Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes

GLIA

Volumn 35, Issue 3, 2001, Pages 246-252

  Waagepetersen, Helle S ^a   Sonnewald, Ursula ^b   Larsson, Orla M ^a   Schousboe, Arne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

GC MS; Glucose; Lactate; Pyruvate carboxylation

Indexed keywords

AMINO ACID; CARBON; CITRIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID; PYRUVIC ACID;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; CELL COMPARTMENTALIZATION; CELL CULTURE; CEREBELLUM; CITRIC ACID CYCLE; CYTOLOGY; ENERGY METABOLISM; INTRACELLULAR FLUID; METABOLISM; MOUSE; PHYSIOLOGY; SECRETION;

AMINO ACIDS; ANIMALS; ASTROCYTES; CARBON RADIOISOTOPES; CELL COMPARTMENTATION; CELLS, CULTURED; CEREBELLUM; CITRIC ACID; CITRIC ACID CYCLE; ENERGY METABOLISM; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; INTRACELLULAR FLUID; LACTIC ACID; MICE; PYRUVIC ACID;

EID: 0034846461     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.1089     Document Type: Article

References (25)

1. The metabolic compartmentation concept
2. 1H NMR study
3. Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase
4. A simulation study of the metabolism and compartmentation in brain of glutamate, aspartate, the Krebs cycle, and related metabolites
5. Astrocytes in primary cultures
6. Preparation of primary cultures of mouse (rat) astrocytes
7. Neuronal-astrocytic interactions in metabolism of transmitter amino acids of the glutamate family
8. Induction by hydrocortisone of glutamine synthetase in mouse primary astrocyte cultures
9. 13C]D-glucose metabolism in cultured astrocytes and neurons using nuclear magnetic resonance spectroscopy
10. Analysis of amino acids as their tert-butyldimethylsilyl derivatives by gas-liquid chromatography and mass spectrometry
11. Energy metabolism in cortical synaptic terminals from weanling and mature rat brain: Evidence for multiple compartments of tricarboxylic acid cycle activity
12. New insight into the compartmentation of glutamate and glutamine in cultured rat brain astrocytes
13. 13C]glucose metabolism in brain cells: Isotopomer analysis of glutamine from cerebellar astrocytes and glutamate from granule cells
14. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
15. Glutamate and glutamine metabolism and compartmentation in astrocytes
16. Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
17. 13C]NMR spectroscopy of cultured neurons and astrocytes
18. 13C glucose metabolism in neocortical astrocytes: Evidence for mitochondrial heterogeneity
19. Mitochondrial heterogeneity in the brain at the cellular level
20. 13C NMR spectroscopy
21. Mitochondrial compartmentation at the cellular level - Astrocytes and neurons
22. A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons
23. Uptake, release and metabolism of citrate in neurons and astrocytes in primary cultures
24. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons