Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

Chemistry and Biology

Volumn 19, Issue 11, 2012, Pages 1423-1436

  Cheng, Xinlai ^a,b   Alborzinia, Hamed ^a   Merz, Karl Heinz ^b   Steinbeisser, Herbert ^a   Mrowka, Ralf ^c   Scholl, Catharina ^a   Kitanovic, Igor ^a   Eisenbrand, Gerhard ^b   Wölfl, Stefan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYCLIN DEPENDENT KINASE; E 738; INDIRUBIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEASOME; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; EMBRYO; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; EMBRYO, NONMAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HELA CELLS; HUMANS; INDOLES; JURKAT CELLS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UBIQUITIN THIOLESTERASE; XENOPUS;

EID: 84869990746     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.09.008     Document Type: Article

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