Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma

Carcinogenesis

Volumn 29, Issue 10, 2008, Pages 1979-1985

  Schuller, Hildegard M ^a   Al Wadei, Hussein A N ^a,b   Majidi, Mourad ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b SANA A UNIVERSITY   (Yemen)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 3; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HAMSTER; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ANIMALS; CELL LINE; CELL LINE, TUMOR; CRICETINAE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GAMMA-AMINOBUTYRIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; NITROSAMINES; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, GABA-B; SMOKING;

EID: 53349145473     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn041     Document Type: Article

References (36)

1. Albertine,K.H. et al. (1998) Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma. Chest, 113, 997-1006.
2. Garber,M.E. et al. (2001) Diversity of gene expression in adenocarcinoma of the lung. Proc. Natl Acad. Sci. USA, 98, 13784-13789.
3. Devesa,S.S. et al. (2005) International lung cancer trends by Eistologic type: Male:female differences diminishing and adenocarcinoma rates rising. Int. J. Cancer, 117, 294-299.
4. Paez,J.G. et al. (2004) EGFR mutations in lung cancer: Correlation with clinical response to Gefitinib therapy. Science, 304, 1497-1500.
5. Roskoski,R.Jr (2004) The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem. Biophys. Res. Commun., 319, 1-11.
6. Yu,Z. et al. (2007) Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Cancer Res., 67, 10417-10427.
7. Laag,E. et al. (2006) NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int. J. Cancer, 119, 1547-1552.
8. Schuller,H.M. et al. (1999) The tobacco-specific carcinogen 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res., 59, 4510-4515.
9. Majidi,M. et al. (2007) Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Res., 67, 6863-6871.
10. Schuller,H.M. et al. (2005) NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways. Lung Cancer, 49, 35-45.
11. Cekanova,M. et al. (2007) Overexpressed Raf-1 and phosphorylated cyclic adenosine 3′-5′-monophosphatate response element-binding protein are early markers for lung adenocarcinoma. Cancer, 109 1164-1173.
12. Schuller,H.M. et al. (2000) Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J. Cancer Res. Clin. Oncol., 126, 624-630.
13. Palm,D. et al. (2006) The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int. J. Cancer, 118, 2744-2749.
14. Masur,K. et al. (2001) Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res., 61, 2866-2869.
15. Drell,T.L. IV et al. (2003) Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res. Treat., 80, 63-70.
16. Shin,V.Y. et al. (2007) Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol. Sci., 96, 21-29.
17. Sood,A.K. et al. (2006) Stress hormone-mediated invasion of ovarian cancer cells. Clin. Cancer Res., 12, 369-375.
18. Franek,M. (2004) History and the present of metabotropic GABAB receptor. Cesk Fysiol, 53, 117-124.
19. Chapman,R.W. et al. (1993) GABAB receptors in the lung. Trends Pharmacol. Sci., 14, 26-29.
20. Nikitin,A.Y. et al. (2004) Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium. Cancer Res., 64, 2307-2316.
21. Masuda,A. et al. (1997) Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor beta1. Cancer Res., 57, 4898-4904.
22. Epperson,C.N. et al. (2005) Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biol. Psychiatry, 57, 44-48.
23. Gladkevich,A. et al. (2006) The peripheral GABAergic system as a target in endocrine disorders. Auton. Neurosci., 124, 1-8.
24. Oka,M. et al. (2006) Functional expression of metabotropic GABAB receptors in primary cultures of astrocyets from rat cerebral cortex. Biochem. Biophys. Res. Commun., 341, 874-881.
25. Osawa,Y. et al. (2006) Functional expression of the GABA receptor in human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol., 291, 923-931.
26. Wogan,G.N. et al. (2004) Environmental and chemical carcinogenesis. Semin. Cancer. Biol., 14, 473-486.
27. Hecht,S.S. (2006) Cigarette smoking: Cancer risks, carcinogens, and mechanisms. Langenbecks Arch. Surg., 391, 603-613.
28. Hecht,S.S. (2006) Smoking and lung cancer-a new role for an old toxicant? Proc. Natl Acad. Sci. USA, 103, 15725-15726.
29. Jin,Z. et al. (2005) Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. J. Biol. Chem., 280, 16045-16052.
30. Wu,W.K. et al. (2005) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Res. 65, 5272-5277.
31. Lang,K. et al. (2004) Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int. J. Cancer, 112, 231-238.
32. Schuller,H.M. et al. (2007) GABA(B) receptor is a novel drug target for pancreatic cancer. Cancer, 112, 767-778.
33. Takehara,A. et al. (2007) Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit. Cancer Res., 67, 9704-9712.
34. Oh,C.H. et al. (2004) Effects of germinated brown rice extracts with enhanced levels of GABA on cancer cell proliferation and apoptosis. J. Med. Food, 7, 18-23.
35. Kleinrok,Z. et al. (1998) GABA content and GAD activity in colon tumors taken from patients with colon cancer or from xenografted human colon cancer cells growing as s.c. tumors in athymic nu/nu mice. J. Physiol. Pharmacol., 49, 303-310.
36. Joseph,J. et al. (2002) The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res., 62, 6467-6469.