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Volumn 4, Issue , 2013, Pages

Metabolic flux and compartmentation analysis in the brain in vivo

Author keywords

Brain energy metabolism; Mathematical modeling; MRS; Neurotransmission; Neurotransmitter metabolism

Indexed keywords


EID: 84901022727     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00156     Document Type: Article
Times cited : (48)

References (175)
  • 2
    • 84866865925 scopus 로고    scopus 로고
    • Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer’s disease
    • Mlynárik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, et al. Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer’s disease. J Alzheimers Dis (2012) 31(Suppl 3):S87–99. doi:10.3233/JAD-2012-112072
    • (2012) J Alzheimers Dis , vol.31 , pp. S87-S99
    • Mlynárik, V.1    Cacquevel, M.2    Sun-Reimer, L.3    Janssens, S.4    Cudalbu, C.5    Lei, H.6
  • 3
    • 0035999512 scopus 로고    scopus 로고
    • 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
    • 13C NMR studies of compartmentalized cerebral carbohydrate metabolism. Neurochem Int (2002) 41:143–54. doi:10.1016/S0197-0186(02) 00034-7
    • (2002) Neurochem Int , vol.41 , pp. 143-154
    • Gruetter, R.1
  • 6
    • 0742305444 scopus 로고    scopus 로고
    • 13C isotopic turnover to determine rates of brain metabolism in vivo
    • 13C isotopic turnover to determine rates of brain metabolism in vivo. Metab Eng (2004) 6: 75–84. doi:10.1016/j.ymben.2003. 10.003
    • (2004) Metab Eng , vol.6 , pp. 75-84
    • Mason, G.F.1    Rothman, D.L.2
  • 11
    • 0141617535 scopus 로고    scopus 로고
    • 13C NMR spectroscopy of the rat brain in vivo at 9.4 T
    • 13C NMR spectroscopy of the rat brain in vivo at 9.4 T. Magn Reson Med (2003) 50:684–92. doi:10. 1002/mrm.10601
    • (2003) Magn Reson Med , vol.50 , pp. 684-692
    • Henry, P.G.1    Tkác, I.2    Gruetter, R.3
  • 12
    • 84883166425 scopus 로고    scopus 로고
    • 13C NMR spectroscopy at 14.1 T
    • 13C NMR spectroscopy at 14.1 T. J Neurochem (2013) 126(5):579–90. doi:10.1111/jnc.12333
    • (2013) J Neurochem , vol.126 , Issue.5 , pp. 579-590
    • Duarte, J.M.N.1    Gruetter, R.2
  • 15
    • 33846400334 scopus 로고    scopus 로고
    • Assessment of input function distortions on kinetic model parameters in simulated dynamic 82Rb PET perfusion studies
    • Meyer C, Peligrad D-N, Weibrecht M. Assessment of input function distortions on kinetic model parameters in simulated dynamic 82Rb PET perfusion studies. Nucl Instrum Methods Phys Res A (2007) 571:199–202. doi:10.1016/j.nima. 2006.10.062
    • (2007) Nucl Instrum Methods Phys Res A , vol.571 , pp. 199-202
    • Meyer, C.1    Peligrad, D.-N.2    Weibrecht, M.3
  • 19
  • 20
    • 0026563676 scopus 로고
    • NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain
    • Mason GF, Rothman DL, Behar KL, Shulman RG. NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain. J Cereb Blood Flow Metab (1992) 12:434–47. doi:10.1038/jcbfm.1992.61
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 434-447
    • Mason, G.F.1    Rothman, D.L.2    Behar, K.L.3    Shulman, R.G.4
  • 22
    • 0028798036 scopus 로고
    • Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR
    • Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG, Novotny EJ. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab (1995) 15:12–25. doi:10. 1038/jcbfm.1995.2
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 12-25
    • Mason, G.F.1    Gruetter, R.2    Rothman, D.L.3    Behar, K.L.4    Shulman, R.G.5    Novotny, E.J.6
  • 27
  • 29
    • 0034814676 scopus 로고    scopus 로고
    • A mathematical model of compartmentalized neurotransmitter metabolism in the human brain
    • Gruetter R, Seaquist ER, Ugurbil K. A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol Endocrinol Metab (2001) 281:E100–12.
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , pp. E100-E112
    • Gruetter, R.1    Seaquist, E.R.2    Ugurbil, K.3
  • 30
    • 35848970073 scopus 로고    scopus 로고
    • 13C label incorporation of the TCA cycle: The concept of composite precursor function
    • 13C label incorporation of the TCA cycle: the concept of composite precursor function. J Neurosci Res (2007) 85:3304–17. doi:10.1002/jnr.21392
    • (2007) J Neurosci Res , vol.85 , pp. 3304-3317
    • Uffmann, K.1    Gruetter, R.2
  • 31
    • 4344672064 scopus 로고    scopus 로고
    • Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo
    • de Graaf RA, Mason GF, Patel AB, Rothman DL, Behar KL. Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo. Proc Natl Acad Sci U S A (2004) 101:12700–5. doi:10. 1073/pnas.0405065101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12700-12705
    • de Graaf, R.A.1    Mason, G.F.2    Patel, A.B.3    Rothman, D.L.4    Behar, K.L.5
  • 32
    • 4544335404 scopus 로고    scopus 로고
    • Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation
    • Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, et al. Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation. J Cereb Blood Flow Metab (2004) 24:972–85. doi:10.1097/01. WCB.0000126234.16188.71
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 972-985
    • Patel, A.B.1    de Graaf, R.A.2    Mason, G.F.3    Kanamatsu, T.4    Rothman, D.L.5    Shulman, R.G.6
  • 33
    • 10644285757 scopus 로고    scopus 로고
    • Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity
    • Oz G, Berkich DA, Henry PG, Xu Y, LaNoue K, Hutson SM, et al. Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity. J Neurosci (2004) 24:11273–9. doi:10. 1523/JNEUROSCI.3564-04.2004
    • (2004) J Neurosci , vol.24 , pp. 11273-11279
    • Oz, G.1    Berkich, D.A.2    Henry, P.G.3    Xu, Y.4    Lanoue, K.5    Hutson, S.M.6
  • 34
    • 81155143335 scopus 로고    scopus 로고
    • A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and 13C-labeled glucose
    • Amaral AI, Teixeira AP, Håkon-sen BI, Sonnewald U, Alves PM. A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and 13C-labeled glucose. Front Neuroenerg (2011) 3:5. doi: 10.3389/fnene.2011.00005
    • (2011) Front Neuroenerg , vol.3 , pp. 5
    • Amaral, A.I.1    Teixeira, A.P.2    Håkon-Sen, B.I.3    Sonnewald, U.4    Alves, P.M.5
  • 36
    • 84982337275 scopus 로고
    • Amino acid and protein metabolism of the brain. VI. Cerebral compartments of glutamic acid metabolism
    • Berl S, Lajtha A, Waelsch H. Amino acid and protein metabolism of the brain. VI. Cerebral compartments of glutamic acid metabolism. J Neurochem (1961) 7:322–32. doi:10.1111/j. 1471-4159.1961.tb13503.x
    • (1961) J Neurochem , vol.7 , pp. 322-332
    • Berl, S.1    Lajtha, A.2    Waelsch, H.3
  • 38
    • 0004813418 scopus 로고
    • A cytophysio-logical study of the functional relationship between oliodendroglial cells and nerve cells of Deiters’ nucleus
    • Hydén H, Pigon A. A cytophysio-logical study of the functional relationship between oliodendroglial cells and nerve cells of Deiters’ nucleus. J Neurochem (1960) 6:57– 72. doi:10.1111/j.1471-4159.1960. tb13449.x
    • (1960) J Neurochem , vol.6 , pp. 57-72
    • Hydén, H.1    Pigon, A.2
  • 39
    • 0007305130 scopus 로고
    • Oxidation of tricarboxylic acid cycle intermediates by nerve cell bodies and glial cells
    • Hamberger A. Oxidation of tricarboxylic acid cycle intermediates by nerve cell bodies and glial cells. J Neurochem (1961) 8:31–5. doi:10. 1111/j.1471-4159.1961.tb13523.x
    • (1961) J Neurochem , vol.8 , pp. 31-35
    • Hamberger, A.1
  • 40
    • 0015885721 scopus 로고
    • K+ induced stimulation of oxygen uptake in cultured cerebral glial cells
    • Hertz L, Dittmann L, Mandel P. K+ induced stimulation of oxygen uptake in cultured cerebral glial cells. Brain Res (1973) 60:517–20. doi:10.1016/0006-8993(73)90814-7
    • (1973) Brain Res , vol.60 , pp. 517-520
    • Hertz, L.1    Dittmann, L.2    Mandel, P.3
  • 41
    • 0017718021 scopus 로고
    • Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres
    • Schousboe A, Svenneby G, Hertz L. Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres. J Neurochem (1977) 29:999–1005. doi:10.1111/j.1471-4159.1977.tb06503.x
    • (1977) J Neurochem , vol.29 , pp. 999-1005
    • Schousboe, A.1    Svenneby, G.2    Hertz, L.3
  • 42
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine syn-thetase in astrocytes of rat brain
    • Norenberg MD, Martinez-Hernandez A. Fine structural localization of glutamine syn-thetase in astrocytes of rat brain. Brain Res (1977) 161:303–10. doi: 10.1016/0006-8993(79)90071-4
    • (1977) Brain Res , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 43
    • 0017579832 scopus 로고
    • Glutamine syn-thetase: Glial localization in brain
    • Martinez-Hernandez A, Bell KP, Norenberg MD. Glutamine syn-thetase: glial localization in brain. Science (1977) 195:1356–8. doi:10. 1126/science.14400
    • (1977) Science , vol.195 , pp. 1356-1358
    • Martinez-Hernandez, A.1    Bell, K.P.2    Norenberg, M.D.3
  • 44
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
    • Shank RP, Bennett GS, Frey-tag SO, Campbell GL. Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res (1985) 329:364–7. doi:10.1016/0006-8993(85)90552-9
    • (1985) Brain Res , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.S.2    Frey-Tag, S.O.3    Campbell, G.L.4
  • 45
    • 0014526611 scopus 로고
    • Compartmentation of glutamate metabolism in brain. Evidence for the existence of two different tricarboxylic acid cycles in brain
    • van den Berg CJ, Krzalic L, Mela P, Waelsch H. Compartmentation of glutamate metabolism in brain. Evidence for the existence of two different tricarboxylic acid cycles in brain. Biochem J (1969) 113:281–90.
    • (1969) Biochem J , vol.113 , pp. 281-290
    • van den Berg, C.J.1    Krzalic, L.2    Mela, P.3    Waelsch, H.4
  • 46
    • 0015071185 scopus 로고
    • A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain
    • van den Berg CJ, Garfinkel D. A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem J (1971) 123:211–8.
    • (1971) Biochem J , vol.123 , pp. 211-218
    • van den Berg, C.J.1    Garfinkel, D.2
  • 47
    • 0018670663 scopus 로고
    • Functional interactions between neurons and astrocytes. I. Turnover and metabolism of putative amino acid transmitters
    • Hertz L. Functional interactions between neurons and astrocytes. I. Turnover and metabolism of putative amino acid transmitters. Prog Neurobiol (1979) 13:277–323. doi: 10.1016/0301-0082(79)90018-2
    • (1979) Prog Neurobiol , vol.13 , pp. 277-323
    • Hertz, L.1
  • 51
    • 84871404862 scopus 로고    scopus 로고
    • 13C NMR multiplet data: Concepts and simulations with a two-compartment neuronal-glial model
    • 13C NMR multiplet data: concepts and simulations with a two-compartment neuronal-glial model. Neurochem Res (2012) 37:2388–401. doi:10.1007/s11064-012-0782-5
    • (2012) Neurochem Res , vol.37 , pp. 2388-2401
    • Shestov, A.A.1    Valette, J.2    Deelchand, D.K.3    Ugurbil, K.4    Henry, P.G.5
  • 53
    • 0029657897 scopus 로고    scopus 로고
    • Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 tesla
    • Gruetter R, Adriany G, Merkle H, Andersen PM. Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 tesla. Magn Reson Med (1996) 36:659–64. doi:10.1002/mrm. 1910360503
    • (1996) Magn Reson Med , vol.36 , pp. 659-664
    • Gruetter, R.1    Adriany, G.2    Merkle, H.3    Andersen, P.M.4
  • 54
    • 0035109917 scopus 로고    scopus 로고
    • 13C NMR measurement of neurotransmitter glutamate cycling, anaplero-sis and TCA cycle flux in rat brain during
    • 13C NMR measurement of neurotransmitter glutamate cycling, anaplero-sis and TCA cycle flux in rat brain during. J Neurochem (2001) 76:975–89. doi:10.1046/j. 1471-4159.2001.00074.x
    • (2001) J Neurochem , vol.76 , pp. 975-989
    • Sibson, N.R.1    Mason, G.F.2    Shen, J.3    Cline, G.W.4    Herskovits, A.Z.5    Wall, J.E.6
  • 55
    • 0025739755 scopus 로고
    • Distribution of glutamine-like immunoreactivity in the cerebellum of rat and baboon (Papio anubis) with reference to the issue of metabolic compartmentation
    • Zhang NH, Laake J, Nagelhus E, Storm-Mathisen J, Ottersen OP. Distribution of glutamine-like immunoreactivity in the cerebellum of rat and baboon (Papio anubis) with reference to the issue of metabolic compartmentation. Anat Embryol (Berl) (1991) 184:213–23. doi:10.1007/BF01673257
    • (1991) Anat Embryol (Berl) , vol.184 , pp. 213-223
    • Zhang, N.H.1    Laake, J.2    Nagelhus, E.3    Storm-Mathisen, J.4    Ottersen, O.P.5
  • 56
    • 0026544324 scopus 로고
    • Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocyto-chemistry in rat cerebellum
    • Ottersen OP, Zhang N, Walberg F. Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocyto-chemistry in rat cerebellum. Neu-roscience (1992) 46:519–34. doi: 10.1016/0306-4522(92)90141-N
    • (1992) Neu-Roscience , vol.46 , pp. 519-534
    • Ottersen, O.P.1    Zhang, N.2    Walberg, F.3
  • 58
    • 0016137008 scopus 로고
    • 2-fixing enzymes in the metabolism of rat brain
    • 2-fixing enzymes in the metabolism of rat brain. J Neurochem (1974) 22:717–24. doi:10.1111/j.1471-4159.1974. tb04285.x
    • (1974) J Neurochem , vol.22 , pp. 717-724
    • Patel, M.S.1
  • 61
    • 17144475351 scopus 로고    scopus 로고
    • The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
    • Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL. The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. Proc Natl Acad Sci U S A (2005) 102:5588–93. doi:10.1073/pnas.0501703102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5588-5593
    • Patel, A.B.1    de Graaf, R.A.2    Mason, G.F.3    Rothman, D.L.4    Shulman, R.G.5    Behar, K.L.6
  • 62
    • 0020322662 scopus 로고
    • The activities in different neural cell types of certain enzymes associated with the metabolic compartmentation glutamate
    • Patel AJ, Hunt A, Gordon RD, Balazs R. The activities in different neural cell types of certain enzymes associated with the metabolic compartmentation glutamate. Brain Res (1982) 256: 3–11.
    • (1982) Brain Res , vol.256 , pp. 3-11
    • Patel, A.J.1    Hunt, A.2    Gordon, R.D.3    Balazs, R.4
  • 63
    • 0025181507 scopus 로고
    • Cerebral metabolism of acetate and glucose studied by 13C-n.M.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain
    • Badar-Goffer RS, Bachelard HS, Morris PG. Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain. Biochem J (1990) 266:133–9.
    • (1990) Biochem J , vol.266 , pp. 133-139
    • Badar-Goffer, R.S.1    Bachelard, H.S.2    Morris, P.G.3
  • 65
    • 84897557838 scopus 로고    scopus 로고
    • Cerebral glucose transport and homeostasis
    • Choi I-Y, Gruetter R, editors, New York: Springer
    • Duarte JMN, Gruetter R. Cerebral glucose transport and homeostasis. In: Choi I-Y, Gruetter R, editors. Neural Metabolism In vivo. New York: Springer (2012). p. 655–73.
    • (2012) Neural Metabolism in Vivo , pp. 655-673
    • Duarte, J.M.N.1    Gruetter, R.2
  • 66
    • 0036522961 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy: Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism
    • 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci (2002) 22:1523–31.
    • (2002) J Neurosci , vol.22 , pp. 1523-1531
    • Lebon, V.1    Petersen, K.F.2    Cline, G.W.3    Shen, J.4    Mason, G.F.5    Dufour, S.6
  • 69
    • 0031940131 scopus 로고    scopus 로고
    • Mitochondrial heterogeneity in the brain at the cellular level
    • Sonnewald U, Hertz L, Schousboe A. Mitochondrial heterogeneity in the brain at the cellular level. J Cereb Blood Flow Metab (1998) 18:231–7. doi:10.1097/00004647-199803000-00001
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 231-237
    • Sonnewald, U.1    Hertz, L.2    Schousboe, A.3
  • 70
    • 0034846461 scopus 로고    scopus 로고
    • Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes
    • Waagepetersen HS, Sonnewald U, Larsson OM, Schousboe A. Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes. Glia (2001) 35:246–52. doi:10.1002/glia.1089
    • (2001) Glia , vol.35 , pp. 246-252
    • Waagepetersen, H.S.1    Sonnewald, U.2    Larsson, O.M.3    Schousboe, A.4
  • 71
    • 33644792251 scopus 로고    scopus 로고
    • Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase
    • Waagepetersen HS, Hansen GH, Fenger K, Lindsay JG, Gibson G, Schousboe A. Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase. Glia (2006) 53:225–31. doi:10.1002/glia.20276
    • (2006) Glia , vol.53 , pp. 225-231
    • Waagepetersen, H.S.1    Hansen, G.H.2    Fenger, K.3    Lindsay, J.G.4    Gibson, G.5    Schousboe, A.6
  • 74
    • 0026615180 scopus 로고
    • 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells
    • 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells. Biochimie (1992) 74:941–8. doi:10. 1016/0300-9084(92)90078-S
    • (1992) Biochimie , vol.74 , pp. 941-948
    • Brand, A.1    Engelmann, J.2    Leibfritz, D.3
  • 75
    • 0029662102 scopus 로고    scopus 로고
    • 5 ] glutamine in cultured astrocytes studied by NMR spectroscopy: First evidence of astrocytic pyruvate recycling
    • 5 ] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling. J Neurochem (1996) 67:2566–72. doi:10.1046/j.1471-4159.1996. 67062566.x
    • (1996) J Neurochem , vol.67 , pp. 2566-2572
    • Sonnewald, U.1    Westergaard, N.2    Jones, P.3    Taylor, A.4    Bachelard, H.S.5    Schousboe, A.6
  • 77
    • 0036866554 scopus 로고    scopus 로고
    • Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons
    • Waagepetersen HS, Qu H, Hertz L, Sonnewald U, Schousboe A. Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons. Neurochem Res (2002) 27:1431–7. doi:10.1023/A:1021636102735
    • (2002) Neurochem Res , vol.27 , pp. 1431-1437
    • Waagepetersen, H.S.1    Qu, H.2    Hertz, L.3    Sonnewald, U.4    Schousboe, A.5
  • 79
    • 0031958583 scopus 로고    scopus 로고
    • Glutamine transport by the blood-brain barrier: A possible mechanism for nitrogen removal
    • Lee WJ, Hawkins RA, Viña JR, Peterson DR. Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal. Am J Physiol (1998) 274:C1101–7.
    • (1998) Am J Physiol , vol.274 , pp. C1101-C1107
    • Lee, W.J.1    Hawkins, R.A.2    Viña, J.R.3    Peterson, D.R.4
  • 80
    • 0038742081 scopus 로고    scopus 로고
    • Glutamine transport at the blood-brain and blood-cerebrospinal fluid barriers
    • Xiang J, Ennis SR, Abdelka-rim GE, Fujisawa M, Kawai N, Keep RF. Glutamine transport at the blood-brain and blood-cerebrospinal fluid barriers. Neurochem Int (2003) 43:279–88. doi:10.1016/S0197-0186(03) 00013-5
    • (2003) Neurochem Int , vol.43 , pp. 279-288
    • Xiang, J.1    Ennis, S.R.2    Abdelka-Rim, G.E.3    Fujisawa, M.4    Kawai, N.5    Keep, R.F.6
  • 82
    • 70349338971 scopus 로고    scopus 로고
    • Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats
    • Duarte JMN, Carvalho RA, Cunha RA, Gruetter R. Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. J Neurochem (2009) 111:368–79. doi:10.1111/j. 1471-4159.2009.06349.x
    • (2009) J Neurochem , vol.111 , pp. 368-379
    • Duarte, J.M.N.1    Carvalho, R.A.2    Cunha, R.A.3    Gruetter, R.4
  • 83
    • 84859592535 scopus 로고    scopus 로고
    • Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood-brain-barrier
    • Duarte JMN, Gruetter R. Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood-brain-barrier. J Neurochem (2012) 121:396–406. doi:10.1111/j.1471-4159.2012. 07688.x
    • (2012) J Neurochem , vol.121 , pp. 396-406
    • Duarte, J.M.N.1    Gruetter, R.2
  • 88
    • 84874659340 scopus 로고    scopus 로고
    • Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy
    • Hyder F, Fulbright RK, Shulman RG, Rothman DL. Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy. J Cereb Blood Flow Metab (2013) 33:339–47. doi:10. 1038/jcbfm.2012.207
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 339-347
    • Hyder, F.1    Fulbright, R.K.2    Shulman, R.G.3    Rothman, D.L.4
  • 89
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A (1994) 91:10625–9. doi:10.1073/pnas.91.22.10625
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 90
    • 0029382123 scopus 로고
    • Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat
    • Eriksson G, Peterson A, Iverfeldt K, Walum E. Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. Glia (1995) 15:152–6. doi:10. 1002/glia.440150207
    • (1995) Glia , vol.15 , pp. 152-156
    • Eriksson, G.1    Peterson, A.2    Iverfeldt, K.3    Walum, E.4
  • 91
    • 0031239472 scopus 로고    scopus 로고
    • + ATPase in mammalian astrocytes
    • + ATPase in mammalian astrocytes. Glia (1997) 21:35–45. doi:10.1002/(SICI)1098-1136(199709)21: 1<35::AID-GLIA4>3.0.CO;2-0
    • (1997) Glia , vol.21 , pp. 35-45
    • Silver, I.A.1    Erecinska, M.2
  • 92
    • 0026009448 scopus 로고
    • Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation
    • Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, et al. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proc Natl Acad Sci U S A (1991) 88:5829–31. doi:10.1073/pnas.88. 13.5829
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 5829-5831
    • Prichard, J.1    Rothman, D.2    Novotny, E.3    Petroff, O.4    Kuwabara, T.5    Avison, M.6
  • 93
    • 0030021266 scopus 로고    scopus 로고
    • Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man
    • Frahm J, Krüger G, Merboldt KD, Kleinschmidt A. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magn Reson Med (1996) 35:143–8. doi:10.1002/mrm.1910350202
    • (1996) Magn Reson Med , vol.35 , pp. 143-148
    • Frahm, J.1    Krüger, G.2    Merboldt, K.D.3    Kleinschmidt, A.4
  • 94
    • 0028840080 scopus 로고
    • Lactate rise in the basal ganglia accompanying finger movements: A localized 1H-MRS study
    • Kuwabara T, Watanabe H, Tsuji S, Yuasa T. Lactate rise in the basal ganglia accompanying finger movements: a localized 1H-MRS study. Brain Res (1995) 670:326–8. doi:10.1016/0006-8993(94)01353-J
    • (1995) Brain Res , vol.670 , pp. 326-328
    • Kuwabara, T.1    Watanabe, H.2    Tsuji, S.3    Yuasa, T.4
  • 96
    • 84875614432 scopus 로고    scopus 로고
    • Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences
    • Just N, Xin L, Frenkel H, Gruetter R. Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences. Neuroimage (2013) 74:343–51. doi:10.1016/j. neuroimage.2013.02.042
    • (2013) Neuroimage , vol.74 , pp. 343-351
    • Just, N.1    Xin, L.2    Frenkel, H.3    Gruetter, R.4
  • 97
    • 84879603781 scopus 로고    scopus 로고
    • Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla
    • Schaller B, Mekle R, Xin L, Kunz N, Gruetter R. Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla. J Neurosci Res (2013) 91(8):1076–83. doi:10. 1002/jnr.23194
    • (2013) J Neurosci Res , vol.91 , Issue.8 , pp. 1076-1083
    • Schaller, B.1    Mekle, R.2    Xin, L.3    Kunz, N.4    Gruetter, R.5
  • 99
    • 0026740232 scopus 로고
    • Decrease of glucose in the human visual cortex during photic stimulation
    • Merboldt KD, Bruhn H, Hänicke W, Michaelis T, Frahm J. Decrease of glucose in the human visual cortex during photic stimulation. Magn Reson Med (1992) 25:187–94. doi:10.1002/mrm.1910250119
    • (1992) Magn Reson Med , vol.25 , pp. 187-194
    • Merboldt, K.D.1    Bruhn, H.2    Hänicke, W.3    Michaelis, T.4    Frahm, J.5
  • 100
    • 84862673316 scopus 로고    scopus 로고
    • Abnormal response to cortical activation in early stages of Huntington disease
    • Mochel F, N’Guyen TM, Deelchand D, Rinaldi D, Valabregue R, Wary C, et al. Abnormal response to cortical activation in early stages of Huntington disease. Mov Disord (2012) 27(7):907–10. doi:10.1002/mds.25009
    • (2012) Mov Disord , vol.27 , Issue.7 , pp. 907-910
    • Mochel, F.1    N’Guyen, T.M.2    Deelchand, D.3    Rinaldi, D.4    Valabregue, R.5    Wary, C.6
  • 101
    • 74049124295 scopus 로고    scopus 로고
    • Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex
    • Lei H, Duarte JM, Mlynárik V, Python A, Gruetter R. Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex. J Neurosci Res (2010) 88:413–9. doi:10.1002/jnr.22212
    • (2010) J Neurosci Res , vol.88 , pp. 413-419
    • Lei, H.1    Duarte, J.M.2    Mlynárik, V.3    Python, A.4    Gruetter, R.5
  • 102
    • 0036842462 scopus 로고    scopus 로고
    • Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: On the correlation of total glucose consumption with glutamatergic action
    • Choi IY, Lei H, Gruetter R. Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action. J Cereb Blood Flow Metab (2002) 22:1343–51. doi:10. 1097/00004647-200211000-00008
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1343-1351
    • Choi, I.Y.1    Lei, H.2    Gruetter, R.3
  • 103
    • 34247471119 scopus 로고    scopus 로고
    • Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex
    • Mangia S, Tkác I, Gruetter R, Van de Moortele PF, Maraviglia B, Ugurbil K. Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex. J Cereb Blood Flow Metab (2007) 27:1055–63.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1055-1063
    • Mangia, S.1    Tkác, I.2    Gruetter, R.3    van de Moortele, P.F.4    Maraviglia, B.5    Ugurbil, K.6
  • 104
    • 0036897552 scopus 로고    scopus 로고
    • Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises
    • Dienel GA, Wang RY, Cruz NF. Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises. J Cereb Blood Flow Metab (2002) 22:1490–502. doi:10.1097/00004647-200212000-00009
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1490-1502
    • Dienel, G.A.1    Wang, R.Y.2    Cruz, N.F.3
  • 108
    • 33748087816 scopus 로고    scopus 로고
    • Increased oxygen consumption in the somatosensory cortex of alpha-chloralose anesthetized rats during forepaw stimulation determined using MRS at 11.7 Tesla
    • Yang J, Shen J. Increased oxygen consumption in the somatosensory cortex of alpha-chloralose anesthetized rats during forepaw stimulation determined using MRS at 11.7 Tesla. Neuroimage (2006) 32:1317–25. doi:10.1016/j. neuroimage.2006.05.010
    • (2006) Neuroimage , vol.32 , pp. 1317-1325
    • Yang, J.1    Shen, J.2
  • 110
    • 84866697175 scopus 로고    scopus 로고
    • Fueling and imaging brain activation
    • Dienel GA. Fueling and imaging brain activation. ASN Neuro (2012) 4(5):e00093. doi:10.1042/AN20120021
    • (2012) ASN Neuro , vol.4 , Issue.5
    • Dienel, G.A.1
  • 111
    • 74449087772 scopus 로고    scopus 로고
    • Deciphering neuron-glia compartmentalization in cortical energy metabolism
    • Jolivet R, Magistretti PJ, Weber B. Deciphering neuron-glia compartmentalization in cortical energy metabolism. Front Neuroenergetics (2009) 1:4. doi:10.3389/neuro.14. 004.2009
    • (2009) Front Neuroenergetics , vol.1 , pp. 4
    • Jolivet, R.1    Magistretti, P.J.2    Weber, B.3
  • 112
    • 84863426424 scopus 로고    scopus 로고
    • Updated energy budgets for neural computation in the neocortex and cerebellum
    • Howarth C, Gleeson P, Attwell D. Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metab (2012) 32:1222–32. doi:10. 1038/jcbfm.2012.35
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1222-1232
    • Howarth, C.1    Gleeson, P.2    Attwell, D.3
  • 113
    • 84883163590 scopus 로고    scopus 로고
    • Brain metabolic compartmentalization, metabolism modeling, and cerebral activity-metabolism relationship
    • Choi I-Y, Gruetter R, editors.,. New York: Springer
    • Merle M, Franconi J-M. Brain metabolic compartmentalization, metabolism modeling, and cerebral activity-metabolism relationship. In: Choi I-Y, Gruetter R, editors. Neural Metabolism In vivo. New York: Springer (2012). p. 947–92.
    • (2012) Neural Metabolism in Vivo , pp. 947-992
    • Merle, M.1    Franconi, J.-M.2
  • 114
    • 36248942923 scopus 로고    scopus 로고
    • Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development
    • Chowdhury GM, Patel AB, Mason GF, Rothman DL, Behar KL. Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development. J Cereb Blood Flow Metab (2007) 27:1895–907. doi:10.1038/sj.jcbfm.9600490
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1895-1907
    • Chowdhury, G.M.1    Patel, A.B.2    Mason, G.F.3    Rothman, D.L.4    Behar, K.L.5
  • 115
    • 71649089074 scopus 로고    scopus 로고
    • 13C] NMR spectroscopy: Cerebral energetics and glutamatergic/GABAergic neurotransmission
    • 13C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission. J Neurochem (2010) 112:24–33. doi:10.1111/j. 1471-4159.2009.06428.x
    • (2010) J Neurochem , vol.112 , pp. 24-33
    • van Eijsden, P.1    Behar, K.L.2    Mason, G.F.3    Braun, K.P.4    de Graaf, R.A.5
  • 116
    • 0028317657 scopus 로고
    • K+-induced alkalinization in mouse cerebral astrocytes mediated by reversal of electrogenic Na+-HCO3-cotransport
    • Brookes N, Turner RJ. K+-induced alkalinization in mouse cerebral astrocytes mediated by reversal of electrogenic Na+-HCO3-cotransport. Am J Physiol (1994) 267:C1633–40.
    • (1994) Am J Physiol , vol.267 , pp. C1633-C1640
    • Brookes, N.1    Turner, R.J.2
  • 117
    • 0030680073 scopus 로고    scopus 로고
    • Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes
    • Gamberino WC, Berkich DA, Lynch CJ, Xu B, LaNoue KF. Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes. J Neurochem (1997) 69:2312–25. doi:10.1046/j. 1471-4159.1997.69062312.x
    • (1997) J Neurochem , vol.69 , pp. 2312-2325
    • Gamberino, W.C.1    Berkich, D.A.2    Lynch, C.J.3    Xu, B.4    Lanoue, K.F.5
  • 119
    • 84885023305 scopus 로고    scopus 로고
    • Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain
    • Tiwari V, Ambadipudi S, Patel AB. Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. J Cereb Blood Flow Metab (2013) 33(10):1523–31. doi: 10.1038/jcbfm.2013.114
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.10 , pp. 1523-1531
    • Tiwari, V.1    Ambadipudi, S.2    Patel, A.B.3
  • 120
    • 0028835732 scopus 로고
    • 13C NMR spectroscopy may indicate compartmentation and mitochondrial heterogeneity
    • 13C NMR spectroscopy may indicate compartmentation and mitochondrial heterogeneity. Neurosci Lett (1995) 185:24–8. doi: 10.1016/0304-3940(94)11216-6
    • (1995) Neurosci Lett , vol.185 , pp. 24-28
    • Westergaard, N.1    Sonnewald, U.2    Petersen, S.B.3    Schousboe, A.4
  • 123
    • 78650897135 scopus 로고    scopus 로고
    • Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation
    • Pardo B, Rodrigues TB, Contreras L, Garzón M, Llorente-Folch I, Kobayashi K, et al. Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation. J Cereb Blood Flow Metab (2011) 31:90–101. doi: 10.1038/jcbfm.2010.146
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 90-101
    • Pardo, B.1    Rodrigues, T.B.2    Contreras, L.3    Garzón, M.4    Llorente-Folch, I.5    Kobayashi, K.6
  • 124
    • 84870301157 scopus 로고    scopus 로고
    • Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes
    • Li B, Hertz L, Peng L. Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes. Neurochem Int (2012) 61:1325–32. doi:10.1016/j.neuint.2012.09.009
    • (2012) Neurochem Int , vol.61 , pp. 1325-1332
    • Li, B.1    Hertz, L.2    Peng, L.3
  • 125
    • 63949085615 scopus 로고    scopus 로고
    • 13C magnetization transfer spectroscopy
    • 13C magnetization transfer spectroscopy. J Cereb Blood Flow Metab (2009) 29:661–9. doi: 10.1038/jcbfm.2008.170
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 661-669
    • Yang, J.1    Xu, S.2    Shen, J.3
  • 126
    • 84870595821 scopus 로고    scopus 로고
    • In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance
    • Mishkovsky M, Comment A, Gruetter R. In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance. J Cereb Blood Flow Metab (2012) 32:2108–13. doi:10.1038/jcbfm.2012.136
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 2108-2113
    • Mishkovsky, M.1    Comment, A.2    Gruetter, R.3
  • 128
    • 79954586028 scopus 로고    scopus 로고
    • Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model
    • Duarte JMN, Morgenthaler FD, Lei H, Poitry-Yamate C, Gruetter R. Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model. Front Neuroenergetics (2009) 1:6. doi:10.3389/neuro.14.006.2009
    • (2009) Front Neuroenergetics , vol.1 , pp. 6
    • Duarte, J.M.N.1    Morgenthaler, F.D.2    Lei, H.3    Poitry-Yamate, C.4    Gruetter, R.5
  • 130
    • 80054897514 scopus 로고    scopus 로고
    • Simultaneous measurement of glucose transport and utilization in the human brain
    • Shestov AA, Emir UE, Kumar A, Henry PG, Seaquist ER, Öz G. Simultaneous measurement of glucose transport and utilization in the human brain. Am J Physiol Endocrinol Metab. (2011) 301(5):E1040–9. doi:10. 1152/ajpendo.00110.2011.
    • (2011) Am J Physiol Endocrinol Metab , vol.301 , Issue.5 , pp. E1040-E1049
    • Shestov, A.A.1    Emir, U.E.2    Kumar, A.3    Henry, P.G.4    Seaquist, E.R.5    Öz, G.6
  • 131
    • 0035018399 scopus 로고    scopus 로고
    • Differentiation of glucose transport in human brain gray and white matter
    • de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotny EJ, et al. Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab (2001) 21(5):483–92. doi:10.1097/00004647-200105000-00002
    • (2001) J Cereb Blood Flow Metab , vol.21 , Issue.5 , pp. 483-492
    • de Graaf, R.A.1    Pan, J.W.2    Telang, F.3    Lee, J.H.4    Brown, P.5    Novotny, E.J.6
  • 132
    • 0031961946 scopus 로고    scopus 로고
    • Steady-state cerebral glucose concentrations and transport in the human brain
    • Gruetter R, Ugurbil K, Seaquist ER. Steady-state cerebral glucose concentrations and transport in the human brain. J Neurochem (1998) 70:397–408. doi:10.1046/j. 1471-4159.1998.70010397.x
    • (1998) J Neurochem , vol.70 , pp. 397-408
    • Gruetter, R.1    Ugurbil, K.2    Seaquist, E.R.3
  • 133
    • 33748688199 scopus 로고    scopus 로고
    • 13C NMR study
    • 13C NMR study. J Neurochem (2006) 99:260–8. doi:10. 1111/j.1471-4159.2006.04115.x
    • (2006) J Neurochem , vol.99 , pp. 260-268
    • Lei, H.1    Gruetter, R.2
  • 134
    • 84859733227 scopus 로고    scopus 로고
    • Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcNZO10/LtJ mice
    • Duarte JMN, Agostinho PM, Carvalho RA, Cunha RA. Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcNZO10/LtJ mice. PLoS One (2012) 7:e21899. doi:10. 1371/journal.pone.0021899
    • (2012) Plos One , vol.7
    • Duarte, J.M.N.1    Agostinho, P.M.2    Carvalho, R.A.3    Cunha, R.A.4
  • 136
    • 50549159930 scopus 로고
    • The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations
    • Cleland WW. The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. Biochim Biophys Acta (1963) 67:104–37. doi:10.1016/0926-6569(63)90226-8
    • (1963) Biochim Biophys Acta , vol.67 , pp. 104-137
    • Cleland, W.W.1
  • 137
    • 0016703741 scopus 로고
    • Kinetic analysis of active membrane transport systems: Equations for net velocity and isotope exchange
    • Cuppoletti J, Segel IH. Kinetic analysis of active membrane transport systems: equations for net velocity and isotope exchange. J Theor Biol (1975) 53:125–44. doi: 10.1016/0022-5193(75)90107-1
    • (1975) J Theor Biol , vol.53 , pp. 125-144
    • Cuppoletti, J.1    Segel, I.H.2
  • 138
    • 34547823401 scopus 로고    scopus 로고
    • A quantitative overview of glucose dynamics in the gliovascular unit
    • Barros LF, Bittner CX, Loaiza A, Porras OH. A quantitative overview of glucose dynamics in the gliovascular unit. Glia (2007) 55:1222–37. doi:10.1002/glia.20375
    • (2007) Glia , vol.55 , pp. 1222-1237
    • Barros, L.F.1    Bittner, C.X.2    Loaiza, A.3    Porras, O.H.4
  • 139
    • 84856006405 scopus 로고    scopus 로고
    • High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice
    • Alf FM, Lei H, Berthet C, Hirt L, Gruetter R, Mlynárik V. High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice. NMR Biomed (2011) 25:247–54. doi:10.1002/nbm.1740
    • (2011) NMR Biomed , vol.25 , pp. 247-254
    • Alf, F.M.1    Lei, H.2    Berthet, C.3    Hirt, L.4    Gruetter, R.5    Mlynárik, V.6
  • 140
    • 85079778709 scopus 로고    scopus 로고
    • Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging
    • Mlynárik V, Cudalbu C, Frenkel H, Gruetter R. Mapping glucose and lactate concentrations with microliter resolution in rat brain using short-echo-time spectroscopic imaging. Proc Intl Soc Mag Reson Med (2009) 17:2386.
    • (2009) Proc Intl Soc Mag Reson Med , vol.17 , pp. 2386
    • Mlynárik, V.1    Cudalbu, C.2    Frenkel, H.3    Gruetter, R.4
  • 142
    • 0344850193 scopus 로고    scopus 로고
    • 13C] glycogen concentrations and metabolism in rat brain in vivo
    • 13C] glycogen concentrations and metabolism in rat brain in vivo. J Neurochem (1999) 73:1300–8. doi:10.1046/j. 1471-4159.1999.0731300.x
    • (1999) J Neurochem , vol.73 , pp. 1300-1308
    • Choi, I.Y.1    Tkac, I.2    Ugurbil, K.3    Gruetter, R.4
  • 143
    • 33947102530 scopus 로고    scopus 로고
    • Human brain glycogen content and metabolism: Implications on its role in brain energy metabolism
    • Oz G, Seaquist ER, Kumar A, Criego AB, Benedict LE, Rao JP, et al. Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Am J Physiol Endocrinol Metab (2007) 292:E946–51. doi: 10.1152/ajpendo.00424.2006
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , pp. E946-E951
    • Oz, G.1    Seaquist, E.R.2    Kumar, A.3    Criego, A.B.4    Benedict, L.E.5    Rao, J.P.6
  • 145
    • 0021527421 scopus 로고
    • Glycogen, its transient occurrence in neurons of the rat CNS during normal postnatal development
    • Borke RC, Nau ME. Glycogen, its transient occurrence in neurons of the rat CNS during normal postnatal development. Brain Res (1984) 318:277–84.
    • (1984) Brain Res , vol.318 , pp. 277-284
    • Borke, R.C.1    Nau, M.E.2
  • 146
    • 0022907958 scopus 로고
    • Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes
    • Cataldo AM, Broadwell RD. Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes. J Neurocytol (1986) 15:511–24. doi: 10.1007/BF01611733
    • (1986) J Neurocytol , vol.15 , pp. 511-524
    • Cataldo, A.M.1    Broadwell, R.D.2
  • 147
    • 84986531942 scopus 로고
    • Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. I. Neurons and glia
    • Cataldo AM, Broadwell RD. Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. I. Neurons and glia. J Electron Microsc Tech (1986) 3:413–37. doi: 10.1002/jemt.1060030406
    • (1986) J Electron Microsc Tech , vol.3 , pp. 413-437
    • Cataldo, A.M.1    Broadwell, R.D.2
  • 148
    • 0015505764 scopus 로고
    • Barbiturate-induced glycogen accumulation in brain. An electron microscopic study
    • Phelps CH. Barbiturate-induced glycogen accumulation in brain. An electron microscopic study. Brain Res (1972) 39:225–34. doi: 10.1016/0006-8993(72)90797-4
    • (1972) Brain Res , vol.39 , pp. 225-234
    • Phelps, C.H.1
  • 149
    • 0025313558 scopus 로고
    • Immunohistochemical demonstration of glycogen phosphorylase in rat brain slices
    • Pfeiffer B, Elmer K, Roggen-dorf W, Reinhart PH, Hamprecht B. Immunohistochemical demonstration of glycogen phosphorylase in rat brain slices. Histo-chemistry (1990) 94:73–80. doi:10. 1007/BF00266792
    • (1990) Histo-Chemistry , vol.94 , pp. 73-80
    • Pfeiffer, B.1    Elmer, K.2    Roggen-Dorf, W.3    Reinhart, P.H.4    Hamprecht, B.5
  • 150
    • 0032323520 scopus 로고    scopus 로고
    • Immunocytochemical localization of glycogen phosphorylase kinase in rat brain sections and in glial and neuronal primary cultures
    • Psarra AM, Pfeiffer B, Gian-nakopoulou M, Sotiroudis TG, Stylianopoulou F, Hamprecht B. Immunocytochemical localization of glycogen phosphorylase kinase in rat brain sections and in glial and neuronal primary cultures. J Neurocytol (1998) 27:779–90. doi: 10.1023/A:1006970429961
    • (1998) J Neurocytol , vol.27 , pp. 779-790
    • Psarra, A.M.1    Pfeiffer, B.2    Gian-Nakopoulou, M.3    Sotiroudis, T.G.4    Stylianopoulou, F.5    Hamprecht, B.6
  • 151
    • 35548995067 scopus 로고    scopus 로고
    • Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
    • Vilchez D, Ros S, Cifuentes D, Pujadas L, Vallès J, García-Fojeda B, et al. Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nat Neurosci (2007) 10:1407–13. doi:10.1038/nn1998
    • (2007) Nat Neurosci , vol.10 , pp. 1407-1413
    • Vilchez, D.1    Ros, S.2    Cifuentes, D.3    Pujadas, L.4    Vallès, J.5    García-Fojeda, B.6
  • 152
    • 33645843954 scopus 로고    scopus 로고
    • Biochemical quantification of total brain glycogen concentration in rats under different glycemic states
    • Morgenthaler FD, Koski DM, Kraftsik R, Henry PG, Gruetter R. Biochemical quantification of total brain glycogen concentration in rats under different glycemic states. Neurochem Int (2006) 48:616–22. doi:10.1016/j. neuint.2005.12.034
    • (2006) Neurochem Int , vol.48 , pp. 616-622
    • Morgenthaler, F.D.1    Koski, D.M.2    Kraftsik, R.3    Henry, P.G.4    Gruetter, R.5
  • 153
    • 55849127507 scopus 로고    scopus 로고
    • Non-invasive quantification of brain glycogen absolute concentration
    • Morgenthaler FD, van Heeswijk RB, Xin L, Laus S, Frenkel H, Lei H, et al. Non-invasive quantification of brain glycogen absolute concentration. J Neurochem (2008) 107:1414–23. doi:10.1111/j.1471-4159.2008.05717.x
    • (2008) J Neurochem , vol.107 , pp. 1414-1423
    • Morgenthaler, F.D.1    van Heeswijk, R.B.2    Xin, L.3    Laus, S.4    Frenkel, H.5    Lei, H.6
  • 154
    • 64949164758 scopus 로고    scopus 로고
    • Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness
    • Morgenthaler FD, Lanz BR, Petit JM, Frenkel H, Magistretti PJ, Gruetter R. Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness. Neurochem Int (2009) 55:45–51. doi:10.1016/j.neuint.2009.02.023
    • (2009) Neurochem Int , vol.55 , pp. 45-51
    • Morgenthaler, F.D.1    Lanz, B.R.2    Petit, J.M.3    Frenkel, H.4    Magistretti, P.J.5    Gruetter, R.6
  • 155
    • 0012641870 scopus 로고    scopus 로고
    • 13C NMR assessment of brain glycogen concentration and turnover in the awake rat
    • 13C NMR assessment of brain glycogen concentration and turnover in the awake rat. Neurochem Int (2003) 43:317–22. doi:10.1016/S0197-0186(03)00018-4
    • (2003) Neurochem Int , vol.43 , pp. 317-322
    • Choi, I.Y.1    Gruetter, R.2
  • 156
    • 0015843351 scopus 로고
    • Factors affecting the turnover of cerebral glycogen and limit dextrin in vivo
    • Watanabe H, Passonneau JV. Factors affecting the turnover of cerebral glycogen and limit dextrin in vivo. J Neurochem (1973) 20:1543–54. doi:10.1111/j. 1471-4159.1973.tb00272.x
    • (1973) J Neurochem , vol.20 , pp. 1543-1554
    • Watanabe, H.1    Passonneau, J.V.2
  • 157
    • 0345074150 scopus 로고    scopus 로고
    • Effect of hypoglycemia on brain glycogen metabolism in vivo
    • Choi IY, Seaquist ER, Gruetter R. Effect of hypoglycemia on brain glycogen metabolism in vivo. J Neurosci Res (2003) 72:25–32. doi: 10.1002/jnr.10574
    • (2003) J Neurosci Res , vol.72 , pp. 25-32
    • Choi, I.Y.1    Seaquist, E.R.2    Gruetter, R.3
  • 158
    • 0026513876 scopus 로고
    • Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of astroglia-rich primary cultures
    • Dringen R, Hamprecht B. Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of astroglia-rich primary cultures. J Neurochem (1992) 58:511–7. doi:10.1111/j. 1471-4159.1992.tb09750.x
    • (1992) J Neurochem , vol.58 , pp. 511-517
    • Dringen, R.1    Hamprecht, B.2
  • 159
    • 0033035588 scopus 로고    scopus 로고
    • L-glutamate and insulin enhance glycogen synthesis in cultured astrocytes from the rat brain through different intracellular mechanisms
    • Hamai M, Minokoshi Y, Shi-mazu T. L-glutamate and insulin enhance glycogen synthesis in cultured astrocytes from the rat brain through different intracellular mechanisms. J Neurochem (1999) 73:400–7. doi:10.1046/j. 1471-4159.1999.0730400.x
    • (1999) J Neurochem , vol.73 , pp. 400-407
    • Hamai, M.1    Minokoshi, Y.2    Shi-Mazu, T.3
  • 161
    • 0017819634 scopus 로고
    • Effects of phenobarbital in cerebral ischemia. Part I: Cerebral energy metabolism during pronounced incomplete ischemia
    • Nordström CH, Siesjö BK. Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia. Stroke (1978) 9:327–35. doi:10.1161/01.STR.9.4.327
    • (1978) Stroke , vol.9 , pp. 327-335
    • Nordström, C.H.1    Siesjö, B.K.2
  • 162
    • 0026541812 scopus 로고
    • Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography
    • Swanson RA, Morton MM, Sagar SM, Sharp FR. Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography. Neuroscience (1992) 51:451–61. doi:10.1016/0306-4522(92)90329-Z
    • (1992) Neuroscience , vol.51 , pp. 451-461
    • Swanson, R.A.1    Morton, M.M.2    Sagar, S.M.3    Sharp, F.R.4
  • 163
    • 0029021443 scopus 로고
    • Medial forebrain bundle stimulation in rats activates glycogen phosphorylase in layers 4, 5b and 6 of ipsilateral granular neocortex
    • Harley CW, Milway JS, Fara-On M. Medial forebrain bundle stimulation in rats activates glycogen phosphorylase in layers 4, 5b and 6 of ipsilateral granular neocortex. Brain Res (1995) 685:217–23. doi:10.1016/0006-8993(95) 00481-5
    • (1995) Brain Res , vol.685 , pp. 217-223
    • Harley, C.W.1    Milway, J.S.2    Fara-On, M.3
  • 164
    • 0036898698 scopus 로고    scopus 로고
    • High glycogen levels in brains of rats with minimal environmental stimuli: Implications for metabolic contributions of working astrocytes
    • Cruz NF, Dienel GA. High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes. J Cereb Blood Flow Metab (2002) 22:1476–89. doi:10.1097/00004647-200212000-00008
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1476-1489
    • Cruz, N.F.1    Dienel, G.A.2
  • 165
    • 34347253931 scopus 로고    scopus 로고
    • A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: Implications for glycogen
    • Dienel GA, Ball KK, Cruz NF. A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen. J Neurochem (2007) 102(2):466–78. doi:10.1111/j.1471-4159.2007. 04595.x
    • (2007) J Neurochem , vol.102 , Issue.2 , pp. 466-478
    • Dienel, G.A.1    Ball, K.K.2    Cruz, N.F.3
  • 166
    • 79952305803 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate transport is required for long-term memory formation
    • Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell (2011) 144:810–23. doi:10. 1016/j.cell.2011.02.018
    • (2011) Cell , vol.144 , pp. 810-823
    • Suzuki, A.1    Stern, S.A.2    Bozdagi, O.3    Huntley, G.W.4    Walker, R.H.5    Magistretti, P.J.6
  • 167
    • 41549117585 scopus 로고    scopus 로고
    • Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration
    • Herzog RI, Chan O, Yu S, Dziura J, McNay EC, Sherwin RS. Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration. Endocrinology (2008) 149:1499–504. doi:10.1210/en.2007-1252
    • (2008) Endocrinology , vol.149 , pp. 1499-1504
    • Herzog, R.I.1    Chan, O.2    Yu, S.3    Dziura, J.4    McNay, E.C.5    Sherwin, R.S.6
  • 168
    • 79751533104 scopus 로고    scopus 로고
    • Brain glycogen supercompensation in the mouse after recovery from insulin-induced hypoglycemia
    • Canada SE, Weaver SA, Sharpe SN, Pederson BA. Brain glycogen supercompensation in the mouse after recovery from insulin-induced hypoglycemia. J Neurosci Res (2011) 89:585–91. doi:10. 1002/jnr.22579
    • (2011) J Neurosci Res , vol.89 , pp. 585-591
    • Canada, S.E.1    Weaver, S.A.2    Sharpe, S.N.3    Pederson, B.A.4
  • 169
    • 70349086613 scopus 로고    scopus 로고
    • Human brain glycogen metabolism during and after hypoglycemia
    • Oz G, Kumar A, Rao JP, Kodl CT, Chow L, Eberly LE, et al. Human brain glycogen metabolism during and after hypoglycemia. Diabetes (2009) 58:1978–85. doi:10. 2337/db09-0226
    • (2009) Diabetes , vol.58 , pp. 1978-1985
    • Oz, G.1    Kumar, A.2    Rao, J.P.3    Kodl, C.T.4    Chow, L.5    Eberly, L.E.6
  • 170
    • 33947428261 scopus 로고    scopus 로고
    • Astrocyte glycogen sustains neuronal activity during hypoglycemia: Studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)
    • Suh SW, Bergher JP, Anderson CM, Treadway JL, Fosgerau K, Swanson RA. Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide). J Pharmacol Exp Ther (2007) 321:45–50. doi:10.1124/jpet.106.115550
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 45-50
    • Suh, S.W.1    Bergher, J.P.2    Anderson, C.M.3    Treadway, J.L.4    Fosgerau, K.5    Swanson, R.A.6
  • 171
    • 84863011313 scopus 로고    scopus 로고
    • Brain glycogen supercompensation following exhaustive exercise
    • Matsui T, Ishikawa T, Ito H, Okamoto M, Inoue K, Lee MC, et al. Brain glycogen supercompensation following exhaustive exercise. J Physiol (2012) 590:607–16. doi:10.1113/jphysiol.2011.217919
    • (2012) J Physiol , vol.590 , pp. 607-616
    • Matsui, T.1    Ishikawa, T.2    Ito, H.3    Okamoto, M.4    Inoue, K.5    Lee, M.C.6
  • 172
    • 33847022735 scopus 로고    scopus 로고
    • Role of hypothalamic adenosine 5’-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia
    • Alquier T, Kawashima J, Tsuji Y, Kahn BB. Role of hypothalamic adenosine 5’-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology (2007) 148:1367–75. doi:10.1210/en.2006-1039
    • (2007) Endocrinology , vol.148 , pp. 1367-1375
    • Alquier, T.1    Kawashima, J.2    Tsuji, Y.3    Kahn, B.B.4
  • 173
    • 84856439323 scopus 로고    scopus 로고
    • Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness
    • Oz G, Tesfaye N, Kumar A, Deelchand DK, Eberly LE, Seaquist ER. Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness. J Cereb Blood Flow Metab (2012) 32:256–63. doi:10.1038/jcbfm.2011.138
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 256-263
    • Oz, G.1    Tesfaye, N.2    Kumar, A.3    Deelchand, D.K.4    Eberly, L.E.5    Seaquist, E.R.6
  • 174
    • 79954824955 scopus 로고    scopus 로고
    • Why does the brain (Not) have glycogen?
    • DiNuzzo M, Maraviglia B, Giove F. Why does the brain (not) have glycogen? Bioessays (2011) 33:319–26. doi:10.1002/bies.201000151
    • (2011) Bioessays , vol.33 , pp. 319-326
    • Dinuzzo, M.1    Maraviglia, B.2    Giove, F.3
  • 175
    • 0031878025 scopus 로고    scopus 로고
    • Control analysis of muscle glycogen metabolism
    • Schulz AR. Control analysis of muscle glycogen metabolism. Arch Biochem Biophys (1998) 353:172–80. doi:10.1006/abbi.1998.0643
    • (1998) Arch Biochem Biophys , vol.353 , pp. 172-180
    • Schulz, A.R.1


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