Selenium and selenoprotein function in brain disorders

IUBMB Life

Volumn 66, Issue 4, 2014, Pages 229-239

  Pillai, Roshan ^a   Uyehara Lock, Jane H ^a   Bellinger, Frederick P ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

Alzheimer's disease; epilepsy; glutathione; glutathione peroxidase; Huntington's disease; Parkinson's disease; phospholipid hydroperoxide glutathione peroxidase; selenium; selenoprotein; thioredoxin reductase

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; GLUTATHIONE PEROXIDASE; METHIONINE SULFOXIDE B1; SELENIUM; SELENOPROTEIN; SELENOPROTEIN H; SELENOPROTEIN K; SELENOPROTEIN M; SELENOPROTEIN P; SELENOPROTEIN S; SELENOPROTEIN T; SELENOPROTEIN W; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BRAIN FUNCTION; COGNITIVE DEFECT; EPILEPSY; HUMAN; HUNTINGTON CHOREA; LIPID PEROXIDATION; NERVE DEGENERATION; NEUROPROTECTION; PARKINSON DISEASE; PATHOPHYSIOLOGY; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; SEIZURE; SELENIUM DEFICIENCY; VITAMIN SUPPLEMENTATION; ANIMAL; BRAIN DISEASES; METABOLISM;

ANIMALS; BRAIN DISEASES; HUMANS; SELENIUM; SELENOPROTEINS;

EID: 84901018660     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1262     Document Type: Review

References (144)

1. Bellinger, F. P., Raman, A. V., Reeves, M. A., and, Berry, M. J., (2009) Regulation and function of selenoproteins in human disease. Biochem. J. 422, 11-22.
2. Hatfield, D. L., Tsuji, P. A., Carlson, B. A., and, Gladyshev, V. N., (2014) Selenium and selenocysteine: roles in cancer, health, and development. Trends Biochem. Sci. 39, 112-120.
3. Reeves, M. A., Bellinger, F. P., and, Berry, M. J., (2010) The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation. Antioxid. Redox Signal. 12, 809-818.
4. Kieliszek, M., and, Blazejak, S., (2013) Selenium: significance, and outlook for supplementation. Nutrition 29, 713-718.
5. Rayman, M. P., Infante, H. G., and, Sargent, M., (2008) Food-chain selenium and human health: spotlight on speciation. Br. J. Nutr. 100, 238-253.
6. Schomburg, L., Schweizer, U., and, Kohrle, J., (2004) Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic. Cell Mol. Life Sci. 61, 1988-1995. (Pubitemid 39149889)
7. Navarro-Alarcon, M., and, Cabrera-Vique, C., (2008) Selenium in food and the human body: a review. Sci. Total Environ. 400, 115-141.
8. Rayman, M. P., (2008) Food-chain selenium and human health: emphasis on intake. Br. J. Nutr. 100, 254-268.
9. Rayman, M. P., (2004) The use of high-selenium yeast to raise selenium status: how does it measure up? Br. J. Nutr. 92, 557-573. (Pubitemid 39406638)
10. Dietary Reference Intakes for vitamin C, vitamin E, selenium, and carotenoids: a report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Washington, DC: National Academy Press, 2000. Reference Intakes, Food and Nutrition Board, Institute of Medicine.
11. Rayman, M. P., (2012) Selenium and human health. Lancet 379, 1256-1268.
12. Hargreaves, M. K., Liu, J., Buchowski, M. S., Patel, K. A., Larson, C. O., et al. (2014) Plasma selenium biomarkers in low income black and white Americans from the southeastern United States. PLoS One 9, e84972.
13. Berry, M. J., Banu, L., Harney, J. W., and, Larsen, P. R., (1993) Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J. 12, 3315-3322. (Pubitemid 23232763)
14. Small-Howard, A., Morozova, N., Stoytcheva, Z., Forry, E. P., Mansell, J. B., et al. (2006) Supramolecular complexes mediate selenocysteine incorporation in vivo. Mol. Cell. Biol. 26, 2337-2346. (Pubitemid 43346933)
15. Howard, M. T., Aggarwal, G., Anderson, C. B., Khatri, S., Flanigan, K. M., et al. (2005) Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons. EMBO J. 24, 1596-1607. (Pubitemid 40646449)
16. Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., et al. (2003) Characterization of mammalian selenoproteomes. Science 300, 1439-1443. (Pubitemid 36638165)
17. Prast-Nielsen, S., Huang, H. H., and, Williams, D. L., (2011) Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim. Biophys. Acta 1810, 1262-1271.
18. Tamura, T., and, Stadtman, T. C., (2002) Mammalian thioredoxin reductases. Methods Enzymol. 347, 297-306. (Pubitemid 34233283)
19. Arner, E. S., and, Holmgren, A., (2000) Physiological functions of thioredoxin and thioredoxin reductase [In Process Citation]. Eur. J. Biochem. 267, 6102-6109.
20. Selenius, M., Rundlof, A. K., Olm, E., Fernandes, A. P., and, Bjornstedt, M., (2010) Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer. Antioxid. Redox Signal. 12, 867-880.
21. Zhang, S., Rocourt, C., and, Cheng, W. H., (2010) Selenoproteins and the aging brain. Mech. Ageing Dev. 131, 253-260.
22. Ansari, M. A., Joshi, G., Huang, Q., Opii, W. O., Abdul, H. M., et al. (2006) In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders. Free Radic. Biol. Med. 41, 1694-1703. (Pubitemid 44634240)
23. Chen, L., Na, R., Gu, M., Richardson, A., and, Ran, Q., (2008) Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease. J. Neurochem. 107, 197-207.
24. Bellinger, F. P., Bellinger, M. T., Seale, L. A., Takemoto, A. S., Raman, A. V., et al. (2011) Glutathione peroxidase 4 is associated with neuromelanin in substantia nigra and dystrophic axons in putamen of Parkinson's brain. Mol. Neurodegener. 6, 8.
25. Blackinton, J., Kumaran, R., van der Brug, M. P., Ahmad, R., Olson, L., et al. (2009) Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease. Neurosci. Lett. 452, 8-11.
26. Panee, J., Liu, W., Nakamura, K., and, Berry, M. J., (2007) The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation. Int. J. Biol. Sci. 3, 335-341. (Pubitemid 47075789)
27. van der Brug, M. P., Blackinton, J., Chandran, J., Hao, L. Y., Lal, A., et al. (2008) RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc. Natl. Acad. Sci. USA 105, 10244-10249.
28. Yuzbasioglu, A., Karatas, H., Gursoy-Ozdemir, Y., Saygi, S., Akalan, N., et al. (2009) Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. Cell Mol. Neurobiol. 29, 1223-1231.
29. Sorolla, M. A., Reverter-Branchat, G., Tamarit, J., Ferrer, I., Ros, J., et al. (2008) Proteomic and oxidative stress analysis in human brain samples of Huntington disease. Free Radic. Biol. Med. 45, 667-678.
30. Sreekala, S., and, Indira, M., (2009) Impact of co administration of selenium and quinolinic acid in the rat's brain. Brain Res. 1281, 101-107.
31. Ursini, F., Maiorino, M., and, Gregolin, C., (1985) The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim. Biophys. Acta 839, 62-70. (Pubitemid 15085303)
32. Schweizer, U., Brauer, A. U., Kohrle, J., Nitsch, R., and, Savaskan, N. E., (2004) Selenium and brain function: a poorly recognized liaison. Brain Res. Brain Res. Rev. 45, 164-178. (Pubitemid 38802869)
33. Lovell, M. A., Xie, C., Gabbita, S. P., and, Markesbery, W. R., (2000) Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain. Free Radic. Biol. Med. 28, 418-427. (Pubitemid 30110658)
34. Bates, J. M., St. Germain, D. L., and, Galton, V. A., (1999) Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat. Endocrinology 140, 844-851. (Pubitemid 29058221)
35. Novoselov, S. V., Kryukov, G. V., Xu, X. M., Carlson, B. A., Hatfield, D. L., et al. (2007) Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J. Biol. Chem. 282, 11960-11968. (Pubitemid 47100687)
36. Panee, J., Stoytcheva, Z. R., Liu, W., and, Berry, M. J., (2007) Selenoprotein H is a redox-sensing HMG family DNA-binding protein that upregulates genes involved in glutathione synthesis and phase II detoxification. J. Biol. Chem. 282, 23759-23765. (Pubitemid 47327999)
37. Shchedrina, V. A., Everley, R. A., Zhang, Y., Gygi, S. P., Hatfield, D. L., et al. (2011) Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. J. Biol. Chem. 286, 42937-42948.
38. Meiler, S., Baumer, Y., Huang, Z., Hoffmann, F. W., Fredericks, G. J., et al. (2013) Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J. Leukoc. Biol. 93, 771-780.
39. Huang, Z., Hoffmann, F. W., Fay, J. D., Hashimoto, A. C., Chapagain, M. L., et al. (2012) Stimulation of unprimed macrophages with immune complexes triggers a low output of nitric oxide by calcium-dependent neuronal nitric-oxide synthase. J. Biol. Chem. 287, 4492-4502.
40. Yim, S. Y., Chae, K. R., Shim, S. B., Hong, J. T., Park, J. Y., et al. (2009) ERK activation induced by selenium treatment significantly downregulates beta/gamma-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Int. J. Mol. Med. 24, 91-96.
41. Du, X., Li, H., Wang, Z., Qiu, S., Liu, Q., et al. (2013) Selenoprotein P and selenoprotein M block Zn2+ -mediated Abeta42 aggregation and toxicity. Metallomics 5, 861-870.
42. Chen, P., Wang, R. R., Ma, X. J., Liu, Q., and, Ni, J. Z., (2013) Different forms of selenoprotein M differentially affect abeta aggregation and ROS generation. Int. J. Mol. Sci. 14, 4385-4399.
43. Hwang, D. Y., Cho, J. S., Oh, J. H., Shim, S. B., Jee, S. W., et al. (2005) Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease. Neurochem. Res. 30, 1009-1019. (Pubitemid 41570036)
44. Nakayama, A., Hill, K. E., Austin, L. M., Motley, A. K., and, Burk, R. F., (2007) All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium. J. Nutr. 137, 690-693. (Pubitemid 46397504)
45. Bellinger, F. P., He, Q. P., Bellinger, M. T., Lin, Y., Raman, A. V., et al. (2008) Association of selenoprotein p with Alzheimer's pathology in human cortex. J. Alzheimers Dis. 15, 465-472.
46. Peters, M. M., Hill, K. E., Burk, R. F., and, Weeber, E. J., (2006) Altered hippocampus synaptic function in selenoprotein P deficient mice. Mol. Neurodegener. 1, 12.
47. Takemoto, A. S., Berry, M. J., and, Bellinger, F. P., (2010) Role of selenoprotein P in Alzheimer's disease. Ethn. Dis. 20, S1-92.
48. Bellinger, F. P., Raman, A. V., Rueli, R. H., Bellinger, M. T., Dewing, A. S., et al. (2012) Changes in Selenoprotein P in substantia nigra and Putamen in Parkinson's disease. J. Parkinsons. Dis. 2, 115-126.
49. Perry, T. L., Godin, D. V., and, Hansen, S., (1982) Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci. Lett. 33, 305-310. (Pubitemid 13119539)
50. Perry, T. L., and, Yong, V. W., (1986) Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci. Lett. 67, 269-274. (Pubitemid 16038336)
51. Fradejas, N., Pastor, M. D., Mora-Lee, S., Tranque, P., and, Calvo, S., (2008) SEPS1 gene is activated during astrocyte ischemia and shows prominent antiapoptotic effects. J. Mol. Neurosci. 35, 259-265.
52. 2+ mobilization and neuroendocrine secretion. FASEB J. 22, 1756-1768. (Pubitemid 351811453)
53. Stefaniuk, M., and, Lukasiuk, K., (2010) Cloning of expressed sequence tags (ESTs) representing putative epileptogenesis-related genes and the localization of their expression in the normal brain. Neurosci. Lett. 482, 230-234.
54. Raman, A. V., Pitts, M. W., Seyedali, A., Hashimoto, A. C., Bellinger, F. P., et al. (2013) Selenoprotein W expression and regulation in mouse brain and neurons. Brain Behav. 3, 562-574.
55. Lee, B. C., Peterfi, Z., Hoffmann, F. W., Moore, R. E., Kaya, A., et al. (2013) MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol. Cell 51, 397-404.
56. Moskovitz, J., Maiti, P., Lopes, D. H., Oien, D. B., Attar, A., et al. (2011) Induction of methionine-sulfoxide reductases protects neurons from amyloid beta-protein insults in vitro and in vivo. Biochemistry 50, 10687-10697.
57. Lu, J., and, Holmgren, A., (2009) Selenoproteins. J. Biol. Chem. 284, 723-727.
58. Holben, D. H., and, Smith, A. M., (1999) The diverse role of selenium within selenoproteins: a review. J. Am. Diet Assoc. 99, 836-843. (Pubitemid 29309892)
59. Ursini, F., Heim, S., Kiess, M., Maiorino, M., Roveri, A., et al. (1999) Dual function of the selenoprotein PHGPx during sperm maturation. Science 285, 1393-1396. (Pubitemid 29411669)
60. Larsen, P. R., and, Berry, M. J., (1995) Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu. Rev. Nutr. 15, 323-352.
61. Beckett, G. J., and, Arthur, J. R., (2005) Selenium and endocrine systems. J. Endocrinol. 184, 455-465. (Pubitemid 40426009)
62. St. Germain, D. L., and, Galton, V. A., (1997) The deiodinase family of selenoproteins. Thyroid 7, 655-668. (Pubitemid 27371808)
63. Burk, R. F., and, Hill, K. E., (2009) Selenoprotein P-expression, functions, and roles in mammals. Biochim. Biophys. Acta 1790, 1441-1447.
64. Shchedrina, V. A., Zhang, Y., Labunskyy, V. M., Hatfield, D. L., and, Gladyshev, V. N., (2010) Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid. Redox Signal. 12, 839-849.
65. Xia, L., Nordman, T., Olsson, J. M., Damdimopoulos, A., Bjorkhem-Bergman, L., et al. (2003) The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. J. Biol. Chem. 278, 2141-2146. (Pubitemid 36801279)
66. Labunskyy, V. M., Yoo, M. H., Hatfield, D. L., and, Gladyshev, V. N., (2009) Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. Biochemistry 48, 8458-8465.
67. Horibata, Y., and, Hirabayashi, Y., (2007) Identification and characterization of human ethanolaminephosphotransferase1. J. Lipid Res. 48, 503-508.
68. Novoselov, S. V., Kim, H. Y., Hua, D., Lee, B. C., Astle, C. M., et al. (2010) Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. Antioxid. Redox Signal. 12, 829-838.
69. Akbaraly, T. N., Hininger-Favier, I., Carriere, I., Arnaud, J., Gourlet, V., et al. (2007) Plasma selenium over time and cognitive decline in the elderly. Epidemiology 18, 52-58. (Pubitemid 46005909)
70. Berr, C., Balansard, B., Arnaud, J., Roussel, A. M., and, Alperovitch, A., (2000) Cognitive decline is associated with systemic oxidative stress: the EVA study. Etude du Vieillissement Arteriel. J. Am. Geriatr. Soc. 48, 1285-1291.
71. Gao, S., Jin, Y., Hall, K. S., Liang, C., Unverzagt, F. W., et al. (2007) Selenium level and cognitive function in rural elderly Chinese. Am. J. Epidemiol. 165, 955-965. (Pubitemid 46536659)
72. Shahar, A., Patel, K. V., Semba, R. D., Bandinelli, S., Shahar, D. R., et al. (2010) Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed. Mov. Disord. 25, 1909-1915.
73. Agamy, O., Ben Zeev, B., Lev, D., Marcus, B., Fine, D., et al. (2010) Mutations disrupting selenocysteine formation cause progressive cerebello-cerebral atrophy. Am. J. Hum. Genet. 87, 538-544.
74. Ben-Zeev, B., Hoffman, C., Lev, D., Watemberg, N., Malinger, G., et al. (2003) Progressive cerebellocerebral atrophy: a new syndrome with microcephaly, mental retardation, and spastic quadriplegia. J. Med. Genet. 40, e96.
75. Palioura, S., Sherrer, R. L., Steitz, T. A., Soll, D., and, Simonovic, M., (2009) The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science 325, 321-325.
76. Prohaska, J. R., and, Ganther, H. E., (1976) Selenium and glutathione peroxidase in developing rat brain. J. Neurochem. 27, 1379-1387.
77. Kyriakopoulos, A., Rothlein, D., Pfeifer, H., Bertelsmann, H., Kappler, S., et al. (2000) Detection of small selenium-containing proteins in tissues of the rat. J. Trace Elem. Med. Biol. 14, 179-183.
78. Ursini, F., and, Bindoli, A., (1987) The role of selenium peroxidases in the protection against oxidative damage of membranes. Chem. Phys. Lipids 44, 255-276. (Pubitemid 17146547)
79. Sun, Y., Gu, Q. P., and, Whanger, P. D., (2001) Selenoprotein W in overexpressed and underexpressed rat glial cells in culture. J. Inorg. Biochem. 84, 151-156. (Pubitemid 32273545)
80. Chen, J., and, Berry, M. J., (2003) Selenium and selenoproteins in the brain and brain diseases. J. Neurochem. 86, 1-12. (Pubitemid 36753840)
81. Ellison, D., Love, S., Chimelli, L., Harding, B. N., Lowe, J. S., Vinters, H. V., Brandner, S., Yong, W.H. (2013) Neuropathology: a reference text of CNS pathology. pp. 567-628. Mosby, Edinburgh.
82. Small, S.A., Mayeux, R. (2010). Alzheimer disease. In Merritt's Neurology, 12th ed. (Rowland, L.P. and Pedley, T.A. eds.) pp. 713-718. Lippincott Williams and Wilkins, Philadelphia.
83. Fahn, S., and, Przedborski, S., (2010) Parkinson disease. In Merritt's Neurology (, Rowland, L.P., and, Pedley, T.A., eds.). pp. 751-769. Lippincott Williams and Wilkins, Philadelphia.
84. Fahn, S., and, Jankovic. J., (2010) Huntington disease. In Merritt's Neurology, 12th, ed. (, Rowland, L.P., and, Pedley, T.A., eds.). pp. 723-726. Lippincott Williams and Wilkins, Philadelphia.
85. Bazil, C. W., and, Pedley, T. A., (2010) Epilepsy. In Merritt's Neurology, 12th ed. (, Rowland, L.P., and, Pedley, T.A., eds.). pp. 927-948. Lippincott Williams and Wilkins, Philadelphia.
86. Miller, D. C., (2009) Modern surgical neuropathology. pp. 467-506. Cambridge University Press, Cambridge.
87. Barral, S., Bird, T., Goate, A., Farlow, M. R., Diaz-Arrastia, R., et al. (2012) Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology 78, 1464-1471.
88. Govert, F., and, Schneider, S. A., (2013) Huntington's disease and Huntington's disease-like syndromes: an overview. Curr. Opin. Neurol. 26, 420-427.
89. Helbig, I., and, Lowenstein, D. H., (2013) Genetics of the epilepsies: where are we and where are we going? Curr. Opin. Neurol. 26, 179-185.
90. Lesage, S., and, Brice, A., (2009) Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum. Mol. Genet. 18, R48-R59.
91. Bellinger, F. P., and, Weeber, E. J., (2012) Selenium in Alzheimer's disease. In Selenium-Its Molecular Biology and Role in Human Health (, Hatfield, D. L., Berry, M. J., and, Gladyshev, V.N., eds.). pp. 433-442, Springer, New York.
92. Chouliaras, L., Sierksma, A. S., Kenis, G., Prickaerts, J., Lemmens, M. A., et al. (2010) Gene-environment interaction research and transgenic mouse models of Alzheimer's disease. Int. J. Alzheimers Dis. 2010.
93. Huse, J. T., and, Doms, R.W., (2001) Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease. Traffic 2, 75-81. (Pubitemid 32219859)
94. Butterfield, D. A., Perluigi, M., and, Sultana, R., (2006) Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics. Eur. J. Pharmacol. 545, 39-50. (Pubitemid 44215876)
95. Spires-Jones, T. L., Stoothoff, W. H., de Calignon, A., Jones, P. B., and, Hyman, B. T., (2009) Tau pathophysiology in neurodegeneration: a tangled issue. Trends Neurosci. 32, 150-159.
96. Vural, H., Demirin, H., Kara, Y., Eren, I., and, Delibas, N., (2010) Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease. J. Trace Elem. Med. Biol. 24, 169-173.
97. Cardoso, B. R., Ong, T. P., Jacob-Filho, W., Jaluul, O., Freitas, M. I., et al. (2010) Nutritional status of selenium in Alzheimer's disease patients. Br. J. Nutr. 103, 803-806.
98. Xiong, S., Markesbery, W. R., Shao, C., and, Lovell, M. A., (2007) Seleno-L-methionine protects against beta-amyloid and iron/hydrogen peroxide-mediated neuron death. Antioxid. Redox Signal. 9, 457-467.
99. Lovell, M. A., Xiong, S., Lyubartseva, G., and, Markesbery, W. R., (2009) Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice. Free Radic. Biol. Med. 46, 1527-1533.
100. Tung, Y. T., Hsu, W. M., Wang, B. J., Wu, S. Y., Yen, C. T., et al. (2008) Sodium selenite inhibits gamma-secretase activity through activation of ERK. Neurosci. Lett. 440, 38-43.
101. Ishrat, T., Parveen, K., Khan, M. M., Khuwaja, G., Khan, M. B., et al. (2009) Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Res. 1281, 117-127.
102. Haratake, M., Yoshida, S., Mandai, M., Fuchigami, T., and, Nakayama, M., (2013) Elevated amyloid-beta plaque deposition in dietary selenium-deficient Tg2576 transgenic mice. Metallomics 5, 479-483.
103. Corcoran, N. M., Martin, D., Hutter-Paier, B., Windisch, M., Nguyen, T., et al. (2010) Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. J. Clin. Neurosci. 17, 1025-1033.
104. van Eersel, J., Ke, Y. D., Liu, X., Delerue, F., Kril, J. J., et al. (2010) Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc. Natl. Acad. Sci. USA 107, 13888-13893.
105. Steinbrenner, H., Alili, L., Bilgic, E., Sies, H., and, Brenneisen, P., (2006) Involvement of selenoprotein P in protection of human astrocytes from oxidative damage. Free Radic. Biol. Med. 40, 1513-1523.
106. Arteel, G. E., Mostert, V., Oubrahim, H., Briviba, K., Abel, J., et al. (1998) Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration. Biol. Chem. 379, 1201-1205. (Pubitemid 28456834)
107. Du, X., Wang, Z., Zheng, Y., Li, H., Ni, J., et al. (2014) Inhibitory effect of selenoprotein P on Cu/Cu-induced abeta aggregation and toxicity. Inorg Chem. 53, 1672-1678.
108. Hwang, D. Y., Sin, J. S., Kim, M. S., Yim, S. Y., Kim, Y. K., et al. (2008) Overexpression of human selenoprotein M differentially regulates the concentrations of antioxidants and H2O2, the activity of antioxidant enzymes, and the composition of white blood cells in a transgenic rat. Int. J. Mol. Med. 21, 169-179. (Pubitemid 351222850)
109. Korotkov, K. V., Novoselov, S. V., Hatfield, D. L., and, Gladyshev, V. N., (2002) Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol. Cell. Biol. 22, 1402-1411. (Pubitemid 34150777)
110. Qiao, X., Tian, J., Chen, P., Wang, C., Ni, J., et al. (2013) Galectin-1 is an interactive protein of selenoprotein M in the brain. Int. J. Mol. Sci. 14, 22233-22245.
111. Manolopoulos, K. N., Klotz, L. O., Korsten, P., Bornstein, S. R., and, Barthel, A., (2010) Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress. Mol. Psychiatry 15, 1046-1052.
112. Pitts, M. W., Reeves, M. A., Hashimoto, A. C., Ogawa, A., Kremer, P., et al. (2013) Deletion of selenoprotein M leads to obesity without cognitive deficits. J. Biol. Chem. 288, 26121-26134.
113. Fahn, S., (2003) Description of Parkinson's disease as a clinical syndrome. Ann. N. Y. Acad. Sci. 991, 1-14. (Pubitemid 36793796)
114. Chinta, S. J., and, Andersen, J. K., (2005) Dopaminergic neurons. Int. J. Biochem. Cell Biol. 37, 942-946. (Pubitemid 40311737)
115. Galvin, J. E., Lee, V. M., Schmidt, M. L., Tu, P. H., et al. (1999) Pathobiology of the Lewy body. Adv. Neurol. 80, 313-324.
116. Greenamyre, J. T., and, Hastings, T. G., (2004) Biomedicine. Parkinson's-divergent causes, convergent mechanisms. Science 304, 1120-1122. (Pubitemid 38661838)
117. Gandhi, S., and, Wood, N. W., (2005) Molecular pathogenesis of Parkinson's disease. Hum. Mol. Genet. 14, 2749-2755. (Pubitemid 41300647)
118. Alladi, P. A., Mahadevan, A., Vijayalakshmi, K., Muthane, U., Shankar, S. K., et al. (2010) Ageing enhances alpha-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians. Neurochem. Int. 57, 530-539.
119. Licker, V., Kovari, E., Hochstrasser, D. F., and, Burkhard P. R., (2009) Proteomics in human Parkinson's disease research. J. Proteomics 73, 10-29.
120. Thobois, S., Guillouet, S., and, Broussolle, E., (2001) Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease. Neurophysiol. Clin. 31, 321-340. (Pubitemid 33054611)
121. Hauser, D. N., Dukes, A. A., Mortimer, A. D., and, Hastings, T. G., (2013) Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4. Free Radic. Biol. Med. 65, 419-427.
122. Barayuga, S. M., Pang, X., Andres, M. A., Panee, J., and, Bellinger, F. P., (2013) Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: protective effects of selenium. Neurotoxicology 37, 240-246.
123. Raymond, L. A., Andre, V. M., Cepeda, C., Gladding, C. M., Milnerwood, A. J., et al. (2011) Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience 198, 252-273.
124. Hickey, M. A., and, Chesselet, M.-F., (2003) Apoptosis in Huntington's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 255-265. (Pubitemid 36351493)
125. Levine, M. S., Cepeda, C., Hickey, M. A., Fleming, S. M., and, Chesselet, M. F., (2004) Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect. Trends Neurosci. 27, 691-697. (Pubitemid 39335840)
126. Hoffner, G., and, Djian, P., (2002) Protein aggregation in Huntington's disease. Biochimie 84, 273-278. (Pubitemid 34790404)
127. Bortolatto, C. F., Jesse, C. R., Wilhelm, E. A., Chagas, P. M., and, Nogueira, C. W., (2013) Organoselenium bis selenide attenuates 3-nitropropionic acid-induced neurotoxicity in rats. Neurotox. Res. 23, 214-224.
128. Chang, B. S., and, Lowenstein, D. H., (2003) Epilepsy. N. Engl. J. Med. 349, 1257-1266.
129. Elger, C. E., and, Schmidt, D., (2008) Modern management of epilepsy: a practical approach. Epilepsy Behav. 12, 501-539.
130. Ashrafi, M. R., Shams, S., Nouri, M., Mohseni, M., Shabanian, R., et al. (2007) A probable causative factor for an old problem: selenium and glutathione peroxidase appear to play important roles in epilepsy pathogenesis. Epilepsia 48, 1750-1755. (Pubitemid 47352872)
131. Ashrafi, M. R., Shabanian, R., Abbaskhanian, A., Nasirian, A., Ghofrani, M., et al. (2007) Selenium and intractable epilepsy: is there any correlation? Pediatr. Neurol. 36, 25-29. (Pubitemid 46427786)
132. Mahyar, A., Ayazi, P., Fallahi, M., and, Javadi, A., (2010) Correlation between serum selenium level and febrile seizures. Pediatr. Neurol. 43, 331-334.
133. Thiel, R., and, Fowkes, S. W., (2007) Down syndrome and thyroid dysfunction: should nutritional support be the first-line treatment? Med. Hypotheses 69, 809-815. (Pubitemid 47248126)
134. Volpe, S. L., Schall, J. I., Gallagher, P. R., Stallings, V. A., and, Bergqvist, A. G., (2007) Nutrient intake of children with intractable epilepsy compared with healthy children. J. Am. Diet Assoc. 107, 1014-1018. (Pubitemid 46764593)
135. Seven, M., Basaran, S. Y., Cengiz, M., Unal, S., and, Yuksel, A., (2013) Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy. Epilepsy Res. 104, 35-39.
136. Ramaekers, V. T., Calomme, M., Vanden Berghe, D., and, Makropoulos, W., (1994) Selenium deficiency triggering intractable seizures. Neuropediatrics 25, 217-223. (Pubitemid 24304611)
137. Naziroglu, M., Kutluhan, S., and, Yilmaz, M., (2008) Selenium and topiramate modulates brain microsomal oxidative stress values, Ca2+-ATPase activity, and EEG records in pentylentetrazol-induced seizures in rats. J. Membr. Biol. 225, 39-49. (Pubitemid 50312412)
138. Oztas, B., Kilic, S., Dural, E., and, Ispir, T., (2001) Influence of antioxidants on the blood-brain barrier permeability during epileptic seizures. J. Neurosci. Res. 66, 674-678.
139. Rehni, A. K., and, Singh, T. G., (2012) Selenium induced anticonvulsant effect: a potential role of prostaglandin E(1) receptor activation linked mechanism. J. Trace Elem. Med. Biol. 27, 31-39.
140. Wirth, E. K., Conrad, M., Winterer, J., Wozny, C., Carlson, B. A., et al. (2010) Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J. 24, 844-852.
141. Seiler, A., Schneider, M., Forster, H., Roth, S., Wirth, E. K., et al. (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8, 237-248.
142. Biswas, S., Talukder, G., and, Sharma, A., (1999) Comparison of clastogenic effects of inorganic selenium salts in mice in vivo as related to concentrations and duration of exposure. Biometals 12, 361-368. (Pubitemid 30139289)
143. Hoefig, C. S., Renko, K., Kohrle, J., Birringer, M., and, Schomburg, L., (2011) Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture. J. Nutr. Biochem. 22, 945-955.
144. Yamashita, Y., and, Yamashita, M., (2010) Identification of a novel selenium-containing compound, selenoneine, as the predominant chemical form of organic selenium in the blood of bluefin tuna. J. Biol. Chem. 285, 18134-18138.