메뉴 건너뛰기




Volumn 32, Issue 12, 2012, Pages 2108-2113

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

Author keywords

2 oxoglutarate; acetate; dynamic nuclear polarization; hyperpolarization; real time metabolism; TCA cycle

Indexed keywords

2 OXOGLUTARIC ACID; TRICARBOXYLIC ACID;

EID: 84870595821     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.136     Document Type: Article
Times cited : (66)

References (44)
  • 1
    • 84944817192 scopus 로고
    • On the regulation of the blood-supply of the brain
    • Roy CS, Sherrington CS. On the regulation of the blood-supply of the brain. J Physiol 1890; 11: 85-108.
    • (1890) J Physiol , vol.11 , pp. 85-108
    • Roy, C.S.1    Sherrington, C.S.2
  • 2
    • 0014840975 scopus 로고
    • The history of the tricarboxylic acid cycle
    • Krebs HA. The history of the tricarboxylic acid cycle. Perspect Biol Med 1970; 14: 154-170.
    • (1970) Perspect Biol Med , vol.14 , pp. 154-170
    • Krebs, H.A.1
  • 5
    • 0034814676 scopus 로고    scopus 로고
    • A mathematical model of compartmentalized neurotransmitter metabolism in the human brain
    • Gruetter R, Seaquist ER, Ugurbil K. A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol 2001; 281: E100-E112.
    • (2001) Am J Physiol , vol.281
    • Gruetter, R.1    Seaquist, E.R.2    Ugurbil, K.3
  • 6
    • 0036522961 scopus 로고    scopus 로고
    • Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism
    • Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S et al. Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 2002; 22: 1523-1531.
    • (2002) J Neurosci , vol.22 , pp. 1523-1531
    • Lebon, V.1    Petersen, K.F.2    Cline, G.W.3    Shen, J.4    Mason, G.F.5    Dufour, S.6
  • 7
    • 0026563676 scopus 로고
    • NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain
    • Mason GF, Rothman DL, Behar KL, Shulman RG. NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain. J Cereb Blood Flow Metab 1992; 12: 434-447.
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 434-447
    • Mason, G.F.1    Rothman, D.L.2    Behar, K.L.3    Shulman, R.G.4
  • 8
    • 0025274269 scopus 로고
    • Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR
    • Cerdan S, Kunnecke B, Seelig J. Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR. J Biol Chem 1990; 265: 12916-12926.
    • (1990) J Biol Chem , vol.265 , pp. 12916-12926
    • Cerdan, S.1    Kunnecke, B.2    Seelig, J.3
  • 10
    • 77953136237 scopus 로고    scopus 로고
    • Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using H-1-[C-13]-NMR
    • Patel AB, De Graaf RA, Rothman DL, Behar KL, Mason GF. Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using H-1-[C-13]-NMR. J Cereb Blood Flow Metab 2010; 30: 1200-1213.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1200-1213
    • Patel, A.B.1    De Graaf, R.A.2    Rothman, D.L.3    Behar, K.L.4    Mason, G.F.5
  • 12
    • 0028170043 scopus 로고
    • Localized C-13 NMR-spectroscopy in the human brain of amino-acid labeling from D-[1-C-13]glucose
    • Gruetter R, Novotny EJ, Boulware SD, Mason GF, Rothman DL, Shulman GI et al. Localized C-13 NMR-spectroscopy in the human brain of amino-acid labeling from D-[1-C-13]glucose. J Neurochem 1994; 63: 1377-1385.
    • (1994) J Neurochem , vol.63 , pp. 1377-1385
    • Gruetter, R.1    Novotny, E.J.2    Boulware, S.D.3    Mason, G.F.4    Rothman, D.L.5    Shulman, G.I.6
  • 13
    • 0001874695 scopus 로고    scopus 로고
    • 13C isotopomer analysis of glutamate: A NMR method to probe metabolic pathways intersecting in the citric acid cycle
    • Berliner LJ, Robitaille P-M (eds) Kluwer Academic Publishers: New York, NY
    • Sherry AD, Malloy CR. 13C isotopomer analysis of glutamate: a NMR method to probe metabolic pathways intersecting in the citric acid cycle. In: Berliner LJ, Robitaille P-M (eds) In Vivo Carbon-13 NMR vol. 15. Kluwer Academic Publishers: New York, NY, 2002, pp 59-97.
    • (2002) Vivo Carbon-13 NMR , vol.15 , pp. 59-97
    • Sherry, A.D.1    Malloy, C.R.2
  • 17
    • 49349084954 scopus 로고    scopus 로고
    • Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP
    • Comment A, Rentsch J, Kurdzesau F, Jannin S, Uffmann K, van Heeswijk RB et al. Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP. J Magn Reson 2008; 194: 152-155.
    • (2008) J Magn Reson , vol.194 , pp. 152-155
    • Comment, A.1    Rentsch, J.2    Kurdzesau, F.3    Jannin, S.4    Uffmann, K.5    Van Heeswijk, R.B.6
  • 18
    • 0034653836 scopus 로고    scopus 로고
    • A new nitroxyl-probe with high retention in the brain and its application for brain imaging
    • Sano H, Naruse M, Matsumoto K, Oi T, Utsumi H. A new nitroxyl-probe with high retention in the brain and its application for brain imaging. Free Radical Bio Med 2000; 28: 959-969.
    • (2000) Free Radical Bio Med , vol.28 , pp. 959-969
    • Sano, H.1    Naruse, M.2    Matsumoto, K.3    Oi, T.4    Utsumi, H.5
  • 19
    • 80054065714 scopus 로고    scopus 로고
    • In vivo detection of intermediate metabolic products of [1-C-13]ethanol in the brain using C-13 MRS
    • Xiang Y, Shen J. In vivo detection of intermediate metabolic products of [1-C-13]ethanol in the brain using C-13 MRS. NMR Biomed 2011; 24: 1054-1062.
    • (2011) NMR Biomed , vol.24 , pp. 1054-1062
    • Xiang, Y.1    Shen, J.2
  • 20
    • 0021961581 scopus 로고
    • Blood volume in the rat
    • Lee HB, Blaufox MD. Blood volume in the rat. J Nucl Med 1985; 26: 72-76.
    • (1985) J Nucl Med , vol.26 , pp. 72-72
    • Lee, H.B.1    Blaufox, M.D.2
  • 21
    • 0025367229 scopus 로고    scopus 로고
    • Effects of hypernatremia on organic brain osmoles
    • Lien YHH, Shapiro JI, Chan L. Effects of hypernatremia on organic brain osmoles. J Clin Invest 1990; 85: 1427-1435.
    • J Clin Invest 1990 , vol.85 , pp. 1427-1435
    • Yhh, L.1    Shapiro, J.I.2    Chan, L.3
  • 23
    • 0344850193 scopus 로고    scopus 로고
    • Noninvasive measurements of [1-(13)C]glycogen concentrations and metabolism in rat brain in vivo
    • Choi IY, Tkac I, Ugurbil K, Gruetter R. Noninvasive measurements of [1-(13)C]glycogen concentrations and metabolism in rat brain in vivo. J Neurochem 1999; 73: 1300-1308.
    • (1999) J Neurochem , vol.73 , pp. 1300-1308
    • Choi, I.Y.1    Tkac, I.2    Ugurbil, K.3    Gruetter, R.4
  • 24
    • 0342948677 scopus 로고    scopus 로고
    • Field mapping without reference scan using asymmetric echoplanar techniques
    • Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echoplanar techniques. Magn Reson Med 2000; 43: 319-323.
    • (2000) Magn Reson Med , vol.43 , pp. 319-323
    • Gruetter, R.1    Tkac, I.2
  • 26
    • 0000633163 scopus 로고
    • Principles of dynamic nuclear-polarization
    • Abragam A, Goldman M. Principles of dynamic nuclear-polarization. Rep Prog Phys 1978; 41: 395-467.
    • (1978) Rep Prog Phys , vol.41 , pp. 395-467
    • Abragam, A.1    Goldman, M.2
  • 27
    • 0001413420 scopus 로고    scopus 로고
    • Metabolite profiling by one-and two-dimensional NMR analysis of complex mixtures
    • Fan WMT. Metabolite profiling by one-and two-dimensional NMR analysis of complex mixtures. Prog Nucl Mag Res Sp 1996; 28: 161-219.
    • (1996) Prog Nucl Mag Res Sp , vol.28 , pp. 161-219
    • Wmt, F.1
  • 28
    • 78650528801 scopus 로고    scopus 로고
    • Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: Evidence for a metabolon
    • Meyer FM, Gerwig J, Hammer E, Herzberg C, Commichau FM, Volker U et al. Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon. Metab Eng 2011; 13: 18-27.
    • (2011) Metab Eng , vol.13 , pp. 18-27
    • Meyer, F.M.1    Gerwig, J.2    Hammer, E.3    Herzberg, C.4    Commichau, F.M.5    Volker, U.6
  • 29
    • 48549111326 scopus 로고
    • Why are enzymes so big
    • Srere PA. Why Are Enzymes So Big. Trends Biochem Sci 1984; 9: 387-390.
    • (1984) Trends Biochem Sci , vol.9 , pp. 387-390
    • Srere, P.A.1
  • 30
    • 0017411635 scopus 로고
    • On the role of organized multienzyme systems in cellular metabolism: A general synthesis
    • Welch GR. On the role of organized multienzyme systems in cellular metabolism: a general synthesis. Prog Biophys Mol Biol 1977; 32: 103-191.
    • (1977) Prog Biophys Mol Biol , vol.32 , pp. 103-191
    • Welch, G.R.1
  • 32
    • 68849099655 scopus 로고    scopus 로고
    • Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy
    • Schroeder MA, Atherton HJ, Ball DR, Cole MA, Heather LC, Griffin JL et al. Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J 2009; 23: 2529-2538.
    • (2009) FASEB J , vol.23 , pp. 2529-2538
    • Schroeder, M.A.1    Atherton, H.J.2    Ball, D.R.3    Cole, M.A.4    Heather, L.C.5    Griffin, J.L.6
  • 33
    • 84870578707 scopus 로고    scopus 로고
    • Improved quantification of mitochondrial exchange TCA cycle rate and neurotransmission flux using 1H{13C} MRS measurements of C4 and C3 of glutamate and glutamine
    • Lanz B, Xin L, Gruetter R. Improved quantification of mitochondrial exchange, TCA cycle rate and neurotransmission flux using 1H{13C} MRS measurements of C4 and C3 of glutamate and glutamine. Proc Int Soc Mag Reson Med 2010; 18.
    • (2010) Proc Int Soc Mag Reson Med , pp. 18
    • Lanz, B.1    Xin, L.2    Gruetter, R.3
  • 34
    • 65449147539 scopus 로고    scopus 로고
    • Calcium signaling in brain mitochondria: Interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways
    • Contreras L, Satrustegui J. Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways. J Biol Chem 2009; 284: 7091-7099.
    • (2009) J Biol Chem , vol.284 , pp. 7091-7099
    • Contreras, L.1    Satrustegui, J.2
  • 35
    • 54249093810 scopus 로고    scopus 로고
    • Hyperpolarized 13C lactate, pyruvate, and alanine: Noninvasive biomarkers for prostate cancer detection and grading
    • Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY et al. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res 2008; 68: 8607-8615.
    • (2008) Cancer Res , vol.68 , pp. 8607-8615
    • Albers, M.J.1    Bok, R.2    Chen, A.P.3    Cunningham, C.H.4    Zierhut, M.L.5    Zhang, V.Y.6
  • 38
    • 35948970970 scopus 로고    scopus 로고
    • Detecting tumor response to treatment using hyperpolarized (13)C magnetic resonance imaging and spectroscopy
    • Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J et al. Detecting tumor response to treatment using hyperpolarized (13)C magnetic resonance imaging and spectroscopy. Nat Med 2007; 13: 1382-1387.
    • (2007) Nat Med , vol.13 , pp. 1382-1387
    • Day, S.E.1    Kettunen, M.I.2    Gallagher, F.A.3    Hu, D.E.4    Lerche, M.5    Wolber, J.6
  • 39
    • 77957942042 scopus 로고    scopus 로고
    • In vivo C-13 spectroscopy in the rat brain using hyperpolarized [1-C-13]pyruvate and [2-C-13]pyruvate
    • Marjań ska M, Iltis I, Shestov AA, Deelchand DK, Nelson C, Ugurbil K et al. In vivo C-13 spectroscopy in the rat brain using hyperpolarized [1-C-13]pyruvate and [2-C-13]pyruvate. J Magn Res 2010; 206: 210-218.
    • (2010) J Magn Res , vol.206 , pp. 210-218
    • Marjańska, M.1    Iltis, I.2    Shestov, A.A.3    Deelchand, D.K.4    Nelson, C.5    Ugurbil, K.6
  • 42
    • 4444352923 scopus 로고    scopus 로고
    • Tricarboxylic acid cycle enzymes following thiamine deficiency
    • Bubber P, Ke ZJ, Gibson GE. Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochem Int 2004; 45: 1021-1028.
    • (2004) Neurochem Int , vol.45 , pp. 1021-1028
    • Bubber, P.1    Ke, Z.J.2    Gibson, G.E.3
  • 43
    • 18244390483 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
    • Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE. Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol 2005; 57: 695-703.
    • (2005) Ann Neurol , vol.57 , pp. 695-703
    • Bubber, P.1    Haroutunian, V.2    Fisch, G.3    Blass, J.P.4    Gibson, G.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.