The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK

Cancer Letters

Volumn 159, Issue 1, 2000, Pages 63-71

  Abdel Rahman, Sherif Z ^a   El Zein, Randa A ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

4 (Methylnitrosamino) 1 (3 pyridyl) 1 butanone; Biomarkers; Cancer; Cytogenetic; DNA repair; Genetic susceptibility; Genotoxicity; Metabolism; Polymorphism; Sister chromatid exchanges; Smoking; XRCC1

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; BIOLOGICAL MARKER; NITROSAMINE;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD SAMPLING; CANCER SUSCEPTIBILITY; CIGARETTE SMOKING; DNA DAMAGE; DNA REPAIR; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; TOBACCO; XENOBIOTIC METABOLISM;

ADULT; ALLELES; CARCINOGENS; DNA; DNA REPAIR; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE FREQUENCY; GENOTYPE; GLUTAMINE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; NITROSAMINES; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SISTER CHROMATID EXCHANGE;

EID: 0034676239     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00532-2     Document Type: Article

References (46)