Mitochondrial heterogeneity in the brain at the cellular level

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 3, 1998, Pages 231-237

  Sonnewald, Ursula ^a   Hertz, Leif ^b   Schousboe, Arne ^c  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Metabolic compartmentation; Mitochondria

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID;

AMINO ACID METABOLISM; BRAIN MITOCHONDRION; CELL COMPARTMENTALIZATION; CELL HETEROGENEITY; CELL SPECIFICITY; CELL TYPE; CITRIC ACID CYCLE; GLIA; HUMAN; MITOCHONDRIAL RESPIRATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0031940131     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199803000-00001     Document Type: Review

References (55)

1. Abood LG (1969) Brain mitochondria. In: Handbook of Neurochemistry (Lajtha A, ed), New York, Plenum Press, pp 303-326
2. 13C-MRS studies on cerebral metabolism. Magma 2:285-289
3. 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain. Biochem J 266:133-139
4. Balazs R, Patel AJ, Richter D (1972) Metabolic compartments in the brain: their properties and relation to morphological structures. In: Metabolic Compartmentation in the Brain (Balazs R, Cremer JE, eds), New York, Macmillan, pp 167-184
5. Beal MF, Hyman BT, Koroshetz W (1993) Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 16:125-131
6. Berl S, Clarke DD (1969) Metabolic compartmentation of glutamate in the CNS. In: Handbook of Neurochemistry (Lajtha A, ed), New York, Plenum Press, pp 447-472
7. Berl S, Clarke DD (1983) The metabolic compartmentation concept. In: Glutamine, Glutamate and GABA in the Central Nervous System (Neurology and Neurobiology) (Hertz L, Kvamme E, McGeer EG, Schousboe A, eds), New York, Liss, pp 215-217
8. Chun J, Gioio AE, Crispino M, Giuditta A, Kaplan BB (1996) Differential compartmentalization of mRNAs in squid giant axon. J Neurochem 67:1806-1812
9. Clark JB, Nicklas WJ (1984) Brain mitochondria. In: Handbook of Neurochemistry (Lajtha A, ed), New York, Plenum Press, pp 135-159
10. Cooper AJL, Plum F (1987) Biochemistry and physiology of brain ammonia. Physiol Rev 67:440-519
11. DeDuve C (1991) Blueprint of a Cell. Burlington, Neil Patterson
12. Dirkx R, Thomas A, Lernmark A, Sherwin RS, De Camilli P, Solimena M (1995) Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J Biol Chem 270:2241-2246
13. 3H-GABA from cultured mouse cerebral cortex interneurons. J Neurosci 7:2910-2916
14. Fitzpatrick SM, Cooper AJ, Hertz L (1988) Effects of ammonia and β-methylene-DL-aspartate on the oxidation of glucose and pyruvate by neurons and astrocytes in primary culture. J Neurochem 51: 1197-1203
15. Friede RL, Pax RA (1961) Mitochondria and mitochondrial enzymes, a comparative study of localization in the cat's brain stem. Histochemie 2:186-191
16. Gallo V, Berrolorro A, Levi G (1987) The proteoglycan chondroitin sulfate is present in a subpopulation of cultured astrocytes and in their precursors. Dev Biol 123:282
17. Hassel B, Paulsen RE, Johnsen A, Fonnum F (1992) Selective inhibition of glial cell metabolism in vivo by fluorocitrate. Brain Res 576:120-124
18. Heroux M, Raghavendra-Rao VL, Lavoi J, Richardson JS, Butterworth RF (1996) Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. Metab Brain Dis 11:81-88
19. 2 and ATP. Am J Physiol 250:C663-C675
20. Kondo S, Sato-Yoshitake R, Noda Y, Aizawa H, Nakata T, Matsuura Y, Hirokawa N (1994) KIF3A is a new microtubule-based anterograde motor in the nerve axon. J Cell Biol 125:1095-1107
21. Krebs HA (1953) Equilibria in transamination systems. Biochem J 54:82-86
22. Kurz GM, Wiesinger H, Hamprecht B (1993) Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in alial cells of neural primary cultures. J Neurochem 60:1467-1474
23. Lai JC, Walsh JM, Dennis SC, Clark JB (1977) Synaptic and nonsynaptic mitochondria from rat brain: isolation and characterization. J Neurochem 28:625-631
24. Landry CF, Watson JB, Kashima T, Campagnoni AT (1994) Cellular influences on RNA sorting in neurons and glia: an in situ hybridization histochemical study. Mol Brain Res 27:1-11
25. Lapidot A, Gopher A (1994) Cerebral metabolic compartmentation. J Biol Chem 269:27198-27208
26. Larsson OM, Drejer J, Kvamme E, Svenneby G, Hertz L, Schousboe A (1985) Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo. Int J Dev Neurosci 3:177-185
27. Lehninger AL (1965) The Mitochondrion. New York, Benjamin
28. 1H NMR. J Biol Chem 271:10648-10653
29. Margulis L (1993) Symbiosis in Cell Evolution, 2nd ed. New York, Freeman
30. McIlwain H, Grinyer I (1950) Properties of preparations from central nervous system which degrade coenzymes I and II; their connexion with carbohydrate metabolism. Biochem J 46:612-619
31. McKenna MC, Tildon JT, Couto R, Stevenson JH, Caprio FJ (1990) The metabolism of malate by cultured rat brain astrocytes. Neurochem Res 15:1211-1220
32. McKenna MC, Sonnewald U, Huang X, Stevenson J, Zielke RH (1996) Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J Neurochem 66:386-393
33. Norenberg MD, Martinez-Hernandez A (1979) Distribution of glutamine synthetase in the rat central nervous system. J Histochem Cytochem 27:756-762
34. Norenberg MD, Neary JT, Bender AS, Dombro RS (1992) Hepatic encephalopathy: a disorder in glial-neuronal communication. Prog Brain Res 94:261-269
35. Oh YJ, Markelonis GJ, Oh TH (1991) Immunocytochemical localization of mitochondrial malate dehydrogenase in primary cultures of rat astrocytes and oligodendrocytes. J Histochem Cytochem 39: 681-688
36. Peng L, Zhang X, Hertz L (1994) High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes but have no stimulatory effect in a GABAergic neuronal culture. Brain Res 663:168-172
37. Plaitakis A, Berl S (1988) Pathology of glutamate dehydrogenase. In: Glutamine and Glutamate in Mammals (Xvamme E, ed), Boca Raton. CRC Press, pp 128-140
38. Raff MC (1989) Glial cell diversification in the rat optic nerve. Science 243:1450-1455
39. Schapira AHV, Cooper LM, Dexter D, Clark JB, Jenner P, Marsden CD (1990) Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 54:823-827
40. Schousboe A, Westergaard N, Sonnewald U, Petersen SB, Huang R, Peng L, Hertz L (1993) Glutamate and glutamine metabolism and compartmentation in astrocytes. Dev Neurosci 15:359-366
41. Shank RP, Campbell GL (1983) Metabolic precursors of glutamate and GABA. In: Glutamine, Glutamate and GABA in the Central Nervous System (Hertz L, Kvamme E, McGeer EG, Schousboe A, eds), New York, Liss, pp 355-369
42. Shank RP, Bennet GS, Freytag SO, Campbell GL (1985) Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res 329:364-367
43. Sheu KF, Cooper AJ, Koike K, Koike M, Lindsay JG, Blass JP (1994) Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann Neurol 35:312-318
44. 13C NMR spectroscopy of cultured neurons and astrocytes. Neurosci Lett 128:235-239
45. 13C glucose metabolism in neocortical astrocytes: evidence for mitochondrial heterogeneity. Dev Neurosci 15:351-358
46. 13C NMR spectroscopy: incorporation of more label into lactate than into glutamine demonstrates the importance of the TCA cycle. J Neurochem 61:1179-1182
47. 13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons. Neurochem Int 22:19-29
48. 13C]glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling. J Neurochem 67:2566-2572
49. Taylor RW, Chinnery PF, Turnbull DM, Lightowlers RN (1997) Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acid. Nature Genet 15:212-215
50. Trimmer PA, Reier PJ, Oh TH, Eng LF (1986) Immunocytochemically defined astroglia from fetal newborn and young adult rats express J-adrenergic receptors m vitro. Dev Brain Res 27:151-165
51. Van den Berg CJ, Matheson DF, Ronda G, Reijnierse GLA, Blokhuis GGD, Kroon MC, Clarke DD, Garfinkel D (1975) A model of glutamate metabolism in brain: a biochemical analysis of a heterogeneous structure. In: Metabolic Compartmentation and Neurotransmission, Relation to Brain Structure and Function (Berl S, Clarke DD, Schneider D, eds), New York, Plenum, pp 515-543
52. 13C-NMR spectroscopy. J Cereb Blood Flow Metab 18:109-117
53. 13C NMR spectroscopy may indicate compartmentation and mitochondrial heterogeneity. Neurosci Lett 185:24-28
54. Yu ACH, Drejer J, Hertz L, Schousboe A (1983) Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J Neurochem 41:1484-1487
55. Yu ACH, Hertz E, Hertz L (1984) Alterations in uptake and release rates for GABA, glutamate, and glutamine during biochemical maturation of highly purified cultures of cerebral cortical neurons, a GABAergic preparation. J Neurochem 42:951-960