-
1
-
-
45849131324
-
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer
-
Barbash O., Zamfirova P., Lin D.I., Chen X., Yang K., Nakagawa H., Lu F., Rustgi A.K., Diehl J.A. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 2008, 14:68-78.
-
(2008)
Cancer Cell
, vol.14
, pp. 68-78
-
-
Barbash, O.1
Zamfirova, P.2
Lin, D.I.3
Chen, X.4
Yang, K.5
Nakagawa, H.6
Lu, F.7
Rustgi, A.K.8
Diehl, J.A.9
-
2
-
-
33947246502
-
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
-
Binné U.K., Classon M.K., Dick F.A., Wei W., Rape M., Kaelin W.G., Näär A.M., Dyson N.J. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat. Cell Biol. 2007, 9:225-232.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 225-232
-
-
Binné, U.K.1
Classon, M.K.2
Dick, F.A.3
Wei, W.4
Rape, M.5
Kaelin, W.G.6
Näär, A.M.7
Dyson, N.J.8
-
3
-
-
22544450728
-
Transformation of human and murine fibroblasts without viral oncoproteins
-
Boehm J.S., Hession M.T., Bulmer S.E., Hahn W.C. Transformation of human and murine fibroblasts without viral oncoproteins. Mol. Cell. Biol. 2005, 25:6464-6474.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 6464-6474
-
-
Boehm, J.S.1
Hession, M.T.2
Bulmer, S.E.3
Hahn, W.C.4
-
4
-
-
19444374383
-
Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box
-
Burton J.L., Tsakraklides V., Solomon M.J. Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box. Mol. Cell 2005, 18:533-542.
-
(2005)
Mol. Cell
, vol.18
, pp. 533-542
-
-
Burton, J.L.1
Tsakraklides, V.2
Solomon, M.J.3
-
5
-
-
0242317756
-
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis
-
Chabes A.L., Pfleger C.M., Kirschner M.W., Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc. Natl. Acad. Sci. USA 2003, 100:3925-3929.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 3925-3929
-
-
Chabes, A.L.1
Pfleger, C.M.2
Kirschner, M.W.3
Thelander, L.4
-
6
-
-
0033145508
-
Temporal and spatial control of cyclin B1 destruction in metaphase
-
Clute P., Pines J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat. Cell Biol. 1999, 1:82-87.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 82-87
-
-
Clute, P.1
Pines, J.2
-
7
-
-
58149086804
-
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells
-
Fukunaga E., Inoue Y., Komiya S., Horiguchi K., Goto K., Saitoh M., Miyazawa K., Koinuma D., Hanyu A., Imamura T. Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. J. Biol. Chem. 2008, 283:35660-35667.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 35660-35667
-
-
Fukunaga, E.1
Inoue, Y.2
Komiya, S.3
Horiguchi, K.4
Goto, K.5
Saitoh, M.6
Miyazawa, K.7
Koinuma, D.8
Hanyu, A.9
Imamura, T.10
-
8
-
-
32444437676
-
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
-
Gallagher E., Gao M., Liu Y.C., Karin M. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc. Natl. Acad. Sci. USA 2006, 103:1717-1722.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1717-1722
-
-
Gallagher, E.1
Gao, M.2
Liu, Y.C.3
Karin, M.4
-
9
-
-
67749145231
-
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways
-
Gao D., Inuzuka H., Korenjak M., Tseng A., Wu T., Wan L., Kirschner M., Dyson N., Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol. Biol. Cell 2009, 20:3305-3316.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 3305-3316
-
-
Gao, D.1
Inuzuka, H.2
Korenjak, M.3
Tseng, A.4
Wu, T.5
Wan, L.6
Kirschner, M.7
Dyson, N.8
Wei, W.9
-
10
-
-
46449095540
-
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
-
García-Higuera I., Manchado E., Dubus P., Cañamero M., Méndez J., Moreno S., Malumbres M. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat. Cell Biol. 2008, 10:802-811.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 802-811
-
-
García-Higuera, I.1
Manchado, E.2
Dubus, P.3
Cañamero, M.4
Méndez, J.5
Moreno, S.6
Malumbres, M.7
-
11
-
-
0035795408
-
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
-
Geley S., Kramer E., Gieffers C., Gannon J., Peters J.M., Hunt T. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J. Cell Biol. 2001, 153:137-148.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 137-148
-
-
Geley, S.1
Kramer, E.2
Gieffers, C.3
Gannon, J.4
Peters, J.M.5
Hunt, T.6
-
12
-
-
0033613270
-
Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
-
Gieffers C., Peters B.H., Kramer E.R., Dotti C.G., Peters J.M. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Proc. Natl. Acad. Sci. USA 1999, 96:11317-11322.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11317-11322
-
-
Gieffers, C.1
Peters, B.H.2
Kramer, E.R.3
Dotti, C.G.4
Peters, J.M.5
-
13
-
-
77954972964
-
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
-
Greenblatt M.B., Shim J.H., Zou W., Sitara D., Schweitzer M., Hu D., Lotinun S., Sano Y., Baron R., Park J.M., et al. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J. Clin. Invest. 2010, 120:2457-2473.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2457-2473
-
-
Greenblatt, M.B.1
Shim, J.H.2
Zou, W.3
Sitara, D.4
Schweitzer, M.5
Hu, D.6
Lotinun, S.7
Sano, Y.8
Baron, R.9
Park, J.M.10
-
14
-
-
0037673933
-
Control of osteoblast function and regulation of bone mass
-
Harada S., Rodan G.A. Control of osteoblast function and regulation of bone mass. Nature 2003, 423:349-355.
-
(2003)
Nature
, vol.423
, pp. 349-355
-
-
Harada, S.1
Rodan, G.A.2
-
15
-
-
0036713310
-
The anaphase-promoting complex: it's not just for mitosis any more
-
Harper J.W., Burton J.L., Solomon M.J. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002, 16:2179-2206.
-
(2002)
Genes Dev.
, vol.16
, pp. 2179-2206
-
-
Harper, J.W.1
Burton, J.L.2
Solomon, M.J.3
-
16
-
-
67349249403
-
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
-
Herrero-Mendez A., Almeida A., Fernández E., Maestre C., Moncada S., Bolaños J.P. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat. Cell Biol. 2009, 11:747-752.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 747-752
-
-
Herrero-Mendez, A.1
Almeida, A.2
Fernández, E.3
Maestre, C.4
Moncada, S.5
Bolaños, J.P.6
-
17
-
-
33744454653
-
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
-
Jones D.C., Wein M.N., Oukka M., Hofstaetter J.G., Glimcher M.J., Glimcher L.H. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 2006, 312:1223-1227.
-
(2006)
Science
, vol.312
, pp. 1223-1227
-
-
Jones, D.C.1
Wein, M.N.2
Oukka, M.3
Hofstaetter, J.G.4
Glimcher, M.J.5
Glimcher, L.H.6
-
18
-
-
0029004815
-
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
-
King R.W., Peters J.M., Tugendreich S., Rolfe M., Hieter P., Kirschner M.W. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 1995, 81:279-288.
-
(1995)
Cell
, vol.81
, pp. 279-288
-
-
King, R.W.1
Peters, J.M.2
Tugendreich, S.3
Rolfe, M.4
Hieter, P.5
Kirschner, M.W.6
-
19
-
-
1142274208
-
Cdh1-APC controls axonal growth and patterning in the mammalian brain
-
Konishi Y., Stegmüller J., Matsuda T., Bonni S., Bonni A. Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science 2004, 303:1026-1030.
-
(2004)
Science
, vol.303
, pp. 1026-1030
-
-
Konishi, Y.1
Stegmüller, J.2
Matsuda, T.3
Bonni, S.4
Bonni, A.5
-
20
-
-
33747087307
-
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
-
Lasorella A., Stegmüller J., Guardavaccaro D., Liu G., Carro M.S., Rothschild G., de la Torre-Ubieta L., Pagano M., Bonni A., Iavarone A. Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature 2006, 442:471-474.
-
(2006)
Nature
, vol.442
, pp. 471-474
-
-
Lasorella, A.1
Stegmüller, J.2
Guardavaccaro, D.3
Liu, G.4
Carro, M.S.5
Rothschild, G.6
de la Torre-Ubieta, L.7
Pagano, M.8
Bonni, A.9
Iavarone, A.10
-
21
-
-
35948951997
-
The dual effects of Cdh1/APC in myogenesis
-
Li W., Wu G., Wan Y. The dual effects of Cdh1/APC in myogenesis. FASEB J. 2007, 21:3606-3617.
-
(2007)
FASEB J.
, vol.21
, pp. 3606-3617
-
-
Li, W.1
Wu, G.2
Wan, Y.3
-
22
-
-
1642458099
-
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells
-
Lindon C., Pines J. Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells. J. Cell Biol. 2004, 164:233-241.
-
(2004)
J. Cell Biol.
, vol.164
, pp. 233-241
-
-
Lindon, C.1
Pines, J.2
-
23
-
-
0036714512
-
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
-
Littlepage L.E., Ruderman J.V. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev. 2002, 16:2274-2285.
-
(2002)
Genes Dev.
, vol.16
, pp. 2274-2285
-
-
Littlepage, L.E.1
Ruderman, J.V.2
-
24
-
-
48649104139
-
Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1
-
Lu K., Yin X., Weng T., Xi S., Li L., Xing G., Cheng X., Yang X., Zhang L., He F. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat. Cell Biol. 2008, 10:994-1002.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 994-1002
-
-
Lu, K.1
Yin, X.2
Weng, T.3
Xi, S.4
Li, L.5
Xing, G.6
Cheng, X.7
Yang, X.8
Zhang, L.9
He, F.10
-
25
-
-
0033592688
-
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
-
Lukas C., Sørensen C.S., Kramer E., Santoni-Rugiu E., Lindeneg C., Peters J.M., Bartek J., Lukas J. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 1999, 401:815-818.
-
(1999)
Nature
, vol.401
, pp. 815-818
-
-
Lukas, C.1
Sørensen, C.S.2
Kramer, E.3
Santoni-Rugiu, E.4
Lindeneg, C.5
Peters, J.M.6
Bartek, J.7
Lukas, J.8
-
26
-
-
47549090432
-
TGFbeta in Cancer
-
Massagué J. TGFbeta in Cancer. Cell 2008, 134:215-230.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massagué, J.1
-
27
-
-
0032526426
-
How p53 binds DNA as a tetramer
-
McLure K.G., Lee P.W. How p53 binds DNA as a tetramer. EMBO J. 1998, 17:3342-3350.
-
(1998)
EMBO J.
, vol.17
, pp. 3342-3350
-
-
McLure, K.G.1
Lee, P.W.2
-
28
-
-
23044505285
-
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain
-
Ogunjimi A.A., Briant D.J., Pece-Barbara N., Le Roy C., Di Guglielmo G.M., Kavsak P., Rasmussen R.K., Seet B.T., Sicheri F., Wrana J.L. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol. Cell 2005, 19:297-308.
-
(2005)
Mol. Cell
, vol.19
, pp. 297-308
-
-
Ogunjimi, A.A.1
Briant, D.J.2
Pece-Barbara, N.3
Le Roy, C.4
Di Guglielmo, G.M.5
Kavsak, P.6
Rasmussen, R.K.7
Seet, B.T.8
Sicheri, F.9
Wrana, J.L.10
-
29
-
-
33747589184
-
The anaphase promoting complex/cyclosome: a machine designed to destroy
-
Peters J.M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 2006, 7:644-656.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 644-656
-
-
Peters, J.M.1
-
30
-
-
0035883946
-
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
-
Pfleger C.M., Lee E., Kirschner M.W. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev. 2001, 15:2396-2407.
-
(2001)
Genes Dev.
, vol.15
, pp. 2396-2407
-
-
Pfleger, C.M.1
Lee, E.2
Kirschner, M.W.3
-
31
-
-
30344466977
-
The processivity of multiubiquitination by the APC determines the order of substrate degradation
-
Rape M., Reddy S.K., Kirschner M.W. The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell 2006, 124:89-103.
-
(2006)
Cell
, vol.124
, pp. 89-103
-
-
Rape, M.1
Reddy, S.K.2
Kirschner, M.W.3
-
32
-
-
67349132223
-
Physiological functions of the HECT family of ubiquitin ligases
-
Rotin D., Kumar S. Physiological functions of the HECT family of ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 2009, 10:398-409.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 398-409
-
-
Rotin, D.1
Kumar, S.2
-
33
-
-
33846688094
-
Balancing BMP signaling through integrated inputs into the Smad1 linker
-
Sapkota G., Alarcón C., Spagnoli F.M., Brivanlou A.H., Massagué J. Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol. Cell 2007, 25:441-454.
-
(2007)
Mol. Cell
, vol.25
, pp. 441-454
-
-
Sapkota, G.1
Alarcón, C.2
Spagnoli, F.M.3
Brivanlou, A.H.4
Massagué, J.5
-
34
-
-
0035903652
-
Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
-
Schwab M., Neutzner M., Möcker D., Seufert W. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J. 2001, 20:5165-5175.
-
(2001)
EMBO J.
, vol.20
, pp. 5165-5175
-
-
Schwab, M.1
Neutzner, M.2
Möcker, D.3
Seufert, W.4
-
35
-
-
34250017680
-
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
-
Tang X., Orlicky S., Lin Z., Willems A., Neculai D., Ceccarelli D., Mercurio F., Shilton B.H., Sicheri F., Tyers M. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell 2007, 129:1165-1176.
-
(2007)
Cell
, vol.129
, pp. 1165-1176
-
-
Tang, X.1
Orlicky, S.2
Lin, Z.3
Willems, A.4
Neculai, D.5
Ceccarelli, D.6
Mercurio, F.7
Shilton, B.H.8
Sicheri, F.9
Tyers, M.10
-
36
-
-
0035930333
-
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction
-
Wan Y., Liu X., Kirschner M.W. The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol. Cell 2001, 8:1027-1039.
-
(2001)
Mol. Cell
, vol.8
, pp. 1027-1039
-
-
Wan, Y.1
Liu, X.2
Kirschner, M.W.3
-
37
-
-
0344758986
-
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
-
Wang H.R., Zhang Y., Ozdamar B., Ogunjimi A.A., Alexandrova E., Thomsen G.H., Wrana J.L. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 2003, 302:1775-1779.
-
(2003)
Science
, vol.302
, pp. 1775-1779
-
-
Wang, H.R.1
Zhang, Y.2
Ozdamar, B.3
Ogunjimi, A.A.4
Alexandrova, E.5
Thomsen, G.H.6
Wrana, J.L.7
-
38
-
-
1642399624
-
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
-
Wei W., Ayad N.G., Wan Y., Zhang G.J., Kirschner M.W., Kaelin W.G. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 2004, 428:194-198.
-
(2004)
Nature
, vol.428
, pp. 194-198
-
-
Wei, W.1
Ayad, N.G.2
Wan, Y.3
Zhang, G.J.4
Kirschner, M.W.5
Kaelin, W.G.6
-
39
-
-
34047255191
-
Fbw7/hCDC4 dimerization regulates its substrate interactions
-
Welcker M., Clurman B.E. Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div. 2007, 2:7.
-
(2007)
Cell Div.
, vol.2
, pp. 7
-
-
Welcker, M.1
Clurman, B.E.2
-
40
-
-
34547958577
-
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain
-
Wiesner S., Ogunjimi A.A., Wang H.R., Rotin D., Sicheri F., Wrana J.L., Forman-Kay J.D. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell 2007, 130:651-662.
-
(2007)
Cell
, vol.130
, pp. 651-662
-
-
Wiesner, S.1
Ogunjimi, A.A.2
Wang, H.R.3
Rotin, D.4
Sicheri, F.5
Wrana, J.L.6
Forman-Kay, J.D.7
-
41
-
-
17044414102
-
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
-
Yamashita M., Ying S.X., Zhang G.M., Li C., Cheng S.Y., Deng C.X., Zhang Y.E. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005, 121:101-113.
-
(2005)
Cell
, vol.121
, pp. 101-113
-
-
Yamashita, M.1
Ying, S.X.2
Zhang, G.M.3
Li, C.4
Cheng, S.Y.5
Deng, C.X.6
Zhang, Y.E.7
-
42
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu H., Kavsak P., Abdollah S., Wrana J.L., Thomsen G.H. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 1999, 400:687-693.
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
-
43
-
-
78650515835
-
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid
-
Zou W., Chen X., Shim J.H., Huang Z., Brady N., Hu D., Drapp R., Sigrist K., Glimcher L.H., Jones D. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat. Cell Biol. 2011, 13:59-65.
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(2011)
Nat. Cell Biol.
, vol.13
, pp. 59-65
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Zou, W.1
Chen, X.2
Shim, J.H.3
Huang, Z.4
Brady, N.5
Hu, D.6
Drapp, R.7
Sigrist, K.8
Glimcher, L.H.9
Jones, D.10
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