Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla

Magnetic Resonance in Medicine

Volumn 36, Issue 5, 1996, Pages 659-664

  Gruetter, Rolf ^a,b   Adriany, Gregor ^a   Merkle, Hellmut ^a   Andersen, Peter M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Center for MR Research   (United States)

Author keywords

13C MRS; decoupling; human brain; polarization transfer

Indexed keywords

ABSORPTION SPECTROSCOPY; AMINO ACIDS; BRAIN; CHEMICAL SHIFT; METABOLITES; POLARIZATION;

DECOUPLING; DISPLACEMENT ERRORS; HUMAN BRAIN; LOCALIZATION METHOD; N-ACETYL ASPARTATE; POLARIZATION TRANSFER; THREE DIMENSIONAL LOCALIZATION; ^13C MRS;

SIGNAL TO NOISE RATIO;

GLUTAMIC ACID; INOSITOL; N ACETYLASPARTIC ACID; ASPARTIC ACID; DRUG DERIVATIVE; GLUTAMINE; N-ACETYLASPARTATE;

ABSORPTION SPECTROSCOPY; ADULT; ARTICLE; BRAIN FUNCTION; BRAIN MAPPING; BRAIN METABOLISM; CELL COMPARTMENTALIZATION; CITRIC ACID CYCLE; HUMAN; HUMAN EXPERIMENT; NEUROTRANSMISSION; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTON TRANSPORT; SIGNAL NOISE RATIO; TUMOR LOCALIZATION; BRAIN LEVEL; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ASPARTIC ACID; BRAIN CHEMISTRY; GLUTAMIC ACID; GLUTAMINE; HUMANS; INOSITOL; MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0029657897     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910360503     Document Type: Article

References (29)

1. F. A. Howe, R. J. Maxwell, D. E. Saunders, M. M. Brown, J. R. Griffiths, Proton spectroscopy in vivo. Magn. Reson. Q. 9, 31-59 (1993).
2. 13C NMR spectroscopy. Proc. Natl. Acad. Sci. USA 89, 1109-1112 (1992).
3. 13C NMR spectroscopy of myo-inositol in the human brain in vivo. Magn. Reson. Med. 25, 204-210 (1992).
4. G. F. Mason, R. Gruetter, D. L. Rothman, K. L. Behar. R. G. Shulman. E. J. Novotny. Simultaneous determination of the rates of the TCA cycle, glucose utilization, α-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J. Cereb. Blood Flow Metab. 15, 12-25 (1995).
5. R. Gruetter, E. J. Novotny, S. D. Boulware, G. F. Mason, D. L. Rothman, J. W. Prichard, R. G. Shulman, Localized 13C NMR spectroscopy of amino acid labeling from [1-13C] D-glucose in the human brain. J. Neurochem. 63, 1377-1385 (1994).
6. R. Fried, N. Beckmann, U. Keller, R. Ninnis, G. Stalder, J. Seelig, Early glycogenolysis and late glycogenesis in human liver after intravenous administration of galactose. Am. J. Physiol. 33, G14-G19 (1996).
7. 13C NMR determination of liver glycogen in vivo. Magn. Reson. Med. 31, 583-588 (1994).
8. 13C NMR. Science 254, 573-576 (1991).
9. P. A. Bottomley, C. J. Hardy, P. B. Roemer, O. M. Mueller, Proton-decoupled, Overhauser-enhanced, spatially localized carbon-13 spectroscopy in humans. Magn. Reson. Med. 12, 348-363 (1989).
10. 1H double-resonance techniques at 4 Tesla. Magn. Reson. Med. 22, 10-22 (1991).
11. 13C NMR for the assessment of human brain glucose metabolism in vivo. Biochemistry 30, 6362-6366 (1991).
12. 1H] magnetic resonance spectroscopy of malignant histiocytoma and skeletal muscle tissue in man. NMR Biomed. 5, 161-170 (1992).
13. 13C NMR spectroscopy of humans at 1.5 Tesla. NMR Biomed. 2, 1-10 (1989).
14. 13C NMR: comparison of normal volunteers with a patient. Magn. Reson. Med. 16, 150 (1990).
15. 13C NMR: a comparison of proton decoupling and polarization transfer. Magn. Reson. Med. 28, 65-73 (1991).
16. H. Bachelard, R. Badar-Goffer, NMR spectroscopy in neurochemistry. J. Neurochem. 61, 412-429 (1993).
17. J. H. Lee, M. Garwood, R. Menon, G. Adriany, P. Andersen, C. L. Truwit, K. Ugurbil, High contrast and fast three-dimensional imaging at high fields. Magn. Reson. Med. 34, 308-312 (1995).
18. A. Haase, J. Frahm, D. Matthael, W. Hänicke, K. D. Merboldt, FLASH Imaging. Rapid NMR imaging using low flip-angle pulses. J. Magn. Reson. 67, 258-266 (1986).
19. R. Gruetter, Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn. Reson. Med. 29, 804-811 (1993).
20. G. Adriany, K. Ugurbil, R. Gruetter, A surface coil design for efficient proton decoupling in humans, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 1431.
21. H. Barfuss, H. Fischer, D. Hentschel, R. Ladebeck, A. Oppelt, R. Wittig, W. Duerr, R. Oppelt, In vivo magnetic resonance imaging and spectroscopy of humans with a 4T whole body magnet. NMR Biomed. 3, 31-45 (1990).
22. R. J. Ordidge, A. Connelly, J. A. B. Lohman, Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J. Magn. Reson. 66, 283-294 (1986).
23. D. M. Doddrell, D. T. Pegg, M. R. Bendall, Distortionless enhancment of NMR signals by polarization transfer. J. Magn. Reson. 48, 323-327 (1982).
24. 13C NMR spectra with enhanced sensitivity obtained by volume-selective excitation. J. Magn. Reson. 61, 392-395 (1985).
25. 1 magnitude. J. Magn. Reson. 80, 448-469 (1988).
26. 13C NMR of brain. Magn. Reson. Med. 2, 289-295 (1985).
27. W. Willker, J. Engelmann, A. Brand, D. Leibfritz, Metabolite identification in cell extracts and culture media by proton-detected 2D-H,C-NMR spectroscopy. J. MR Anal. 2, 21-32 (1996).
28. 1 insensitive heteronuclear adiabatic polarization transfer for signal enhancement. J. Magn. Reson. 99, 480-494 (1992).
29. S.-G. Kim, M. Garwood, Double DEPT using adiabatic pulses. Indirect heteronuclear T1 measurement with B1 insensitivity. J. Magn. Reson. 99, 660-667 (1992).