The pharmacokinetics of a novel anti-tumor agent, β-elemene, in Sprague-Dawley rats

Biopharmaceutics and Drug Disposition

Volumn 26, Issue 7, 2005, Pages 301-307

  Wang, Kun ^a   Li, Zi ^b   Chen, Yuren ^b   Su, Chengye ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Dalian Institute of Medical and Pharmaceutical Science   (China)

Author keywords

elemene; Biotransformation; Blood brain barrier

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ELEMENE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DOSE RESPONSE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG PENETRATION; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BILE; BIOTRANSFORMATION; BLOOD PROTEINS; CHROMATOGRAPHY, GAS; MALE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; TISSUE DISTRIBUTION;

EID: 27744471944     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.463     Document Type: Article

References (13)

1. Guo YT. Isolation and identification of elemene from the essential oil of Curcuma wenyujin. Zhong Yao Tong Bao 1983; 8: 31-33.
2. Tan PG, Zhong WJ, Cai WQ. Continuously infused chemotherapy in treatment of malignant brain tumors. Zhongguo Zhongliu Linchuang 2001; 28: 682-684.
3. Wang JW, Zhang HP, Sun Y. Results of phase II clinical trials of elemene emulsion in the management of advanced malignancies. Chin J New Drug 1995; 4: 26-29.
4. Wang J, Zhang H, Sun Y. Phase III clinical trial of elemenum emulsion in the management of malignant pleural and peritoneal effusions. Zhongguo Lin Chuang 1996; 23: 301-304.
5. Fu NW. Anti-tumor effect and pharmacological actions of beta-elemene isolated from the rhizome of Curcuma aromatica. Zhong Yao Tong Bao 1984; 9: 83-87.
6. Yang H, Wang X, Yu L. The antitumor activity of elemene is associated with apoptosis. Zhonghua Zhong Liu Za Zhi 1996; 18: 169-172.
7. Yuan J, Gu ZL, Chou WH, Kwok CY. Elemene induces apoptosis and regulates expression of bcl-2 protein in human leukemia K562 cells. Zhongguo Yao Li Xue Bao 1999; 20: 103-106.
8. Wu W, Liu K, Tang X. Preliminary study on the antitumor immuno-protective mechanism of β-elemene. Zhonghua Zhong Liu Za Zhi 1999; 21: 405-408.
9. Zhou HY, Shen JK, Hou JS, Qiu YM, Luo QZ. Experimental study on apoptosis induced by elemene in glioma cells. Ai Zheng 2003; 22: 959-963.
10. Zhou HY, Lu LM, Wang Y, Jiang JR, Luo QZ. A comparison study of the proliferation effect of elemene on glioma cell. Chin J Exp Surg 2004; 21: 1241-1243.
11. Fan Y, Li GJ, Qian LP, Li H, Zhang ZY. Effects of β-elemene on both telomerase activity and expression of c-myc gene of gastric cancer SGC-7901 cell. Zhongguo Zhongliu Linchuang 2001; 28: 848-851.
12. Bai L, Zhang FY. Study on the cytotoxicity of human salivary SACC-83 induced by paclitaxel and β-elemene. J Modern Somatol 2004; 18: 496-499.
13. Huang FC, Fan Y, Zheng S. Effect of elemene on the telomerase activity, apoptosis and cell cycle of the colon cancer Lovo cell line. Herald of Medicine 2004; 23: 712-714.