-
1
-
-
77956328777
-
Notch: The past, the present, and the future
-
Artavanis-Tsakonas S, Muskavitch MA,. Notch: The past, the present, and the future. Curr Top Dev Biol 2010; 92: 1-29.
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 1-29
-
-
Artavanis-Tsakonas, S.1
Muskavitch, M.A.2
-
2
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas S, Rand MD, Lake RJ,. Notch signaling: Cell fate control and signal integration in development. Science 1999; 284 (5415): 770-776.
-
(1999)
Science
, vol.284
, Issue.5415
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
3
-
-
33847168133
-
Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
-
Ohlstein B, Spradling A,. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 2007; 315 (5814): 988-992.
-
(2007)
Science
, vol.315
, Issue.5814
, pp. 988-992
-
-
Ohlstein, B.1
Spradling, A.2
-
4
-
-
0033136717
-
Deficient T cell fate specification in mice with an induced inactivation of Notch1
-
Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, MacDonald HR, Aguet M,. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999; 10 (5): 547-558.
-
(1999)
Immunity
, vol.10
, Issue.5
, pp. 547-558
-
-
Radtke, F.1
Wilson, A.2
Stark, G.3
Bauer, M.4
Van Meerwijk, J.5
Macdonald, H.R.6
Aguet, M.7
-
5
-
-
84879870498
-
Notch signaling at a glance
-
Hori K, Sen A, Artavanis-Tsakonas S,. Notch signaling at a glance. J Cell Sci 2013; 126 (Pt 10): 2135-2140.
-
(2013)
J Cell Sci
, vol.126
, Issue.PART 10
, pp. 2135-2140
-
-
Hori, K.1
Sen, A.2
Artavanis-Tsakonas, S.3
-
6
-
-
84859098510
-
Possible roles of DLK1 in the Notch pathway during development and disease
-
Falix FA, Aronson DC, Lamers WH, Gaemers IC,. Possible roles of DLK1 in the Notch pathway during development and disease. Biochim Biophys Acta 2012; 1822 (6): 988-995.
-
(2012)
Biochim Biophys Acta
, vol.1822
, Issue.6
, pp. 988-995
-
-
Falix, F.A.1
Aronson, D.C.2
Lamers, W.H.3
Gaemers, I.C.4
-
7
-
-
33751084319
-
Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms
-
Jhas S, Ciura S, Belanger-Jasmin S, Dong Z, Llamosas E, Theriault FM, Joachim K, Tang Y, Liu L, Liu J, Stifani S,. Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms. J Neurosci 2006; 26 (43): 11061-11071.
-
(2006)
J Neurosci
, vol.26
, Issue.43
, pp. 11061-11071
-
-
Jhas, S.1
Ciura, S.2
Belanger-Jasmin, S.3
Dong, Z.4
Llamosas, E.5
Theriault, F.M.6
Joachim, K.7
Tang, Y.8
Liu, L.9
Liu, J.10
Stifani, S.11
-
8
-
-
0036304110
-
The role of notch in promoting glial and neural stem cell fates
-
Gaiano N, Fishell G,. The role of notch in promoting glial and neural stem cell fates. Annu Rev Neurosci 2002; 25: 471-490.
-
(2002)
Annu Rev Neurosci
, vol.25
, pp. 471-490
-
-
Gaiano, N.1
Fishell, G.2
-
9
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J,. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66 (4): 649-661.
-
(1991)
Cell
, vol.66
, Issue.4
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
Soreng, A.L.4
Reynolds, T.C.5
Smith, S.D.6
Sklar, J.7
-
10
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, Baltimore D,. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183 (5): 2283-2291.
-
(1996)
J Exp Med
, vol.183
, Issue.5
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
Hasserjian, R.P.4
Soffer, B.5
Sklar, J.6
Baltimore, D.7
-
11
-
-
33744812702
-
NOTCH1 mutations in T-cell acute lymphoblastic leukemia: Prognostic significance and implication in multifactorial leukemogenesis
-
Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ,. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: Prognostic significance and implication in multifactorial leukemogenesis. Clin Cancer Res 2006; 12 (10): 3043-3049.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.10
, pp. 3043-3049
-
-
Zhu, Y.M.1
Zhao, W.L.2
Fu, J.F.3
Shi, J.Y.4
Pan, Q.5
Hu, J.6
Gao, X.D.7
Chen, B.8
Li, J.M.9
Xiong, S.M.10
Gu, L.J.11
Tang, J.Y.12
Liang, H.13
Jiang, H.14
Xue, Y.Q.15
Shen, Z.X.16
Chen, Z.17
Chen, S.J.18
-
12
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC,. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306 (5694): 269-271.
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
13
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS, Berman DM,. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432 (7015): 324-331.
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
14
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
Taipale J, Beachy PA,. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411 (6835): 349-354.
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
15
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL,. Stem cells, cancer, and cancer stem cells. Nature 2001; 414 (6859): 105-111.
-
(2001)
Nature
, vol.414
, Issue.6859
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
16
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474 (7353): 609-615.
-
(2011)
Nature
, vol.474
, Issue.7353
, pp. 609-615
-
-
-
17
-
-
33745685874
-
Notch3 gene amplification in ovarian cancer
-
Park JT, Li M, Nakayama K, Mao TL, Davidson B, Zhang Z, Kurman RJ, Eberhart CG, Shih Ie M, Wang TL,. Notch3 gene amplification in ovarian cancer. Cancer Res 2006; 66 (12): 6312-6318.
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 6312-6318
-
-
Park, J.T.1
Li, M.2
Nakayama, K.3
Mao, T.L.4
Davidson, B.5
Zhang, Z.6
Kurman, R.J.7
Eberhart, C.G.8
Shih Ie, M.9
Wang, T.L.10
-
18
-
-
84856091317
-
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
-
Robinson DR, Kalyana-Sundaram S, Wu YM, Shankar S, Cao X, Ateeq B, Asangani IA, Iyer M, Maher CA, Grasso CS, Lonigro RJ, Quist M, Siddiqui J, Mehra R, Jing X, Giordano TJ, Sabel MS, Kleer CG, Palanisamy N, Natrajan R, Lambros MB, Reis-Filho JS, Kumar-Sinha C, Chinnaiyan AM,. Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med 2011; 17 (12): 1646-1651.
-
(2011)
Nat Med
, vol.17
, Issue.12
, pp. 1646-1651
-
-
Robinson, D.R.1
Kalyana-Sundaram, S.2
Wu, Y.M.3
Shankar, S.4
Cao, X.5
Ateeq, B.6
Asangani, I.A.7
Iyer, M.8
Maher, C.A.9
Grasso, C.S.10
Lonigro, R.J.11
Quist, M.12
Siddiqui, J.13
Mehra, R.14
Jing, X.15
Giordano, T.J.16
Sabel, M.S.17
Kleer, C.G.18
Palanisamy, N.19
Natrajan, R.20
Lambros, M.B.21
Reis-Filho, J.S.22
Kumar-Sinha, C.23
Chinnaiyan, A.M.24
more..
-
19
-
-
77949366450
-
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
-
Liefke R, Oswald F, Alvarado C, Ferres-Marco D, Mittler G, Rodriguez P, Dominguez M, Borggrefe T,. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev 2010; 24 (6): 590-601.
-
(2010)
Genes Dev
, vol.24
, Issue.6
, pp. 590-601
-
-
Liefke, R.1
Oswald, F.2
Alvarado, C.3
Ferres-Marco, D.4
Mittler, G.5
Rodriguez, P.6
Dominguez, M.7
Borggrefe, T.8
-
20
-
-
77649253330
-
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
-
Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV,. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci USA 2010; 107 (8): 3534-3539.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.8
, pp. 3534-3539
-
-
Yustein, J.T.1
Liu, Y.C.2
Gao, P.3
Jie, C.4
Le, A.5
Vuica-Ross, M.6
Chng, W.J.7
Eberhart, C.G.8
Bergsagel, P.L.9
Dang, C.V.10
-
21
-
-
27644561755
-
Hypoxia requires notch signaling to maintain the undifferentiated cell state
-
Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M,. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005; 9 (5): 617-628.
-
(2005)
Dev Cell
, vol.9
, Issue.5
, pp. 617-628
-
-
Gustafsson, M.V.1
Zheng, X.2
Pereira, T.3
Gradin, K.4
Jin, S.5
Lundkvist, J.6
Ruas, J.L.7
Poellinger, L.8
Lendahl, U.9
Bondesson, M.10
-
22
-
-
33644660241
-
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors
-
Hu C, Dievart A, Lupien M, Calvo E, Tremblay G, Jolicoeur P,. Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol 2006; 168 (3): 973-990.
-
(2006)
Am J Pathol
, vol.168
, Issue.3
, pp. 973-990
-
-
Hu, C.1
Dievart, A.2
Lupien, M.3
Calvo, E.4
Tremblay, G.5
Jolicoeur, P.6
-
23
-
-
0033613401
-
Involvement of Notch1 in the development of mouse mammary tumors
-
Dievart A, Beaulieu N, Jolicoeur P,. Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 1999; 18 (44): 5973-5981.
-
(1999)
Oncogene
, vol.18
, Issue.44
, pp. 5973-5981
-
-
Dievart, A.1
Beaulieu, N.2
Jolicoeur, P.3
-
24
-
-
3342952083
-
Notch in mammary gland development and breast cancer
-
Politi K, Feirt N, Kitajewski J,. Notch in mammary gland development and breast cancer. Semin Cancer Biol 2004; 14 (5): 341-347.
-
(2004)
Semin Cancer Biol
, vol.14
, Issue.5
, pp. 341-347
-
-
Politi, K.1
Feirt, N.2
Kitajewski, J.3
-
25
-
-
24944506696
-
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
-
Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE,. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005; 65 (18): 8530-8537.
-
(2005)
Cancer Res
, vol.65
, Issue.18
, pp. 8530-8537
-
-
Reedijk, M.1
Odorcic, S.2
Chang, L.3
Zhang, H.4
Miller, N.5
McCready, D.R.6
Lockwood, G.7
Egan, S.E.8
-
26
-
-
48549103124
-
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
-
Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L,. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 2008; 68 (13): 5226-5235.
-
(2008)
Cancer Res
, vol.68
, Issue.13
, pp. 5226-5235
-
-
Rizzo, P.1
Miao, H.2
D'Souza, G.3
Osipo, C.4
Song, L.L.5
Yun, J.6
Zhao, H.7
Mascarenhas, J.8
Wyatt, D.9
Antico, G.10
Hao, L.11
Yao, K.12
Rajan, P.13
Hicks, C.14
Siziopikou, K.15
Selvaggi, S.16
Bashir, A.17
Bhandari, D.18
Marchese, A.19
Lendahl, U.20
Qin, J.Z.21
Tonetti, D.A.22
Albain, K.23
Nickoloff, B.J.24
Miele, L.25
more..
-
27
-
-
80052494506
-
Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence
-
Pandya K, Meeke K, Clementz AG, Rogowski A, Roberts J, Miele L, Albain KS, Osipo C,. Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence. Br J Cancer 2011; 105 (6): 796-806.
-
(2011)
Br J Cancer
, vol.105
, Issue.6
, pp. 796-806
-
-
Pandya, K.1
Meeke, K.2
Clementz, A.G.3
Rogowski, A.4
Roberts, J.5
Miele, L.6
Albain, K.S.7
Osipo, C.8
-
28
-
-
34547096751
-
Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu
-
Piechocki MP, Yoo GH, Dibbley SK, Lonardo F,. Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer Res 2007; 67 (14): 6825-6843.
-
(2007)
Cancer Res
, vol.67
, Issue.14
, pp. 6825-6843
-
-
Piechocki, M.P.1
Yoo, G.H.2
Dibbley, S.K.3
Lonardo, F.4
-
29
-
-
50649125794
-
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
-
Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L,. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene 2008; 27 (37): 5019-5032.
-
(2008)
Oncogene
, vol.27
, Issue.37
, pp. 5019-5032
-
-
Osipo, C.1
Patel, P.2
Rizzo, P.3
Clementz, A.G.4
Hao, L.5
Golde, T.E.6
Miele, L.7
-
30
-
-
77957591579
-
Targeting breast cancer stem cells
-
Liu S, Wicha MS,. Targeting breast cancer stem cells. J Clin Oncol 2010; 28 (25): 4006-4012.
-
(2010)
J Clin Oncol
, vol.28
, Issue.25
, pp. 4006-4012
-
-
Liu, S.1
Wicha, M.S.2
-
31
-
-
54049096261
-
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
-
Korkaya H, Paulson A, Iovino F, Wicha MS,. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008; 27 (47): 6120-6130.
-
(2008)
Oncogene
, vol.27
, Issue.47
, pp. 6120-6130
-
-
Korkaya, H.1
Paulson, A.2
Iovino, F.3
Wicha, M.S.4
-
32
-
-
84879092200
-
HER2 and breast cancer stem cells: More than meets the eye
-
Korkaya H, Wicha MS,. HER2 and breast cancer stem cells: More than meets the eye. Cancer Res 2013; 73 (12): 3489-3493.
-
(2013)
Cancer Res
, vol.73
, Issue.12
, pp. 3489-3493
-
-
Korkaya, H.1
Wicha, M.S.2
-
33
-
-
78549254600
-
Breast cancer stem cells: Something out of notching
-
Harrison H, Farnie G, Brennan KR, Clarke RB,. Breast cancer stem cells: Something out of notching ? Cancer Res 2010; 70 (22): 8973-8976.
-
(2010)
Cancer Res
, vol.70
, Issue.22
, pp. 8973-8976
-
-
Harrison, H.1
Farnie, G.2
Brennan, K.R.3
Clarke, R.B.4
-
34
-
-
77953700950
-
Targeting Notch to target cancer stem cells
-
Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L,. Targeting Notch to target cancer stem cells. Clin Cancer Res 2010; 16 (12): 3141-3152.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.12
, pp. 3141-3152
-
-
Pannuti, A.1
Foreman, K.2
Rizzo, P.3
Osipo, C.4
Golde, T.5
Osborne, B.6
Miele, L.7
-
35
-
-
0018936098
-
Correlation of early cytodifferentiation of the human fetal prostate and Leydig cells
-
Kellokumpu-Lehtinen P, Santti R, Pelliniemi LJ,. Correlation of early cytodifferentiation of the human fetal prostate and Leydig cells. Anat Rec 1980; 196 (3): 263-273.
-
(1980)
Anat Rec
, vol.196
, Issue.3
, pp. 263-273
-
-
Kellokumpu-Lehtinen, P.1
Santti, R.2
Pelliniemi, L.J.3
-
36
-
-
0028326109
-
Ductal budding and branching patterns in the developing prostate
-
Timms BG, Mohs TJ, Didio LJ,. Ductal budding and branching patterns in the developing prostate. J Urol 1994; 151 (5): 1427-1432.
-
(1994)
J Urol
, vol.151
, Issue.5
, pp. 1427-1432
-
-
Timms, B.G.1
Mohs, T.J.2
Didio, L.J.3
-
37
-
-
0015535245
-
The role of androgens in the epithelio-mesenchymal interactions involved in prostatic morphogenesis in embryonic mice
-
Cunha GR,. The role of androgens in the epithelio-mesenchymal interactions involved in prostatic morphogenesis in embryonic mice. Anat Rec 1973; 175 (1): 87-96.
-
(1973)
Anat Rec
, vol.175
, Issue.1
, pp. 87-96
-
-
Cunha, G.R.1
-
38
-
-
0035495974
-
Cell differentiation lineage in the prostate
-
Wang Y, Hayward S, Cao M, Thayer K, Cunha G,. Cell differentiation lineage in the prostate. Differentiation 2001; 68 (4-5): 270-279.
-
(2001)
Differentiation
, vol.68
, Issue.45
, pp. 270-279
-
-
Wang, Y.1
Hayward, S.2
Cao, M.3
Thayer, K.4
Cunha, G.5
-
39
-
-
57649140583
-
Generation of a prostate from a single adult stem cell
-
Leong KG, Wang BE, Johnson L, Gao WQ,. Generation of a prostate from a single adult stem cell. Nature 2008; 456 (7223): 804-808.
-
(2008)
Nature
, vol.456
, Issue.7223
, pp. 804-808
-
-
Leong, K.G.1
Wang, B.E.2
Johnson, L.3
Gao, W.Q.4
-
40
-
-
70349438989
-
A luminal epithelial stem cell that is a cell of origin for prostate cancer
-
Wang X, Kruithof-de Julio M, Economides KD, Walker D, Yu H, Halili MV, Hu YP, Price SM, Abate-Shen C, Shen MM,. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 2009; 461 (7263): 495-500.
-
(2009)
Nature
, vol.461
, Issue.7263
, pp. 495-500
-
-
Wang, X.1
Kruithof-De Julio, M.2
Economides, K.D.3
Walker, D.4
Yu, H.5
Halili, M.V.6
Hu, Y.P.7
Price, S.M.8
Abate-Shen, C.9
Shen, M.M.10
-
41
-
-
80052449394
-
In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells
-
Blackwood JK, Williamson SC, Greaves LC, Wilson L, Rigas AC, Sandher R, Pickard RS, Robson CN, Turnbull DM, Taylor RW, Heer R,. In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells. J Pathol 2011; 225 (2): 181-188.
-
(2011)
J Pathol
, vol.225
, Issue.2
, pp. 181-188
-
-
Blackwood, J.K.1
Williamson, S.C.2
Greaves, L.C.3
Wilson, L.4
Rigas, A.C.5
Sandher, R.6
Pickard, R.S.7
Robson, C.N.8
Turnbull, D.M.9
Taylor, R.W.10
Heer, R.11
-
42
-
-
80052473223
-
Clonal architecture of human prostatic epithelium in benign and malignant conditions
-
Gaisa NT, Graham TA, McDonald SA, Poulsom R, Heidenreich A, Jakse G, Knuechel R, Wright NA,. Clonal architecture of human prostatic epithelium in benign and malignant conditions. J Pathol 2011; 225 (2): 172-180.
-
(2011)
J Pathol
, vol.225
, Issue.2
, pp. 172-180
-
-
Gaisa, N.T.1
Graham, T.A.2
McDonald, S.A.3
Poulsom, R.4
Heidenreich, A.5
Jakse, G.6
Knuechel, R.7
Wright, N.A.8
-
43
-
-
84863078902
-
Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation
-
Choi N, Zhang B, Zhang L, Ittmann M, Xin L,. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell 2012; 21 (2): 253-265.
-
(2012)
Cancer Cell
, vol.21
, Issue.2
, pp. 253-265
-
-
Choi, N.1
Zhang, B.2
Zhang, L.3
Ittmann, M.4
Xin, L.5
-
44
-
-
84869084046
-
Multipotent and unipotent progenitors contribute to prostate postnatal development
-
Ousset M, Van Keymeulen A, Bouvencourt G, Sharma N, Achouri Y, Simons BD, Blanpain C,. Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol 2012; 14 (11): 1131-1138.
-
(2012)
Nat Cell Biol
, vol.14
, Issue.11
, pp. 1131-1138
-
-
Ousset, M.1
Van Keymeulen, A.2
Bouvencourt, G.3
Sharma, N.4
Achouri, Y.5
Simons, B.D.6
Blanpain, C.7
-
45
-
-
0035476048
-
Dynamics of notch expression during murine prostate development and tumorigenesis
-
Shou J, Ross S, Koeppen H, de Sauvage FJ, Gao WQ,. Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res 2001; 61 (19): 7291-7297.
-
(2001)
Cancer Res
, vol.61
, Issue.19
, pp. 7291-7297
-
-
Shou, J.1
Ross, S.2
Koeppen, H.3
De Sauvage, F.J.4
Gao, W.Q.5
-
46
-
-
84868360665
-
Notch and TGFbeta form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity
-
Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L,. Notch and TGFbeta form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell 2012; 11 (5): 676-688.
-
(2012)
Cell Stem Cell
, vol.11
, Issue.5
, pp. 676-688
-
-
Valdez, J.M.1
Zhang, L.2
Su, Q.3
Dakhova, O.4
Zhang, Y.5
Shahi, P.6
Spencer, D.M.7
Creighton, C.J.8
Ittmann, M.M.9
Xin, L.10
-
47
-
-
84868660527
-
Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells
-
Martinez HD, Hsiao JJ, Jasavala RJ, Hinkson IV, Eng JK, Wright ME,. Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells. Genes Cancer 2011; 2 (10): 956-978.
-
(2011)
Genes Cancer
, vol.2
, Issue.10
, pp. 956-978
-
-
Martinez, H.D.1
Hsiao, J.J.2
Jasavala, R.J.3
Hinkson, I.V.4
Eng, J.K.5
Wright, M.E.6
-
48
-
-
29044443239
-
BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling
-
Grishina IB, Kim SY, Ferrara C, Makarenkova HP, Walden PD,. BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol 2005; 288 (2): 334-347.
-
(2005)
Dev Biol
, vol.288
, Issue.2
, pp. 334-347
-
-
Grishina, I.B.1
Kim, S.Y.2
Ferrara, C.3
Makarenkova, H.P.4
Walden, P.D.5
-
49
-
-
30544452875
-
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation
-
Wang XD, Leow CC, Zha J, Tang Z, Modrusan Z, Radtke F, Aguet M, de Sauvage FJ, Gao WQ,. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol 2006; 290 (1): 66-80.
-
(2006)
Dev Biol
, vol.290
, Issue.1
, pp. 66-80
-
-
Wang, X.D.1
Leow, C.C.2
Zha, J.3
Tang, Z.4
Modrusan, Z.5
Radtke, F.6
Aguet, M.7
De Sauvage, F.J.8
Gao, W.Q.9
-
50
-
-
2642533802
-
Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement
-
Wang XD, Shou J, Wong P, French DM, Gao WQ,. Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement. J Biol Chem 2004; 279 (23): 24733-24744.
-
(2004)
J Biol Chem
, vol.279
, Issue.23
, pp. 24733-24744
-
-
Wang, X.D.1
Shou, J.2
Wong, P.3
French, D.M.4
Gao, W.Q.5
-
51
-
-
55449114581
-
Delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate
-
Ceder JA, Jansson L, Helczynski L, Abrahamsson PA,. Delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate. Eur Urol 2008; 54 (6): 1344-1353.
-
(2008)
Eur Urol
, vol.54
, Issue.6
, pp. 1344-1353
-
-
Ceder, J.A.1
Jansson, L.2
Helczynski, L.3
Abrahamsson, P.A.4
-
52
-
-
58149468056
-
A role for notch signaling in stromal survival and differentiation during prostate development
-
Orr B, Grace OC, Vanpoucke G, Ashley GR, Thomson AA,. A role for notch signaling in stromal survival and differentiation during prostate development. Endocrinology 2009; 150 (1): 463-472.
-
(2009)
Endocrinology
, vol.150
, Issue.1
, pp. 463-472
-
-
Orr, B.1
Grace, O.C.2
Vanpoucke, G.3
Ashley, G.R.4
Thomson, A.A.5
-
53
-
-
84875176528
-
Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1
-
Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA,. Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1. Dis Model Mech 2013; 6 (2): 530-536.
-
(2013)
Dis Model Mech
, vol.6
, Issue.2
, pp. 530-536
-
-
Orr, B.1
Grace, O.C.2
Brown, P.3
Riddick, A.C.4
Stewart, G.D.5
Franco, O.E.6
Hayward, S.W.7
Thomson, A.A.8
-
54
-
-
77956793432
-
Molecular genetics of prostate cancer: New prospects for old challenges
-
Shen MM, Abate-Shen C,. Molecular genetics of prostate cancer: New prospects for old challenges. Genes Dev 2010; 24 (18): 1967-2000.
-
(2010)
Genes Dev
, vol.24
, Issue.18
, pp. 1967-2000
-
-
Shen, M.M.1
Abate-Shen, C.2
-
55
-
-
68049137909
-
Targeting the PI3K/AKT pathway for the treatment of prostate cancer
-
Sarker D, Reid AH, Yap TA, de Bono JS,. Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res 2009; 15 (15): 4799-4805.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.15
, pp. 4799-4805
-
-
Sarker, D.1
Reid, A.H.2
Yap, T.A.3
De Bono, J.S.4
-
56
-
-
0026939531
-
Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome
-
Batch JA, Williams DM, Davies HR, Brown BD, Evans BA, Hughes IA, Patterson MN,. Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome. Hum Mol Genet 1992; 1 (7): 497-503.
-
(1992)
Hum Mol Genet
, vol.1
, Issue.7
, pp. 497-503
-
-
Batch, J.A.1
Williams, D.M.2
Davies, H.R.3
Brown, B.D.4
Evans, B.A.5
Hughes, I.A.6
Patterson, M.N.7
-
57
-
-
0035815749
-
Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer
-
Han G, Foster BA, Mistry S, Buchanan G, Harris JM, Tilley WD, Greenberg NM,. Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer. J Biol Chem 2001; 276 (14): 11204-11213.
-
(2001)
J Biol Chem
, vol.276
, Issue.14
, pp. 11204-11213
-
-
Han, G.1
Foster, B.A.2
Mistry, S.3
Buchanan, G.4
Harris, J.M.5
Tilley, W.D.6
Greenberg, N.M.7
-
58
-
-
13444282183
-
Hey1, a mediator of notch signaling, is an androgen receptor corepressor
-
Belandia B, Powell SM, Garcia-Pedrero JM, Walker MM, Bevan CL, Parker MG,. Hey1, a mediator of notch signaling, is an androgen receptor corepressor. Mol Cell Biol 2005; 25 (4): 1425-1436.
-
(2005)
Mol Cell Biol
, vol.25
, Issue.4
, pp. 1425-1436
-
-
Belandia, B.1
Powell, S.M.2
Garcia-Pedrero, J.M.3
Walker, M.M.4
Bevan, C.L.5
Parker, M.G.6
-
59
-
-
82555170322
-
PI3K/mTOR signaling regulates prostatic branching morphogenesis
-
Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, De Marzo AM, Berman DM, Lotan TL,. PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol 2011; 360 (2): 329-342.
-
(2011)
Dev Biol
, vol.360
, Issue.2
, pp. 329-342
-
-
Ghosh, S.1
Lau, H.2
Simons, B.W.3
Powell, J.D.4
Meyers, D.J.5
De Marzo, A.M.6
Berman, D.M.7
Lotan, T.L.8
-
60
-
-
4344698040
-
PTENless means more
-
Stiles B, Groszer M, Wang S, Jiao J,., Wu H,. PTENless means more. Dev Biol 2004; 273 (2): 175-184.
-
(2004)
Dev Biol
, vol.273
, Issue.2
, pp. 175-184
-
-
Stiles, B.1
Groszer, M.2
Wang, S.3
Jiao, J.4
Wu, H.5
-
61
-
-
0033152165
-
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
-
Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA,. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 1999; 59 (11): 2551-2556.
-
(1999)
Cancer Res
, vol.59
, Issue.11
, pp. 2551-2556
-
-
Davies, M.A.1
Koul, D.2
Dhesi, H.3
Berman, R.4
McDonnell, T.J.5
McConkey, D.6
Yung, W.K.7
Steck, P.A.8
-
62
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
-
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H,. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003; 4 (3): 209-221.
-
(2003)
Cancer Cell
, vol.4
, Issue.3
, pp. 209-221
-
-
Wang, S.1
Gao, J.2
Lei, Q.3
Rozengurt, N.4
Pritchard, C.5
Jiao, J.6
Thomas, G.V.7
Li, G.8
Roy-Burman, P.9
Nelson, P.S.10
Liu, X.11
Wu, H.12
-
63
-
-
0033200172
-
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
-
McMenamin ME, Soung P, Perera S, Kaplan I, Loda M, Sellers WR,. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999; 59 (17): 4291-4296.
-
(1999)
Cancer Res
, vol.59
, Issue.17
, pp. 4291-4296
-
-
McMenamin, M.E.1
Soung, P.2
Perera, S.3
Kaplan, I.4
Loda, M.5
Sellers, W.R.6
-
64
-
-
67749135444
-
Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression
-
Whelan JT, Kellogg A, Shewchuk BM, Hewan-Lowe K, Bertrand FE,. Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression. J Cell Biochem 2009; 107 (5): 992-1001.
-
(2009)
J Cell Biochem
, vol.107
, Issue.5
, pp. 992-1001
-
-
Whelan, J.T.1
Kellogg, A.2
Shewchuk, B.M.3
Hewan-Lowe, K.4
Bertrand, F.E.5
-
65
-
-
79955975429
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
-
Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL,. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011; 19 (5): 575-586.
-
(2011)
Cancer Cell
, vol.19
, Issue.5
, pp. 575-586
-
-
Carver, B.S.1
Chapinski, C.2
Wongvipat, J.3
Hieronymus, H.4
Chen, Y.5
Chandarlapaty, S.6
Arora, V.K.7
Le, C.8
Koutcher, J.9
Scher, H.10
Scardino, P.T.11
Rosen, N.12
Sawyers, C.L.13
-
66
-
-
80054111295
-
PTEN protein loss by immunostaining: Analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
-
Lotan TL, Gurel B, Sutcliffe S, Esopi D, Liu W, Xu J, Hicks JL, Park BH, Humphreys E, Partin AW, Han M, Netto GJ, Isaacs WB, De Marzo AM,. PTEN protein loss by immunostaining: Analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients. Clin Cancer Res 2011; 17 (20): 6563-6573.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6563-6573
-
-
Lotan, T.L.1
Gurel, B.2
Sutcliffe, S.3
Esopi, D.4
Liu, W.5
Xu, J.6
Hicks, J.L.7
Park, B.H.8
Humphreys, E.9
Partin, A.W.10
Han, M.11
Netto, G.J.12
Isaacs, W.B.13
De Marzo, A.M.14
-
67
-
-
59449107891
-
Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
-
Bin Hafeez B, Adhami VM, Asim M, Siddiqui IA, Bhat KM, Zhong W, Saleem M, Din M, Setaluri V, Mukhtar H,. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res 2009; 15 (2): 452-459.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.2
, pp. 452-459
-
-
Bin Hafeez, B.1
Adhami, V.M.2
Asim, M.3
Siddiqui, I.A.4
Bhat, K.M.5
Zhong, W.6
Saleem, M.7
Din, M.8
Setaluri, V.9
Mukhtar, H.10
-
68
-
-
33748872289
-
Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells
-
Zhang Y, Wang Z, Ahmed F, Banerjee S, Li Y, Sarkar FH,. Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells. Int J Cancer 2006; 119 (9): 2071-2077.
-
(2006)
Int J Cancer
, vol.119
, Issue.9
, pp. 2071-2077
-
-
Zhang, Y.1
Wang, Z.2
Ahmed, F.3
Banerjee, S.4
Li, Y.5
Sarkar, F.H.6
-
69
-
-
78549247887
-
Poking CD40 for cancer therapy, another example of the Goldilocks effect
-
Drabick JJ, Schell TD,. Poking CD40 for cancer therapy, another example of the Goldilocks effect. Cancer Biol Ther 2010; 10 (10): 994-996.
-
(2010)
Cancer Biol Ther
, vol.10
, Issue.10
, pp. 994-996
-
-
Drabick, J.J.1
Schell, T.D.2
-
70
-
-
0344274396
-
Long-term culture of murine epidermal keratinocytes
-
Hager B, Bickenbach JR, Fleckman P,. Long-term culture of murine epidermal keratinocytes. J Invest Dermatol 1999; 112 (6): 971-976.
-
(1999)
J Invest Dermatol
, vol.112
, Issue.6
, pp. 971-976
-
-
Hager, B.1
Bickenbach, J.R.2
Fleckman, P.3
-
71
-
-
27144476439
-
Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells
-
Dalrymple S, Antony L, Xu Y, Uzgare AR, Arnold JT, Savaugeot J, Sokoll LJ, De Marzo AM, Isaacs JT,. Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells. Cancer Res 2005; 65 (20): 9269-9279.
-
(2005)
Cancer Res
, vol.65
, Issue.20
, pp. 9269-9279
-
-
Dalrymple, S.1
Antony, L.2
Xu, Y.3
Uzgare, A.R.4
Arnold, J.T.5
Savaugeot, J.6
Sokoll, L.J.7
De Marzo, A.M.8
Isaacs, J.T.9
-
72
-
-
4944241544
-
JAGGED1 expression is associated with prostate cancer metastasis and recurrence
-
Santagata S, Demichelis F, Riva A, Varambally S, Hofer MD, Kutok JL, Kim R, Tang J, Montie JE, Chinnaiyan AM, Rubin MA, Aster JC,. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res 2004; 64 (19): 6854-6857.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 6854-6857
-
-
Santagata, S.1
Demichelis, F.2
Riva, A.3
Varambally, S.4
Hofer, M.D.5
Kutok, J.L.6
Kim, R.7
Tang, J.8
Montie, J.E.9
Chinnaiyan, A.M.10
Rubin, M.A.11
Aster, J.C.12
-
73
-
-
0034817278
-
Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience
-
Han M, Partin AW, Pound CR, Epstein JI, Walsh PC,. Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. Urol Clin North Am 2001; 28 (3): 555-565.
-
(2001)
Urol Clin North Am
, vol.28
, Issue.3
, pp. 555-565
-
-
Han, M.1
Partin, A.W.2
Pound, C.R.3
Epstein, J.I.4
Walsh, P.C.5
-
74
-
-
70349313376
-
Prostate cancer-specific mortality after radical prostatectomy for patients treated in the prostate-specific antigen era
-
Stephenson AJ, Kattan MW, Eastham JA, Bianco FJ Jr, Yossepowitch O, Vickers AJ, Klein EA, Wood DP, Scardino PT,. Prostate cancer-specific mortality after radical prostatectomy for patients treated in the prostate-specific antigen era. J Clin Oncol 2009; 27 (26): 4300-4305.
-
(2009)
J Clin Oncol
, vol.27
, Issue.26
, pp. 4300-4305
-
-
Stephenson, A.J.1
Kattan, M.W.2
Eastham, J.A.3
Bianco, Jr.F.J.4
Yossepowitch, O.5
Vickers, A.J.6
Klein, E.A.7
Wood, D.P.8
Scardino, P.T.9
-
75
-
-
80755172262
-
Prostate size as a predictor of Gleason score upgrading in patients with low risk prostate cancer
-
Davies JD, Aghazadeh MA, Phillips S, Salem S, Chang SS, Clark PE, Cookson MS, Davis R, Herrell SD, Penson DF, Smith JA Jr, Barocas DA,. Prostate size as a predictor of Gleason score upgrading in patients with low risk prostate cancer. J Urol 2011; 186 (6): 2221-2227.
-
(2011)
J Urol
, vol.186
, Issue.6
, pp. 2221-2227
-
-
Davies, J.D.1
Aghazadeh, M.A.2
Phillips, S.3
Salem, S.4
Chang, S.S.5
Clark, P.E.6
Cookson, M.S.7
Davis, R.8
Herrell, S.D.9
Penson, D.F.10
Smith, Jr.J.A.11
Barocas, D.A.12
-
76
-
-
67149126604
-
Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: A population-based study
-
Kvale R, Moller B, Wahlqvist R, Fossa SD, Berner A, Busch C, Kyrdalen AE, Svindland A, Viset T, Halvorsen OJ,. Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: A population-based study. BJU Int 2009; 103 (12): 1647-1654.
-
(2009)
BJU Int
, vol.103
, Issue.12
, pp. 1647-1654
-
-
Kvale, R.1
Moller, B.2
Wahlqvist, R.3
Fossa, S.D.4
Berner, A.5
Busch, C.6
Kyrdalen, A.E.7
Svindland, A.8
Viset, T.9
Halvorsen, O.J.10
-
77
-
-
84891050693
-
Gene expression pathways of high grade localized prostate cancer
-
Ross AE, Marchionni L, Vuica-Ross M, Cheadle C, Fan J, Berman DM, Schaeffer EM,. Gene expression pathways of high grade localized prostate cancer. Prostate 2011; 25: 1-11.
-
(2011)
Prostate
, vol.25
, pp. 1-11
-
-
Ross, A.E.1
Marchionni, L.2
Vuica-Ross, M.3
Cheadle, C.4
Fan, J.5
Berman, D.M.6
Schaeffer, E.M.7
-
78
-
-
33746602208
-
A molecular correlate to the Gleason grading system for prostate adenocarcinoma
-
True L, Coleman I, Hawley S, Huang CY, Gifford D, Coleman R, Beer TM, Gelmann E, Datta M, Mostaghel E, Knudsen B, Lange P, Vessella R, Lin D, Hood L, Nelson PS,. A molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad Sci USA 2006; 103 (29): 10991-10996.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.29
, pp. 10991-10996
-
-
True, L.1
Coleman, I.2
Hawley, S.3
Huang, C.Y.4
Gifford, D.5
Coleman, R.6
Beer, T.M.7
Gelmann, E.8
Datta, M.9
Mostaghel, E.10
Knudsen, B.11
Lange, P.12
Vessella, R.13
Lin, D.14
Hood, L.15
Nelson, P.S.16
-
79
-
-
33845884027
-
Integrative molecular concept modeling of prostate cancer progression
-
Tomlins SA, Mehra R, Rhodes DR, Cao X, Wang L, Dhanasekaran SM, Kalyana-Sundaram S, Wei JT, Rubin MA, Pienta KJ, Shah RB, Chinnaiyan AM,. Integrative molecular concept modeling of prostate cancer progression. Nat Genet 2007; 39 (1): 41-51.
-
(2007)
Nat Genet
, vol.39
, Issue.1
, pp. 41-51
-
-
Tomlins, S.A.1
Mehra, R.2
Rhodes, D.R.3
Cao, X.4
Wang, L.5
Dhanasekaran, S.M.6
Kalyana-Sundaram, S.7
Wei, J.T.8
Rubin, M.A.9
Pienta, K.J.10
Shah, R.B.11
Chinnaiyan, A.M.12
-
80
-
-
67149138004
-
Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
-
Rasul S, Balasubramanian R, Filipovic A, Slade MJ, Yague E, Coombes RC,. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer 2009; 100 (12): 1879-1888.
-
(2009)
Br J Cancer
, vol.100
, Issue.12
, pp. 1879-1888
-
-
Rasul, S.1
Balasubramanian, R.2
Filipovic, A.3
Slade, M.J.4
Yague, E.5
Coombes, R.C.6
-
81
-
-
34548572895
-
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
-
Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP,. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res 2007; 67 (17): 8051-8057.
-
(2007)
Cancer Res
, vol.67
, Issue.17
, pp. 8051-8057
-
-
Konishi, J.1
Kawaguchi, K.S.2
Vo, H.3
Haruki, N.4
Gonzalez, A.5
Carbone, D.P.6
Dang, T.P.7
-
82
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H,. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005; 435 (7044): 959-963.
-
(2005)
Nature
, vol.435
, Issue.7044
, pp. 959-963
-
-
Van Es, J.H.1
Van Gijn, M.E.2
Riccio, O.3
Van Den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
83
-
-
11144355129
-
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
-
Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM,. Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 2004; 279 (13): 12876-12882.
-
(2004)
J Biol Chem
, vol.279
, Issue.13
, pp. 12876-12882
-
-
Wong, G.T.1
Manfra, D.2
Poulet, F.M.3
Zhang, Q.4
Josien, H.5
Bara, T.6
Engstrom, L.7
Pinzon-Ortiz, M.8
Fine, J.S.9
Lee, H.J.10
Zhang, L.11
Higgins, G.A.12
Parker, E.M.13
-
84
-
-
58149336788
-
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
-
Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, Sulis ML, Barnes K, Sawai C, Homminga I, Meijerink J, Aifantis I, Basso G, Cordon-Cardo C, Ai W, Ferrando A,. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 2009; 15 (1): 50-58.
-
(2009)
Nat Med
, vol.15
, Issue.1
, pp. 50-58
-
-
Real, P.J.1
Tosello, V.2
Palomero, T.3
Castillo, M.4
Hernando, E.5
De Stanchina, E.6
Sulis, M.L.7
Barnes, K.8
Sawai, C.9
Homminga, I.10
Meijerink, J.11
Aifantis, I.12
Basso, G.13
Cordon-Cardo, C.14
Ai, W.15
Ferrando, A.16
-
85
-
-
77953368267
-
Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design
-
Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T,. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther 2010; 9 (6): 1618-1628.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.6
, pp. 1618-1628
-
-
Wei, P.1
Walls, M.2
Qiu, M.3
Ding, R.4
Denlinger, R.H.5
Wong, A.6
Tsaparikos, K.7
Jani, J.P.8
Hosea, N.9
Sands, M.10
Randolph, S.11
Smeal, T.12
-
86
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW,. Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464 (7291): 1052-1057.
-
(2010)
Nature
, vol.464
, Issue.7291
, pp. 1052-1057
-
-
Wu, Y.1
Cain-Hom, C.2
Choy, L.3
Hagenbeek, T.J.4
De Leon, G.P.5
Chen, Y.6
Finkle, D.7
Venook, R.8
Wu, X.9
Ridgway, J.10
Schahin-Reed, D.11
Dow, G.J.12
Shelton, A.13
Stawicki, S.14
Watts, R.J.15
Zhang, J.16
Choy, R.17
Howard, P.18
Kadyk, L.19
Yan, M.20
Zha, J.21
Callahan, C.A.22
Hymowitz, S.G.23
Siebel, C.W.24
more..
-
87
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G,. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006; 444 (7122): 1032-1037.
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1032-1037
-
-
Noguera-Troise, I.1
Daly, C.2
Papadopoulos, N.J.3
Coetzee, S.4
Boland, P.5
Gale, N.W.6
Lin, H.C.7
Yancopoulos, G.D.8
Thurston, G.9
-
88
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
-
Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y, Kowalski J, Watts RJ, Callahan C, Kasman I, Singh M, Chien M, Tan C, Hongo JA, de Sauvage F, Plowman G, Yan M,. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006; 444 (7122): 1083-1087.
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1083-1087
-
-
Ridgway, J.1
Zhang, G.2
Wu, Y.3
Stawicki, S.4
Liang, W.C.5
Chanthery, Y.6
Kowalski, J.7
Watts, R.J.8
Callahan, C.9
Kasman, I.10
Singh, M.11
Chien, M.12
Tan, C.13
Hongo, J.A.14
De Sauvage, F.15
Plowman, G.16
Yan, M.17
-
89
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE,. Direct inhibition of the NOTCH transcription factor complex. Nature 2009; 462 (7270): 182-188.
-
(2009)
Nature
, vol.462
, Issue.7270
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
Del Bianco, C.4
Aster, J.C.5
Blacklow, S.C.6
Kung, A.L.7
Gilliland, D.G.8
Verdine, G.L.9
Bradner, J.E.10
-
90
-
-
84864018642
-
Phase i study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors
-
Tolcher AW, Messersmith WA, Mikulski SM, Papadopoulos KP, Kwak EL, Gibbon DG, Patnaik A, Falchook GS, Dasari A, Shapiro GI, Boylan JF, Xu ZX, Wang K, Koehler A, Song J, Middleton SA, Deutsch J, Demario M, Kurzrock R, Wheler JJ,. Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol 2012; 30 (19): 2348-2353.
-
(2012)
J Clin Oncol
, vol.30
, Issue.19
, pp. 2348-2353
-
-
Tolcher, A.W.1
Messersmith, W.A.2
Mikulski, S.M.3
Papadopoulos, K.P.4
Kwak, E.L.5
Gibbon, D.G.6
Patnaik, A.7
Falchook, G.S.8
Dasari, A.9
Shapiro, G.I.10
Boylan, J.F.11
Xu, Z.X.12
Wang, K.13
Koehler, A.14
Song, J.15
Middleton, S.A.16
Deutsch, J.17
Demario, M.18
Kurzrock, R.19
Wheler, J.J.20
more..
-
91
-
-
84864005118
-
Phase i pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors
-
Krop I, Demuth T, Guthrie T, Wen PY, Mason WP, Chinnaiyan P, Butowski N, Groves MD, Kesari S, Freedman SJ, Blackman S, Watters J, Loboda A, Podtelezhnikov A, Lunceford J, Chen C, Giannotti M, Hing J, Beckman R, Lorusso P,. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol 2012; 30 (19): 2307-2313.
-
(2012)
J Clin Oncol
, vol.30
, Issue.19
, pp. 2307-2313
-
-
Krop, I.1
Demuth, T.2
Guthrie, T.3
Wen, P.Y.4
Mason, W.P.5
Chinnaiyan, P.6
Butowski, N.7
Groves, M.D.8
Kesari, S.9
Freedman, S.J.10
Blackman, S.11
Watters, J.12
Loboda, A.13
Podtelezhnikov, A.14
Lunceford, J.15
Chen, C.16
Giannotti, M.17
Hing, J.18
Beckman, R.19
Lorusso, P.20
more..
-
92
-
-
0036796421
-
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
-
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lubke T, Lena Illert A, von Figura K, Saftig P,. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 2002; 11 (21): 2615-2624.
-
(2002)
Hum Mol Genet
, vol.11
, Issue.21
, pp. 2615-2624
-
-
Hartmann, D.1
De Strooper, B.2
Serneels, L.3
Craessaerts, K.4
Herreman, A.5
Annaert, W.6
Umans, L.7
Lubke, T.8
Lena Illert, A.9
Von Figura, K.10
Saftig, P.11
-
93
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R,. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999; 398 (6727): 518-522.
-
(1999)
Nature
, vol.398
, Issue.6727
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
94
-
-
8844229536
-
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
-
Fryer CJ, White JB, Jones KA,. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 2004; 16 (4): 509-520.
-
(2004)
Mol Cell
, vol.16
, Issue.4
, pp. 509-520
-
-
Fryer, C.J.1
White, J.B.2
Jones, K.A.3
-
95
-
-
79751472667
-
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
-
Sethi N, Dai X, Winter CG, Kang Y,. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011; 19 (2): 192-205.
-
(2011)
Cancer Cell
, vol.19
, Issue.2
, pp. 192-205
-
-
Sethi, N.1
Dai, X.2
Winter, C.G.3
Kang, Y.4
-
96
-
-
85027941540
-
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
-
Xing F, Okuda H, Watabe M, Kobayashi A, Pai SK, Liu W, Pandey PR, Fukuda K, Hirota S, Sugai T, Wakabayshi G, Koeda K, Kashiwaba M, Suzuki K, Chiba T, Endo M, Mo YY, Watabe K,. Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene 2011; 30 (39): 4075-4086.
-
(2011)
Oncogene
, vol.30
, Issue.39
, pp. 4075-4086
-
-
Xing, F.1
Okuda, H.2
Watabe, M.3
Kobayashi, A.4
Pai, S.K.5
Liu, W.6
Pandey, P.R.7
Fukuda, K.8
Hirota, S.9
Sugai, T.10
Wakabayshi, G.11
Koeda, K.12
Kashiwaba, M.13
Suzuki, K.14
Chiba, T.15
Endo, M.16
Mo, Y.Y.17
Watabe, K.18
-
97
-
-
0023201213
-
Mammary tumorigenesis in feral mice: Identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
-
Gallahan D, Callahan R,. Mammary tumorigenesis in feral mice: Identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. J Virol 1987; 61 (1): 66-74.
-
(1987)
J Virol
, vol.61
, Issue.1
, pp. 66-74
-
-
Gallahan, D.1
Callahan, R.2
-
98
-
-
0027175171
-
An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice
-
Jhappan C, Stahle C, Wolff M, Merlino G, Pastan I,. An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice. Cell Immunol 1993; 149 (1): 99-106.
-
(1993)
Cell Immunol
, vol.149
, Issue.1
, pp. 99-106
-
-
Jhappan, C.1
Stahle, C.2
Wolff, M.3
Merlino, G.4
Pastan, I.5
-
99
-
-
11244304299
-
Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh)
-
Raafat A, Bargo S, Anver MR, Callahan R,. Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Oncogene 2004; 23 (58): 9401-9407.
-
(2004)
Oncogene
, vol.23
, Issue.58
, pp. 9401-9407
-
-
Raafat, A.1
Bargo, S.2
Anver, M.R.3
Callahan, R.4
-
100
-
-
0034674896
-
Chromosome 19 translocation, overexpression of Notch3, and human lung cancer
-
Dang TP, Gazdar AF, Virmani AK, Sepetavec T, Hande KR, Minna JD, Roberts JR, Carbone DP,. Chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J Natl Cancer Inst 2000; 92 (16): 1355-1357.
-
(2000)
J Natl Cancer Inst
, vol.92
, Issue.16
, pp. 1355-1357
-
-
Dang, T.P.1
Gazdar, A.F.2
Virmani, A.K.3
Sepetavec, T.4
Hande, K.R.5
Minna, J.D.6
Roberts, J.R.7
Carbone, D.P.8
-
101
-
-
77951880179
-
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
-
Eliasz S, Liang S, Chen Y, De Marco MA, Machek O, Skucha S, Miele L, Bocchetta M,. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene 2010; 29 (17): 2488-2498.
-
(2010)
Oncogene
, vol.29
, Issue.17
, pp. 2488-2498
-
-
Eliasz, S.1
Liang, S.2
Chen, Y.3
De Marco, M.A.4
Machek, O.5
Skucha, S.6
Miele, L.7
Bocchetta, M.8
-
102
-
-
38149015554
-
Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo
-
Sjolund J, Johansson M, Manna S, Norin C, Pietras A, Beckman S, Nilsson E, Ljungberg B, Axelson H,. Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest 2008; 118 (1): 217-228.
-
(2008)
J Clin Invest
, vol.118
, Issue.1
, pp. 217-228
-
-
Sjolund, J.1
Johansson, M.2
Manna, S.3
Norin, C.4
Pietras, A.5
Beckman, S.6
Nilsson, E.7
Ljungberg, B.8
Axelson, H.9
-
103
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Trevino L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN,. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011; 333 (6046): 1154-1157.
-
(2011)
Science
, vol.333
, Issue.6046
, pp. 1154-1157
-
-
Agrawal, N.1
Frederick, M.J.2
Pickering, C.R.3
Bettegowda, C.4
Chang, K.5
Li, R.J.6
Fakhry, C.7
Xie, T.X.8
Zhang, J.9
Wang, J.10
Zhang, N.11
El-Naggar, A.K.12
Jasser, S.A.13
Weinstein, J.N.14
Trevino, L.15
Drummond, J.A.16
Muzny, D.M.17
Wu, Y.18
Wood, L.D.19
Hruban, R.H.20
Westra, W.H.21
Koch, W.M.22
Califano, J.A.23
Gibbs, R.A.24
Sidransky, D.25
Vogelstein, B.26
Velculescu, V.E.27
Papadopoulos, N.28
Wheeler, D.A.29
Kinzler, K.W.30
Myers, J.N.31
more..
-
104
-
-
67649304460
-
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
-
Demehri S, Turkoz A, Kopan R,. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 2009; 16 (1): 55-66.
-
(2009)
Cancer Cell
, vol.16
, Issue.1
, pp. 55-66
-
-
Demehri, S.1
Turkoz, A.2
Kopan, R.3
|