Different forms of selenoprotein M differentially affect Aβ aggregation and ROS generation

International Journal of Molecular Sciences

Volumn 14, Issue 3, 2013, Pages 4385-4399

  Chen, Ping ^a   Wang, Ruo Ran ^a   Ma, Xiao Jie ^a   Liu, Qiong ^a   Ni, Jia Zuan ^a  

^a SHENZHEN UNIVERSITY   (China)

Author keywords

Antioxidant; Neuroprotection; Reactive oxygen species (ROS); Selenoprotein M (SelM)

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CHOLECYSTOKININ OCTAPEPTIDE; COPPER ZINC SUPEROXIDE DISMUTASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SELENOPROTEIN; SELENOPROTEIN M; SODIUM SELENITE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EXPRESSION VECTOR; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; UPREGULATION; WESTERN BLOTTING;

EID: 84875065421     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14034385     Document Type: Article

References (32)

1. Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006, 160, 1-40.
2. Van Schooten, F.J.; Knaapen, A.M.; Izzotti, A. DNA damage, mutagenesis and cardiovascular disease. Mutat. Res. 2007, 621, 1-4.
3. Melo, A.; Monteiro, L.; Lima, R.M.; Oliveira, D.M.; Cerqueira, M.D.; El-Bacha, R.S. Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives. Oxid. Med. Cell Longev. 2011, 2011, 467180.
4. Kryukov, G.V.; Castellano, S.; Novoselov, S.V.; Lobanov, A.V.; Zehtab, O.; Guigo, R.; Gladyshev, V.N. Characterization of mammalian selenoproteomes. Science 2003, 300, 1439-1443.
5. Bellinger, F.P.; Raman, A.V.; Reeves, M.A.; Berry, M.J. Regulation and function of selenoproteins in human disease. Biochem. J. 2009, 422, 11-22.
6. Loef, M.; Schrauzer, G.N.; Walach, H. Selenium and Alzheimer's disease: A systematic review. J. Alzheimers Dis. 2011, 26, 81-104.
7. Korotkov, K.V.; Novoselov, S.V.; Hatfield, D.L.; Gladyshev, V.N. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol. Cell. Biol. 2002, 22, 1402-1411.
8. Ferguson, A.D.; Labunskyy, V.M.; Fomenko, D.E.; Arac, D.; Chelliah, Y.; Amezcua, C.A.; Rizo, J.; Gladyshev, V.N.; Deisenhofer, J. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J. Biol. Chem. 2006, 281, 3536-3543.
9. Dikiy, A.; Novoselov, S.V.; Fomenko, D.E.; Sengupta, A.; Carlson, B.A.; Cerny, R.L.; Ginalski, K.; Grishin, N.V.; Hatfield, D.L.; Gladyshev, V.N. SelT, SelW, SelH, and Rdx12: Genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry 2007, 46, 6871-6882.
10. Hwang, D.Y.; Sin, J.S.; Kim, M.S.; Yim, S.Y.; Kim, Y.K.; Kim, C.K.; Kim, B.G.; Shim, S.B.; Jee, S.W.; Lee, S.H, et al. Overexpression of human selenoprotein M differentially regulates the concentrations of antioxidants and H2O2, the activity of antioxidant enzymes, and the composition of white blood cells in a transgenic rat. Int. J. Mol. Med. 2008, 21, 169-179.
11. Wirth, E.K.; Conrad, M.; Winterer, J.; Wozny, C.; Carlson, B.A.; Roth, S.; Schmitz, D.; Bornkamm, G.W.; Coppola, V.; Tessarollo, L, et al. Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J. 2010, 24, 844-852.
12. Hwang, D.Y.; Cho, J.S.; Oh, J.H.; Shim, S.B.; Jee, S.W.; Lee, S.H.; Seo, S.J.; Lee, S.K.; Kim, Y.K. Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): Correlation of selenoprotein M with Alzheimer's disease. Neurochem. Res. 2005, 30, 1009-1019.
13. Yim, S.Y.; Chae, K.R.; Shim, S.B.; Hong, J.T.; Park, J.Y.; Lee, C.Y.; Son, H.J.; Sheen, Y.Y.; Hwang, D.Y. ERK activation induced by selenium treatment significantly downregulates beta/gamma-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Int. J. Mol. Med. 2009, 24, 91-96.
14. Reeves, M.A.; Bellinger, F.P.; Berry, M.J. The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation. Antioxid. Redox Signal. 2010, 12, 809-818.
15. Driscoll, D.M.; Copeland, P.R. Mechanism and regulation of selenoprotein synthesis. Annu. Rev. Nutr. 2003, 23, 17-40.
16. Arner, E.S.; Sarioglu, H.; Lottspeich, F.; Holmgren, A.; Bock, A. High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes. J. Mol. Biol. 1999, 292, 1003-1016.
17. Eckenroth, B.; Harris, K.; Turanov, A.A.; Gladyshev, V.N.; Raines, R.T.; Hondal, R.J. Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry 2006, 45, 5158-5170.
18. Rengby, O.; Johansson, L.; Carlson, L.A.; Serini, E.; Vlamis-Gardikas, A.; Karsnas, P.; Arner, E.S. Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis. Appl. Environ. Microbiol. 2004, 70, 5159-5167.
19. Novoselov, S.V.; Lobanov, A.V.; Hua, D.; Kasaikina, M.V.; Hatfield, D.L.; Gladyshev, V.N. A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells. Proc. Natl. Acad. Sci. USA 2007, 104, 7857-7862.
20. Madeja, Z.; Sroka, J.; Nystrom, C.; Bjorkhem-Bergman, L.; Nordman, T.; Damdimopoulos, A.; Nalvarte, I.; Eriksson, L.C.; Spyrou, G.; Olsson, J.M, et al. The role of thioredoxin reductase activity in selenium-induced cytotoxicity. Biochem. Pharmacol. 2005, 69, 1765-1772.
21. Sunde, R.A.; Raines, A.M.; Barnes, K.M.; Evenson, J.K. Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Biosci. Rep. 2009, 29, 329-338.
22. Sec in selenoprotein synthesis. RNA 2004, 10, 1142-1152.
23. Mitsui, A.; Hirakawa, T.; Yodoi, J. Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. Biochem. Biophys. Res. Commun. 1992, 186, 1220-1226.
24. Zhong, L.; Arner, E.S.; Holmgren, A. Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. Proc. Natl. Acad. Sci. USA 2000, 97, 5854-5859.
25. Anestal, K.; Arner, E.S. Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine. J. Biol. Chem. 2003, 278, 15966-15972.
26. Onyango, I.G.; Khan, S.M. Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease. Curr. Alzheimer Res. 2006, 3, 339-349.
27. Chakrabortee, S.; Boschetti, C.; Walton, L.J.; Sarkar, S.; Rubinsztein, D.C.; Tunnacliffe, A. Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function. Proc. Natl. Acad. Sci. USA 2007, 104, 18073-18078.
28. Beal, M.F. Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurosci. 2000, 23, 298-304.
29. Sultana, R.; Butterfield, D.A. Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment. J. Bioenerg. Biomembr. 2009, 41, 441-446.
30. Du, H.; Yan, S.S. Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta. Biochim. Biophys. Acta 2010, 1802, 198-204.
31. Heckman, K.L.; Pease, L.R. Gene splicing and mutagenesis by PCR-driven overlap extension. Nat. Protoc. 2007, 2, 924-932.
32. Wang, H.; Kwok, D.T.; Wang, W.; Wu, Z.; Tong, L.; Zhang, Y.; Chu, P.K. Osteoblast behavior on polytetrafluoroethylene modified by long pulse, high frequency oxygen plasma immersion ion implantation. Biomaterials 2010, 31, 413-419.