Effect of acute hypoglycemia on human cerebral glucose metabolism measured by13C magnetic resonance spectroscopy

Diabetes

Volumn 60, Issue 5, 2011, Pages 1467-1473

  Van De Ven, Kim C C ^a   De Galan, Bastiaan E ^a   Van Der Graaf, Marinette ^a   Shestov, Alexander A ^b   Henry, Pierre Gilles ^b   Tack, Cees J J ^a   Heerschap, Arend ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CARBON 13; GLUCAGON; GLUCOSE; GLUTAMIC ACID; GROWTH HORMONE; HYDROCORTISONE; NORADRENALIN; TRICARBOXYLIC ACID;

ACUTE HYPOGLYCEMIA; ADULT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HUMAN; HYPOGLYCEMIA; LACTATE BLOOD LEVEL; MALE; METABOLIC RATE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; OCCIPITAL CORTEX; PRIORITY JOURNAL;

ADULT; CEREBRUM; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPOGLYCEMIA; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, BIOLOGICAL;

EID: 79959480446     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1592     Document Type: Article

References (40)

1. Cryer PE. The barrier of hypoglycemia in diabetes. Diabetes 2008;57:3169-3176
2. Friers BM, Fisher BM (Eds.). Hypoglycemia in Clinical Diabetes. New York, Wiley, 1999
3. Cox DJ, Gonder-Frederick LA, Kovatchev BP, Julian DM, Clarke WL. Progressive hypoglycemia's impact on driving simulation performance: occurrence, awareness and correction. Diabetes Care 2000;23:163-170 (Pubitemid 30071018)
4. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J. Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 1993;42:1233-1237 (Pubitemid 23259841)
5. Maran A, Crepaldi C, Trupiani S, et al. Brain function rescue effect of lactate following hypoglycaemia is not an adaptation process in both normal and type I diabetic subjects. Diabetologia 2000;43:733-741 (Pubitemid 30409149)
6. Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes 2006;55:929-934 (Pubitemid 44100166)
7. Bischof MG, Brehm A, Bernroider E, et al. Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans. Eur J Clin Invest 2006;36:164-169 (Pubitemid 43341266)
8. Bingham EM, Dunn JT, Smith D, et al. Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11C]-3-O-methyl-D-glucose PET study. Diabetologia 2005;48:2080-2089 (Pubitemid 41416920)
9. Cranston I, Reed LJ, Marsden PK, Amiel SA. Changes in regional brain (18)F-fluorodeoxyglucose uptake at hypoglycemia in type 1 diabetic men associated with hypoglycemia unawareness and counter-regulatory failure. Diabetes 2001;50:2329-2336
10. McCrimmon RJ, Sherwin RS. Hypoglycemia in type 1 diabetes. Diabetes 2010;59:2333-2339
11. 13C]- NMR spectroscopy of cerebral metabolism. NMR Biomed 2003;16:339-357
12. 13C magnetic resonance spectroscopy at 3T of human brain glucose metabolism under euglycemic and hypoglycemic conditions. J Neurosci Methods 2010;186:68-71
13. Mason GF, Rothman DL. Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivo. Metab Eng 2004;6:75-84
14. 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective. Magn Reson Imaging 2006;24:527-539
15. Serlie MJ, de Haan JH, Tack CJ, et al. Glycogen synthesis in human gastrocnemius muscle is not representative of whole-body muscle glycogen synthesis. Diabetes 2005;54:1277-1282 (Pubitemid 40586654)
16. Van Den Bergh AJ, Tack CJ, Van Den Boogert HJ, Vervoort G, Smits P, Heerschap A. Assessment of human muscle glycogen synthesis and total glucose content by in vivo 13C MRS. Eur J Clin Invest 2000;30:122-128 (Pubitemid 30079569)
17. 13C MR spectroscopy of the human brain at 3 Tesla. Magn Reson Med 2006;55:271-278
18. Klomp DW, Kentgens AP, Heerschap A. Polarization transfer for sensitivity-enhanced MRS using a single radio frequency transmit channel. NMR Biomed 2008;21:444-452 (Pubitemid 351895432)
19. Shaka AJ, Keeler J, Frenkiel T, Freeman R. An improved sequence for broadband decoupling: WALTZ-16. J Magn Reson 1983;52:335-338
20. Vanhamme L, van den Boogaart A, Van Huffel S, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997;129:35-43 (Pubitemid 127454051)
21. Naressi A, Couturier C, Devos JM, et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA 2001;12:141-152 (Pubitemid 32510133)
22. 13C MRS in vivo. NMR Biomed 2003;16:358-369
23. 13C] NMR spectroscopy. J Neurochem 2002;82:857-866
24. Henry PG, Criego AB, Kumar A, Seaquist ER. Measurement of cerebral oxidative glucose consumption in patients with type 1 diabetes mellitus and hypoglycemia unawareness using (13)C nuclear magnetic resonance spectroscopy. Metabolism 2010;59:100-106
25. Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG, Novotny EJ. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab 1995;15:12-25
26. Choi IY, Lei H, Gruetter R. Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action. J Cereb Blood Flow Metab 2002; 22:1343-1351 (Pubitemid 35285092)
27. Mason GF, Falk Petersen K, de Graaf RA, et al. A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose. Brain Res Brain Res Protoc 2003;10:181-190
28. Gruetter R, Seaquist ER, Ugurbil K. A mathematical model of compart-mentalized neurotransmitter metabolism in the human brain. Am J Physiol Endocrinol Metab 2001;281:E100-E112
29. Boumezbeur F, Mason GF, de Graaf RA, et al. Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cereb Blood Flow Metab 2010;30:211-221
30. Jiang L, Herzog RI, Mason GF, et al. Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo. Diabetes 2009;58:1266-1274
31. Pan JW, Stein DT, Telang F, et al. Spectroscopic imaging of glutamate C4 turnover in human brain. Magn Reson Med 2000;44:673-679
32. 13C NMR. Proc Natl Acad Sci USA 1999;96:8235-8240
33. Abi-Saab WM, Maggs DG, Jones T, et al. Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. J Cereb Blood Flow Metab 2002;22:271-279 (Pubitemid 34203054)
34. van Hall G, Strømstad M, Rasmussen P, et al. Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab 2009;29: 1121-1129
35. Smith D, Pernet A, Hallett WA, Bingham E, Marsden PK, Amiel SA. Lactate: a preferred fuel for human brain metabolism in vivo. J Cereb Blood Flow Metab 2003;23:658-664 (Pubitemid 36713670)
36. 13C nuclear magnetic resonance spectroscopy. J Neurosci 2010;30:13983-13991
37. 13C-labelled microdialysis and highre-solution nuclear magnetic resonance study. Brain 2009;132:2839-2849
38. Oz G, Kumar A, Rao JP, et al. Human brain glycogen metabolism during and after hypoglycemia. Diabetes 2009;58:1978-1985
39. Brown AM, Ransom BR. Astrocyte glycogen and brain energy metabolism. Glia 2007;55:1263-1271 (Pubitemid 47235367)
40. Gruetter R, Ugurbil K, Seaquist ER. Steady-state cerebral glucose concentrations and transport in the human brain. J Neurochem 1998;70:397-408 (Pubitemid 28020868)