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Volumn 27, Issue 11, 2002, Pages 1431-1437

Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

Author keywords

Astrocytes; Glutamate metabolism; Glutamine; Malic enzyme; Metabolic compartmentation; Neurons

Indexed keywords

2 OXOGLUTARIC ACID; ACETYL COENZYME A; CARBON 13; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID; MALATE DEHYDROGENASE (DECARBOXYLATING); MALIC ACID; OXALOACETIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVIC ACID;

EID: 0036866554     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021636102735     Document Type: Article
Times cited : (77)

References (40)
  • 3
    • 0014475517 scopus 로고
    • The turnover of glutamate, glutamine, aspartate and GABA labeled with [1-14C]acetate in caudate nucleus, thalamus and motor cortex (cat)
    • Berl, S. and Frigyesi, T. L. 1969. The turnover of glutamate, glutamine, aspartate and GABA labeled with [1-14C]acetate in caudate nucleus, thalamus and motor cortex (cat). Brain Res. 12:444-455.
    • (1969) Brain Res. , vol.12 , pp. 444-455
    • Berl, S.1    Frigyesi, T.L.2
  • 4
    • 0032527892 scopus 로고    scopus 로고
    • Preferential utilization of acetate by astrocytes is attributable to transport
    • Waniewski, R. A. and Martin, D. L. 1998. Preferential utilization of acetate by astrocytes is attributable to transport. J. Neurosci. 18:5225-5233.
    • (1998) J. Neurosci. , vol.18 , pp. 5225-5233
    • Waniewski, R.A.1    Martin, D.L.2
  • 7
    • 0027338137 scopus 로고
    • 13C NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle
    • 13C NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle. J. Neurochem. 61:1179-1182.
    • (1993) J. Neurochem. , vol.61 , pp. 1179-1182
    • Sonnewald, U.1    Westergaard, N.2    Hassel, B.3    Müller, T.B.4    Unsgård, G.5    Schousboe, A.6
  • 8
    • 0027465673 scopus 로고
    • Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures
    • Kurz, G. M., Wiesinger, H., and Hamprecht, B. 1993. Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures. J. Neurochem. 60:1467-1474.
    • (1993) J. Neurochem. , vol.60 , pp. 1467-1474
    • Kurz, G.M.1    Wiesinger, H.2    Hamprecht, B.3
  • 9
    • 0031782834 scopus 로고    scopus 로고
    • Mitochondrial malic enzyme: Purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain
    • Vogel, R., Jennemann, G., Seitz, J., Wiesinger, H., and Hamprecht, B. 1998. Mitochondrial malic enzyme: Purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain. J. Neurochem, 71:844-52.
    • (1998) J. Neurochem. , vol.71 , pp. 844-852
    • Vogel, R.1    Jennemann, G.2    Seitz, J.3    Wiesinger, H.4    Hamprecht, B.5
  • 10
    • 0028802388 scopus 로고
    • Glial formation of pyruvate and lactate from TCA cycle intermediates: Implications for the inactivation of transmitter amino acids
    • Hassel, B. and Sonnewald, U. 1995. Glial formation of pyruvate and lactate from TCA cycle intermediates: implications for the inactivation of transmitter amino acids. J. Neurochem. 65:2227-2234.
    • (1995) J. Neurochem. , vol.65 , pp. 2227-2234
    • Hassel, B.1    Sonnewald, U.2
  • 11
    • 0034257070 scopus 로고    scopus 로고
    • Neuronal-astrocytic and cytosolic mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation
    • Hertz, L., Yu, A. C. H., Kala, G., and Schousboe, A. 2000. Neuronal-astrocytic and cytosolic mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation. Neurochem. Int. 37:83-102.
    • (2000) Neurochem. Int. , vol.37 , pp. 83-102
    • Hertz, L.1    Yu, A.C.H.2    Kala, G.3    Schousboe, A.4
  • 14
    • 0031595179 scopus 로고    scopus 로고
    • 13C]Aspartate metabolism in cultured cortical astrocytes and cerebellar granule neurons studied by NMR spectroscopy
    • 13C]Aspartate metabolism in cultured cortical astrocytes and cerebellar granule neurons studied by NMR spectroscopy. Glia 23:271-277.
    • (1998) Glia , vol.23 , pp. 271-277
    • Bakken, I.J.1    White, L.R.2    Aasly, J.3    Unsgård, G.4    Sonnewald, U.5
  • 15
    • 0035947220 scopus 로고    scopus 로고
    • The effect of thiopental on glutamate metabolism in mouse cerebellar astrocytes in vitro
    • Qu, H., van der Gaag, M., Le Maire, T., and Sonnewald, U. 2001. The effect of thiopental on glutamate metabolism in mouse cerebellar astrocytes in vitro. Neurosci. Lett. 304:141-144.
    • (2001) Neurosci. Lett. , vol.304 , pp. 141-144
    • Qu, H.1    Van der Gaag, M.2    Le Maire, T.3    Sonnewald, U.4
  • 17
    • 0033982623 scopus 로고    scopus 로고
    • Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells
    • McKenna, M. C., Stevenson, J., Huang, X., Tildon, J. T., Zielke, C. L., and Hopkins, I. B. 2000. Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells. Neurochem. Int. 36:451-459.
    • (2000) Neurochem. Int. , vol.36 , pp. 451-459
    • McKenna, M.C.1    Stevenson, J.2    Huang, X.3    Tildon, J.T.4    Zielke, C.L.5    Hopkins, I.B.6
  • 18
    • 0001325330 scopus 로고
    • Preparation of primary cultures of mouse (rat) astrocytes
    • Shahar, A., de Vellis, J., Vernadakis, A., and Haber, B., eds. Alan R. Liss, New York
    • Hertz, L., Juurlink, B. H. J., Hertz, E., Fosmark, H., and Schousboe, A. 1989. Preparation of primary cultures of mouse (rat) astrocytes. In: Shahar, A., de Vellis, J., Vernadakis, A., and Haber, B., eds. A Dissection and Tissue Culture Manual for the Nervous System. Alan R. Liss, New York, pp, 105-108.
    • (1989) A Dissection and Tissue Culture Manual for the Nervous System , pp. 105-108
    • Hertz, L.1    Juurlink, B.H.J.2    Hertz, E.3    Fosmark, H.4    Schousboe, A.5
  • 20
    • 0001607156 scopus 로고
    • Preparation of primary cultures of mouse cortical neurons
    • Shahar, A., de Vellis, J., Vernadakis, A., and Haber, B., eds. Alan R. Liss, New York
    • Hertz, E., Yu, A. C. H., Hertz, L., Juurlink, B. H. J., and Schousboe, A. 1989. Preparation of primary cultures of mouse cortical neurons. In: Shahar, A., de Vellis, J., Vernadakis, A., and Haber, B., eds. A Dissection and Tissue Culture Manual for the Nervous System. Alan R. Liss, New York, pp. 183-186.
    • (1989) A Dissection and Tissue Culture Manual for the Nervous System , pp. 183-186
    • Hertz, E.1    Yu, A.C.H.2    Hertz, L.3    Juurlink, B.H.J.4    Schousboe, A.5
  • 21
    • 0002602845 scopus 로고
    • Primary cultures of GABAergic and glutamatergic neurons as model systems to study neurotransmitter functions. I. Developmental aspects
    • Vernadakis, A., Privat, A., Lauder, J. M., Timiras, P. S., and Giacobini, E., eds. Martinus Nijhoff Publishers. Mass
    • Schousboe, A. and Hertz, L. 1987. Primary cultures of GABAergic and glutamatergic neurons as model systems to study neurotransmitter functions. I. Developmental aspects. In: Vernadakis, A., Privat, A., Lauder, J. M., Timiras, P. S., and Giacobini, E., eds. Model Systems of Development and Aging of the Nervous System. Martinus Nijhoff Publishers. Mass., pp. 33-42.
    • (1987) Model Systems of Development and Aging of the Nervous System , pp. 33-42
    • Schousboe, A.1    Hertz, L.2
  • 22
    • 0025961176 scopus 로고
    • Metabolism and release of glutamate in cerebellar granule cells cocultured with astrocytes from cerebellum or cerebral cortex
    • Westergaard, N., Fosmark, H., and Schousboe, A. 1991. Metabolism and release of glutamate in cerebellar granule cells cocultured with astrocytes from cerebellum or cerebral cortex. J. Neurochem. 56:59-66.
    • (1991) J. Neurochem. , vol.56 , pp. 59-66
    • Westergaard, N.1    Fosmark, H.2    Schousboe, A.3
  • 24
    • 0021339969 scopus 로고
    • Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and 4-aminobutyric acid
    • Geddes, J. W. and Wood, J. D. 1984. Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and 4-aminobutyric acid. J. Neurochem. 42:16-24.
    • (1984) J. Neurochem. , vol.42 , pp. 16-24
    • Geddes, J.W.1    Wood, J.D.2
  • 27
    • 0035577699 scopus 로고    scopus 로고
    • Glucose and lactate metabolism during brain activation
    • Dienel, G. A. and Hertz, L. 2001. Glucose and lactate metabolism during brain activation. J. Neurosci. Res. 66:824-838.
    • (2001) J. Neurosci. Res. , vol.66 , pp. 824-838
    • Dienel, G.A.1    Hertz, L.2
  • 29
    • 0024260649 scopus 로고
    • Lactate release from cultured astrocytes and neurons: A comparison
    • Waiz, W. and Mukerji, S. 1988. Lactate release from cultured astrocytes and neurons: A comparison. Glia 1:366-370.
    • (1988) Glia , vol.1 , pp. 366-370
    • Waiz, W.1    Mukerji, S.2
  • 30
    • 0028631489 scopus 로고
    • Signalling effect of monoamines and of elevated potassium concentrations on brain energy metabolism at the cellular level
    • Huang, R., Peng, L., Chen, Y., Hajek, I., Zhao, Z., and Hertz, L. 1994. Signalling effect of monoamines and of elevated potassium concentrations on brain energy metabolism at the cellular level. Dev. Neurosci. 16:337-351.
    • (1994) Dev. Neurosci. , vol.16 , pp. 337-351
    • Huang, R.1    Peng, L.2    Chen, Y.3    Hajek, I.4    Zhao, Z.5    Hertz, L.6
  • 31
    • 0028819598 scopus 로고
    • Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme
    • Schmoll, D., Führmann, E., Gebhardt, R., and Hamprecht B. 1995. Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme. Eur. J. Biochem. 227:308-315.
    • (1995) Eur. J. Biochem. , vol.227 , pp. 308-315
    • Schmoll, D.1    Führmann, E.2    Gebhardt, R.3    Hamprecht, B.4
  • 32
    • 0026046438 scopus 로고
    • The intracellular distribution and activities of phosphoenolpyruvate carboxykinase isozymes in various tissues of several mammals and birds
    • Wiese, T. J., Lambeth, D. O., and Ray, P. D. 1991. The intracellular distribution and activities of phosphoenolpyruvate carboxykinase isozymes in various tissues of several mammals and birds. Comp. Biochem. Physiol. B. 100:297-302.
    • (1991) Comp. Biochem. Physiol. B , vol.100 , pp. 297-302
    • Wiese, T.J.1    Lambeth, D.O.2    Ray, P.D.3
  • 33
    • 0031800050 scopus 로고    scopus 로고
    • Ontogeny and cellular localization of the pyruvate recycling system in rat brain
    • Cruz, F., Scott, S. R., Barroso, I., Santisteban, P., and Cerdan S. 1998. Ontogeny and cellular localization of the pyruvate recycling system in rat brain. J. Neurochem. 70:2613-2619.
    • (1998) J. Neurochem. , vol.70 , pp. 2613-2619
    • Cruz, F.1    Scott, S.R.2    Barroso, I.3    Santisteban, P.4    Cerdan, S.5
  • 34
    • 0030061356 scopus 로고    scopus 로고
    • Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes
    • McKenna, M. C., Sonnewald, U., Huang, X., Stevenson, J., and Zielke, H. R. 1996. Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J. Neurochem. 66:386-393.
    • (1996) J. Neurochem. , vol.66 , pp. 386-393
    • McKenna, M.C.1    Sonnewald, U.2    Huang, X.3    Stevenson, J.4    Zielke, H.R.5
  • 35
    • 0033007130 scopus 로고    scopus 로고
    • Does "the mystery of the extra glucose" during CNS activation reflect glutamate synthesis?
    • Hertz, L. and Fillenz, M. 1999. Does "the mystery of the extra glucose" during CNS activation reflect glutamate synthesis? Neurochem. Int. 34:71-75.
    • (1999) Neurochem. Int. , vol.34 , pp. 71-75
    • Hertz, L.1    Fillenz, M.2
  • 37
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • Norenberg, M. D. and Martinez-Hernandez, A. 1979. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161:303-310.
    • (1979) Brain Res. , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 38
    • 0025958468 scopus 로고
    • Glutamine synthetase in oligodendrocytes and astrocytes: New biochemical and immunocytochemical evidence
    • Tansey, F. A., Farooq, M., and Cammer, W. 1991. Glutamine synthetase in oligodendrocytes and astrocytes: New biochemical and immunocytochemical evidence. J. Neurochem. 56:266-272.
    • (1991) J. Neurochem. , vol.56 , pp. 266-272
    • Tansey, F.A.1    Farooq, M.2    Cammer, W.3


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