Determination of oxidative glucose metabolism in vivo in the young rat brain using localized direct-detected 13C NMR spectroscopy

Neurochemical Research

Volumn 36, Issue 11, 2011, Pages 1962-1968

  Ennis, Kathleen ^a   Deelchand, Dinesh Kumar ^a   Tkac, Ivan ^a   Henry, Pierre Gilles ^a   Rao, Raghavendra ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

13C NMR spectroscopy; Brain; Development; Glucose; Oxidative metabolism; Rat

Indexed keywords

CHLORALOSE; GLUCOSE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN METABOLISM; CARBOHYDRATE ANALYSIS; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; COMPARTMENT MODEL; CONTROLLED STUDY; EX VIVO STUDY; GLUCOSE BRAIN LEVEL; GLUCOSE INFUSION; GLUCOSE METABOLISM; IN VIVO STUDY; ISOTOPE LABELING; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; CARBON ISOTOPES; CITRIC ACID CYCLE; GLUCOSE; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 80055013088     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0519-x     Document Type: Article

References (29)

1. A Nehlig 1996 Respective roles of glucose and ketone bodies as substrates for cerebral energy metabolism in the suckling rat Dev Neurosci 18 5-6 426 433 8940615 10.1159/000111437 1:CAS:528:DyaK28Xntl2gtLo%3D (Pubitemid 26371585)
2. A Nehlig 1997 Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia Diabetes Metab 23 1 18 29 9059763 1:CAS:528:DyaK2sXitFCmtLY%3D (Pubitemid 27099753)
3. RC Vannucci SJ Vannucci 2000 Glucose metabolism in the developing brain Semin Perinatol 24 2 107 115 10805166 10.1053/sp.2000.6361 1:STN:280: DC%2BD3c3mt12itA%3D%3D (Pubitemid 30228403)
4. R Gruetter ER Seaquest S Kim K Ugurbil 1998 Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla Dev Neurosci 20 380 388 9778575 10.1159/000017334 1:CAS:528:DyaK1cXntl2lsbc%3D (Pubitemid 28495533)
5. PG Henry V Lebon F Vaufrey E Brouillet P Hantraye G Bloch 2002 Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy J Neurochem 82 4 857 866 12358791 10.1046/j.1471-4159. 2002.01006.x 1:CAS:528:DC%2BD38XmsF2hur0%3D
6. F Hyder DL Rothman GF Mason A Rangarajan KL Behar RG Shulman 1997 Oxidative glucose metabolism in rat brain during single forepaw stimulation: a spatially localized 1H[13C] nuclear magnetic resonance study J Cereb Blood Flow Metab 17 10 1040 1047 9346428 10.1097/00004647-199710000-00005 1:CAS:528:DyaK2sXntV2mt7k%3D (Pubitemid 27459331)
7. GF Mason R Gruetter DL Rothman KL Behar RG Shulman EJ Novotny 1995 Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR J Cereb Blood Flow Metab 15 1 12 25 7798329 10.1038/jcbfm.1995.2 1:CAS:528:DyaK2MXjsVWmu7w%3D
8. PG Henry AB Criego A Kumar ER Seaquist 2010 Measurement of cerebral oxidative glucose consumption in patients with type 1 diabetes mellitus and hypoglycemia unawareness using (13)C nuclear magnetic resonance spectroscopy Metabolism 59 1 100 106 19766263 10.1016/j.metabol.2009.07.012 1:CAS:528:DC%2BD1MXhsFamsr7K
9. R Gruetter G Adriany IY Choi PG Henry H Lei G Oz 2003 Localized in vivo 13C NMR spectroscopy of the brain NMR Biomed 16 6-7 313 338 14679498 10.1002/nbm.841 1:CAS:528:DC%2BD2cXkslCluw%3D%3D (Pubitemid 38008361)
10. PG Henry G Adriany D Deelchand R Gruetter M Marjanska G Oz ER Seaquist A Shestov K Ugurbil 2006 In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective Magn Reson Imaging 24 4 527 539 16677959 10.1016/j.mri.2006.01.003 1:CAS:528:DC%2BD28XktVyjuro%3D
11. GF Mason DL Rothman 2004 Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivo Metab Eng 6 1 75 84 14734257 10.1016/j.ymben.2003.10.003 1:CAS:528:DC%2BD2cXkvFOrtA%3D%3D (Pubitemid 38157797)
12. S Scafidi J O'Brien I Hopkins C Robertson G Fiskum M McKenna 2009 Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats J Neurochem 109 Suppl 1 189 197 19393027 10.1111/j.1471-4159.2009.05896.x 1:CAS:528:DC%2BD1MXlsFyktrw%3D
13. TR Pirttila SO Auriola RA Kauppinen 1995 Glucose metabolism in the developing cerebral cortex as detected by 1H(13C) nuclear magnetic resonance spectroscopy ex vivo J Neurochem 64 1 417 423 7798941 10.1046/j.1471-4159.1995. 64010417.x 1:CAS:528:DyaK2MXislSjt7s%3D
14. EJ Novotny Jr C Ariyan GF Mason J O'Reilly GG Haddad KL Behar 2001 Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro Brain Res 888 2 193 202 11150475 10.1016/S0006-8993(00)03051-1 1:CAS:528:DC%2BD3MXitlyqtA%3D%3D (Pubitemid 32058783)
15. GM Chowdhury AB Patel GF Mason DL Rothman KL Behar 2007 Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development J Cereb Blood Flow Metab 27 12 1895 1907 17440492 10.1038/sj.jcbfm.9600490 1:CAS:528:DC%2BD2sXhtlWqurvI (Pubitemid 350129159)
16. CI Nabuurs DW Klomp A Veltien HE Kan A Heerschap 2008 Localized sensitivity enhanced in vivo 13C MRS to detect glucose metabolism in the mouse brain Magn Reson Med 59 3 626 630 18224699 10.1002/mrm.21498 1:CAS:528:DC%2BD1cXktFarsrs%3D (Pubitemid 351348234)
17. J Valette F Boumezbeur P Hantraye V Lebon 2009 Simplified (13)C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo Magn Reson Med 62 6 1641 1645 19780166 10.1002/mrm.22160 1:CAS:528:DC%2BD1MXhs1Sks7nL
18. KA Yamada N Rensing Y Izumi GA De Erausquin V Gazit DA Dorsey DG Herrera 2004 Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation Pediatr Res 55 3 372 379 14681492 10.1203/01.PDR.0000110523.07240. C1 1:CAS:528:DC%2BD2cXht1akt7s%3D (Pubitemid 38240812)
19. Kohn DF, Clifford CB (2002) Biology and disease of rats. In: Fox JG, Anderson LC, Loew FM, Quimby FW (eds) Laboratory animal medicine, 2nd edn. Academic Press, New York, pp 121-165
20. SL Wood BK Beyer GD Cappon 2003 Species comparison of postnatal CNS development: functional measures Birth Defects Res B Dev Reprod Toxicol 68 5 391 407 14745989 10.1002/bdrb.10037 1:CAS:528:DC%2BD3sXptFOjtr0%3D (Pubitemid 38222015)
21. HB Lee MD Blaufox 1985 Blood volume in the rat J Nucl Med 26 1 72 76 3965655 1:STN:280:DyaL2M%2Fot1ehsQ%3D%3D (Pubitemid 15161428)
22. R Rao K Ennis JD Long K Ugurbil R Gruetter I Tkac 2010 Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia J Neurochem 114 3 728 738 20477939 10.1111/j.1471-4159.2010.06797.x 1:CAS:528:DC%2BC3cXpslygtb0%3D
23. DK Deelchand AA Shestov DM Koski K Ugurbil PG Henry 2009 Acetate transport and utilization in the rat brain J Neurochem 109 Suppl 1 46 54 19393008 10.1111/j.1471-4159.2009.05895.x 1:CAS:528:DC%2BD1MXlsFyksL0%3D
24. DK Deelchand K Ugurbil PG Henry 2006 Investigating brain metabolism at high fields using localized 13C NMR spectroscopy without 1H decoupling Magn Reson Med 55 2 279 286 16345037 10.1002/mrm.20756 1:CAS:528:DC%2BD28XhvVSqsro%3D (Pubitemid 43238095)
25. R Gruetter ER Seaquist K Ugurbil 2001 A mathematical model of compartmentalized neurotransmitter metabolism in the human brain Am J Physiol Endocrinol Metab 281 1 E100 E112 11404227 1:CAS:528:DC%2BD3MXltVKhtr4%3D
26. PG Henry G Oz S Provencher R Gruetter 2003 Toward dynamic isotopomer analysis in the rat brain in vivo: automatic quantitation of 13C NMR spectra using LCModel NMR Biomed 16 6-7 400 412 14679502 10.1002/nbm.840 1:CAS:528:DC%2BD2cXkslCksQ%3D%3D (Pubitemid 38008365)
27. I Tkac R Rao MK Georgieff R Gruetter 2003 Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy Magn Reson Med 50 1 24 32 12815675 10.1002/mrm.10497 1:CAS:528:DC%2BD3sXmtVajt74%3D (Pubitemid 36841856)
28. AA Shestov J Valette K Ugurbil PG Henry 2007 On the reliability of (13)C metabolic modeling with two-compartment neuronal-glial models J Neurosci Res 85 15 3294 3303 17393498 10.1002/jnr.21269 1:CAS:528:DC%2BD1cXjtFClsLs%3D (Pubitemid 350058517)
29. L Hertz GA Dienel 2002 Energy metabolism in the brain Int Rev Neurobiol 51 1 102 12420357 10.1016/S0074-7742(02)51003-5 1:CAS:528:DC%2BD38XpsVyis7o%3D