A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype

Molecular and Cellular Biochemistry

Volumn 349, Issue 1-2, 2011, Pages 97-106

  Kato, Satoshi ^a,b   Sangadala, Sreedhara ^a,c   Tomita, Katsuro ^b   Titus, Louisa ^a   Boden, Scott D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

BMP 2; Potentiating; Smad; Smurf1; Virtual screening

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; LIGASE; MESSENGER RNA; OSTEOCALCIN;

ANIMAL CELL; ARTICLE; BONE; BONE DEVELOPMENT; CELL TRANSDIFFERENTIATION; COMPUTER MODEL; GENE EXPRESSION; KNOCKOUT MOUSE; MARKER GENE; MEMBRANE STEADY POTENTIAL; MOLECULAR WEIGHT; MOUSE; MYOBLAST; NONHUMAN; OSTEOBLAST; PHENOTYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; CELL TRANSDIFFERENTIATION; DRUG SYNERGISM; ENZYME ACTIVATION; GENES, REPORTER; HUMANS; LUCIFERASES, RENILLA; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MYOBLASTS; OSTEOBLASTS; OSTEOCALCIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SMAD PROTEINS; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

MUS;

EID: 79952283228     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0664-6     Document Type: Article

References (17)

1. D Chen M Zhao GR Mundy 2004 Bone morphogenetic proteins Growth Factors 22 233 241 1:CAS:528:DC%2BD2MXhtFWrsQ%3D%3D 10.1080/08977190412331279890 15621726 (Pubitemid 40136452)
2. DW Polly Jr SJ Ackerman CI Shaffrey JW Ogilvie JC Wang SW Stralka MS Mafilios SE Heim HS Sandhu 2003 A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion Orthopedics 26 1027 1037 14577525 (Pubitemid 37304414)
3. SD Boden J Kang H Sandhu JG Heller 2002 Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies Spine 27 2662 2673 10.1097/00007632-200212010-00005 12461392 (Pubitemid 35425320)
4. SD Boden JH Schimandle WC Hutton 1995 The use of an osteoinductive growth factor for lumbar spinal fusion. Part I: Biology of spinal fusion Spine 20 2633 2644 1:STN:280:DyaK28zmtlKgtQ%3D%3D 10.1097/00007632-199512150-00004 8747241 (Pubitemid 26011476)
5. K Kusumoto K Bessho K Fujimura J Akioka Y Okubo Y Wang T Iizuka Y Ogawa 2002 Osteoinduction by recombinant human bone morphogenetic protein-2 in muscles of non-human primates J Int Med Res 30 251 259 1:CAS:528:DC%2BD38XlvFGkt70%3D 12166341 (Pubitemid 34823302)
6. SJ Ackerman MS Mafilios DW Polly Jr 2002 Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: an evidence-based modeling approach Spine 27 S94 S99 10.1097/00007632-200208151-00017 12205426
7. M Yamashita S Ying G Zhang C Li SY Cheng C Deng Y Zhang 2005 Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation Cell 121 101 113 1:CAS:528:DC%2BD2MXjsVaksL8%3D 10.1016/j.cell.2005.01.035 15820682
8. M Zhao M Qiao SE Harris BO Oyajobi GR Mundy D Chen 2004 Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo J Biol Chem 279 12854 12859 1:CAS:528:DC%2BD2cXitl2gtb4%3D 10.1074/jbc.M313294200 14701828 (Pubitemid 38445859)
9. S Sangadala SD Boden M Viggeswarapu Y Liu L Titus 2006 LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads J Biol Chem 281 17212 17219 1:CAS:528:DC%2BD28XlvVGktrw%3D 10.1074/jbc.M511013200 16611643
10. S Sangadala M Okada Y Liu M Viggeswarapu L Titus SD Boden 2009 Engineering, cloning and functional characterization of recombinant LIM mineralization protein-1 containing an N-terminal HIV-derived membrane transduction domain Protein Expr Purif 65 165 173 1:CAS:528:DC%2BD1MXjt1Kntb4%3D 10.1016/j.pep.2009.01.006 19284982
11. S Sangadala SD Boden RP Metpally BV Reddy 2007 Modeling and analysis of molecular interaction between Smurf1-WW2 domain and various isoforms of LIM mineralization protein Proteins 68 690 701 1:CAS:528:DC%2BD2sXnvFymsbs%3D 10.1002/prot.21429 17510966 (Pubitemid 47068308)
12. HJ Bohm 1992 The computer program LUDI: a new method for the de novo design of enzyme inhibitors J Comput Aided Mol Des 6 61 78 1:STN:280: DyaK383mtVarsw%3D%3D 10.1007/BF00124387 1583540
13. S Sangadala RP Metpally BV Reddy 2007 Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6-modeling and analysis J Biomol Struct Dyn 25 11 23 1:CAS:528:DC%2BD2sXos1Ghtr4%3D 17676934 (Pubitemid 47124363)
14. HJ Bohm 1994 On the use of LUDI to search the fine chemicals directory for ligands of proteins of known three-dimensional structure J Comput Aided Mol Des 8 623 632 1:STN:280:DyaK2M7ot1Wktw%3D%3D 10.1007/BF00123669 7876904
15. N Guex MC Peitsch 1997 SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling Electrophoresis 18 2714 2723 1:CAS:528:DyaK1cXhvFaks70%3D 10.1002/elps.1150181505 9504803 (Pubitemid 28059943)
16. T Schwede J Kopp N Guex MC Peitsch 2003 SWISS-MODEL: an automated protein homology-modeling server Nucleic Acids Res 31 3381 3385 1:CAS:528: DC%2BD3sXltVWjsLg%3D 10.1093/nar/gkg520 12824332 (Pubitemid 37442164)
17. M Okada S Sangadala Y Liu M Yoshida BV Reddy L Titus SD Boden 2009 Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity Cell Biochem Funct 27 526 534 1:CAS:528:DC%2BD1MXhsV2mtb3N 10.1002/cbf.1615 19862690