Shorter telomeres are associated with mortality in those with APOE ε4 and dementia

Annals of Neurology

Volumn 60, Issue 2, 2006, Pages 181-187

  Honig, Lawrence S ^a,b   Schupf, Nicole ^a,b   Lee, Joseph H ^a,b   Tang, Ming X ^a,b   Mayeux, Richard ^a,b  

^a Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; DNA; RIBOSOME PROTEIN;

AGE; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; DEMENTIA; EDUCATION; FEMALE; FOLLOW UP; GENOTYPE; HISPANIC; HUMAN; LEUKOCYTE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEGRO; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TELOMERE;

EID: 33746812586     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20894     Document Type: Article

References (35)

1. Hodes RJ, Hathcock KS, Weng NP. Telomeres in T and B cells. Nat Rev Immunol 2002;2:699-706.
2. Benetos A, Okuda K, Lajemi M, et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 2001;37: 381-385.
3. Blackburn EH. Telomere states and cell fates. Nature 2000; 408:53-56.
4. Linskens MH, Harley CB, West MD, et al. Replicative senescence and cell death. Science 1995;267:17.
5. Martin-Ruiz C, Saretzki G, Petrie J, et al. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem 2004;279: 17826-17833.
6. von Zglinicki T. Telomeres: influencing the rate of aging. Ann N Y Acad Sci 1998;854:318-327.
7. Zou Y, Sfeir A, Gryaznov SM, et al. Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell 2004;15:3709-3718.
8. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-344.
9. Ahmed A, Tollefsbol T. Telomeres and telomerase: basic science implications for aging. J Am Geriatr Soc 2001;49: 1105-1109.
10. Martin-Ruiz CM, Gussekloo J, van Heemst D, et al. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005;4:287-290.
11. Brouilette S, Singh RK, Thompson JR, et al. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 2003;23:842-846.
12. Cawthon RM, Smith KR, O'Brien E, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393-395.
13. Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 2004;101:17312-17315.
14. Honig LS, Mayeux R. Natural history of Alzheimer's disease. Aging (Milano) 2001;13:171-182.
15. Bassuk SS, Wypij D, Berkman LF. Cognitive impairment and mortality in the community-dwelling elderly. Am J Epidemiol 2000;151:676-688.
16. Fried LP, Kronmal RA, Newman AB, et al. Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA 1998;279:585-592.
17. Liu IY, LaCroix AZ, White LR, et al. Cognitive impairment and mortality: a study of possible confounders. Am J Epidemiol 1990;132:136-143.
18. Panossian LA, Porter VR, Valenzuela HF, et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 2003;24:77-84.
19. Jenkins EC, Velinov MT, Ye L, et al. Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia. Neurobiol Aging (in press).
20. Lee JH, Tang MX, Schupf N, et al. Mortality and apolipoprotein E in Hispanic, African-American, and Caucasian elders. Am J Med Genet 2001;103:121-127.
21. Mayeux R, Small SA, Tang M, et al. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiol Aging 2001;22:683-689.
22. Schachter F, Faure-Delanef L, Guenot F, et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994;6:29-32.
23. Tang MX, Stern Y, Marder K, et al. The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA 1998;279:751-755.
24. Stern Y, Andrews H, Pittman J, et al. Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education. Arch Neurol 1992;49:453-460.
25. Honig LS, Tang MX, Albert S, et al. Stroke and the risk of Alzheimer disease. Arch Neurol 2003;60:1707-1712.
26. Maestre G, Ottman R, Stern Y, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol 1995;37:254-259.
27. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002;30:e47.
28. Londono-Vallejo JA, DerSarkissian H, Cazes L, Thomas G. Differences in telomere length between homologous chromosomes in humans. Nucleic Acids Res 2001;29:3164-3171.
29. Graakjaer J, Pascoe L, Der-Sarkissian H, et al. The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell 2004;3:97-102.
30. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994;55:876-882.
31. Vasa-Nicotera M, Brouilette S, Mangino M, et al. Mapping of a major locus that determines telomere length m humans. Am J Hum Genet 2005;76:147-151.
32. Aviv A. Chronology versus biology: telomeres, essential hypertension, and vascular aging. Hypertension 2002;40: 229-232.
33. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
34. Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann Neurol 1993;34:752-754.
35. Baerlocher GM, Mak J, Tien T, Lansdorp PM. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 2002;47:89-99.