Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen

Carcinogenesis

Volumn 17, Issue 10, 1996, Pages 2183-2191

  Jansen, J G ^a   De Groot, A J L ^a,b   Van Teijlingen, C M M ^a   Tates, A D ^a   Vrieling, H ^a,b   Van Zeeland, A A ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b JA Cohen Institute Interuniversity Research Institute for Radiopathology and Radiation Protection   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 6 O METHYLGUANINE; 7 METHYLGUANINE; CARCINOGEN; COMPLEMENTARY DNA; DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METHYLNITROSOUREA; N ACETOXYMETHYL N METHYLNITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; ELECTROCHEMICAL DETECTION; GENE MUTATION; MALE; MUTAGEN TESTING; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPLEEN; T LYMPHOCYTE;

ALKYLATING AGENTS; ANIMALS; BONE MARROW; GUANINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LUNG; MALE; METHYLATION; MUTAGENICITY TESTS; MUTAGENS; POINT MUTATION; RATS; RATS, INBRED LEW; SPLEEN; T-LYMPHOCYTES;

EID: 0029846345     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.10.2183     Document Type: Article

References (60)

1. Belinsky, S.A., Devereux, T.R. and Anderson, M.W. (1990) Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines. Mutat. Res., 233, 105-116.
2. Hecht, S.S. and Hoffmann, D. (1988) Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis, 9, 875-884.
3. Hecht, S.S., Carmella, S.G., Foiles, P.G. and Murphy, S.E. (1994) Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosamines. Cancer Res., 54(Suppl.), 1912s-1917s.
4. Hecht, S. S., Trushin, N., Castonguay, A. and Riverson, A. (1986) Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine. Cancer Res., 46, 498-502.
5. Hecht, S.S., Spratt, T.E. and Trushin, N. (1988) Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine. Carcinogenesis, 9, 161-165.
6. Jiao, J., Zielenska, M., Anderson, M.W. and Glickman, B.W. (1991) Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli: IV. The tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone. Carcinogenesis, 12, 221-224.
7. Belinsky, S.A., Devereux, T.R., Maronpot, R.R., Stoner, G.D. and Anderson, M.W. (1989) Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res., 49, 5305-5311.
8. Chen, B., Liu, L., Castonguay, A., Maronpot, R.R., Anderson, M.W. and You, M. (1993) Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors. Carcinogenesis, 14, 1603-1608.
9. Oreffo, V.I.C., Lin, H.-W., Padmanabhan, R. and Witschi, H. (1993) K-ras and p53 point mutations in 4-(methylmtrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors. Carcinogenesis, 14, 451-455.
10. Ronai, Z.A., Gradia, S., Peterson, L.A. and Hecht, S.S. (1993) G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis, 14, 2419-2422.
11. 1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate. Carcinogenesis, 16, 2487-2492.
12. 6-methylguanine built into a unique site in a viral genome. Proc. Natl Acad. Sci. USA, 81, 6271-6275.
13. 4-methylthymine in Escherichia coli. Biochemistry, 30, 7027-7033.
14. 6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 50, 3772-3780.
15. Castonguay, A., Tharp, R. and Hecht, S.S. (1984) Kinetics of DNA methylation by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. In O'Neill, K., Miller, C.T., von Borstel, R.C., Long, J.E. and Bartsch, H. (eds). N-Nitroso Compounds: Occurence, Biological Effects and Relevance to Human Cancer, IARC Scientific Publications No. 57. Lyon, France, pp. 805-810.
16. Bianchini, F. and Wild, C.P. (1994) Comparison of 7-medG formation in white blood cells, liver and target organs in rats treated with methylating carcinogens. Cardnogenesis, 15, 1137-1141.
17. Aidoo, A., Lyn-Cook, L.E., Mittelstaed, R.A., Heflich, R.H. and Casciano, D.A. (1991) Induction of 6-thioguanine-resistant lymphocytes in Fischer F344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ. Mol. Mutagen., 17, 141-151.
18. Van Dam, F.J., Natarajan, A.T. and Tates, A.D. (1992) Use of a T-lymphocyte clonal assay for determining HPRT mutant frequencies in individual rats. Mutat. Res., 271, 231-242.
19. Jones, I.M., Burkhart-Schultz, K. and Carrano, A.V. (1985) A method to quantify spontaneous and in vivo induced 6-thioguanine-resistant mouse lymphocytes. Mutat. Res., 147, 97-105.
20. Albertini, R.J., Castle, K.L. and Borcherding, W.R. (1982) T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood. Proc. Natl Acad. Sci. USA, 79, 6617-6621.
21. Zimmer, D.M., Aaron, C.S., O'Neill, J.P. and Albertini, R.J. (1991) Enumeration of 6-thioguanine-resistant T-lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys). Environ. Mol. Mutagen., 18, 161-167.
22. Vrieling, H., Simons, J.W.I.M. and Van Zeeland, A.A. (1988) Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences. Mutat. Res., 198, 107-113.
23. 6-alkytguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N′-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts. Mutat. Res., 250, 397-409.
24. Zhang, L.-H. and Jenssen, D. (1991) Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene. Cardnogenesis, 12, 1903-1909.
25. Yang, J.-L., Hu, M.-C. and Wu, C.-W. (1991) Novel mutational spectrum induced by N-methyl-N′-nitro-N-nitrosoguanidine in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts. J. Mol. Biol., 221, 421-430.
26. 1-S and late S phase of diploid human fibroblasts. Cancer Res., 53, 2865-2873.
27. 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells. Cancer Res., 54, 3857-3863.
28. Jansen, J.G., Mohn, G.R., Vrieling, H., Van Teijlingen, C.M.M., Lohman, P.H.M. and Van Zeeland, A.A. (1994) Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Cancer Res., 54, 2478-2485.
29. 6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyetnyl)-N-nitrosourea, or N-ethyl-N-nitrosourea. Cancer Res., 55, 1875-1882.
30. Mitlelstaedt, R.A., Smith, B.A. and Heflich, R.H. (1995) Analysis of in vim mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes. Environ. Mol. Mutagen., 26, 261-269.
31. Kleihues, P., Doerjer, G., Keefer, L.K., Rice, J.M., Roller, P.P. and Hodgson, R.M. (1979) Correlation of DNA methylation by methyl(acetoxymethyl)nitrosamine with organ-specific carcinogenicity in rats. Cancer Res., 39, 5136-5140.
32. Druckrey, H., Preussmann, R., Ivankovic, S. and Schmähl, D. (1967) Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Zeitschrift für Krebsforschung, 69, 103-201.
33. Frei, J.V., Swenson, D.H., Warren, W. and Lawley, P.D. (1978) Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl ethanesulphonate in relation to induction of thymic lymphoma. Biochem. J., 174, 1031-1044.
34. Lijinski, W. (1984) Structure-activity relations in carcinogenesis by N-nitroso compounds. Tropics in Chemical Mutagenexis. Plenum Press, New York, Vol. 1, pp. 189-231.
35. 6-alkylguanine in DNA by electrochemical detection. Mutat. Res., 307, 61-66.
36. Jansen, J.G., De Groot, A.J.L., Van Teijlingen, C.M.M., Lohman, P.H.M., Mohn, G.R., Vrieling, H. and Van Zeeland, A.A. (1994) Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed in vivo to the monofunctional alkylating agents N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Mutat. Res., 307, 95-105.
37. Mohn, G.R., Kerklaan, P.R.M., Van Zeeland, A.A., Ellenberger, J., Baan, R.A., Lohman, P.H.M. and Pons, F.-W. (1984) Methodologies for the determination of various genetic effects in permeable strains of E.coli K-12 differing in DNA repair capacity. Quantification of DNA adduct formation, experiments with organ homogenates and hepatocytes, and animal-mediated assays. Mutat. Res., 125, 153-184.
38. Aidoo, A., Lyn-Cook, L.E., Heflich, R.H., Olusegun George, E. and Casciano, D.A. (1993) The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistam T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea. Mutat. Res., 298, 169-178.
39. Pool-Zobel, B.L., Klein, R.G., Liegibel, U.M., Kuchenmeister, F., Weber, S. and Schmezer, P. (1992) Systemic genotoxic effects of tobacco-related nitrosamines following oral and inhalational administration to Sprague-Dawley rats. Clin. Investig., 70, 299-306.
40. 6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis. Carcinogenesis, 16, 2381-2387.
41. Beranek, D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res., 231, 11-30.
42. Van Zeeland, A.A., De Groot, A.J.L. and Neuhauser-Klaus, A. (1990) DNA adduct formation in mouse testis by ethylating agents: a comparison with germ-cell mutagenesis. Mutat. Res., 231, 55-62.
43. 6-alkylguanine-DNA transferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis, 7, 745-749.
44. Smith, T.J., Guo, Z., Hong, J.-Y., Ning, S.M., Thomas, P.E. and Yang, C.S. (1992) Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in microsomes of rat lung and nasal mucosa. Carcinogenesis, 13, 1409-1414.
45. Gonzales, F.J. (1989) The molecular biology of cytochrome P450s. Pharmacol. Rev., 40, 243-288.
46. Caesar, R., Frank, N. and Wiessler, M. (1984) Stability of various alpha-esters of 1-(N-methyl-N-nitrosamino)-methanol in vitro and in vivo. Carcinogenesis, 5, 1231-1234.
47. Appel, K.E., Frank, N. and Wiessler, M. (1981) Metabolism of nitrosoacetoxymethylmethylamine in liver microsomes. Biochem. Pharmacol., 30, 2767-2772.
48. Swann, P.F. (1968) The rate of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the rat. Biochem. J., 110, 49-52.
49. Likhachev, A.J., Ohshima, H., Anisimov, V.N., Ovsyannikov, A.I., Revskoy, S.Y., Keefer, L.K. and Reist, E.J. (1983) Carcinogenesis and aging. II. Modifying effect of aging on metabolism of methyl(acetoxymethyl)-nitrosamine and its interaction with DNA of various tissues in rats. Carcinogenesis, 4, 967-973.
50. Freitas, A.A. and Rocha, B.B. (1993) Lymphocyte lifespans: homeostasis, selection and competition. Immunology Today, 14, 25-29.
51. Richardson, K.K., Richardson, F.C., Crosby, R.M., Swenberg, J.A. and Skopek, T.R. (1987) DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Proc. Natl Acad. Sci. USA, 84, 344-348.
52. Burns, P.A., Gordon, A.J.E. and Glickman, B.W. (1988) Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli. Carcinogenesis, 9, 1607-1610.
53. Lee, G.S.-F., Blonsky, K.S., Lee Van On, D., Savage, E.A., Morgan, A.R. and Von Borstel, R.C. (1992) Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants. J. Mol. Biol., 223, 617-627.
54. Newbold, R.F., Warren, W., Medcalf, A.S.C. and Amos, J. (1980) Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification. Nature, 283, 596-598.
55. Beranek, D.T., Heflich, R.H., Kodell, R.L., Morris, S.M. and Casciano, D.A. (1983) Correlations between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells. Mutat. Res., 110, 171-180.
56. Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zanca, D. and Barbacid, M. (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature, 315, 382-385.
57. Sukamar, S. and Barbacid, M. (1990) Specific patterns of oncogene activation in transplacentally induced tumors. Proc. Natl Acad. Sci. USA, 87, 718-722.
58. Brown, K., Buchmann, A. and Balmain, A. (1990) Carcinogen-induced mutations in the mouse r-Ha-ras gene provide evidence of multiple pathways for tumor progression. Proc. Natl Acad. Sci. USA, 87, 538-542.
59. Nivard, M.J.M. (1991) Genetic and molecular analysis of alkylation-induced DNA damage in Drosophila Melanogaster. Thesis, Leiden University, Leiden, The Netherlands.
60. Casciano, D.A., Aidoo, A., Heflich, R., Lyn-Cook, L., Mittelslaedt, R. and Manjanatha, M. (1995) Development and Characterization of an In Vivo Somatic Mutation Assay. Abstracts EEMS 25th Annual Meeting Noordwijkerhout, The Netherlands.