. The Causes of Cancer; Oxford Press: New York, NY, USA, 1981; pp. 1-144.
    • (1981) The Causes of Cancer , pp. 1-144
    • Doll, R.1    Peto, R.2
  • 10
    • 0003937964 scopus 로고
    • US Department of Health and Human Services, A Report of the Surgeon General; Centers for Disease Control and Prevention: Atlanta, GA, USA
    • US Department of Health and Human Services. Reducing the Health Consequences of Smoking: 25 Years of Progress. A Report of the Surgeon General; Centers for Disease Control and Prevention: Atlanta, GA, USA, 1989.
    • (1989) Reducing the Health Consequences of Smoking: 25 Years of Progress
  • 12
    • 79952213804 scopus 로고    scopus 로고
    • US Department of Health and Human Services, A Report of the Surgeon General; Centers for Disease Control and Prevention: Atlanta, GA, USA
    • US Department of Health and Human Services. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-attributable Disease. A Report of the Surgeon General; Centers for Disease Control and Prevention: Atlanta, GA, USA; 2010.
    • (2010) How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis For Smoking-attributable Disease
  • 13
    • 38949106034 scopus 로고    scopus 로고
    • Smokeless tobacco and some tobacco-specific N-nitrosamines
    • International Agency for Research on Cancer
    • International Agency for Research on Cancer. Smokeless tobacco and some tobacco-specific N-nitrosamines. IARC Monogr. Eval. Carcinog. Risks Hum. 2007, 89, 419-548.
    • (2007) IARC Monogr. Eval. Carcinog. Risks Hum , vol.89 , pp. 419-548
  • 14
    • 73649112422 scopus 로고    scopus 로고
    • Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta-and JNK1-dependent inflammation
    • Takahashi, H.; Ogata, H.; Nishigaki, R.; Broide, D.H.; Karin, M. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta-and JNK1-dependent inflammation. Cancer Cell 2010, 17, 89-97.
    • (2010) Cancer Cell , vol.17 , pp. 89-97
    • Takahashi, H.1    Ogata, H.2    Nishigaki, R.3    Broide, D.H.4    Karin, M.5
  • 15
    • 84901196647 scopus 로고    scopus 로고
    • Available online, accessed on 15 November 2013
    • International Union Against Cancer, 2007. Available online: http://www.deathsfromsmoking.net/ (accessed on 15 November 2013).
    • International Union Against Cancer, 2007
  • 16
    • 13744254796 scopus 로고    scopus 로고
    • Betel-quid and areca-nut chewing and some arece-nut-derived nitrosamines
    • International Agency for Research on Cancer
    • International Agency for Research on Cancer. Betel-quid and areca-nut chewing and some arece-nut-derived nitrosamines. IARC Monogr. Eval. Carcinog. Risks Hum. 2004, 85, 44-300.
    • (2004) IARC Monogr. Eval. Carcinog. Risks Hum , vol.85 , pp. 44-300
  • 18
    • 20144369093 scopus 로고    scopus 로고
    • Tobacco smoke and involuntary smoking
    • International Agency for Research on Cancer
    • International Agency for Research on Cancer. Tobacco smoke and involuntary smoking. IARC Monogr. Eval. Carcinog. Risks Hum. 2004, 83, 1-1438.
    • (2004) IARC Monogr. Eval. Carcinog. Risks Hum , vol.83 , pp. 1-1438
  • 19
    • 59849088241 scopus 로고    scopus 로고
    • Alphabetical component index
    • Rodgman, A., Perfetti, T.A., Eds.; CRC Press: Boca Raton, FL, USA
    • Rodgman, A.; Perfetti, T.A. Alphabetical component index. In The Chemical Components of Tobacco and Tobacco Smoke; Rodgman, A., Perfetti, T.A., Eds.; CRC Press: Boca Raton, FL, USA, 2009; pp. 1483-1784.
    • (2009) The Chemical Components of Tobacco and Tobacco Smoke , pp. 1483-1784
    • Rodgman, A.1    Perfetti, T.A.2
  • 20
    • 20344372167 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of nicotine
    • Tutka, P.; Mosiewicz, J.; Wielosz, M. Pharmacokinetics and metabolism of nicotine. Pharmacol. Rev. 2005, 57,143-153.
    • (2005) Pharmacol. Rev , vol.57 , pp. 143-153
    • Tutka, P.1    Mosiewicz, J.2    Wielosz, M.3
  • 21
    • 0022127404 scopus 로고
    • Tobacco habits other than smoking: Betel quid and Areca nut chewing and some related nitrosamines
    • International Agency for Research on Cancer
    • International Agency for Research on Cancer. Tobacco habits other than smoking: Betel quid and Areca nut chewing and some related nitrosamines. IARC Monogr. Eval. Carcinog. Risks Hum. 1985, 37, 37-202.
    • (1985) IARC Monogr. Eval. Carcinog. Risks Hum , vol.37 , pp. 37-202
  • 22
    • 71349086684 scopus 로고    scopus 로고
    • Smoking and aggressive prostate cancer: A review of the epidemiologic evidence
    • Zu, K.; Giovannucci, E. Smoking and aggressive prostate cancer: A review of the epidemiologic evidence. Cancer Causes Control 2009, 20, 1799-1810.
    • (2009) Cancer Causes Control , vol.20 , pp. 1799-1810
    • Zu, K.1    Giovannucci, E.2
  • 23
    • 0038032435 scopus 로고    scopus 로고
    • US Department of Health and Human Services, 12th ed.; US Department of Health and Human Services, Public Health Service, National Toxicology Program: Research Triangle Park, NC, USA
    • US Department of Health and Human Services. Report on Carcinogens, 12th ed.; US Department of Health and Human Services, Public Health Service, National Toxicology Program: Research Triangle Park, NC, USA, 2011.
    • (2011) Report On Carcinogens
  • 24
    • 33747741256 scopus 로고    scopus 로고
    • US Department of Health and Human Services, A Report of the Surgeon General; US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health: Atlanta, GA, USA
    • US Department of Health and Human Services. The Health Consequences of Involuntary Exposure to Tobacco Smoke. A Report of the Surgeon General; US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health: Atlanta, GA, USA, 2006.
    • (2006) The Health Consequences of Involuntary Exposure to Tobacco Smoke
  • 25
    • 0003424963 scopus 로고    scopus 로고
    • National Cancer Institutes, n Smoking and Tobacco Control Monograph; National Cancer Institute: Bethesda, MD, USA
    • National Cancer Institutes. Health effects of exposure to environmental tobacco smoke. In Smoking and Tobacco Control Monograph; National Cancer Institute: Bethesda, MD, USA, 1999; Volume 10.
    • (1999) Health Effects of Exposure to Environmental Tobacco Smoke , vol.10
  • 26
    • 84858940957 scopus 로고    scopus 로고
    • National Cancer Institute, National Cancer Institute, NIH, DHHS: Bethesda, MD, USA
    • National Cancer Institute. Cancer Progress Report-2003 Update; National Cancer Institute, NIH, DHHS: Bethesda, MD, USA, 2004.
    • (2004) Cancer Progress Report-2003 Update
  • 27
    • 84901245030 scopus 로고    scopus 로고
    • National Cancer Institute, FactSheet. Available online, accessed on 22 March
    • National Cancer Institute. Smokeless Tobacco and Cancer. FactSheet. Available online: http://www.cancer.gov/cancertopics/factsheet/Tobacco/smokeless/ (accessed on 22 March 2014).
    • (2014) Smokeless Tobacco and Cancer
  • 30
    • 0032874041 scopus 로고    scopus 로고
    • Smokeless tobacco cessation
    • Severson, H.H.; Hatsukami, D. Smokeless tobacco cessation. Prim. Care 1999, 26, 529-551.
    • (1999) Prim. Care , vol.26 , pp. 529-551
    • Severson, H.H.1    Hatsukami, D.2
  • 31
    • 0034917171 scopus 로고    scopus 로고
    • The less harmful cigarette: A controversial issue: A tribute to Ernst L. Wynder
    • Hoffmann, D.; Hoffmann, I.; El-Bayoumy, K. The less harmful cigarette: A controversial issue: A tribute to Ernst L. Wynder. Chem. Res. Toxicol. 2001, 14, 767-790.
    • (2001) Chem. Res. Toxicol , vol.14 , pp. 767-790
    • Hoffmann, D.1    Hoffmann, I.2    El-Bayoumy, K.3
  • 32
    • 0037152628 scopus 로고    scopus 로고
    • Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
    • Pfeifer, G.P.; Denissenko, M.F.; Olivier, M.; Tretyakova, N.; Hecht, S.S.; Hainaut, P. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene 2002, 21, 7435-7451.
    • (2002) Oncogene , vol.21 , pp. 7435-7451
    • Pfeifer, G.P.1    Denissenko, M.F.2    Olivier, M.3    Tretyakova, N.4    Hecht, S.S.5    Hainaut, P.6
  • 33
    • 70350539591 scopus 로고    scopus 로고
    • Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products
    • Stepanov, I.; Carmella, S.G.; Briggs, A.; Hertsgaard, L.; Lindgren, B.; Hatsukami, D.; Hecht, S.S. Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. Cancer Res. 2009, 69, 8236-8240.
    • (2009) Cancer Res , vol.69 , pp. 8236-8240
    • Stepanov, I.1    Carmella, S.G.2    Briggs, A.3    Hertsgaard, L.4    Lindgren, B.5    Hatsukami, D.6    Hecht, S.S.7
  • 34
    • 0031831381 scopus 로고    scopus 로고
    • Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines
    • Hecht, S.S. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem. Res. Toxicol. 1998, 11, 559-603.
    • (1998) Chem. Res. Toxicol , vol.11 , pp. 559-603
    • Hecht, S.S.1
  • 35
    • 0021998299 scopus 로고
    • Nicotine-derived N-nitrosamines and tobacco-related cancer: Current status and future directions
    • Hoffmann, D.; Hecht, S.S. Nicotine-derived N-nitrosamines and tobacco-related cancer: Current status and future directions. Cancer Res. 1985, 45, 935-944.
    • (1985) Cancer Res , vol.45 , pp. 935-944
    • Hoffmann, D.1    Hecht, S.S.2
  • 36
    • 0033535375 scopus 로고    scopus 로고
    • DNA adduct formation from tobacco-specific N-nitrosamines
    • Hecht, S.S. DNA adduct formation from tobacco-specific N-nitrosamines. Mutat. Res. 1999, 424, 127-142.
    • (1999) Mutat. Res , vol.424 , pp. 127-142
    • Hecht, S.S.1
  • 37
    • 0023898409 scopus 로고
    • Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
    • Hecht, S.S.; Hoffmann, D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 1988, 9, 875-884.
    • (1988) Carcinogenesis , vol.9 , pp. 875-884
    • Hecht, S.S.1    Hoffmann, D.2
  • 38
    • 0028177696 scopus 로고
    • Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans
    • Hoffmann, D.; Brunnemann, K.D.; Prokopczyk, B.; Djordjevic, M.V. Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans. J. Toxicol. Environ. Health 1994, 41, 1-52.
    • (1994) J. Toxicol. Environ. Health , vol.41 , pp. 1-52
    • Hoffmann, D.1    Brunnemann, K.D.2    Prokopczyk, B.3    Djordjevic, M.V.4
  • 39
    • 21144433997 scopus 로고    scopus 로고
    • Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Sturla, S.J.; Scott, J.; Lao, Y.; Hecht, S.S.; Villalta, P.W. Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chem. Res. Toxicol. 2005, 18, 1048-1055.
    • (2005) Chem. Res. Toxicol , vol.18 , pp. 1048-1055
    • Sturla, S.J.1    Scott, J.2    Lao, Y.3    Hecht, S.S.4    Villalta, P.W.5
  • 40
    • 33644874090 scopus 로고    scopus 로고
    • EPHX1 polymorphisms and the risk of lung cancer: A HuGE review
    • Kiyohara, C.; Yoshimasu, K.; Takayama, K.; Nakanishi, Y. EPHX1 polymorphisms and the risk of lung cancer: A HuGE review. Epidemiology 2006, 17, 89-99.
    • (2006) Epidemiology , vol.17 , pp. 89-99
    • Kiyohara, C.1    Yoshimasu, K.2    Takayama, K.3    Nakanishi, Y.4
  • 41
  • 42
    • 2942536030 scopus 로고    scopus 로고
    • Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Singapore Chinese
    • Hecht, S.S.; Carmella, S.G.; Kenney, P.M.; Low, S.H., Arakawa, K.; Yu, M.C. Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Singapore Chinese. Cancer Epidemiol. Biomark. Prev. 2004, 13, 997-1004.
    • (2004) Cancer Epidemiol. Biomark. Prev , vol.13 , pp. 997-1004
    • Hecht, S.S.1    Carmella, S.G.2    Kenney, P.M.3    Low, S.H.4    Arakawa, K.5    Yu, M.C.6
  • 43
    • 0010490441 scopus 로고
    • Induction of Pulmonary tumors in mice by nitrosonornicotine, a possible constituent of tobacco smoke
    • Boyland, E.; Roe, F.J.; Gorrod, J.W. Induction of Pulmonary tumors in mice by nitrosonornicotine, a possible constituent of tobacco smoke. Nature 1964, 202, 1126.
    • (1964) Nature , vol.202 , pp. 1126
    • Boyland, E.1    Roe, F.J.2    Gorrod, J.W.3
  • 44
    • 0029021796 scopus 로고
    • Glucuronidation of 4-((hydroxymethyl) nitrosamino)-1-(3-pyridyl)-1-butanone, a metabolically activated form of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, by phenobarbital-treated rats
    • Murphy, S.E.; Spina, D.A.; Nunes, M.G.; Pullo, D.A. Glucuronidation of 4-((hydroxymethyl) nitrosamino)-1-(3-pyridyl)-1-butanone, a metabolically activated form of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, by phenobarbital-treated rats. Chem. Res. Toxicol. 1995, 8, 772-779.
    • (1995) Chem. Res. Toxicol , vol.8 , pp. 772-779
    • Murphy, S.E.1    Spina, D.A.2    Nunes, M.G.3    Pullo, D.A.4
  • 45
    • 79955122770 scopus 로고    scopus 로고
    • Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines
    • doi:10.4061/2010/284935
    • Peterson, L.A. Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines. J. Nucleic. Acids 2010, doi:10.4061/2010/284935.
    • (2010) J. Nucleic. Acids
    • Peterson, L.A.1
  • 46
    • 0029974367 scopus 로고    scopus 로고
    • The identification of 11 beta-hydroxysteroid dehydrogenase as carbonyl reductase of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Maser, E.; Richter, E.; Friebertshauser, J. The identification of 11 beta-hydroxysteroid dehydrogenase as carbonyl reductase of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Eur. J. Biochem.1996, 238, 484-489.
    • (1996) Eur. J. Biochem , vol.238 , pp. 484-489
    • Maser, E.1    Richter, E.2    Friebertshauser, J.3
  • 47
    • 12144265866 scopus 로고    scopus 로고
    • Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine
    • Wong, H.L.; Murphy, S.E.; Hecht, S.S. Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 2005, 18, 61-79.
    • (2005) Chem. Res. Toxicol , vol.18 , pp. 61-79
    • Wong, H.L.1    Murphy, S.E.2    Hecht, S.S.3
  • 48
    • 0033790325 scopus 로고    scopus 로고
    • Specificity of cytochrome P450 2A3-catalyzed alpha-hydroxylation of N′-nitrosonornicotine enantiomers
    • Murphy, S.E.; Isaac, I.S.; Ding, X.; McIntee, E.J. Specificity of cytochrome P450 2A3-catalyzed alpha-hydroxylation of N′-nitrosonornicotine enantiomers. Drug Metab. Dispos. 2000, 28, 1263-1266.
    • (2000) Drug Metab. Dispos , vol.28 , pp. 1263-1266
    • Murphy, S.E.1    Isaac, I.S.2    Ding, X.3    McIntee, E.J.4
  • 49
    • 80052426180 scopus 로고    scopus 로고
    • Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers
    • Yuan, J.M.; Knezevich, A.D.; Wang, R.; Gao, Y.T.; Hecht, S.S.; Stepanov, I. Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. Carcinogenesis 2011, 32, 1366-1371.
    • (2011) Carcinogenesis , vol.32 , pp. 1366-1371
    • Yuan, J.M.1    Knezevich, A.D.2    Wang, R.3    Gao, Y.T.4    Hecht, S.S.5    Stepanov, I.6
  • 50
    • 0031419535 scopus 로고    scopus 로고
    • Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes
    • Patten, C.J.; Smith, T.J.; Friesen, M.J.; Tynes, R.E.; Yang, C.S.; Murphy, S.E. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes. Carcinogenesis 1997, 18, 1623-1630.
    • (1997) Carcinogenesis , vol.18 , pp. 1623-1630
    • Patten, C.J.1    Smith, T.J.2    Friesen, M.J.3    Tynes, R.E.4    Yang, C.S.5    Murphy, S.E.6
  • 51
    • 0029846345 scopus 로고    scopus 로고
    • Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen
    • Jansen, J.G.; de Groot, A.J.; van Teijlingen, C.M.; Tates, A.D.; Vrieling, H.; van Zeeland, A.A. Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen. Carcinogenesis 1996, 17, 2183-2191.
    • (1996) Carcinogenesis , vol.17 , pp. 2183-2191
    • Jansen, J.G.1    de Groot, A.J.2    van Teijlingen, C.M.3    Tates, A.D.4    Vrieling, H.5    van Zeeland, A.A.6
  • 52
    • 0036856459 scopus 로고    scopus 로고
    • Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine
    • Margison, G.P.; Santibanez Koref, M.F.; Povey, A.C. Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine. Mutagenesis 2002, 17, 483-487.
    • (2002) Mutagenesis , vol.17 , pp. 483-487
    • Margison, G.P.1    Santibanez, K.M.F.2    Povey, A.C.3
  • 55
    • 0026454595 scopus 로고
    • Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Liu, L.; Castonguay, A.; Gerson, S.L. Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 1992, 13, 2137-2140.
    • (1992) Carcinogenesis , vol.13 , pp. 2137-2140
    • Liu, L.1    Castonguay, A.2    Gerson, S.L.3
  • 56
    • 0030612110 scopus 로고    scopus 로고
    • Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase
    • Wang, L.; Spratt, T.E.; Liu, X.K.; Hecht, S.S.; Pegg, A.E.; Peterson, L.A. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase. Chem. Res. Toxicol. 1997, 10, 562-567.
    • (1997) Chem. Res. Toxicol , vol.10 , pp. 562-567
    • Wang, L.1    Spratt, T.E.2    Liu, X.K.3    Hecht, S.S.4    Pegg, A.E.5    Peterson, L.A.6
  • 57
    • 0037256361 scopus 로고    scopus 로고
    • The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice
    • Thomson, N.M.; Kenney, P.M.; Peterson, L.A. The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice. Chem. Res. Toxicol. 2003, 16, 1-6.
    • (2003) Chem. Res. Toxicol , vol.16 , pp. 1-6
    • Thomson, N.M.1    Kenney, P.M.2    Peterson, L.A.3
  • 58
    • 0036174214 scopus 로고    scopus 로고
    • Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells
    • Pauly, G.T.; Peterson, L.A.; Moschel, R.C. Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells. Chem. Res. Toxicol. 2002, 15, 165-169.
    • (2002) Chem. Res. Toxicol , vol.15 , pp. 165-169
    • Pauly, G.T.1    Peterson, L.A.2    Moschel, R.C.3
  • 59
    • 38149049320 scopus 로고    scopus 로고
    • Repair of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair
    • Brown, P.J.; Bedard, L.L.; Massey, T.E. Repair of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair. Cancer Lett. 2008, 260, 48-55.
    • (2008) Cancer Lett , vol.260 , pp. 48-55
    • Brown, P.J.1    Bedard, L.L.2    Massey, T.E.3
  • 60
  • 61
    • 15944381621 scopus 로고    scopus 로고
    • Protein-protein interactions and posttranslational modifications in mammalian base excision repair
    • Fan, J.; Wilson, D.M. Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic. Biol. Med. 2005, 38, 1121-1138.
    • (2005) Free Radic. Biol. Med , vol.38 , pp. 1121-1138
    • Fan, J.1    Wilson, D.M.2
  • 62
    • 0032716382 scopus 로고    scopus 로고
    • Nucleotide excision repair: From E. coli to man
    • Petit, C.; Sancar, A. Nucleotide excision repair: From E. coli to man. Biochimie 1999, 81, 15-25.
    • (1999) Biochimie , vol.81 , pp. 15-25
    • Petit, C.1    Sancar, A.2
  • 63
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar, A.; Lindsey-Boltz, L.A.; Unsal-Kacmaz, K.; Linn, S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 2004, 73, 39-85.
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 64
    • 0020394578 scopus 로고
    • Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions
    • Thompson, L.H.; Brookman, K.W.; Dillehay, L.E.; Mooney, C.L.; Carrano, A.V. Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions. Somatic Cell Genet. 1982, 8, 759-573.
    • (1982) Somatic Cell Genet , vol.8 , pp. 759-773
    • Thompson, L.H.1    Brookman, K.W.2    Dillehay, L.E.3    Mooney, C.L.4    Carrano, A.V.5
  • 65
    • 0033591845 scopus 로고    scopus 로고
    • Tobacco smoke carcinogens and lung cancer
    • Hecht, S.S. Tobacco smoke carcinogens and lung cancer. J. Natl. Cancer Inst. 1999, 91, 1194-1210.
    • (1999) J. Natl. Cancer Inst , vol.91 , pp. 1194-1210
    • Hecht, S.S.1
  • 66
    • 0034676239 scopus 로고    scopus 로고
    • The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK
    • Abdel-Rahman, S.Z.; El-Zein, R.A. The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK. Cancer Lett. 2000, 159, 63-71.
    • (2000) Cancer Lett , vol.159 , pp. 63-71
    • Abdel-Rahman, S.Z.1    El-Zein, R.A.2
  • 67
    • 3242772932 scopus 로고    scopus 로고
    • Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK
    • Affatato, A.A.; Wolfe, K.J.; Lopez, M.S.; Hallberg, C.; Ammenheuser, M.M.; Abdel-Rahman, S.Z. Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. Environ. Mol. Mutagen 2004, 44, 65-73.
    • (2004) Environ. Mol. Mutagen , vol.44 , pp. 65-73
    • Affatato, A.A.1    Wolfe, K.J.2    Lopez, M.S.3    Hallberg, C.4    Ammenheuser, M.M.5    Abdel-Rahman, S.Z.6
  • 68
    • 84874041648 scopus 로고    scopus 로고
    • Oxidative stress and HPV carcinogenesis
    • De Marco, F. Oxidative stress and HPV carcinogenesis. Viruses 2013, 5, 708-731.
    • (2013) Viruses , vol.5 , pp. 708-731
    • de Marco, F.1
  • 70
    • 0031748203 scopus 로고    scopus 로고
    • Fractionation of aqueous cigarette tar extracts: Fractions that contain the tar radical cause DNA damage
    • Pryor, W.A.; Stone, K.; Zang, L.Y.; Bermudez, E. Fractionation of aqueous cigarette tar extracts: Fractions that contain the tar radical cause DNA damage. Chem. Res. Toxicol. 1998, 11, 441-448.
    • (1998) Chem. Res. Toxicol , vol.11 , pp. 441-448
    • Pryor, W.A.1    Stone, K.2    Zang, L.Y.3    Bermudez, E.4
  • 71
    • 0031688975 scopus 로고    scopus 로고
    • Elevated 8-hydroxy-2'-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylene-bis(methylene)selenocyanate
    • Rosa, J.G.; Prokopczyk, B.; Desai, D.H.; Amin, S.G.; El-Bayoumy, K. Elevated 8-hydroxy-2'-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylene-bis(methylene)selenocyanate. Carcinogenesis 1998, 19, 1783-1788.
    • (1998) Carcinogenesis , vol.19 , pp. 1783-1788
    • Rosa, J.G.1    Prokopczyk, B.2    Desai, D.H.3    Amin, S.G.4    El-Bayoumy, K.5
  • 72
    • 0026735007 scopus 로고
    • Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone
    • Chung, F.L.; Xu, Y. Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone. Carcinogenesis 1992, 13, 1269-1272.
    • (1992) Carcinogenesis , vol.13 , pp. 1269-1272
    • Chung, F.L.1    Xu, Y.2
  • 73
    • 0028891693 scopus 로고
    • Effects of nonsteroidal anti-inflammatory drugs on oxidative pathways in A/J mice
    • Bilodeau, J.F.; Wang, M.; Chung, F.L.; Castonguay, A. Effects of nonsteroidal anti-inflammatory drugs on oxidative pathways in A/J mice. Free Radic. Biol. Med. 1995, 18, 47-54.
    • (1995) Free Radic. Biol. Med , vol.18 , pp. 47-54
    • Bilodeau, J.F.1    Wang, M.2    Chung, F.L.3    Castonguay, A.4
  • 74
    • 0035237613 scopus 로고    scopus 로고
    • Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA
    • Nishimura, S. Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA. Progr. Nucleic Acid Res. Mol. Biol. 2001, 68, 107-123.
    • (2001) Progr. Nucleic Acid Res. Mol. Biol , vol.68 , pp. 107-123
    • Nishimura, S.1
  • 75
    • 0036569713 scopus 로고    scopus 로고
    • Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA
    • Nishimura, S. Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA. Free Radic Biol. Med. 2002, 32, 813-821.
    • (2002) Free Radic Biol. Med , vol.32 , pp. 813-821
    • Nishimura, S.1
  • 76
    • 84886875955 scopus 로고    scopus 로고
    • Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells
    • Lee, J.W.; Kim, J.H. Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells. J. Biol. Chem. 2013, 288, 30054-30063.
    • (2013) J. Biol. Chem , vol.288 , pp. 30054-30063
    • Lee, J.W.1    Kim, J.H.2
  • 77
    • 0025884565 scopus 로고
    • Functional architecture of the nicotinic acetylcholine receptor: From electric organ to brain
    • Galzi, J.L.; Revah, F.; Bessis, A.; Changeux, J.P. Functional architecture of the nicotinic acetylcholine receptor: From electric organ to brain. Annu. Rev. Pharmacol. Toxicol. 1991, 31, 37-72.
    • (1991) Annu. Rev. Pharmacol. Toxicol , vol.31 , pp. 37-72
    • Galzi, J.L.1    Revah, F.2    Bessis, A.3    Changeux, J.P.4
  • 78
    • 0029690580 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors
    • Lindstrom, J. Neuronal nicotinic acetylcholine receptors. Ion Channels 1996, 4, 377-450.
    • (1996) Ion Channels , vol.4 , pp. 377-450
    • Lindstrom, J.1
  • 80
    • 79959222735 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor signaling in tumor growth and metastasis
    • doi: 10.1155/2011/456743
    • Singh, S.; Pillai, S.; Chellappan, S. Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. J. Oncol. 2011, doi: 10.1155/2011/456743.
    • (2011) J. Oncol
    • Singh, S.1    Pillai, S.2    Chellappan, S.3
  • 81
    • 60749101452 scopus 로고    scopus 로고
    • Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
    • Schuller, H.M. Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat. Rev. Cancer 2009, 9, 195-205.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 195-205
    • Schuller, H.M.1
  • 82
    • 0032499397 scopus 로고    scopus 로고
    • Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells
    • Schuller, H.M.; Orloff, M. Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells. Biochem. Pharmacol. 1998, 55, 1377-1384.
    • (1998) Biochem. Pharmacol , vol.55 , pp. 1377-1384
    • Schuller, H.M.1    Orloff, M.2
  • 83
    • 33646800564 scopus 로고    scopus 로고
    • Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    • Arredondo, J.; Chernyavsky, A.I.; Grando, S.A. Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells. Cancer Biol. Ther. 2006, 5, 511-517.
    • (2006) Cancer Biol. Ther , vol.5 , pp. 511-517
    • Arredondo, J.1    Chernyavsky, A.I.2    Grando, S.A.3
  • 84
    • 24344492234 scopus 로고    scopus 로고
    • Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells
    • Plummer, H.K.; Dhar, M.; Schuller, H.M. Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. Respir. Res. 2005, 6, 29.
    • (2005) Respir. Res , vol.6 , pp. 29
    • Plummer, H.K.1    Dhar, M.2    Schuller, H.M.3
  • 86
    • 49449094458 scopus 로고    scopus 로고
    • Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans
    • Wessler, I.; Kirkpatrick, C.J. Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans. Br. J. Pharmacol. 2008, 154, 1558-1571.
    • (2008) Br. J. Pharmacol , vol.154 , pp. 1558-1571
    • Wessler, I.1    Kirkpatrick, C.J.2
  • 87
    • 34548664396 scopus 로고    scopus 로고
    • Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells
    • Arredondo, J.; Chernyavsky, A.I.; Grando, S.A. Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. Biochem. Pharmacol. 2007, 74, 1315-1359.
    • (2007) Biochem. Pharmacol , vol.74 , pp. 1315-1359
    • Arredondo, J.1    Chernyavsky, A.I.2    Grando, S.A.3
  • 88
    • 0034146188 scopus 로고    scopus 로고
    • Activation of voltage-operated Ca2+-channels in human small cell lung carcinoma by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Sheppard, B.J.; Williams, M.; Plummer, H.K.; Schuller, H.M. Activation of voltage-operated Ca2+-channels in human small cell lung carcinoma by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Int. J. Oncol. 2000, 16, 513-518.
    • (2000) Int. J. Oncol , vol.16 , pp. 513-518
    • Sheppard, B.J.1    Williams, M.2    Plummer, H.K.3    Schuller, H.M.4
  • 89
    • 0035170498 scopus 로고    scopus 로고
    • Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of C-MYC in human small cell lung carcinoma cells and pulmonary neuroendocrine cells
    • Jull, B.A.; Plummer, H.K.; Schuller, H.M. Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of C-MYC in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. J. Cancer Res. Clin. Oncol. 2001, 127, 707-717.
    • (2001) J. Cancer Res. Clin. Oncol , vol.127 , pp. 707-717
    • Jull, B.A.1    Plummer, H.K.2    Schuller, H.M.3
  • 90
    • 0027442825 scopus 로고
    • Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma
    • Cattaneo, M.G.; Codignola, A.; Vicentini, L.M.; Clementi, F.; Sher, E. Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma. Cancer Res. 1993, 53, 5566-5568.
    • (1993) Cancer Res , vol.53 , pp. 5566-5568
    • Cattaneo, M.G.1    Codignola, A.2    Vicentini, L.M.3    Clementi, F.4    Sher, E.5
  • 91
    • 4544305469 scopus 로고    scopus 로고
    • Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and C-MYC through phosphorylation in regulating cell survival and proliferation
    • Jin, Z.; Gao, F.; Flagg, T.; Deng, X. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and C-MYC through phosphorylation in regulating cell survival and proliferation. J. Biol. Chem. 2004, 279, 40209-40219.
    • (2004) J. Biol. Chem , vol.279 , pp. 40209-40219
    • Jin, Z.1    Gao, F.2    Flagg, T.3    Deng, X.4
  • 92
    • 84893235639 scopus 로고    scopus 로고
    • US Department of Health and Human Services, US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health: Atlanta, GA, USA
    • US Department of Health and Human Services. The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General; US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health: Atlanta, GA, USA, 2014.
    • (2014) The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General
  • 93
    • 33846215065 scopus 로고    scopus 로고
    • Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers
    • Purdue, M.P.; Gold, L.; Jarvholm, B.; Alavanja, M.C.; Ward, M.H.; Vermeulen, R. Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers. Thorax 2007, 62, 51-56.
    • (2007) Thorax , vol.62 , pp. 51-56
    • Purdue, M.P.1    Gold, L.2    Jarvholm, B.3    Alavanja, M.C.4    Ward, M.H.5    Vermeulen, R.6
  • 94
    • 2342573099 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Definition and epidemiology
    • Mannino, D.M. Chronic obstructive pulmonary disease: Definition and epidemiology. Respir. Care 2003, 48, 1185-1191.
    • (2003) Respir. Care , vol.48 , pp. 1185-1191
    • Mannino, D.M.1
  • 95
    • 34447289205 scopus 로고    scopus 로고
    • The non-neuronal cholinergic system in the airways: An unappreciated regulatory role in pulmonary inflammation?
    • Gwilt, C.R.; Donnelly, L.E.; Rogers, D.F. The non-neuronal cholinergic system in the airways: An unappreciated regulatory role in pulmonary inflammation? Pharmacol. Ther. 2007, 115, 208-222.
    • (2007) Pharmacol. Ther , vol.115 , pp. 208-222
    • Gwilt, C.R.1    Donnelly, L.E.2    Rogers, D.F.3
  • 96
    • 0028588676 scopus 로고
    • Carbon dioxide potentiates the mitogenic effects of nicotine and its carcinogenic derivative, NNK, in normal and neoplastic neuroendocrine lung cells via stimulation of autocrine and protein kinase C-dependent mitogenic pathways
    • Schuller, H.M. Carbon dioxide potentiates the mitogenic effects of nicotine and its carcinogenic derivative, NNK, in normal and neoplastic neuroendocrine lung cells via stimulation of autocrine and protein kinase C-dependent mitogenic pathways. Neurotoxicology 1994, 15, 877-886.
    • (1994) Neurotoxicology , vol.15 , pp. 877-886
    • Schuller, H.M.1
  • 97
    • 34249284421 scopus 로고    scopus 로고
    • Nitrosamines as nicotinic receptor ligands
    • Schuller, H.M. Nitrosamines as nicotinic receptor ligands. Life Sci. 2007, 80, 2274-2280.
    • (2007) Life Sci , vol.80 , pp. 2274-2280
    • Schuller, H.M.1
  • 98
    • 51049114513 scopus 로고    scopus 로고
    • Neurotransmission and cancer: Implications for prevention and therapy
    • Schuller, H.M. Neurotransmission and cancer: Implications for prevention and therapy. Anticancer Drugs 2008, 19, 655-671.
    • (2008) Anticancer Drugs , vol.19 , pp. 655-671
    • Schuller, H.M.1
  • 99
    • 0033568544 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid
    • Schuller, H.M.; Tithof, P.K.; Williams, M.; Plummer, H. The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res. 1999, 59, 4510-4515.
    • (1999) Cancer Res , vol.59 , pp. 4510-4515
    • Schuller, H.M.1    Tithof, P.K.2    Williams, M.3    Plummer, H.4
  • 100
    • 0033784638 scopus 로고    scopus 로고
    • Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    • Schuller, H.M.; Porter, B.; Riechert, A. Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J. Cancer Res. Clin. Oncol. 2000, 126, 624-630.
    • (2000) J. Cancer Res. Clin. Oncol , vol.126 , pp. 624-630
    • Schuller, H.M.1    Porter, B.2    Riechert, A.3
  • 101
    • 34547700771 scopus 로고    scopus 로고
    • PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast
    • Boswell-Smith, V.; Spina, D. PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast. Int. J. Chron. Obstruct. Pulmon. Dis. 2007, 2, 121-129.
    • (2007) Int. J. Chron. Obstruct. Pulmon. Dis , vol.2 , pp. 121-129
    • Boswell-Smith, V.1    Spina, D.2
  • 105
    • 33646598093 scopus 로고    scopus 로고
    • Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin
    • Dasgupta, P.; Kinkade, R.; Joshi, B.; Decook, C.; Haura, E.; Chellappan, S. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc. Natl. Acad. Sci. USA 2006, 103, 6332-6337.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6332-6337
    • Dasgupta, P.1    Kinkade, R.2    Joshi, B.3    Decook, C.4    Haura, E.5    Chellappan, S.6
  • 106
    • 33746672599 scopus 로고    scopus 로고
    • Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways
    • Dasgupta, P.; Rastogi, S.; Pillai, S.; Ordonez-Ercan, D.; Morris, M.; Haura, E.; Chellappan, S. Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J. Clin. Invest. 2006, 116, 2208-2217.
    • (2006) J. Clin. Invest , vol.116 , pp. 2208-2217
    • Dasgupta, P.1    Rastogi, S.2    Pillai, S.3    Ordonez-Ercan, D.4    Morris, M.5    Haura, E.6    Chellappan, S.7
  • 107
    • 33748184886 scopus 로고    scopus 로고
    • The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells
    • Arredondo, J.; Chernyavsky, A.I.; Grando, S.A. The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells. J. Cancer Res. Clin. Oncol. 2006, 32, 653-663.
    • (2006) J. Cancer Res. Clin. Oncol , vol.32 , pp. 653-663
    • Arredondo, J.1    Chernyavsky, A.I.2    Grando, S.A.3
  • 108
    • 33747450166 scopus 로고    scopus 로고
    • NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells
    • Laag, E.; Majidi, M.; Cekanova, M.; Masi, T.; Takahashi, T.; Schuller, H.M. NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int. J. Cancer 2006, 119, 1547-1552.
    • (2006) Int. J. Cancer , vol.119 , pp. 1547-1552
    • Laag, E.1    Majidi, M.2    Cekanova, M.3    Masi, T.4    Takahashi, T.5    Schuller, H.M.6
  • 109
    • 34547116879 scopus 로고    scopus 로고
    • Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells
    • Majidi, M.; Al-Wadei, H.A.; Takahashi, T.; Schuller, H.M. Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Res. 2007, 67, 6863-6871.
    • (2007) Cancer Res , vol.67 , pp. 6863-6871
    • Majidi, M.1    Al-Wadei, H.A.2    Takahashi, T.3    Schuller, H.M.4
  • 111
    • 0034801191 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure
    • Kawai, H.; Berg, D.K. Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. J. Neurochem. 2001, 78, 1367-1378.
    • (2001) J. Neurochem , vol.78 , pp. 1367-1378
    • Kawai, H.1    Berg, D.K.2
  • 112
    • 53349145473 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid, a potential umor suppressor for small airway-derived lung adenocarcinoma
    • Schuller, H.M.; Al-Wadei, H.A.; Majidi, M. Gamma-aminobutyric acid, a potential umor suppressor for small airway-derived lung adenocarcinoma. Carcinogenesis 2008, 29, 1979-1985.
    • (2008) Carcinogenesis , vol.29 , pp. 1979-1985
    • Schuller, H.M.1    Al-Wadei, H.A.2    Majidi, M.3
  • 113
    • 0141955258 scopus 로고    scopus 로고
    • Block by phytoestrogens of recombinant human neuronal nicotinic receptors
    • Nakazawa, K.; Ohno, Y. Block by phytoestrogens of recombinant human neuronal nicotinic receptors. J. Pharmacol. Sci. 2003, 93, 118-121.
    • (2003) J. Pharmacol. Sci , vol.93 , pp. 118-121
    • Nakazawa, K.1    Ohno, Y.2
  • 114
    • 11144227597 scopus 로고    scopus 로고
    • Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu-and m-calpain in association with increased secretion, cell migration, and invasion
    • Xu, L.; Deng, X. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu-and m-calpain in association with increased secretion, cell migration, and invasion. J. Biol. Chem. 2004, 279, 53683-53690.
    • (2004) J. Biol. Chem , vol.279 , pp. 53683-53690
    • Xu, L.1    Deng, X.2
  • 115
    • 33644507072 scopus 로고    scopus 로고
    • Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    • Sato, M.; Vaughan, M.B.; Girard, L.; Peyton, M.; Lee, W.; Shames, D.S.; Ramirez, R.D.; Sunaga, N.; Gazdar, A.F.; Shay, J.W. et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res. 2006, 66, 2116-2128.
    • (2006) Cancer Res , vol.66 , pp. 2116-2128
    • Sato, M.1    Vaughan, M.B.2    Girard, L.3    Peyton, M.4    Lee, W.5    Shames, D.S.6    Ramirez, R.D.7    Sunaga, N.8    Gazdar, A.F.9    Shay, J.W.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.