Hypoxia inducible factor-1α correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma

Journal of Experimental and Clinical Cancer Research

Volumn 28, Issue 1, 2009, Pages

  Orevi, Gordana ^a   Matuan Ilija, Koviljka ^a   Babarovi, Emina ^a   Hadisejdi, Ita ^a   Grahovac, Maja ^a   Grahovac, Blaenka ^a  

^a UNIVERSITY OF RIJEKA   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; VASCULOTROPIN A; VASCULOTROPIN C;

ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CLEAR CELL CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY;

EID: 63849150122     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-28-40     Document Type: Article

References (29)

1. Tumor angiogenesis: therapeutic implications. J Folkman, N Engl J Med 1971 285 1182 6 4938153
2. Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: regulation by the von Hippel-Lindau gene and hypoxia. SP Gunningham MJ Currie C Han K Turner PA Scott BA Robinson AL Harris SB Fox, Cancer Res 2001 61 3206 11 11306510
3. WHO Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. JN Eble G Sauter JI Epstein IA Sesterhenn, IARC Press, Lyon (France) 2004 6 9 87
4. Inverse regulation of vascular endothelial growth factor and VHL tumor suppressor gene in sporadic renal cell carcinomas is correlated with vascular growth: an in vivo study on 29 tumors. J Brieger EJ Weidt P Schirmacher S Störkel C Huber HJ Decker, J Mol Med 1999 77 505 10 10.1007/s001099900022 10475065
5. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. JK Maranchie JR Vasselli J Riss JS Bonifacino WM Linehan RD Klausner, Cancer Cell 2002 1 247 55 10.1016/S1535-6108(02)00044-2 12086861
6. A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma. JC Strefford I Stasevich TM Lane YJ Lu T Oliver BD Young, Cancer Genet Cytogenet 2005 159 1 9 10.1016/j.cancergencyto.2004.09.020 15860350
7. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. K Kondo J Klco E Nakamura M Lechpammer WG Kaelin Jr, Cancer Cell 2002 1 237 46 10.1016/S1535-6108(02)00043-0 12086860
8. Modern therapeutic approaches in Metastatic Renal cell carcinoma. M Staehler N Haseke G Schoeppler T Stadler C Gratzke C Stief, EAU-EBU Update series 2007 5 26 37 10.1016/j.eeus.2006.08.004
9. Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors. D Mukhopadhyay K Datta, Semin Cancer Biol 2004 14 123 30 10.1016/j.semcancer.2003.09.019 15018896
10. Lymphangiogenesis and angiogenesis in conventional renal cell carcinoma: association with vascular endothelial growth factors A to D immunohistochemistry. T Iwata Y Miyata S Kanda M Nishikido T Hayashi H Sakai H Kanetake, Urology 2008 71 749 54 10.1016/j.urology.2007.10.063 18295862
11. Lymphangiogenesis in development and human disease. K Alitalo T Tammela TV Petrova, Nature 2005 438 946 53 10.1038/nature04480 16355212
12. VEGF-C promotes survival in podocytes. RR Foster SC Satchell J Seckley MS Emmett K Joory CY Xing MA Saleem PW Mathieson DO Bates SJ Harper, Am J Physiol Renal Physiol 2006 291 F196 207 10.1152/ajprenal.00431.2005 16525158
13. Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells. S Aydin S Signorelli T Lechleitner M Joannidis C Pleban P Perco W Pfaller P Jennings, Am J Physiol Cell Physiol 2008 294 C543 54 10.1152/ajpcell.00307.2007 18057119
14. Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. A Tufro VF Norwood RM Carey RA Gomez, J Am Soc Nephrol 1999 10 2125 34 10505689
15. Prognostic significance of vascular endothelial growth factor expression in clear cell renal cell carcinoma. G Djordjevic V Mozetic DV Mozetic V Licul KM Ilijas E Mustac R Oguic Z Fuckar N Jonjic, Pathol Res Pract 2007 203 99 106 10.1016/j.prp.2006.12.002 17270362
16. Prognostic significance of morphologic parameters in renal cell carcinoma. SA Fuhrman LC Lasky C Limas, Am J Surg Pathol 1982 6 655 63 7180965
17. Molecular pathways of tumour angiogenesis and new targeted therapeutic approaches in renal cancer. P Fergelot N Rioux-Leclercq JJ Patard, Prog Urol 2005 15 1021 9 16429647
18. The significance of VEGF-C/VEGFR-2 interaction in the neovascularization and prognosis of nephroblastoma (Wilms' tumour). M Nowicki D Ostalska-Nowicka M Kaczmarek B Miskowiak M Witt, Histopathology 2007 50 358 64 10.1111/j.1365-2559. 2007.02613.x 17257131
19. Expression of vascular endothelial growth factor in renal cell carcinomas. V Paradis NB Lagha L Zeimoura P Blanchet P Eschwege N Ba G Benot A Jardin P Bedossa, Virchows Arch 2000 436 351 6 10.1007/s004280050458 10834538
20. Prognostic value of the expression of Ki-67, CD44 and vascular endothelial growth factor, and microvessel invasion, in renal cell carcinoma. E Yildiz G Gokce H Kilicarslan S Ayan OF Goze EY Gultekin, BJU Int 2004 93 1087 93 10.1111/j.1464-410X.2004.04786.x 15142169
21. Expression of vascular endothelial growth factor protein in human renal cell carcinoma. J Jacobsen K Grankvist T Rasmuson A Bergh G Landberg B Ljungberg, BJU Int 2004 93 297 302 10.1111/j.1464-410X.2004.04605.x 14764126
22. Targeting the vascular endothelial growth factor pathway in renal cell carcinoma: a tissue array based analysis. JT Leppert JS Lam H Yu DB Seligson J Dong S Horvath, J Clin Oncol ASCO Annual Meeting Proceedings 2005 23 165 (June 1 Supplement) 4536
23. Nuclear expression of hypoxia-inducible factor-1alpha in clear cell renal cell carcinoma is involved in tumor progression. C Di Cristofano A Minervini M Menicagli G Salinitri G Bertacca G Pefanis L Masieri F Lessi P Collecchi R Minervini M Carini G Bevilacqua A Cavazzana, Am J Surg Pathol 2007 31 1875 81 10.1097/PAS.0b013e318094fed8 18043042
24. Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. T Klatte DB Seligson SB Riggs JT Leppert MK Berkman MD Kleid H Yu FF Kabbinavar AJ Pantuck AS Belldegrun, Clin Cancer Res 2007 13 7388 93 10.1158/1078-0432.CCR- 07-0411 18094421
25. Accumulation and nuclear import of HIF1 alpha during high and low oxygen concentration in skeletal muscle cells in primary culture. HP Kubis N Hanke RJ Scheibe G Gros, Biochim Biophys Acta 2005 1745 2 187 195 10.1016/j.bbamcr.2005. 05.007 15967517
26. Hypoxia-inducible factor 1 alpha expression in renal cell carcinoma analyzed by tissue microarray. A Minervini C Di Cristofano S Serni M Carini Anders Lidgren Ylva Hedberg Kjell Grankvist Torgny Rasmuson Anders Bergh Börje Ljungberg, Eur Urol 2006 50 1272 7 Eur Urol 2007, 51 :14512 10.1016/j.eururo.2006.05.043 16814458
27. Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. R Bos PJ van Diest JS de Jong P van der Groep P van der Valk E van der Wall, Histopathology 2005 46 31 6 10.1111/j.1365-2559.2005.02045.x 15656883
28. Hypoxia-inducible factor 1alpha expression in renal cell carcinoma analyzed by tissue microarray. A Lidgren Y Hedberg K Grankvist T Rasmuson A Bergh B Ljungberg, Eur Urol 2006 50 1272 7 10.1016/j.eururo.2006.05.043 16814458
29. The potential role of intrinsic hypoxia markers as prognostic variables in cancer. EJ Moon DM Brizel JT Chi MW Dewhirst, Antioxid Redox Signal 2007 9 1237 94 10.1089/ars.2007.1623 17571959