메뉴 건너뛰기




Volumn 27, Issue 11, 2004, Pages 691-697

Genetic mouse models of Huntington's and Parkinson's diseases: Illuminating but imperfect

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR; CELL LOSS; CLINICAL FEATURE; DISEASE COURSE; GENE IDENTIFICATION; GENETIC MODEL; HUNTINGTON CHOREA; MEDICAL INFORMATION; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW;

EID: 5044224807     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2004.08.008     Document Type: Review
Times cited : (162)

References (69)
  • 2
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group
    • Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 72 1993 971 983
    • (1993) Cell , vol.72 , pp. 971-983
  • 3
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • M.H. Polymeropoulos Mutation in the α-synuclein gene identified in families with Parkinson's disease Science 276 1997 2045 2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 4
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-synuclein locus triplication causes Parkinson's disease
    • A.B. Singleton Alpha-synuclein locus triplication causes Parkinson's disease Science 302 2003 841
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1
  • 5
    • 0030882856 scopus 로고    scopus 로고
    • Alpha-synuclein in Lewy bodies
    • M.G. Spillantini Alpha-synuclein in Lewy bodies Nature 388 1997 839 840
    • (1997) Nature , vol.388 , pp. 839-840
    • Spillantini, M.G.1
  • 6
    • 0038289754 scopus 로고    scopus 로고
    • Genes and parkinsonism
    • J. Hardy Genes and parkinsonism Lancet Neurol. 2 2003 221 228
    • (2003) Lancet Neurol. , vol.2 , pp. 221-228
    • Hardy, J.1
  • 7
    • 2442668926 scopus 로고    scopus 로고
    • Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    • E.M. Valente Hereditary early-onset Parkinson's disease caused by mutations in PINK1 Science 304 2004 1158 1160
    • (2004) Science , vol.304 , pp. 1158-1160
    • Valente, E.M.1
  • 8
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • T.M. Dawson, and V.L. Dawson Molecular pathways of neurodegeneration in Parkinson's disease Science 302 2003 819 822
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 10
    • 0036533795 scopus 로고    scopus 로고
    • Lessons from animal models of Huntington's disease
    • D.C. Rubinsztein Lessons from animal models of Huntington's disease Trends Genet. 18 2002 202 209
    • (2002) Trends Genet. , vol.18 , pp. 202-209
    • Rubinsztein, D.C.1
  • 11
    • 0344961865 scopus 로고    scopus 로고
    • The use of transgenic and knock-in mice to study Huntington's disease
    • M.A. Hickey, and M.F. Chesselet The use of transgenic and knock-in mice to study Huntington's disease Cytogenet. Genome Res. 100 2003 276 286
    • (2003) Cytogenet. Genome Res. , vol.100 , pp. 276-286
    • Hickey, M.A.1    Chesselet, M.F.2
  • 12
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • L. Mangiarini Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice Cell 87 1996 493 506
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1
  • 13
    • 0033560924 scopus 로고    scopus 로고
    • Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
    • R.J. Carter Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation J. Neurosci. 19 1999 3248 3257
    • (1999) J. Neurosci. , vol.19 , pp. 3248-3257
    • Carter, R.J.1
  • 14
    • 0033500593 scopus 로고    scopus 로고
    • Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
    • L.A. Lione Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation J. Neurosci. 19 1999 10428 10437
    • (1999) J. Neurosci. , vol.19 , pp. 10428-10437
    • Lione, L.A.1
  • 15
    • 0034234519 scopus 로고    scopus 로고
    • Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
    • K.P. Murphy Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation J. Neurosci. 20 2000 5115 5123
    • (2000) J. Neurosci. , vol.20 , pp. 5115-5123
    • Murphy, K.P.1
  • 16
    • 1642418261 scopus 로고    scopus 로고
    • Early exploratory behavior abnormalities in R6/1 Huntington's disease transgenic mice
    • V.J. Bolivar Early exploratory behavior abnormalities in R6/1 Huntington's disease transgenic mice Brain Res. 1005 2004 29 35
    • (2004) Brain Res. , vol.1005 , pp. 29-35
    • Bolivar, V.J.1
  • 17
    • 0035575858 scopus 로고    scopus 로고
    • Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease
    • G.A. Laforet Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease J. Neurosci. 21 2001 9112 9123
    • (2001) J. Neurosci. , vol.21 , pp. 9112-9123
    • Laforet, G.A.1
  • 18
    • 0033136692 scopus 로고    scopus 로고
    • A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
    • J.G. Hodgson A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration Neuron 23 1999 181 192
    • (1999) Neuron , vol.23 , pp. 181-192
    • Hodgson, J.G.1
  • 19
    • 10744227174 scopus 로고    scopus 로고
    • Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
    • E.J. Slow Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease Hum. Mol. Genet. 12 2003 1555 1567
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1555-1567
    • Slow, E.J.1
  • 20
    • 0037107191 scopus 로고    scopus 로고
    • Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice
    • L.B. Menalled Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice J. Neurosci. 22 2002 8266 8276
    • (2002) J. Neurosci. , vol.22 , pp. 8266-8276
    • Menalled, L.B.1
  • 21
    • 0041691176 scopus 로고    scopus 로고
    • Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    • L.B. Menalled Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats J. Comp. Neurol. 465 2003 11 26
    • (2003) J. Comp. Neurol. , vol.465 , pp. 11-26
    • Menalled, L.B.1
  • 22
    • 0035862896 scopus 로고    scopus 로고
    • Neurological abnormalities in a knock-in mouse model of Huntington's disease
    • C.H. Lin Neurological abnormalities in a knock-in mouse model of Huntington's disease Hum. Mol. Genet. 10 2001 137 144
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 137-144
    • Lin, C.H.1
  • 23
    • 0037087771 scopus 로고    scopus 로고
    • Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
    • V.C. Wheeler Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice Hum. Mol. Genet. 11 2002 633 640
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 633-640
    • Wheeler, V.C.1
  • 24
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • S.W. Davies Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation Cell 90 1997 537 548
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1
  • 25
    • 0034958203 scopus 로고    scopus 로고
    • Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation
    • A.J. Morton Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation J. Neurocytol. 29 2000 679 702
    • (2000) J. Neurocytol. , vol.29 , pp. 679-702
    • Morton, A.J.1
  • 26
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • M. DiFiglia Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain Science 277 1997 90 1993
    • (1997) Science , vol.277 , pp. 90-1993
    • Difiglia, M.1
  • 27
    • 0032811511 scopus 로고    scopus 로고
    • Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice
    • H. Li Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice Hum. Mol. Genet. 8 1999 1227 1236
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1227-1236
    • Li, H.1
  • 28
    • 0035503511 scopus 로고    scopus 로고
    • Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice
    • H. Li Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice J. Neurosci. 21 2001 8473 8481
    • (2001) J. Neurosci. , vol.21 , pp. 8473-8481
    • Li, H.1
  • 29
    • 0037452775 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
    • E. Hockly Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 2041 2046
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 2041-2046
    • Hockly, E.1
  • 30
    • 0033571743 scopus 로고    scopus 로고
    • Enhanced sensitivity to N-methyl-d-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease
    • M.S. Levine Enhanced sensitivity to N-methyl-d-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease J. Neurosci. Res. 58 1999 515 532
    • (1999) J. Neurosci. Res. , vol.58 , pp. 515-532
    • Levine, M.S.1
  • 31
    • 0035214922 scopus 로고    scopus 로고
    • Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice
    • G.J. Klapstein Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice J. Neurophysiol. 86 2001 2667 2677
    • (2001) J. Neurophysiol. , vol.86 , pp. 2667-2677
    • Klapstein, G.J.1
  • 32
    • 2942620844 scopus 로고    scopus 로고
    • Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    • T.L. Spires Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice Eur. J. Neurosci. 19 2004 2799 2807
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 2799-2807
    • Spires, T.L.1
  • 33
    • 0034571171 scopus 로고    scopus 로고
    • Huntington's disease: The challenge for cell biologists
    • A.J. Tobin, and E.R. Signer Huntington's disease: the challenge for cell biologists Trends Cell Biol. 10 2000 531 536
    • (2000) Trends Cell Biol. , vol.10 , pp. 531-536
    • Tobin, A.J.1    Signer, E.R.2
  • 34
    • 0034608857 scopus 로고    scopus 로고
    • Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease
    • M. Turmaine Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease Proc. Natl. Acad. Sci. U. S. A. 97 2000 8093 8097
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 8093-8097
    • Turmaine, M.1
  • 35
    • 0035889535 scopus 로고    scopus 로고
    • NMDA receptor function in mouse models of Huntington disease
    • C. Cepeda NMDA receptor function in mouse models of Huntington disease J. Neurosci. Res. 66 2001 525 539
    • (2001) J. Neurosci. Res. , vol.66 , pp. 525-539
    • Cepeda, C.1
  • 36
    • 0034612255 scopus 로고    scopus 로고
    • Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
    • J.A. Bibb Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice Proc. Natl. Acad. Sci. U. S. A. 97 2000 6809 6814
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 6809-6814
    • Bibb, J.A.1
  • 37
    • 0032987513 scopus 로고    scopus 로고
    • Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease
    • E. Sapp Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease J. Neuropathol. Exp. Neurol. 58 1999 165 173
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 165-173
    • Sapp, E.1
  • 38
    • 0036403826 scopus 로고    scopus 로고
    • Pyramidal cell loss in motor cortices in Huntington's disease
    • V. MacDonald, and G. Halliday Pyramidal cell loss in motor cortices in Huntington's disease Neurobiol. Dis. 10 2002 378 386
    • (2002) Neurobiol. Dis. , vol.10 , pp. 378-386
    • MacDonald, V.1    Halliday, G.2
  • 39
    • 0035158533 scopus 로고    scopus 로고
    • Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease
    • A.J. Morton, and J.M. Edwardson Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease J. Neurochem. 76 2001 166 172
    • (2001) J. Neurochem. , vol.76 , pp. 166-172
    • Morton, A.J.1    Edwardson, J.M.2
  • 40
    • 0037101835 scopus 로고    scopus 로고
    • Dysregulation of gene expression in the R6/2 model of polyglutamine disease: Parallel changes in muscle and brain
    • R. Luthi-Carter Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain Hum. Mol. Genet. 11 2002 1911 1926
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1911-1926
    • Luthi-Carter, R.1
  • 41
    • 0036382909 scopus 로고    scopus 로고
    • Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic mice
    • J.C. Liévens Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic mice Mol. Cell. Neurosci. 20 2002 638 648
    • (2002) Mol. Cell. Neurosci. , vol.20 , pp. 638-648
    • Liévens, J.C.1
  • 42
    • 0042921188 scopus 로고    scopus 로고
    • Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release
    • H. Li Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release Hum. Mol. Genet. 12 2003 2021 2030
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2021-2030
    • Li, H.1
  • 43
    • 0037322570 scopus 로고    scopus 로고
    • Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease
    • C. Cepeda Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease J. Neurosci. 23 2003 961 969
    • (2003) J. Neurosci. , vol.23 , pp. 961-969
    • Cepeda, C.1
  • 44
    • 0035919701 scopus 로고    scopus 로고
    • Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    • C. Zuccato Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease Science 293 2001 493 498
    • (2001) Science , vol.293 , pp. 493-498
    • Zuccato, C.1
  • 45
    • 5044238597 scopus 로고    scopus 로고
    • GABAergic synaptic activity and receptor expression in transgenic mouse models of Huntington's disease
    • Society for Neuroscience, Online
    • Cepeda, C. et al. (2003) GABAergic synaptic activity and receptor expression in transgenic mouse models of Huntington's disease. Program No. 206.11 2003 Abstract Viewer and Itinerary Planner. Society for Neuroscience, Online
    • (2003) Program No. 206.11 2003 Abstract Viewer and Itinerary Planner
    • Cepeda, C.1
  • 46
    • 0032897760 scopus 로고    scopus 로고
    • Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
    • M.T. Usdin Impaired synaptic plasticity in mice carrying the Huntington's disease mutation Hum. Mol. Genet. 8 1999 839 846
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 839-846
    • Usdin, M.T.1
  • 47
    • 0037075624 scopus 로고    scopus 로고
    • Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
    • M.M. Zeron Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease Neuron 33 2002 849 860
    • (2002) Neuron , vol.33 , pp. 849-860
    • Zeron, M.M.1
  • 48
    • 0344413576 scopus 로고    scopus 로고
    • Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease
    • L. Li Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease Neurobiol. Aging 24 2003 1113 1121
    • (2003) Neurobiol. Aging , vol.24 , pp. 1113-1121
    • Li, L.1
  • 49
    • 0034004473 scopus 로고    scopus 로고
    • Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity
    • R. Sattler Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity J. Neurosci. 20 2000 22 33
    • (2000) J. Neurosci. , vol.20 , pp. 22-33
    • Sattler, R.1
  • 50
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • G.E. Hardingham Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways Nat. Neurosci. 5 2002 405 414
    • (2002) Nat. Neurosci. , vol.5 , pp. 405-414
    • Hardingham, G.E.1
  • 51
    • 0042126676 scopus 로고    scopus 로고
    • Experimental therapeutics in Huntington's disease: Are models useful for therapeutic trials?
    • G.P. Bates, and E. Hockly Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials? Curr. Opin. Neurol. 16 2003 465 470
    • (2003) Curr. Opin. Neurol. , vol.16 , pp. 465-470
    • Bates, G.P.1    Hockly, E.2
  • 52
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 2003 889 909
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 53
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • H. Braak Staging of brain pathology related to sporadic Parkinson's disease Neurobiol. Aging 24 2003 197 211
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 54
    • 10744221260 scopus 로고    scopus 로고
    • Transgenic mice expressing mutant A53T human α-synuclein show neuronal dysfunction in the absence of aggregate formation
    • S. Gispert Transgenic mice expressing mutant A53T human α-synuclein show neuronal dysfunction in the absence of aggregate formation Mol. Cell. Neurosci. 24 2003 419 429
    • (2003) Mol. Cell. Neurosci. , vol.24 , pp. 419-429
    • Gispert, S.1
  • 55
    • 0038389601 scopus 로고    scopus 로고
    • Transgenic models of α-synuclein pathology: Past, present, and future
    • M. Hashimoto Transgenic models of α-synuclein pathology: past, present, and future Ann. N. Y. Acad. Sci. 991 2003 171 188
    • (2003) Ann. N. Y. Acad. Sci. , vol.991 , pp. 171-188
    • Hashimoto, M.1
  • 57
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • B.I. Giasson Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein Neuron 34 2002 521 533
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1
  • 58
    • 0037173006 scopus 로고    scopus 로고
    • Human α-synuclein-harboring familial Parkinson's disease linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
    • M.K. Lee Human α-synuclein-harboring familial Parkinson's disease linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 8968 8973
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 8968-8973
    • Lee, M.K.1
  • 59
    • 0034663176 scopus 로고    scopus 로고
    • Neuropathology in mice expressing human α-synuclein
    • H. van der Putten Neuropathology in mice expressing human α-synuclein J. Neurosci. 20 2000 6021 6029
    • (2000) J. Neurosci. , vol.20 , pp. 6021-6029
    • Van Der Putten, H.1
  • 60
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
    • E. Masliah Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders Science 287 2000 1265 1269
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1
  • 61
    • 0034979314 scopus 로고    scopus 로고
    • Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter
    • Y. Matsuoka Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter Neurobiol. Dis. 8 2001 535 539
    • (2001) Neurobiol. Dis. , vol.8 , pp. 535-539
    • Matsuoka, Y.1
  • 62
    • 0035017068 scopus 로고    scopus 로고
    • Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant α-synuclein transgenic mice
    • S. Rathke-Hartlieb Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant α-synuclein transgenic mice J. Neurochem. 77 2001 1181 1184
    • (2001) J. Neurochem. , vol.77 , pp. 1181-1184
    • Rathke-Hartlieb, S.1
  • 63
    • 0036245056 scopus 로고    scopus 로고
    • Behavioral and neurochemical effects of wild-type and mutated human α-synuclein in transgenic mice
    • E.K. Richfield Behavioral and neurochemical effects of wild-type and mutated human α-synuclein in transgenic mice Exp. Neurol. 175 2002 35 48
    • (2002) Exp. Neurol. , vol.175 , pp. 35-48
    • Richfield, E.K.1
  • 64
    • 1542359628 scopus 로고    scopus 로고
    • Risk factors for dopaminergic neuron loss in human α-synuclein transgenic mice
    • M.J. Thiruchelvam Risk factors for dopaminergic neuron loss in human α-synuclein transgenic mice Eur. J. Neurosci. 19 2004 845 854
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 845-854
    • Thiruchelvam, M.J.1
  • 65
    • 0033933048 scopus 로고    scopus 로고
    • Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
    • H. Shimura Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase Nat. Genet. 25 2000 302 305
    • (2000) Nat. Genet. , vol.25 , pp. 302-305
    • Shimura, H.1
  • 66
    • 1842441089 scopus 로고    scopus 로고
    • It's a double knock-out! the quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)
    • P.J. Lockhart It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG) Mov. Disord. 19 2004 101 104
    • (2004) Mov. Disord. , vol.19 , pp. 101-104
    • Lockhart, P.J.1
  • 67
    • 0141891953 scopus 로고    scopus 로고
    • Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
    • M.S. Goldberg Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons J. Biol. Chem. 278 2003 43628 43635
    • (2003) J. Biol. Chem. , vol.278 , pp. 43628-43635
    • Goldberg, M.S.1
  • 68
    • 10744221310 scopus 로고    scopus 로고
    • Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
    • J.M. Itier Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse Hum. Mol. Genet. 12 2003 2277 2291
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2277-2291
    • Itier, J.M.1
  • 69
    • 2442481789 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in Parkin-deficient mice
    • J.J. Palacino Mitochondrial dysfunction and oxidative damage in Parkin-deficient mice J. Biol. Chem. 279 2004 18614 18622
    • (2004) J. Biol. Chem. , vol.279 , pp. 18614-18622
    • Palacino, J.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.