Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 22818-22830

  Nie, Jing ^a,b   Xie, Ping ^a,b   Liu, Lin ^c   Xing, Guichun ^b   Chang, Zhijie ^a,b   Yin, Yuxin ^d   Tian, Chunyan ^b   He, Fuchu ^a,b   Zhang, Lingqiang ^b  

^a TSINGHUA UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; E3 LIGASE; E3 UBIQUITIN LIGASES; HETERODIMERIZATION; LIGASES; MOUSE DOUBLE MINUTE 2; P53 PROTEIN; PROTEASOMAL DEGRADATION; REGULATORY FACTORS; TUMOR SUPPRESSORS; UBIQUITIN; UBIQUITYLATION;

CELL DEATH; ENZYMES; LAWS AND LEGISLATION;

DEGRADATION;

PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; SMAD UBIQUITYLATION REGULATORY FACTOR 1; SMAD UBIQUITYLATION REGULATORY FACTOR 2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; TRANSACTIVATION; UBIQUITINATION;

AMINO ACID MOTIFS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; ENZYME STABILITY; HUMANS; MICE; NUCLEAR PROTEINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77954894530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.126920     Document Type: Article

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