Telomere length in human natural killer cell subsets

Annals of the New York Academy of Sciences

Volumn 1106, Issue , 2007, Pages 240-252

  Ouyang, Qin ^a,b   Baerlocher, Gabriela ^a,c   Vulto, Irma ^a   Lansdorp, Peter M ^a,d  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Flow cytometry; Flow FISH; NK cells; Telomere length

Indexed keywords

CD16 ANTIGEN; CD161 ANTIGEN; CD56 ANTIGEN; CD94 ANTIGEN; DNA; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MARKER; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D; FC RECEPTOR; IMMUNOGLOBULIN RECEPTOR; LECTIN; MEMBRANE ANTIGEN; NATURAL KILLER CELL ACTIVATING RECEPTORS; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; B LYMPHOCYTE; BLOOD; CELL AGING; CELL DIVISION; CELL FUNCTION; CELL ISOLATION; CELL SELECTION; CELL SEPARATION; CELL SUBPOPULATION; COMPARATIVE STUDY; CONFERENCE PAPER; DONOR; FLOW CYTOMETRY; FLUORESCENCE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE PROBE; HEMATOPOIETIC CELL; HUMAN; HYBRIDIZATION; NATURAL KILLER CELL; OBSERVATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; TELOMERE; TUBE; ADULT; AGED; ARTICLE; BIOSYNTHESIS; CYTOLOGY; FEMALE; MALE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; ULTRASTRUCTURE;

ADULT; AGED; ANTIGENS, CD56; ANTIGENS, CD94; ANTIGENS, SURFACE; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RECEPTORS, IGG; RECEPTORS, IMMUNOLOGIC; TELOMERE;

EID: 34548257990     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1392.001     Document Type: Conference Paper

References (55)

1. MOYZIS, R.K., J.M. BUCKINGHAM, L.S. CRAM, et al. 1988. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85: 6622-6626.
2. SMOGORZEWSKA, A. & T. DE LANGE. 2004. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73: 177-208.
3. LANSDORP, P.M., N.P. VERWOERD, F.M. VAN DE RIJKE, et al. 1996. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5: 685-691.
4. HARLEY, C.B., A.B. FUTCHER & C.W. GREIDER. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460.
5. HASTIE, N.D., M. DEMPSTER, M.G. DUNLOP, et al. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868.
6. GREIDER, C.W. & E.H. BLACKBURN. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413.
7. LINGNER, J., T.R. HUGHES, A. SHEVCHENKO, et al. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276: 561-567.
8. BODNAR, A.G., M. OUELLETTE, M. FROLKIS, et al. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352.
9. + T cell clones by ectopic expression of telomerase reverse transcriptase. J. Immunol. 165: 4239-4245.
10. + helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 101: 4512-4519.
11. ROTH, A., H. YSSEL, J. PENE, et al. 2003. Telomerase levels control the lifespan of human T lymphocytes. Blood 102: 849-857.
12. RUFER, N., M. MIGLIACCIO, J. ANTONCHUK, et al. 2001. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98: 597-603.
13. VAZIRI, H. & S. BENCHIMOL. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8: 279-282.
14. RUFER, N., W. DRAGOWSKA, G. THORNBURY, et al. 1998. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16: 743-747.
15. WENG, N.P., L.D. PALMER, B.L. LEVINE, et al. 1997. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol. Rev. 160: 43-54.
16. MARTENS, U.M., V. BRASS, L. SEDLACEK, et al. 2002. Telomere maintenance in human B lymphocytes. Br. J. Haematol. 119: 810-818.
17. BATLIWALLA, F.M., N. RUFER, P.M. LANSDORP & P.K. GREGERSEN. 2000. Oligoclonal expansions in the CD8(+)CD28(-) T cells largely explain the shorter telomeres detected in this subset: analysis by flow FISH. Hum. Immunol. 61: 951-958.
18. WENG, N.P., L. GRANGER & R.J. HODES. 1997.Telomere lengthening and telomerase activation during human B cell differentiation. Proc. Natl. Acad. Sci. USA 94: 10827-10832.
19. LANIER, L.L. 1998. NK cell receptors. Annu. Rev. Immunol. 16: 359-393.
20. MORETTA, L., M.C. MINGARI, D. PENDE, et al. 1996. The molecular basis of natural killer (NK) cell recognition and function. J. Clin. Immunol. 16: 243-253.
21. ROBERTSON, M.J., M.A. CALIGIURI, T.J. MANLEY, et al. 1990. Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis. J. Immunol. 145: 3194-3201.
22. COOPER, M.A., T.A. FEHNIGER & M.A. CALIGIURI. 2001. The biology of human natural killer-cell subsets. Trends Immunol. 22: 633-640.
23. TAKEDA, K., M.J. SMYTH, E. CRETNEY, et al. 2001. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol. 214: 194-200.
24. MCQUEEN, K.L. & P. PARHAM. 2002. Variable receptors controlling activation and inhibition of NK cells. Curr. Opin. Immunol. 14: 615-621.
25. BERMAN, M.E., Y. XIE & W.A. MULLER. 1996. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation. J. Immunol. 156: 1515-1524.
26. BIANCHI, G., M. SIRONI, E. GHIBAUDI, et al. 1993. Migration of natural killer cells across endothelial cell monolayers. J. Immunol. 151: 5135-5144.
27. FACCHINI, A., E. MARIANI, A.R. MARIANI, et al. 1987. Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing. Clin. Exp. Immunol. 68: 340-347.
28. MARIANI, E., G. RAVAGLIA, P. FORTI, et al. 1999. Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians. Clin. Exp. Immunol. 116: 19-27.
29. PAWELEC, G., Y. BARNETT, R. FORSEY, et al. 2002. T cells and aging, January 2002 update. Front Biosci. 7: d1056-d1183.
30. SOLANA, R. & E. MARIANI. 2000. NK and NK/T cells in human senescence. Vaccine 18: 1613-1620.
31. MARIANI, E., A. MENEGHETTI, I. FORMENTINI, et al. 2003. Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing. Exp. Gerontol. 38: 653-659.
32. BAERLOCHER, G.M. & P.M. LANSDORP. 2003. Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A. 55: 1-6.
33. BAERLOCHER, G.M., J. MAK, T. TIEN & P.M. LANSDORP. 2002. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 47: 89-99.
34. RUFER, N., T.H. BRUMMENDORF, S. KOLVRAA, et al. 1999. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J. Exp. Med. 190: 157-167.
35. WENG, N.P., B.L. LEVINE, C.H. JUNE & R.J. HODES. 1995. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA 92: 11091-11094.
36. KRISHNARAJ, R. & A. SVANBORG. 1992. Preferential accumulation of mature NK cells during human immunosenescence. J. Cell Biochem. 50: 386-391.
37. NAGLER, A., L.L. LANIER, S. CWIRLA & J.H. PHILLIPS. 1989. Comparative studies of human FcRIII-positive and negative natural killer cells. J. Immunol. 143: 3183-3191.
38. FREY, M., N.B. PACKIANATHAN, T.A. FEHNIGER, et al. 1998. Differential expression and function of L-selectin on CD56bright and CD56dim natural killer cell subsets. J. Immunol. 161: 400-408.
39. DIEFENBACH, A., E.R. JENSEN, A.M. JAMIESON & D.H. RAULET. 2001. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413: 165-171.
40. MOSER, J.M., A.M. BYERS & A.E. LUKACHER. 2002. NK cell receptors in antiviral immunity. Curr. Opin. Immunol. 14: 509-516.
41. LANIER, L.L. 2005. NK cell recognition. Annu. Rev. Immunol. 23: 225-274.
42. LOPEZ-BOTET, M., M. LLANO, F. NAVARRO & T. BELLON. 2000. NK cell recognition of non-classical HLA class I molecules. Semin. Immunol. 12: 109-119.
43. RAVETCH, J.V. & L.L. LANIER. 2000. Immune inhibitory receptors. Science 290: 84-89.
44. COSMAN, D., J. MULLBERG, C.L. SUTHERLAND, et al. 2001. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14: 123-133.
45. JAMIESON, A.M., A. DIEFENBACH, C.W. MCMAHON, et al. 2002. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17: 19-29.
46. GLAS, R., L. FRANKSSON, C. UNE, et al. 2000. Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses. J. Exp. Med. 191: 129-138.
47. BAERLOCHER, G.M., J. MAK, A. ROTH, et al. 2003. Telomere shortening in leukocyte subpopulations from baboons. J. Leukoc. Biol. 73: 289-296.
48. DELLABONA, P., E. PADOVAN, G. CASORATI, et al. 1994. An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J. Exp. Med. 180: 1171-1176.
49. PORCELLI, S., C.E. YOCKEY, M.B. BRENNER & S.P. BALK. 1993. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J. Exp. Med. 178: 1-16.
50. GODFREY, D.I., K.J. HAMMOND, L.D. POULTON, et al. 2000. NKT cells: facts, functions and fallacies. Immunol. Today 21: 573-583.
51. DELAROSA, O., R. TARAZONA, J.G. CASADO, et al. 2002. Valpha24+ NKT cells are decreased in elderly humans. Exp. Gerontol. 37: 213-217.
52. OISHI, Y., T. SUMIDA, A. SAKAMOTO, et al. 2001. Selective reduction and recovery of invariant Valpha24JalphaQ T cell receptor T cells in correlation with disease activity in patients with systemic lupus erythematosus. J. Rheumatol. 28: 275-283.
53. YANAGIHARA, Y., K. SHIOZAWA, M. TAKAI, et al. 1999. Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA). Clin. Exp. Immunol. 118: 131-136.
54. HOBBS, J.A., S. CHO, T.J. ROBERTS, et al. 2001. Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus. J. Virol. 75: 10746-10754.
55. VAN DER VLIET, H.J., N. NISHI, T.D. DE GRUIJL, et al. 2000. Human natural killer T cells acquire a memory-activated phenotype before birth. Blood 95: 2440-2442.