Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation

Toxicology in Vitro

Volumn 28, Issue 5, 2014, Pages 982-989

  Alloul Ramdhani, Mariam ^a   Tensen, Cornelis P ^a   El Ghalbzouri, Abdoelwaheb ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

DNCB; Keap1; N TERT; Nrf2; Reconstructed human epidermis; Skin sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ARE PROTEIN; CELL PROTEIN; DODECYL SULFATE SODIUM; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ALLERGEN; IRRITANT AGENT; KEAP1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TELOMERASE; TERT PROTEIN, HUMAN;

ARTICLE; CELL ASSAY; CELL LEVEL; CELL PROLIFERATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KERATINOCYTE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SKIN SENSITIZATION; ANIMAL TESTING ALTERNATIVE; ANTIOXIDANT RESPONSIVE ELEMENT; CELL CULTURE; CELL LINE; DRUG EFFECTS; EPIDERMIS; GENETICS; METABOLISM; TOXICITY; TOXICITY TESTING;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; ANTIOXIDANT RESPONSE ELEMENTS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IRRITANTS; KERATINOCYTES; NF-E2-RELATED FACTOR 2; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN IRRITANCY TESTS; TELOMERASE;

EID: 84900825922     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.04.007     Document Type: Article

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