Acquisition of epithelialmesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

Cell Death and Disease

Volumn 4, Issue 10, 2013, Pages

  Chang, L ^a,b   Graham, P H ^a,b   Hao, J ^a,b   Ni, J ^a,b   Bucci, J ^a,b   Cozzi, P J ^a,b   Kearsley, J H ^a,b   Li, Y ^a,b  

^a ST GEORGE HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

BEZ235; CSC; EMT; PI3K Akt mTOR; Prostate cancer; Radiation therapy; Radioresistance

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; ALPHA SMOOTH MUSCLE ACTIN; CD44V6 ANTIGEN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; EPITHELIAL CELL ADHESION MOLECULE; HERMES ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; NERVE CELL ADHESION MOLECULE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX2; UVOMORULIN; VIMENTIN; DACTOLISIB; IMIDAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CANCER STEM CELL; CELL INVASION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; IC 50; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE CHECKPOINT; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; MALE; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PROSTATE TUMOR; RADIATION EXPOSURE; REPRODUCIBILITY; TUMOR CELL LINE; TUMOR INVASION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; PROSTATIC NEOPLASMS; RADIATION RESPONSE;

ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; IMIDAZOLES; MALE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; RADIATION TOLERANCE; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TOR SERINE-THREONINE KINASES;

EID: 84887495550     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.407     Document Type: Article

References (30)

1. Curtin WM, Weinstein L. A review of HELLP syndrome. J Perinatol 1999; 19: 138-143
2. Goodburn E, Campbell O. Reducing maternal mortality in the developing world: Sectorwide approaches may be the key. BMJ 2001; 322: 917-920
3. Smulian J, Shen-Schwarz S, Scorza W, Kinzler W, Vintzileos A. A clinicohistopathologic comparison between HELLP syndrome and severe preeclampsia. J Matern Fetal Neonatal Med 2004; 16: 287-293
4. McKinney ET, Shouri R, Hunt RS, Ahokas RA, Sibai BM. Plasma urinary, and salivary 8-epi-prostaglandin f2alpha levels in normotensive and preeclamptic pregnancies. Am J Obstet Gynecol 2000; 183: 874-877
5. Walsh SW, Vaughan JE, Wang Y, Roberts LJ II. Placental isoprostane is significantly increased in preeclampsia. FASEB J 2000; 14: 1289-1296
6. Hass R, Sohn C. Increased oxidative stress in pre-eclamptic placenta is associated with altered proteasome activity and protein patterns. Placenta 2003; 24: 979-984
7. Hass R, Staboulidou I, Wüstemann M, Kundu S, Oehler K, Scharf A. Preeclampsia as a multifactorial pregnancy disorder: Clinical symptoms, diagnostic tools and research strategies. Curr Womens Health Rev 2007; 3: 166-176
8. Abildgaard U, Heimdal K. Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): A review. Eur J Obstet Gynecol Reprod Biol 2013; 166: 117-123
9. Straszewski-Chavez SL, Abrahams VM, Mor G. The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev 2005; 26: 877-897
10. Abrahams VM, Bole-Aldo P, Kim YM, Straszewski-Chavez SL, Chaiworapongsa T, Romero R et al. Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol 2004; 173: 4286-4296
11. Leung DN, Smith SC, To KF, Sahota DS, Baker PN. Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 2001; 184: 1249-1250
12. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol 2000; 96: 271-276
13. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 2002; 186: 158-166
14. Crocker IP, Cooper S, Ong SC, Baker PN. Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol 2003; 162: 637-643
15. Guicciardi ME, Gores GJ. Life and death by death receptors. FASEB J 2009; 23: 1625-1637
16. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem 1998; 254: 439-459
17. Los M, Wesselborg S, Schulze-Osthoff K. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice. Immunity 1999; 10: 629-639
18. Bantel H, Ruck P, Gregor M, Schulze-Osthoff K. Detection of elevated caspase activation and early apoptosis in liver diseases. Eur J Cell Biol 2001; 80: 230-239
19. Hefler LA, Tempfer CB, Bancher-Todesca D, Schatten C, Husslein P, Heinze G et al. Placental expression and serum levels of cytokeratin-18 are increased in women with preeclampsia. J Soc Gynecol Investig 2001; 8: 169-173
20. Bantel H, Lugering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP et al. Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004; 40: 1078-1087
21. Hamad RR, Bremme K, Kallner A, Sten-Linder M. Increased levels of an apoptotic product in the sera from women with pre-eclampsia. Scand J Clin Lab Invest 2009; 69: 204-208
22. Seidel N, Volkmann X, Langer F, Flemming P, Manns MP, Schulze-Osthoff K et al. The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology 2005; 42: 113-120
23. Joka D, Wahl K, Moeller S, Schlue J, Vaske B, Bahr MJ et al. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 2012; 55: 455-465
24. MacFarlane M, Merrison W, Dinsdale D, Cohen GM. Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis. J Cell Biol 2000; 148: 1239-1254
25. Strand S, Strand D, Seufert R, Mann A, Lotz J, Blessing M et al. Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome. Gastroenterology 2004; 126: 849-858
26. Prusac IK, Zekic Tomas S, Roje D. Apoptosis, proliferation and Fas ligand expression in placental trophoblast from pregnancies complicated by HELLP syndrome or pre-eclampsia. Acta Obstet Gynecol Scand 2011; 90: 1157-1163
27. Eide IP, Isaksen CV, Salvesen KA, Langaas M, Gunther CC, Iversen AC et al. Fetal growth restriction is associated with reduced FasL expression by decidual cells. J Reprod Immunol 2007; 74: 7-14
28. Cali U, Cavkaytar S, Sirvan L, Danisman N. Placental apoptosis in preeclampsia, intrauterine growth retardation, and HELLP syndrome: An immunohistochemical study with caspase-3 and bcl-2. Clin Exp Obstet Gynecol 2013; 40: 45-48
29. Krueger A, Fas SC, Baumann S, Krammer PH. The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev 2003; 193: 58-69
30. Volkmann X, Fischer U, Bahr MJ, Ott M, Lehner F, MacFarlane M et al. Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 2007; 46: 1498-1508