Telomere length, comorbidity, functional, nutritional and cognitive status as predictors of 5 years post hospital discharge survival in the oldest old

Journal of Nutrition, Health and Aging

Volumn 16, Issue 3, 2012, Pages 225-230

  Zekry, D ^a   Krause, K H ^a   Irminger Finger, I ^a   Graf, C E ^a   Genet, C ^a   Vitale, A M ^a   Michel, J P ^a   Gold, G ^a   Herrmann, F R ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Aging; Biomarker; Mortality; Survival; Telomere

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER;

AGE; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BODY MASS; COGNITION; COMORBIDITY; DAILY LIFE ACTIVITY; DEMENTIA; FEMALE; FLOW CYTOMETRY; FUNCTIONAL STATUS; GENDER; GERIATRIC HOSPITAL; HOSPITAL DISCHARGE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUTRITIONAL STATUS; OBESITY; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR; SURVIVAL PREDICTION; TELOMERE HOMEOSTASIS; AGING; COGNITIVE DEFECT; CYTOLOGY; GERIATRIC ASSESSMENT; HEALTH STATUS; PHYSIOLOGY; STATISTICS; SURVIVAL; TELOMERE; ULTRASTRUCTURE;

AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; BODY MASS INDEX; COGNITION DISORDERS; COMORBIDITY; FEMALE; FLOW CYTOMETRY; GERIATRIC ASSESSMENT; HEALTH STATUS; HUMANS; LEUKOCYTES; MALE; NUTRITIONAL STATUS; OBESITY; PATIENT DISCHARGE; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84860875209     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-011-0138-x     Document Type: Article

References (38)

1. Wong JM, Collins K. Telomere maintenance and disease. Lancet 2001; 362: 983-988. (Pubitemid 37159296)
2. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-460.
3. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994; 55: 876-882. (Pubitemid 24334278)
4. Martens UM, Brass V, Sedlacek L. Telomere maintenance in human B lymphocytes. Br J Haematol 2002; 119: 810-818. (Pubitemid 35366228)
5. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992; 89: 10114-10118.
6. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ. In vivo loss of telomeric repeats with age in humans. Mutat Res 1991; 256: 45-48.
7. Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ. Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med 2008; 44: 235-246.
8. Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci USA 2007; 104: 12135-12139. (Pubitemid 47185642)
9. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393-395. (Pubitemid 36164975)
10. Bischoff C, Graakjaer J, Petersen HC, Hjelmborg JB, Vaupel JW, Bohr Vet al. The heritability of telomere length among the elderly and oldest-old. Twin Res Hum Genet 2005; 8: 433-439. (Pubitemid 41499484)
11. Bischoff C, Petersen HC, Graakjaer J, Andersen-Ranberg K, Vaupel JW, Bohr VA et al. No association between telomere length and survival among the elderly and oldest old. Epidemiology 2006; 17: 190-194.
12. Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RG. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study. Aging Cell 2005; 4: 287-290.
13. Njajou OT, Hsueh WC, Blackburn EH, Newman AB, Wu SH, Li R et al. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci 2009; 8: 860-864.
14. Zekry D, Herrmann FR, Grandjean R, Meynet MP, Michel JP, Gold G, Krause KH. Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing 2008; 37: 83-89. (Pubitemid 351146981)
15. Zekry D, Herrmann FR, Grandjean R, Vitale AM, De Pinho MF, Michel JP et al. Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry 2009; 24: 283-291.
16. Zekry D, Herrmann FR, Irminger-Finger I, Ortolan L, Genet C, Vitale AM et al. Telomere length is not predictive of dementia or MCI conversion in the oldest old. Neurobiol Aging 2010; 31: 719-20.
17. Hultdin M, Gronlund E, Norrback K, Eriksson-Lindstrom E, Just T, Roos G. Telomere analysis by fluorescence in situ hybridization and flow cytometry. Nucleic Acids Res 1998; 26: 3651-3656. (Pubitemid 28367969)
18. Rubenstein LZ, Harker JO, Salva A, Guigoz Y, Vellas B. Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). J Gerontol A Biol Sci Med Sci 2001; 56: 366-372.
19. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychological function. JAMA 1963; 185: 914-919.
20. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969; 9: 179-186.
21. Zekry D, Hermont Loures Valle B, Esposito F, Michel JP, Gold G, Krause KH, Herrmann FR. Prospective comparison of six comorbidity indices as predictors of 5 years post hospital discharge survival in the elderly. Rej Res 2010; Sept 6, PMID: 20818930.
22. Rozzini R, Frisoni GB, Ferrucci L, Barbisoni P, Sabatini T, Ranieri P et al. Geriatric Index of Comorbidity: validation and comparison with other measures of comorbidity. Age Ageing 2002; 31: 277-285.
23. Folstein MF, Folstein SE, MacHugh PR. Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
24. Solomon PR, Hirschoff A, Kelly B, Relin M, Brush M, DeVeaux RD, Pendlebury WW. A 7 minute neurocognitive screening battery highly sensitive to Alzheimer's disease. Arch Neurol 1998; 55: 349-355. (Pubitemid 28146200)
25. Robert PH, Schuck S, Dubois B, Olie JP, Lepine JP, Gallarda T et al. Screening for Alzheimer's Disease with the Short Cognitive Evaluation Battery. Dement Geriatr Cogn Disord 2003; 15: 92-98. (Pubitemid 36098762)
26. American Psychiatric Association. 2000. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed Text Revision (DSM IV-TR). American Psychiatric Association: Washington, DC.
27. McKahnn G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
28. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDSAIREN International Workshop. Neurology 1993; 43: 250-260.
29. Royston P. Explained variation for survival models. The Stata Journal 2006; 6: 83-96. (Pubitemid 43708445)
30. Bakaysa SL , Mucci LA , Slagboom PE , Boomsma DI, McClearn GE, Johansson B, Pedersen NL. Telomere length predicts survival independent of genetic influences. Aging Cell 2007; 6: 769-774. (Pubitemid 350131045)
31. Terry DF, Nolan VG, Andersen SL, Perls TT, Cawthon R. Association of longer telomeres with better health in centenarians. J Gerontol A Biol Sci Med Sci 2008; 63: 809-812.
32. Covinsky KE, Justice AM, Rosenthal GE, Palmer R, Landefeld CS. Measuring prognosis and case mix in hospitalized elders: the importance of functional status. J Gen Intern Med 1997; 12: 203-208. (Pubitemid 27175893)
33. Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J. Importance of functional measures in predicting mortality among older hospitalized patients. JAMA 1998; 279: 1187-1193.
34. Espaulella J, Arnau A, Cubi D, Amblas J, Yanez A. Time-dependent prognostic factors of 6-month mortality in frail elderly patients admitted to post-acute care. Age Ageing 2007; 36: 407-413. (Pubitemid 47261032)
35. Drame M, Jovenin N, Novella JL, Lang PO, Somme D, Laniece I et al. Predicting early mortality among elderly patients hospitalised in medical wards via emergency department: the SAFES cohort study. J Nutr Health Aging 2008; 12: 599-604.
36. Tschanz JT, Corcoran C, Skoog I, Khachaturian AS, Herrick J, Hayden KM et al. Dementia: the leading predictor of death in a defined elderly population: the Cache County Study. Neurology 2004; 62: 1156-1162. (Pubitemid 38456511)
37. Ganguli M, Dodge HH, Shen C, Pandav RS, DeKosky ST. Alzheimer disease and mortality: a 15-year epidemiological study. Arch Neurol 2005; 62: 779-784. (Pubitemid 40656094)
38. Andersen K, Lolk A, Martinussen T, Kragh-Sorensen P. Very mild to severe dementia and mortality: A 14-year follow-up-The Odense study. Dement Geriatr Cogn Disord 2010; 29: 61-67