Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

Journal of Biological Chemistry

Volumn 289, Issue 19, 2014, Pages 13335-13346

  Patterson, Jessica N ^a   Cousteils, Katelyn ^a   Lou, Jennifer W ^a   Fox, Jocelyn E Manning ^b   MacDonald, Patrick E ^b   Joseph, Jamie W ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLONE CELLS; GLUCOSE; INSULIN; MEDICAL PROBLEMS; METABOLISM; MITOCHONDRIA; MODEL PREDICTIVE CONTROL;

BRANCHING POINTS; GLUCOSE HOMEOSTASIS; GLUCOSE-STIMULATED INSULIN SECRETIONS; IMPAIRED GLUCOSE TOLERANCES; INSULIN SECRETION; MITOCHONDRIAL METABOLISM; PHARMACOLOGICAL INHIBITORS; SIGNALING MOLECULES;

PHYSIOLOGY;

2 CYANO 3 (1 PHENYLINDOL 3 YL)ACRYLIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CARRIER PROTEINS AND BINDING PROTEINS; GLUCOSE; MITOCHONDRIAL PYRUVATE CARRIER 1; MITOCHONDRIAL PYRUVATE CARRIER 2; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CHEMICAL PARAMETERS; CONTROLLED STUDY; GENE; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; MALE; MITOCHONDRION; MOUSE; MPC1 GENE; MPC2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

CELL METABOLISM; GLUCOSE METABOLISM; MITOCHONDRIA; PANCREATIC ISLETS; PYRUVATE; Β-CELL;

ACRYLATES; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANION TRANSPORT PROTEINS; CELL LINE, TUMOR; FEMALE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NADP; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84900459053     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.521666     Document Type: Article

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