-
1
-
-
0032863685
-
Intrinsic drug resistance in primary and metastatic renal cell carcinoma
-
Jul
-
Gamelin E, Mertins SD, Regis JT, Mickley L, Abati A, Worrell RA, et al. Intrinsic drug resistance in primary and metastatic renal cell carcinoma. J Urol. 1999 Jul; 162(1): 217-24.
-
(1999)
J Urol
, vol.162
, Issue.1
, pp. 217-224
-
-
Gamelin, E.1
Mertins, S.D.2
Regis, J.T.3
Mickley, L.4
Abati, A.5
Worrell, R.A.6
-
2
-
-
84864007524
-
State-of-The-science: An update on renal cell carcinoma
-
Jul
-
Jonasch E, Futreal A, Davis I, Bailey S, Kim WY, Brugarolas J, et al. State-of-the-science: An update on renal cell carcinoma. Mol Cancer Res. 2012 Jul; 10(7): 859-80.
-
(2012)
Mol Cancer Res
, vol.10
, Issue.7
, pp. 859-880
-
-
Jonasch, E.1
Futreal, A.2
Davis, I.3
Bailey, S.4
Kim, W.Y.5
Brugarolas, J.6
-
3
-
-
63849150122
-
Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor a and c indicating worse prognosis in clear cell renal cell carcinoma
-
Dorević G, Matusan-Ilijas K, Babarović E, Hadzisejdić I, Grahovac M, Grahovac B, et al. Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma. J Exp Clin Cancer Res CR. 2009; 28: 40.
-
(2009)
J Exp Clin Cancer Res CR
, vol.28
, pp. 40
-
-
Dorević, G.1
Matusan-Ilijas, K.2
Babarović, E.3
Hadzisejdić, I.4
Grahovac, M.5
Grahovac, B.6
-
4
-
-
0030895147
-
Vascular endothelial growth factor expression is increased in renal cell carcinoma
-
DOI 10.1016/S0022-5347(01)65028-6
-
Nicol D, Hii SI, Walsh M, Teh B, Thompson L, Kennett C, et al. Vascular endothelial growth factor expression is increased in renal cell carcinoma. J Urol. 1997 Apr; 157(4): 1482- 6. (Pubitemid 27130856
-
(1997)
Journal of Urology
, vol.157
, Issue.4
, pp. 1482-1486
-
-
Nicol, D.1
Hii, S.U.-I.2
Walsh, M.3
Teh, B.4
Thompson, L.5
Kennett, C.6
Gotley, D.7
-
5
-
-
48749092867
-
First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma
-
Aug
-
Melichar B, Koralewski P, Ravaud A, Pluzanska A, Bracarda S, Szczylik C, et al. First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2008 Aug; 19(8): 1470-6.
-
(2008)
Ann Oncol Off J Eur Soc Med Oncol ESMO
, vol.19
, Issue.8
, pp. 1470-1476
-
-
Melichar, B.1
Koralewski, P.2
Ravaud, A.3
Pluzanska, A.4
Bracarda, S.5
Szczylik, C.6
-
6
-
-
77955917461
-
Long-term safety of sorafenib in advanced renal cell carcinoma: Follow-up of patients from phase iii target
-
Sep
-
Hutson TE, Bellmunt J, Porta C, Szczylik C, Staehler M, Nadel A, et al. Long-term safety of sorafenib in advanced renal cell carcinoma: follow-up of patients from phase III TARGET. Eur J Cancer Oxf Engl 1990. 2010 Sep; 46(13): 2432-40.
-
(2010)
Eur J Cancer Oxf Engl 1990
, vol.46
, Issue.13
, pp. 2432-2440
-
-
Hutson, T.E.1
Bellmunt, J.2
Porta, C.3
Szczylik, C.4
Staehler, M.5
Nadel, A.6
-
7
-
-
84858699792
-
Phase 1 trial of everolimus plus sunitinib in patients with metastatic renal cell carcinoma
-
Apr 1
-
Molina AM, Feldman DR, Voss MH, Ginsberg MS, Baum MS, Brocks DR, et al. Phase 1 trial of everolimus plus sunitinib in patients with metastatic renal cell carcinoma. Cancer. 2012 Apr 1; 118(7): 1868-76.
-
(2012)
Cancer
, vol.118
, Issue.7
, pp. 76
-
-
Molina, A.M.1
Feldman, D.R.2
Voss, M.H.3
Ginsberg, M.S.4
Baum, M.S.5
Brocks, D.R.6
-
8
-
-
84875690904
-
A randomised, double-blind phase iii study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: Final overall survival results and safety update
-
Apr
-
Sternberg CN, Hawkins RE, Wagstaff J, Salman P, Mardiak J, Barrios CH, et al. A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update. Eur J Cancer Oxf Engl 1990. 2013 Apr; 49(6): 1287-96.
-
(2013)
Eur J Cancer Oxf Engl 1990
, vol.49
, Issue.6
, pp. 1287-1296
-
-
Sternberg, C.N.1
Hawkins, R.E.2
Wagstaff, J.3
Salman, P.4
Mardiak, J.5
Barrios, C.H.6
-
9
-
-
84863712300
-
Re: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (axis): A randomised phase 3 trial
-
Aug
-
Taneja SS. Re: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. J Urol. 2012 Aug; 188(2): 412-3.
-
(2012)
J Urol
, vol.188
, Issue.2
, pp. 412-413
-
-
Taneja, S.S.1
-
10
-
-
84865494478
-
Temsirolimus: A safety and efficacy review
-
Sep
-
Bukowski RM. Temsirolimus: a safety and efficacy review. Expert Opin Drug Saf. 2012 Sep; 11(5): 861-79.
-
(2012)
Expert Opin Drug Saf
, vol.11
, Issue.5
, pp. 861-879
-
-
Bukowski, R.M.1
-
11
-
-
77956227464
-
Phase 3 trial of everolimus for metastatic renal cell carcinoma : Final results and analysis of prognostic factors
-
Sep 15
-
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factors. Cancer. 2010 Sep 15; 116(18): 4256-65.
-
(2010)
Cancer
, vol.116
, Issue.18
, pp. 4256-4265
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
-
12
-
-
84885656672
-
Targeting angiogenesis in renal cell carcinoma
-
Nov
-
Posadas EM, Limvorasak S, Sharma S, Figlin RA. Targeting angiogenesis in renal cell carcinoma. Expert Opin Pharmacother. 2013 Nov; 14(16): 2221-36.
-
(2013)
Expert Opin Pharmacother
, vol.14
, Issue.16
, pp. 2221-2236
-
-
Posadas, E.M.1
Limvorasak, S.2
Sharma, S.3
Figlin, R.A.4
-
13
-
-
84900456422
-
Antineoplastic effects of mammalian target of rapamycine inhibitors
-
Oct 24
-
Salvadori M. Antineoplastic effects of mammalian target of rapamycine inhibitors. World J Transplant. 2012 Oct 24; 2(5): 74- 83.
-
(2012)
World J Transplant
, vol.2
, Issue.5
, pp. 74-83
-
-
Salvadori, M.1
-
14
-
-
84879890360
-
Comprehensive molecular characterization of clear cell renal cell carcinoma
-
Cancer Genome Atlas Research Network Jul 4
-
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013 Jul 4; 499(7456): 43-9.
-
(2013)
Nature
, vol.499
, Issue.7456
, pp. 43-49
-
-
-
15
-
-
84877904949
-
Efficacy of temsirolimus in metastatic chromophobe renal cell carcinoma
-
Venugopal B, Ansari J, Aitchison M, Tho LM, Campbell R, Jones RJ. Efficacy of temsirolimus in metastatic chromophobe renal cell carcinoma. BMC Urol. 2013; 13: 26.
-
(2013)
BMC Urol
, vol.13
, pp. 26
-
-
Venugopal, B.1
Ansari, J.2
Aitchison, M.3
Tho, L.M.4
Campbell, R.5
Jones, R.J.6
-
16
-
-
84856877365
-
Combination or sequencing strategies to improve the outcome of metastatic renal cell carcinoma patients: A critical review
-
Jun
-
Porta C, Szczylik C, Escudier B. Combination or sequencing strategies to improve the outcome of metastatic renal cell carcinoma patients: a critical review. Crit Rev Oncol Hematol. 2012 Jun; 82(3): 323-37.
-
(2012)
Crit Rev Oncol Hematol
, vol.82
, Issue.3
, pp. 323-337
-
-
Porta, C.1
Szczylik, C.2
Escudier, B.3
-
17
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
May 2271-81
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007 May 31; 356(22): 2271-81.
-
(2007)
N Engl J Med
, vol.31
, pp. 35622
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
-
18
-
-
79952114176
-
Everolimus in renal cell carcinoma
-
Aug
-
Wang Y. Everolimus in renal cell carcinoma. Drugs Today Barc Spain 1998. 2010 Aug; 46(8): 557-66.
-
(2010)
Drugs Today Barc Spain 1998
, vol.46
, Issue.8
, pp. 557-566
-
-
Wang, Y.1
-
19
-
-
79961060638
-
Mtor inhibitors in renal cell carcinoma
-
Jul
-
Battelli C, Cho DC. mTOR inhibitors in renal cell carcinoma. Therapy. 2011 Jul; 8(4): 359-67.
-
(2011)
Therapy.
, vol.8
, Issue.4
, pp. 359-367
-
-
Battelli, C.1
Cho, D.C.2
-
21
-
-
70350418625
-
Mtor signaling at a glance
-
Oct 12220
-
Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009 Oct 15; 122(20): 3589-94.
-
(2009)
J Cell Sci
, vol.15
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
22
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
Feb
-
Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006 Feb; 7(2): 85-96.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, Issue.2
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
23
-
-
33747690458
-
Activation of mammalian target of rapamycin (mtor) by insulin is associated with stimulation of 4ebp1 binding to dimeric mtor complex 1
-
Aug 28134
-
Wang L, Rhodes CJ, Lawrence JC. Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1. J Biol Chem. 2006 Aug 25; 281(34): 24293-303.
-
(2006)
J Biol Chem
, vol.25
, pp. 24293-24303
-
-
Wang, L.1
Rhodes, C.J.2
Lawrence, J.C.3
-
24
-
-
51049083138
-
Oncogenic mapk signaling stimulates mtorc1 activity by promoting rsk-mediated raptor phosphorylation
-
Sep
-
Carrière A, Cargnello M, Julien L-A, Gao H, Bonneil E, Thibault P, et al. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol CB. 2008 Sep 9; 18(17): 1269-77.
-
(2008)
Curr Biol CB
, vol.9
, Issue.1817
, pp. 1269-1277
-
-
Carrière, A.1
Cargnello, M.2
Julien, L.-A.3
Gao, H.4
Bonneil, E.5
Thibault, P.6
-
25
-
-
0037810249
-
Signal transduction mediated by the ras/raf/mek/erk pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
-
Jul
-
Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia. 2003 Jul; 17(7): 1263-93.
-
(2003)
Leukemia
, vol.17
, Issue.7
, pp. 1263-1293
-
-
Chang, F.1
Steelman, L.S.2
Lee, J.T.3
Shelton, J.G.4
Navolanic, P.M.5
Blalock, W.L.6
-
26
-
-
0036713778
-
Tsc2 is phosphorylated and inhibited by akt and suppresses mtor signalling
-
Sep
-
Inoki K, Li Y, Zhu T, Wu J, Guan K-L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002 Sep; 4(9): 648-57.
-
(2002)
Nat Cell Biol
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
27
-
-
17444431201
-
Phosphorylation and functional inactivation of tsc2 by erk implications for tuberous sclerosis and cancer pathogenesis
-
Apr
-
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 2005 Apr 22; 121(2): 179-93.
-
(2005)
Cell
, vol.22
, Issue.1212
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
28
-
-
44449161481
-
The tsc1-tsc2 complex: A molecular switchboard controlling cell growth
-
Jun
-
Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008 Jun 1; 412(2): 179-90.
-
(2008)
Biochem J
, vol.1
, Issue.4122
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
29
-
-
18044381192
-
Rheb binds and regulates the mtor kinase
-
Apr
-
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol CB. 2005 Apr 26; 15(8): 702-13.
-
(2005)
Curr Biol CB
, vol.26
, Issue.158
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
30
-
-
34547099855
-
Pras40 regulates mtorc1 kinase activity by functioning as a direct inhibitor of substrate binding
-
July; t. 282, nr 27, ss
-
Wang L, Harris T. E, Roth R. A, Lawrence J. C. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding, J. Biol. Chem., 2007 July; t. 282, nr 27, ss. 20036-20044.
-
(2007)
J. Biol. Chem.
, pp. 20036-20044
-
-
Wang, L.1
Harris, T.E.2
Roth, R.A.3
Lawrence, J.C.4
-
31
-
-
0033049424
-
Eukaryotic translation initiation factor 4e control of 4e-binding protein 1 and p70 s6 kinase activities
-
Jun
-
Khaleghpour K, Pyronnet S, Gingras A-C, Sonenberg N. Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities. Mol Cell Biol. 1999 Jun; 19(6): 4302-10.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.6
, pp. 4302-4310
-
-
Khaleghpour, K.1
Pyronnet, S.2
Gingras, A.-C.3
Sonenberg, N.4
Homeostasis, T.5
-
32
-
-
56249147509
-
Rapamycin differentially inhibits s6ks and 4e-bp1 to mediate cell-typespecific repression of mrna translation
-
Nov 10545
-
Choo AY, Yoon S-O, Kim SG, Roux PP, Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-typespecific repression of mRNA translation. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45): 17414-9.
-
(2008)
Proc Natl Acad Sci U S A
, vol.11
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.-O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
33
-
-
70349385645
-
Resistance to targeted therapy in renal-cell carcinoma
-
Oct
-
Rini BI, Atkins MB. Resistance to targeted therapy in renal-cell carcinoma. Lancet Oncol. 2009 Oct; 10(10): 992-1000.
-
(2009)
Lancet Oncol
, vol.10
, Issue.10
, pp. 992-1000
-
-
Rini, B.I.1
Atkins, M.B.2
-
34
-
-
80052837898
-
Interplay between pvhl and mtorc1 pathways in clear-cell renal cell carcinoma
-
Sep
-
Kucejova B, Pena-Llopis S, Yamasaki T, Sivanand S, Tran TAT, Alexander S, et al. Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma. Mol Cancer Res MCR. 2011 Sep; 9(9): 1255-65.
-
(2011)
Mol Cancer Res MCR
, vol.9
, Issue.9
, pp. 1255-1265
-
-
Kucejova, B.1
Pena-Llopis, S.2
Yamasaki, T.3
Sivanand, S.4
Tran, T.A.T.5
Alexander, S.6
-
35
-
-
13844312400
-
Phosphorylation and regulation of akt/pkb by the rictor-mtor complex
-
Feb 3075712
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex. Science. 2005 Feb 18; 307(5712): 1098-101.
-
(2005)
Science
, vol.18
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
36
-
-
84876685913
-
Pi3k regulation of the skp- 2/p27 axis through mtorc2
-
Apr 18
-
Shanmugasundaram K, Block K, Nayak BK, Livi CB, Venkatachalam MA, Sudarshan S. PI3K regulation of the SKP- 2/p27 axis through mTORC2. Oncogene. 2013 Apr 18; 32(16): 2027-36.
-
(2013)
Oncogene
, vol.32
, Issue.16
, pp. 2027-2036
-
-
Shanmugasundaram, K.1
Block, K.2
Nayak, B.K.3
Livi, C.B.4
Venkatachalam, M.A.5
Sudarshan, S.6
-
37
-
-
51349164790
-
Inhibition of mtorc1 leads to mapk pathway activation through a pi3k-dependent feedback loop in human cancer
-
Sep
-
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest. 2008 Sep; 118(9): 3065-74.
-
(2008)
J Clin Invest
, vol.118
, Issue.9
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
-
38
-
-
77950386275
-
Chronic inhibition of the mtorc1/s6k1 pathway increases insulin-induced pi3k activity but inhibits akt2 and glucose transport stimulation in 3t3- l1 adipocytes
-
Apr
-
Veilleux A, Houde VP, Bellmann K, Marette A. Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3- L1 adipocytes. Mol Endocrinol Baltim Md. 2010 Apr; 24(4): 766- 78.
-
(2010)
Mol Endocrinol Baltim Md
, vol.24
, Issue.4
, pp. 766-778
-
-
Veilleux, A.1
Houde, V.P.2
Bellmann, K.3
Marette, A.4
-
39
-
-
0034638599
-
Increased activity and intranuclear expression of phospholipase d2 in human renal cancer
-
Nov
-
Zhao Y, Ehara H, Akao Y, Shamoto M, Nakagawa Y, Banno Y, et al. Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Biochem Biophys Res Commun. 2000 Nov 11; 278(1): 140-3.
-
(2000)
Biochem Biophys Res Commun
, vol.11
, Issue.2781
, pp. 140-143
-
-
Zhao, Y.1
Ehara, H.2
Akao, Y.3
Shamoto, M.4
Nakagawa, Y.5
Banno, Y.6
-
40
-
-
62849111751
-
Regulation of mtorc1 and mtorc2 complex assembly by phosphatidic acid: Competition with rapamycin
-
Mar
-
Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009 Mar; 29(6): 1411-20.
-
(2009)
Mol Cell Biol
, vol.29
, Issue.6
, pp. 1411-1420
-
-
Toschi, A.1
Lee, E.2
Xu, L.3
Garcia, A.4
Gadir, N.5
Foster, D.A.6
-
41
-
-
33644780111
-
Histone deacetylase inhibitors induce vhl and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha
-
Mar
-
Kong X, Lin Z, Liang D, Fath D, Sang N, Caro J. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2006 Mar; 26(6): 2019-28.
-
(2006)
Mol Cell Biol
, vol.26
, Issue.6
, pp. 2019-2028
-
-
Kong, X.1
Lin, Z.2
Liang, D.3
Fath, D.4
Sang, N.5
Caro, J.6
-
42
-
-
27744471944
-
The pharmacokinetics of a novel anti-tumor agent, beta-elemene, in sprague-dawley rats
-
Oct
-
Wang K, Li Z, Chen Y, Su C. The pharmacokinetics of a novel anti-tumor agent, beta-elemene, in Sprague-Dawley rats. Biopharm Drug Dispos. 2005 Oct; 26(7): 301-7.
-
(2005)
Biopharm Drug Dispos
, vol.26
, Issue.7
, pp. 301-307
-
-
Wang, K.1
Li, Z.2
Chen, Y.3
Su, C.4
-
43
-
-
84874062469
-
β- Elemene Induces Apoptosis In Human Renal-cell Carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways
-
Zhan Y-H, Liu J, Qu X-J, Hou K-Z, Wang K-F, Liu Y-P, et al. β- Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways. Asian Pac J Cancer Prev APJCP. 2012; 13(6): 2739-44.
-
(2012)
Asian Pac J Cancer Prev APJCP
, vol.13
, Issue.6
, pp. 2739-2744
-
-
Zhan, Y.-H.1
Liu, J.2
Qu, X.-J.3
Hou, K.-Z.4
Wang, K.-F.5
Liu, Y.-P.6
-
44
-
-
84864874958
-
Mtorc1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of tfeb
-
Jun
-
Martina JA, Chen Y, Gucek M, Puertollano R. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy. 2012 Jun; 8(6): 903-14.
-
(2012)
Autophagy
, vol.8
, Issue.6
, pp. 903-914
-
-
Martina, J.A.1
Chen, Y.2
Gucek, M.3
Puertollano, R.4
-
45
-
-
65549145048
-
An atp-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mtorc1
-
Mar 28412
-
Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, et al. An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1. J Biol Chem. 2009 Mar 20; 284(12): 8023-32.
-
(2009)
J Biol Chem
, vol.20
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
Gao, Y.6
-
46
-
-
58049216350
-
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mtorc1 and mtorc2
-
Dec 28350
-
Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem. 2008 Dec 12; 283(50): 34495-9.
-
(2008)
J Biol Chem
, vol.12
, pp. 34495-34499
-
-
Toschi, A.1
Lee, E.2
Gadir, N.3
Ohh, M.4
Foster, D.A.5
-
47
-
-
56849096837
-
Hif-alpha effects on c-myc distinguish two subtypes of sporadic vhl-deficient clear cell renal carcinoma
-
Dec
-
Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell. 2008 Dec 9; 14(6): 435-46.
-
(2008)
Cancer Cell
, vol.9
, Issue.146
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
-
48
-
-
84887022988
-
Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mtorc2
-
Oct 29
-
Harada K, Miyake H, Kumano M, Fujisawa M. Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2. Br J Cancer. 2013 Oct 29; 109(9): 2389-95.
-
(2013)
Br J Cancer
, vol.109
, Issue.9
, pp. 2389-2395
-
-
Harada, K.1
Miyake, H.2
Kumano, M.3
Fujisawa, M.4
-
49
-
-
77953504198
-
Mammalian target of rapamycin (mtor) and s6 kinase downregulate phospholipase d2 basal expression and function
-
Jun 18
-
Tabatabaian F, Dougherty K, Di Fulvio M, Gomez-Cambronero J. Mammalian target of rapamycin (mTOR) and S6 kinase downregulate phospholipase D2 basal expression and function. J Biol Chem. 2010 Jun 18; 285(25): 18991-9001.
-
(2010)
J Biol Chem
, vol.285
, Issue.25
, pp. 18991-19001
-
-
Tabatabaian, F.1
Dougherty, K.2
Di Fulvio, M.3
Gomez-Cambronero, J.4
-
50
-
-
74949089953
-
Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels
-
Jan 1
-
Mahalingam D, Medina EC, Esquivel JA 2nd, Espitia CM, Smith S, Oberheu K, et al. Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels. Clin Cancer Res Off J Am Assoc Cancer Res. 2010 Jan 1; 16(1): 141-53.
-
(2010)
Clin Cancer Res Off J Am Assoc Cancer Res
, vol.16
, Issue.1
, pp. 141-153
-
-
Mahalingam, D.1
Medina, E.C.2
Esquivel II, J.A.3
Espitia, C.M.4
Smith, S.5
Oberheu, K.6
-
51
-
-
84882333832
-
A novel hdac inhibitor obp-801 and a pi3k inhibitor ly294002 synergistically induce apoptosis via the suppression of survivin and xiap in renal cell carcinoma
-
Oct
-
Yamada T, Horinaka M, Shinnoh M, Yoshioka T, Miki T, Sakai T. A novel HDAC inhibitor OBP-801 and a PI3K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma. Int J Oncol. 2013 Oct; 43(4): 1080-6.
-
(2013)
Int J Oncol
, vol.43
, Issue.4
, pp. 1080-1086
-
-
Yamada, T.1
Horinaka, M.2
Shinnoh, M.3
Yoshioka, T.4
Miki, T.5
Sakai, T.6
-
52
-
-
84880967722
-
Integrated molecular analysis of clear-cell renal cell carcinoma
-
Aug
-
Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 2013 Aug; 45(8): 860-7.
-
(2013)
Nat Genet
, vol.45
, Issue.8
, pp. 860-867
-
-
Sato, Y.1
Yoshizato, T.2
Shiraishi, Y.3
Maekawa, S.4
Okuno, Y.5
Kamura, T.6
-
54
-
-
77952263737
-
The genetic basis of kidney cancer: A metabolic disease
-
May
-
Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol. 2010 May; 7(5): 277-85.
-
(2010)
Nat Rev Urol
, vol.7
, Issue.5
, pp. 277-285
-
-
Linehan, W.M.1
Srinivasan, R.2
Schmidt, L.S.3
-
55
-
-
84875481104
-
Targeting both igf-1r and mtor synergistically inhibits growth of renal cell carcinoma in vitro
-
Apr 1
-
Cardillo TM, Trisal P, Arrojo R, Goldenberg DM, Chang C-H. Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro. BMC Cancer. 2013 Apr 1; 13: 170.
-
(2013)
BMC Cancer
, vol.13
, pp. 170
-
-
Cardillo, T.M.1
Trisal, P.2
Arrojo, R.3
Goldenberg, D.M.4
Chang, C.-H.5
-
56
-
-
34948858983
-
The vhl tumor suppressor inhibits expression of the igf1r and its loss induces igf1r upregulation in human clear cell renal carcinoma
-
Oct
-
Yuen JSP, Cockman ME, Sullivan M, Protheroe A, Turner GDH, Roberts IS, et al. The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma. Oncogene. 2007 Oct 4; 26(45): 6499-508.
-
(2007)
Oncogene
, vol.4
, Issue.2645
, pp. 6499-6508
-
-
Yuen, J.S.P.1
Cockman, M.E.2
Sullivan, M.3
Protheroe, A.4
Turner, G.D.H.5
Roberts, I.S.6
-
57
-
-
84856989746
-
Inhibition of pi3k/mtor leads to adaptive resistance in matrix-attached cancer cells
-
Feb 14
-
Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, et al. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14; 21(2): 227-39.
-
(2012)
Cancer Cell
, vol.21
, Issue.2
, pp. 227-239
-
-
Muranen, T.1
Selfors, L.M.2
Worster, D.T.3
Iwanicki, M.P.4
Song, L.5
Morales, F.C.6
-
58
-
-
41849128523
-
The foxo code
-
Apr
-
Calnan DR, Brunet A. The FoxO code. Oncogene. 2008 Apr 7; 27(16): 2276-88.
-
(2008)
Oncogene
, vol.7
, Issue.2716
, pp. 2276-2288
-
-
Calnan, D.R.1
Brunet, A.2
-
59
-
-
34648828532
-
Amp-activated/snf1 protein kinases: Conserved guardians of cellular energy
-
Oct
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007 Oct; 8(10): 774-85.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.10
, pp. 774-785
-
-
Hardie, D.G.1
-
60
-
-
0345167800
-
Tsc2 mediates cellular energy response to control cell growth and survival
-
Nov
-
Inoki K, Zhu T, Guan K-L. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 Nov 26; 115(5): 577-90.
-
(2003)
Cell
, vol.26
, Issue.1155
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
61
-
-
80053483270
-
Targeting the tumor microenvironment: Focus on angiogenesis
-
Fan F, Schimming A, Jaeger D, Podar K. Targeting the tumor microenvironment: focus on angiogenesis. J Oncol. 2012; 2012: 281261.
-
(2012)
J Oncol
, vol.2012
, pp. 281261
-
-
Fan, F.1
Schimming, A.2
Jaeger, D.3
Podar, K.4
-
62
-
-
84900566175
-
Hif-1 regulation through crosstalk between mtor and mt1-mmp
-
Oct 28
-
Sakamoto T, Weng JS, Hara T, Yoshino S, Kozuka-Hata H, Oyama M, et al. HIF-1 regulation through crosstalk between mTOR and MT1-MMP. Mol Cell Biol. 2013 Oct 28;
-
(2013)
Mol Cell Biol
-
-
Sakamoto, T.1
Weng, J.S.2
Hara, T.3
Yoshino, S.4
Kozuka-Hata, H.5
Oyama, M.6
-
63
-
-
84872781534
-
A comparison of ku0063794, a dual mtorc1 and mtorc2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models
-
Zhang H, Berel D, Wang Y, Li P, Bhowmick NA, Figlin RA, et al. A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models. PloS One. 2013; 8(1): e54918.
-
(2013)
PloS One
, vol.8
, Issue.1
-
-
Zhang, H.1
Berel, D.2
Wang, Y.3
Li, P.4
Bhowmick, N.A.5
Figlin, R.A.6
-
64
-
-
45749101295
-
Cancer stem cells: The theory and perspectives in cancer therapy
-
Gil J, Stembalska A, Pesz KA, Sasiadek MM. Cancer stem cells: the theory and perspectives in cancer therapy. J Appl Genet. 2008; 49(2): 193-9.
-
(2008)
J Appl Genet
, vol.49
, Issue.2
, pp. 193-199
-
-
Gil, J.1
Stembalska, A.2
Pesz, K.A.3
Sasiadek, M.M.4
-
65
-
-
84886877514
-
Nutrient-sensing pathways and metabolic regulation in stem cells
-
Oct 14
-
Ochocki JD, Simon MC. Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol. 2013 Oct 14; 203(1): 23-33.
-
(2013)
J Cell Biol
, vol.203
, Issue.1
, pp. 23-33
-
-
Ochocki, J.D.1
Simon, M.C.2
-
66
-
-
84887495550
-
Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the pi3k/akt/mtor pathway in prostate cancer radioresistance
-
Chang L, Graham PH, Hao J, Ni J, Bucci J, Cozzi PJ, et al. Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death Dis. 2013; 4: e875.
-
(2013)
Cell Death Dis
, vol.4
-
-
Chang, L.1
Graham, P.H.2
Hao, J.3
Ni, J.4
Bucci, J.5
Cozzi, P.J.6
-
67
-
-
84887178635
-
Mtor activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo
-
Aug 7
-
Yang C, Peng J, Jiang W, Zhang Y, Chen X, Wu X, et al. mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo. Cancer Lett. 2013 Aug 7.
-
(2013)
Cancer Lett
-
-
Yang, C.1
Peng, J.2
Jiang, W.3
Zhang, Y.4
Chen, X.5
Wu, X.6
-
68
-
-
84891746463
-
Significance of mtor signaling and its inhibitor against cancer stem-like cells in colorectal cancer
-
Aug 2
-
Cai Z, Ke J, He X, Yuan R, Chen Y, Wu X, et al. Significance of mTOR Signaling and Its Inhibitor Against Cancer Stem-Like Cells in Colorectal Cancer. Ann Surg Oncol. 2013 Aug 2.
-
(2013)
Ann Surg Oncol
-
-
Cai, Z.1
Ke, J.2
He, X.3
Yuan, R.4
Chen, Y.5
Wu, X.6
-
69
-
-
84873084662
-
Renal stem cells and their implications for kidney cancer
-
Feb
-
Axelson H, Johansson ME. Renal stem cells and their implications for kidney cancer. Semin Cancer Biol. 2013 Feb; 23(1): 56-61.
-
(2013)
Semin Cancer Biol
, vol.23
, Issue.1
, pp. 56-61
-
-
Axelson, H.1
Johansson, M.E.2
-
70
-
-
84880049075
-
Cancer stem cell-like side population cells in clear cell renal cell carcinoma cell line 769p
-
Huang B, Huang YJ, Yao ZJ, Chen X, Guo SJ, Mao XP, et al. Cancer stem cell-like side population cells in clear cell renal cell carcinoma cell line 769P. PloS One. 2013; 8(7): e68293.
-
(2013)
PloS One
, vol.8
, Issue.7
-
-
Huang, B.1
Huang, Y.J.2
Yao, Z.J.3
Chen, X.4
Guo, S.J.5
Mao, X.P.6
-
71
-
-
84878834146
-
Targeting pi3k and mtorc2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to vegfr and mtorc1 inhibitors
-
Aug 15
-
Figlin RA, Kaufmann I, Brechbiel J. Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: new strategies for overcoming resistance to VEGFR and mTORC1 inhibitors. Int J Cancer J Int Cancer. 2013 Aug 15; 133(4): 788-96.
-
(2013)
Int J Cancer J Int Cancer
, vol.133
, Issue.4
, pp. 788-796
-
-
Figlin, R.A.1
Kaufmann, I.2
Brechbiel, J.3
-
72
-
-
84876848578
-
Dual inhibition of pi3-kinase and mtor in renal cell carcinoma
-
Feb
-
Cho DC, Mier JW. Dual inhibition of PI3-kinase and mTOR in renal cell carcinoma. Curr Cancer Drug Targets. 2013 Feb; 13(2): 126-42.
-
(2013)
Curr Cancer Drug Targets
, vol.13
, Issue.2
, pp. 126-142
-
-
Cho, D.C.1
Mier, J.W.2
-
73
-
-
84879843923
-
Inhibition of autophagy enhances apoptosis induced by the pi3k/akt/mtor inhibitor nvp-bez235 in renal cell carcinoma cells
-
Jul
-
Li H, Jin X, Zhang Z, Xing Y, Kong X. Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells. Cell Biochem Funct. 2013 Jul; 31(5): 427-33.
-
(2013)
Cell Biochem Funct
, vol.31
, Issue.5
, pp. 427-433
-
-
Li, H.1
Jin, X.2
Zhang, Z.3
Xing, Y.4
Kong, X.5
|