Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

Journal of Cell Biology

Volumn 165, Issue 3, 2004, Pages 433-445

  Horiki, Mitsuru ^a   Imamura, Takeshi ^b   Okamoto, Mina ^a   Hayashi, Makoto ^b   Murai, Junko ^a   Myoui, Akira ^a   Ochi, Takahiro ^a   Miyazono, Kohei ^b,c   Yoshikawa, Hideki ^a   Tsumaki, Noriyuki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CANCER INSTITUTE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Chondrocyte; Dwarfism; Hypertrophy; Osteopenia; Transgenic mice

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; SMAD6 PROTEIN; SMURF1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSORTATIVE MATING; BIOCHEMISTRY; BONE GROWTH; CARTILAGE CELL; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CHONDRODYSPLASIA; CONTROLLED STUDY; DWARFISM; ENCHONDRAL OSSIFICATION; GENE OVEREXPRESSION; GROWTH DISORDER; HYPERTROPHY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOPENIA; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRABECULAR BONE; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BONE AND BONES; BONE DISEASES, METABOLIC; BONE MORPHOGENETIC PROTEINS; CARTILAGE; CELL DIFFERENTIATION; CELL SIZE; CHONDROCYTES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOWN-REGULATION; DWARFISM; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, TRANSGENIC; OSTEOGENESIS; PHOSPHORYLATION; SMAD PROTEINS; SMAD1 PROTEIN; SMAD6 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; MUS MUSCULUS;

EID: 2442459812     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200311015     Document Type: Article

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