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Volumn 57, Issue 5, 2010, Pages 530-539

Ageing enhances α-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians

Author keywords

Caspase12; Glucose regulated protein 78 (GRP78); Immunofluoresence analysis; Laser scanning confocal microscopy; Ubiquitin; Unbiased stereology

Indexed keywords

ALPHA SYNUCLEIN; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; UBIQUITIN;

EID: 77956231550     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.06.018     Document Type: Article
Times cited : (36)

References (47)
  • 1
    • 77952546947 scopus 로고    scopus 로고
    • Expression of GDNF receptors GFRα1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians
    • Alladi P.A., Mahadevan A., Shankar S.K., Raju T.R., Muthane U. Expression of GDNF receptors GFRα1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians. J. Chem. Neuroanat. 2010, 40(1):43-52.
    • (2010) J. Chem. Neuroanat. , vol.40 , Issue.1 , pp. 43-52
    • Alladi, P.A.1    Mahadevan, A.2    Shankar, S.K.3    Raju, T.R.4    Muthane, U.5
  • 2
    • 60349100004 scopus 로고    scopus 로고
    • Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: relevance to lower incidence of Parkinson's disease
    • Alladi P.A., Mahadevan A., Yasha T.C., Raju T.R., Shankar S.K., Muthane U. Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: relevance to lower incidence of Parkinson's disease. Neuroscience 2009, 159:236-245.
    • (2009) Neuroscience , vol.159 , pp. 236-245
    • Alladi, P.A.1    Mahadevan, A.2    Yasha, T.C.3    Raju, T.R.4    Shankar, S.K.5    Muthane, U.6
  • 3
    • 10444275253 scopus 로고    scopus 로고
    • Developmentally regulated expression of c-Fos and c-Jun in the brainstem auditory nuclei of Gallus domesticus is modified by prenatal auditory enrichment
    • Alladi P.A., Roy T., Singh N., Wadhwa S. Developmentally regulated expression of c-Fos and c-Jun in the brainstem auditory nuclei of Gallus domesticus is modified by prenatal auditory enrichment. J. Neurobiol. 2005, 62:92-105.
    • (2005) J. Neurobiol. , vol.62 , pp. 92-105
    • Alladi, P.A.1    Roy, T.2    Singh, N.3    Wadhwa, S.4
  • 4
    • 73449102905 scopus 로고    scopus 로고
    • ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells
    • Arduino D.M., Esteves A.R., Domingues A.F., Pereira C.M., Cardoso S.M., Oliveira C.R. ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells. BMB Rep. 2009, 42(11):719-724.
    • (2009) BMB Rep. , vol.42 , Issue.11 , pp. 719-724
    • Arduino, D.M.1    Esteves, A.R.2    Domingues, A.F.3    Pereira, C.M.4    Cardoso, S.M.5    Oliveira, C.R.6
  • 5
    • 73649130269 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: emerging role of molecular chaperones
    • Bandopadhyay R., de Belleroche J. Pathogenesis of Parkinson's disease: emerging role of molecular chaperones. Trends Mol. Med. 2010, 16(1):27-36.
    • (2010) Trends Mol. Med. , vol.16 , Issue.1 , pp. 27-36
    • Bandopadhyay, R.1    de Belleroche, J.2
  • 6
    • 1842563060 scopus 로고    scopus 로고
    • Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers
    • Beach T.G., Walker D.G., Sue L.I., Newell A., Adler C.C., Joyce J.N. Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers. J. Neuropathol. Exp. Neurol. 2004, 63:329-337.
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , pp. 329-337
    • Beach, T.G.1    Walker, D.G.2    Sue, L.I.3    Newell, A.4    Adler, C.C.5    Joyce, J.N.6
  • 8
    • 0015262390 scopus 로고
    • Nigrostriatal and nigrothalamic fibers in the rhesus monkey
    • Carpenter M.B., Peter P. Nigrostriatal and nigrothalamic fibers in the rhesus monkey. J. Comp. Neurol. 1972, 144:93-115.
    • (1972) J. Comp. Neurol. , vol.144 , pp. 93-115
    • Carpenter, M.B.1    Peter, P.2
  • 9
    • 33751019425 scopus 로고    scopus 로고
    • Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients
    • Chiba-Falek O., Lopez G.J., Nussbaum R.L. Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov. Disord. 2006, 21:1703-1708.
    • (2006) Mov. Disord. , vol.21 , pp. 1703-1708
    • Chiba-Falek, O.1    Lopez, G.J.2    Nussbaum, R.L.3
  • 10
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease?
    • Chu Y., Kordower J.H. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease?. Neurobiol. Dis. 2007, 25:134-149.
    • (2007) Neurobiol. Dis. , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 11
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
    • Chung K.K., Zhang Y., Lim K.L., Tanaka Y., Huang H., Gao J., Ross C.A., Dawson V.L., Dawson T.M. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat. Med. 2001, 7:1144-1150.
    • (2001) Nat. Med. , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 12
    • 44049099669 scopus 로고    scopus 로고
    • Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
    • Devi L., Raghavendran V., Prabhu B.M., Avadhani N.G., Anandatheerthavarada H.K. Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J. Biol. Chem. 2008, 283(14):9089-9100.
    • (2008) J. Biol. Chem. , vol.283 , Issue.14 , pp. 9089-9100
    • Devi, L.1    Raghavendran, V.2    Prabhu, B.M.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 13
    • 0033566286 scopus 로고    scopus 로고
    • Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease
    • Duan W., Mattson M.P. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res. 1999, 57:195-206.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 195-206
    • Duan, W.1    Mattson, M.P.2
  • 15
    • 0033669319 scopus 로고    scopus 로고
    • In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
    • Gai W.P., Yuan H.X., Li X.Q., Power J.T., Blumbergs P.C., Jensen P.H. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 2000, 166:324-333.
    • (2000) Exp. Neurol. , vol.166 , pp. 324-333
    • Gai, W.P.1    Yuan, H.X.2    Li, X.Q.3    Power, J.T.4    Blumbergs, P.C.5    Jensen, P.H.6
  • 16
    • 0028096074 scopus 로고
    • Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease
    • Gertz H.J., Siegers A., Kuchinke J. Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease. Brain Res. 1994, 637(1-2):339-341.
    • (1994) Brain Res. , vol.637 , Issue.1-2 , pp. 339-341
    • Gertz, H.J.1    Siegers, A.2    Kuchinke, J.3
  • 17
    • 0343527226 scopus 로고    scopus 로고
    • Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining
    • Gomez-Tortosa E., Newell K., Irizarry M.C., Sanders J.L., Hyman B.T. alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol. 2000, 99:352-357.
    • (2000) Acta Neuropathol. , vol.99 , pp. 352-357
    • Gomez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 18
    • 70449532484 scopus 로고    scopus 로고
    • A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    • Greffard S., Verny M., Bonnet A.M., Seilhean D., Hauw J.J., Duyckaerts C. A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol. Aging 2010, 31(1):99-103.
    • (2010) Neurobiol. Aging , vol.31 , Issue.1 , pp. 99-103
    • Greffard, S.1    Verny, M.2    Bonnet, A.M.3    Seilhean, D.4    Hauw, J.J.5    Duyckaerts, C.6
  • 20
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • Hirsch E., Graybiel A.M., Agid Y.A. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 1988, 334:345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.1    Graybiel, A.M.2    Agid, Y.A.3
  • 21
    • 1242269804 scopus 로고    scopus 로고
    • Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12
    • Hitomi J., Katayama T., Taniguchi M., Honda A., Imaizumi K., Tohyama M. Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. Neurosci. Lett. 2004, 357:127-130.
    • (2004) Neurosci. Lett. , vol.357 , pp. 127-130
    • Hitomi, J.1    Katayama, T.2    Taniguchi, M.3    Honda, A.4    Imaizumi, K.5    Tohyama, M.6
  • 22
    • 0038143287 scopus 로고    scopus 로고
    • Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
    • Holtz W.A., O'Malley K.L. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J. Biol. Chem. 2003, 278:19367-19377.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19367-19377
    • Holtz, W.A.1    O'Malley, K.L.2
  • 23
    • 0031944830 scopus 로고    scopus 로고
    • Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity
    • Irizarry M.C., Growdon W., Gomez-Isla T., Newell K., George J.M., Clayton D.F., Hyman B.T. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J. Neuropathol. Exp. Neurol. 1998, 57:334-337.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 334-337
    • Irizarry, M.C.1    Growdon, W.2    Gomez-Isla, T.3    Newell, K.4    George, J.M.5    Clayton, D.F.6    Hyman, B.T.7
  • 24
    • 0034889140 scopus 로고    scopus 로고
    • Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum
    • Jakowec M.W., Donaldson D.M., Barba J., Petzinger G.M. Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum. Dev. Neurosci. 2001, 23:91-99.
    • (2001) Dev. Neurosci. , vol.23 , pp. 91-99
    • Jakowec, M.W.1    Donaldson, D.M.2    Barba, J.3    Petzinger, G.M.4
  • 27
    • 0033562966 scopus 로고    scopus 로고
    • Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
    • Kaufman R.J. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 1999, 13:1211-1233.
    • (1999) Genes Dev. , vol.13 , pp. 1211-1233
    • Kaufman, R.J.1
  • 28
    • 77149159091 scopus 로고    scopus 로고
    • Long-term dietary restriction modulates the level of presynaptic proteins in the cortex and hippocampus of the aging rat
    • Mladenovic Djordjevic A., Perovic M., Tesic V., Tanic N., Rakic L., Ruzdijic S., Kanazir S. Long-term dietary restriction modulates the level of presynaptic proteins in the cortex and hippocampus of the aging rat. Neurochem. Int. 2010, 56:250-255.
    • (2010) Neurochem. Int. , vol.56 , pp. 250-255
    • Mladenovic Djordjevic, A.1    Perovic, M.2    Tesic, V.3    Tanic, N.4    Rakic, L.5    Ruzdijic, S.6    Kanazir, S.7
  • 29
    • 0035758117 scopus 로고    scopus 로고
    • Hunting genes in Parkinson's disease from the roots
    • Muthane U., Jain S., Gururaj G. Hunting genes in Parkinson's disease from the roots. Med. Hypotheses 2001, 57:51-55.
    • (2001) Med. Hypotheses , vol.57 , pp. 51-55
    • Muthane, U.1    Jain, S.2    Gururaj, G.3
  • 30
    • 0031914408 scopus 로고    scopus 로고
    • Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India
    • Muthane U., Yasha T.C., Shankar S.K. Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Ann. Neurol. 1998, 43:283-287.
    • (1998) Ann. Neurol. , vol.43 , pp. 283-287
    • Muthane, U.1    Yasha, T.C.2    Shankar, S.K.3
  • 31
    • 77953912384 scopus 로고    scopus 로고
    • Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation
    • May, (Epub ahead of print)
    • Nagamine S., Kabuta T., Furuta A., Yamamoto K., Takahashi A., Wada K. Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation. Neurochem. Int. 2010, 4(May). (Epub ahead of print).
    • (2010) Neurochem. Int. , vol.4
    • Nagamine, S.1    Kabuta, T.2    Furuta, A.3    Yamamoto, K.4    Takahashi, A.5    Wada, K.6
  • 36
    • 61649109808 scopus 로고    scopus 로고
    • Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects
    • Shehadeh L., Mitsi G., Adi N., Bishopric N., Papapetropoulos S. Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects. Mov. Disord. 2009, 24(2):204-210.
    • (2009) Mov. Disord. , vol.24 , Issue.2 , pp. 204-210
    • Shehadeh, L.1    Mitsi, G.2    Adi, N.3    Bishopric, N.4    Papapetropoulos, S.5
  • 37
    • 33847330077 scopus 로고    scopus 로고
    • Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients
    • Shobha K., Vijayalakshmi K., Alladi P.A., Nalini A., Sathyaprabha T.N., Raju T.R. Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients. J. Neurol. Sci. 2007, 254:9-16.
    • (2007) J. Neurol. Sci. , vol.254 , pp. 9-16
    • Shobha, K.1    Vijayalakshmi, K.2    Alladi, P.A.3    Nalini, A.4    Sathyaprabha, T.N.5    Raju, T.R.6
  • 38
    • 0032862994 scopus 로고    scopus 로고
    • Age-related neuronal loss from the substantia nigra-pars compacta and ventral tegmental area of the rhesus monkey
    • Siddiqi Z., Kemper T.L., Killiany R. Age-related neuronal loss from the substantia nigra-pars compacta and ventral tegmental area of the rhesus monkey. J. Neuropathol. Exp. Neurol. 1999, 58:959-971.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 959-971
    • Siddiqi, Z.1    Kemper, T.L.2    Killiany, R.3
  • 39
    • 0032874037 scopus 로고    scopus 로고
    • The effect of aging on pars compacta of the substantia nigra in rhesus monkey
    • Siddiqi Z.A., Peters A. The effect of aging on pars compacta of the substantia nigra in rhesus monkey. J. Neuropathol. Exp. Neurol. 1999, 58:903-920.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 903-920
    • Siddiqi, Z.A.1    Peters, A.2
  • 40
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:6469-6473.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 42
    • 77953090478 scopus 로고    scopus 로고
    • Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of {alpha}-synuclein, and apoptotic cell death in aged mice
    • Tong Y., Yamaguchi H., Giaime E., Boyle S., Kopan R., Kelleher R.J., Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of {alpha}-synuclein, and apoptotic cell death in aged mice. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(21):9879-9884.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.21 , pp. 9879-9884
    • Tong, Y.1    Yamaguchi, H.2    Giaime, E.3    Boyle, S.4    Kopan, R.5    Kelleher, R.J.6    Shen, J.7
  • 43
    • 0031474418 scopus 로고    scopus 로고
    • Contribution of somal Lewy bodies to neuronal death
    • Tompkins M.M., Hill W.D. Contribution of somal Lewy bodies to neuronal death. Brain Res. 1997, 775:24-29.
    • (1997) Brain Res. , vol.775 , pp. 24-29
    • Tompkins, M.M.1    Hill, W.D.2
  • 45
    • 33645156429 scopus 로고    scopus 로고
    • From acute ER stress to physiological roles of the unfolded protein response
    • Wu J., Kaufman R.J. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ. 2006, 13:374-384.
    • (2006) Cell Death Differ. , vol.13 , pp. 374-384
    • Wu, J.1    Kaufman, R.J.2
  • 46
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
    • Xu J., Kao S.Y., Lee F.J., Song W., Jin L.W., Yankner B.A. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 2002, 8(6):600-606.
    • (2002) Nat. Med. , vol.8 , Issue.6 , pp. 600-606
    • Xu, J.1    Kao, S.Y.2    Lee, F.J.3    Song, W.4    Jin, L.W.5    Yankner, B.A.6


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