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Volumn 24, Issue 5, 2014, Pages 595-609

Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila

Author keywords

Crn; Cul3; Hh; HIB; SPOP; Su(fu)

Indexed keywords

CRN PROTEIN, DROSOPHILA; CULLIN; DROSOPHILA PROTEIN; GFT PROTEIN, DROSOPHILA; HIB PROTEIN, DROSOPHILA; NUCLEAR PROTEIN; REPRESSOR PROTEIN; SIGNAL PEPTIDE; SONIC HEDGEHOG PROTEIN; SUFU PROTEIN, DROSOPHILA;

EID: 84899941599     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.29     Document Type: Article
Times cited : (21)

References (72)
  • 1
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15:3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 2
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science 2004; 304:1755-1759.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 3
    • 33646861115 scopus 로고    scopus 로고
    • Decoding the Hedgehog signal in animal development
    • Jia J, Jiang J. Decoding the Hedgehog signal in animal development. Cell Mol Life Sci: CMLS 2006; 63:1249-1265.
    • (2006) Cell Mol Life Sci: CMLS , vol.63 , pp. 1249-1265
    • Jia, J.1    Jiang, J.2
  • 4
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008; 15:801-812.
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 5
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411:349-354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 6
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003; 3:903-911.
    • (2003) Nat Rev Cancer , vol.3 , pp. 903-911
    • Pasca Di Magliano, M.1    Hebrok, M.2
  • 7
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011; 12:393-406.
    • (2011) Nat Rev Genet , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 8
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper JE, Scott MP. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 1989; 59:751-765.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 9
    • 4544331178 scopus 로고    scopus 로고
    • Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein
    • Casali A, Struhl G. Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature 2004; 431:76-80.
    • (2004) Nature , vol.431 , pp. 76-80
    • Casali, A.1    Struhl, G.2
  • 10
  • 11
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • Stone DM, Hynes M, Armanini M, et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996; 384:129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3
  • 12
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • Zhao Y, Tong C, Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007; 450:252-258.
    • (2007) Nature , vol.450 , pp. 252-258
    • Zhao, Y.1    Tong, C.2    Jiang, J.3
  • 14
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007; 317:372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 15
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    • van den Heuvel M, Ingham PW. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 1996; 382:547-551.
    • (1996) Nature , vol.382 , pp. 547-551
    • Van Den Heuvel, M.1    Ingham, P.W.2
  • 16
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef N, Neubuser D, Perez L, Cohen SM. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000; 102:521-531.
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 17
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996; 86:221-232.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 18
    • 10744233219 scopus 로고    scopus 로고
    • Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    • Lum L, Zhang C, Oh S, et al. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 2003; 12:1261-1274.
    • (2003) Mol Cell , vol.12 , pp. 1261-1274
    • Lum, L.1    Zhang, C.2    Oh, S.3
  • 19
    • 0242361620 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    • Jia J, Tong C, Jiang J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 2003; 17:2709-2720.
    • (2003) Genes Dev , vol.17 , pp. 2709-2720
    • Jia, J.1    Tong, C.2    Jiang, J.3
  • 20
    • 80053647419 scopus 로고    scopus 로고
    • Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus
    • Zhang Y, Mao F, Lu Y, Wu W, Zhang L, Zhao Y. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res 2011; 21:1436-1451.
    • (2011) Cell Res , vol.21 , pp. 1436-1451
    • Zhang, Y.1    Mao, F.2    Lu, Y.3    Wu, W.4    Zhang, L.5    Zhao, Y.6
  • 21
    • 79958243351 scopus 로고    scopus 로고
    • Hedgehog activates fused through phos-phorylation to elicit a full spectrum of pathway responses
    • Zhou Q, Kalderon D. Hedgehog activates fused through phos-phorylation to elicit a full spectrum of pathway responses. Dev Cell 2011; 20:802-814.
    • (2011) Dev Cell , vol.20 , pp. 802-814
    • Zhou, Q.1    Kalderon, D.2
  • 22
    • 80052515585 scopus 로고    scopus 로고
    • The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phos-phorylation
    • Shi Q, Li S, Jia J, Jiang J. The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phos-phorylation. Development 2011; 138:4219-4231.
    • (2011) Development , vol.138 , pp. 4219-4231
    • Shi, Q.1    Li, S.2    Jia, J.3    Jiang, J.4
  • 23
    • 0141728540 scopus 로고    scopus 로고
    • Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
    • Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Therond P P. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol 2003; 5:907-913.
    • (2003) Nat Cell Biol , vol.5 , pp. 907-913
    • Ruel, L.1    Rodriguez, R.2    Gallet, A.3    Lavenant-Staccini, L.4    Therond, P.P.5
  • 24
    • 0032585515 scopus 로고    scopus 로고
    • Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
    • Ohlmeyer JT, Kalderon D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 1998; 396:749-753.
    • (1998) Nature , vol.396 , pp. 749-753
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 25
    • 0028911915 scopus 로고
    • CAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
    • Pan D, Rubin GM. cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 1995; 80:543-552.
    • (1995) Cell , vol.80 , pp. 543-552
    • Pan, D.1    Rubin, G.M.2
  • 26
    • 0035098013 scopus 로고    scopus 로고
    • An absolute requirement for Cubitus in-terruptus in Hedgehog signaling
    • Methot N, Basler K. An absolute requirement for Cubitus in-terruptus in Hedgehog signaling. Development 2001; 128:733-742.
    • (2001) Development , vol.128 , pp. 733-742
    • Methot, N.1    Basler, K.2
  • 27
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata T, Kornberg TB. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 1994; 76:89-102.
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 28
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler K, Struhl G. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 1994; 368:208-214.
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 29
    • 0030663064 scopus 로고    scopus 로고
    • A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    • Strigini M, Cohen SM. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 1997; 124:4697-4705.
    • (1997) Development , vol.124 , pp. 4697-4705
    • Strigini, M.1    Cohen, S.M.2
  • 30
    • 0343967010 scopus 로고    scopus 로고
    • Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs
    • Tanimoto H, Itoh S, ten Dijke P, Tabata T. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol Cell 2000; 5:59-71.
    • (2000) Mol Cell , vol.5 , pp. 59-71
    • Tanimoto, H.1    Itoh, S.2    Ten Dijke, P.3    Tabata, T.4
  • 31
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    • Jiang J, Struhl G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 1998; 391:493-496.
    • (1998) Nature , vol.391 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 32
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc P, Ramirez-Weber FA, Laget MP, Schwartz C, Kornberg TB. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 1997; 89:1043-1053.
    • (1997) Cell , vol.89 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez-Weber, F.A.2    Laget, M.P.3    Schwartz, C.4    Kornberg, T.B.5
  • 33
    • 0033582908 scopus 로고    scopus 로고
    • Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
    • Methot N, Basler K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 1999; 96:819-831.
    • (1999) Cell , vol.96 , pp. 819-831
    • Methot, N.1    Basler, K.2
  • 34
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 2002; 416:548-552.
    • (2002) Nature , vol.416 , pp. 548-552
    • Jia, J.1    Amanai, K.2    Wang, G.3    Tang, J.4    Wang, B.5    Jiang, J.6
  • 35
    • 28444449828 scopus 로고    scopus 로고
    • Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
    • Jia J, Zhang L, Zhang Q, et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell 2005; 9:819-830.
    • (2005) Dev Cell , vol.9 , pp. 819-830
    • Jia, J.1    Zhang, L.2    Zhang, Q.3
  • 36
    • 30044442183 scopus 로고    scopus 로고
    • Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb
    • Smelkinson MG, Kalderon D. Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr Biol: CB 2006; 16:110-116.
    • (2006) Curr Biol: CB , vol.16 , pp. 110-116
    • Smelkinson, M.G.1    Kalderon, D.2
  • 37
    • 34848892735 scopus 로고    scopus 로고
    • Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
    • Smelkinson MG, Zhou Q, Kalderon D. Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev Cell 2007; 13:481-495.
    • (2007) Dev Cell , vol.13 , pp. 481-495
    • Smelkinson, M.G.1    Zhou, Q.2    Kalderon, D.3
  • 38
    • 33646875414 scopus 로고    scopus 로고
    • Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
    • Kent D, Bush EW, Hooper JE. Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 2006; 133:2001-2010.
    • (2006) Development , vol.133 , pp. 2001-2010
    • Kent, D.1    Bush, E.W.2    Hooper, J.E.3
  • 39
    • 33646893705 scopus 로고    scopus 로고
    • A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    • Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell 2006; 10:719-729.
    • (2006) Dev Cell , vol.10 , pp. 719-729
    • Zhang, Q.1    Zhang, L.2    Wang, B.3    Ou, C.Y.4    Chien, C.T.5    Jiang, J.6
  • 40
    • 33751208606 scopus 로고    scopus 로고
    • Regulation of Hh/Gli signaling by dual ubiquitin pathways
    • Jiang J. Regulation of Hh/Gli signaling by dual ubiquitin pathways. Cell Cycle 2006; 5:2457-2463.
    • (2006) Cell Cycle , vol.5 , pp. 2457-2463
    • Jiang, J.1
  • 41
    • 34447631014 scopus 로고    scopus 로고
    • Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors
    • Ou CY, Wang CH, Jiang J, Chien CT. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol 2007; 308:106-119.
    • (2007) Dev Biol , vol.308 , pp. 106-119
    • Ou, C.Y.1    Wang, C.H.2    Jiang, J.3    Chien, C.T.4
  • 42
    • 0037106185 scopus 로고    scopus 로고
    • Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development
    • Ou CY, Lin YF, Chen YJ, Chien CT. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev 2002; 16:2403-2414.
    • (2002) Genes Dev , vol.16 , pp. 2403-2414
    • Ou, C.Y.1    Lin, Y.F.2    Chen, Y.J.3    Chien, C.T.4
  • 43
    • 75849129292 scopus 로고    scopus 로고
    • Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
    • Zhang Q, Shi Q, Chen Y, et al. Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc Natl Acad Sci USA 2009; 106:21191-21196.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21191-21196
    • Zhang, Q.1    Shi, Q.2    Chen, Y.3
  • 44
    • 0038813753 scopus 로고    scopus 로고
    • Characterization of the physical interaction of Gli proteins with SUFU proteins
    • Dunaeva M, Michelson P, Kogerman P, Toftgard R. Characterization of the physical interaction of Gli proteins with SUFU proteins. J Biol Chem 2003; 278:5116-5122.
    • (2003) J Biol Chem , vol.278 , pp. 5116-5122
    • Dunaeva, M.1    Michelson, P.2    Kogerman, P.3    Toftgard, R.4
  • 45
    • 33646235390 scopus 로고    scopus 로고
    • Regulation of Ci and Su(fu) nuclear import in Drosophila
    • Sisson BE, Ziegenhorn SL, Holmgren RA. Regulation of Ci and Su(fu) nuclear import in Drosophila. Dev Biol 2006; 294:258-270.
    • (2006) Dev Biol , vol.294 , pp. 258-270
    • Sisson, B.E.1    Ziegenhorn, S.L.2    Holmgren, R.A.3
  • 46
    • 31744450041 scopus 로고    scopus 로고
    • Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    • Barnfeld PC, Zhang X, Thanabalasingham V, Yoshida M, Hui CC. Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 2005; 73:397-405.
    • (2005) Differentiation , vol.73 , pp. 397-405
    • Barnfeld, P.C.1    Zhang, X.2    Thanabalasingham, V.3    Yoshida, M.4    Hui, C.C.5
  • 47
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen MH, Wilson CW, Li YJ, et al. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev 2009; 23:1910-1928.
    • (2009) Genes Dev , vol.23 , pp. 1910-1928
    • Chen, M.H.1    Wilson, C.W.2    Li, Y.J.3
  • 48
    • 13344261324 scopus 로고    scopus 로고
    • Costal-2: A scaffold for kinases mediates Hedgehog signaling
    • Ishii S. Costal-2: a scaffold for kinases mediates Hedgehog signaling. Dev Cell 2005; 8:140-141.
    • (2005) Dev Cell , vol.8 , pp. 140-141
    • Ishii, S.1
  • 49
    • 0032492995 scopus 로고    scopus 로고
    • Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway
    • Monnier V, Dussillol F, Alves G, Lamour-Isnard C, Plessis A. Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Curr Biol 1998; 8:583-586.
    • (1998) Curr Biol , vol.8 , pp. 583-586
    • Monnier, V.1    Dussillol, F.2    Alves, G.3    Lamour-Isnard, C.4    Plessis, A.5
  • 50
    • 0027383291 scopus 로고
    • Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2
    • Preat T, Therond P, Limbourg-Bouchon B, et al. Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 1993; 135:1047-1062.
    • (1993) Genetics , vol.135 , pp. 1047-1062
    • Preat, T.1    Therond, P.2    Limbourg-Bouchon, B.3
  • 51
    • 0030754171 scopus 로고    scopus 로고
    • Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
    • Sisson JC, Ho KS, Suyama K, Scott MP. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 1997; 90:235-245.
    • (1997) Cell , vol.90 , pp. 235-245
    • Sisson, J.C.1    Ho, K.S.2    Suyama, K.3    Scott, M.P.4
  • 52
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Therond PP. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 1997; 90:225-234.
    • (1997) Cell , vol.90 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 53
    • 0033529667 scopus 로고    scopus 로고
    • Nuclear traffcking of Cubitus interruptus in the transcrip-tional regulation of Hedgehog target gene expression
    • Chen CH, von Kessler DP, Park W, Wang B, Ma Y, Beachy PA. Nuclear traffcking of Cubitus interruptus in the transcrip-tional regulation of Hedgehog target gene expression. Cell 1999; 98:305-316.
    • (1999) Cell , vol.98 , pp. 305-316
    • Chen, C.H.1    Von Kessler, D.P.2    Park, W.3    Wang, B.4    Ma, Y.5    Beachy, P.A.6
  • 55
    • 0034669178 scopus 로고    scopus 로고
    • Interactions with Cos-tal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
    • Wang G, Amanai K, Wang B, Jiang J. Interactions with Cos-tal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev 2000; 14:2893-2905.
    • (2000) Genes Dev , vol.14 , pp. 2893-2905
    • Wang, G.1    Amanai, K.2    Wang, B.3    Jiang, J.4
  • 56
    • 0013014880 scopus 로고    scopus 로고
    • Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Cos-tal2
    • Monnier V, Ho KS, Sanial M, Scott MP, Plessis A. Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Cos-tal2. BMC Dev Biol 2002; 2:4.
    • (2002) BMC Dev Biol , vol.2 , pp. 4
    • Monnier, V.1    Ho, K.S.2    Sanial, M.3    Scott, M.P.4    Plessis, A.5
  • 57
    • 0037117611 scopus 로고    scopus 로고
    • Suppressor of Fused represses Gli-me-diated transcription by recruiting the SAP18-mSin3 corepres-sor complex
    • Cheng SY, Bishop JM. Suppressor of Fused represses Gli-me-diated transcription by recruiting the SAP18-mSin3 corepres-sor complex. Proc Natl Acad Sci USA 2002; 99:5442-5447.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5442-5447
    • Cheng, S.Y.1    Bishop, J.M.2
  • 58
    • 0033194243 scopus 로고    scopus 로고
    • Mammalian sup-pressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
    • Kogerman P, Grimm T, Kogerman L, et al. Mammalian sup-pressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1999; 1:312-319.
    • (1999) Nat Cell Biol , vol.1 , pp. 312-319
    • Kogerman, P.1    Grimm, T.2    Kogerman, L.3
  • 59
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of Suppressor of fused reveals an essential repres-sor function in the mammalian Hedgehog signaling pathway
    • Svard J, Heby-Henricson K, Persson-Lek M, et al. Genetic elimination of Suppressor of fused reveals an essential repres-sor function in the mammalian Hedgehog signaling pathway. Dev Cell 2006; 10:187-197.
    • (2006) Dev Cell , vol.10 , pp. 187-197
    • Svard, J.1    Heby-Henricson, K.2    Persson-Lek, M.3
  • 60
    • 27644584608 scopus 로고    scopus 로고
    • Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
    • Cooper AF, Yu KP, Brueckner M, et al. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 2005; 132:4407-4417.
    • (2005) Development , vol.132 , pp. 4407-4417
    • Cooper, A.F.1    Yu, K.P.2    Brueckner, M.3
  • 61
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002; 31:306-310.
    • (2002) Nat Genet , vol.31 , pp. 306-310
    • Taylor, M.D.1    Liu, L.2    Raffel, C.3
  • 62
    • 59149087474 scopus 로고    scopus 로고
    • Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway
    • Yue S, Chen Y, Cheng SY. Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. Oncogene 2009; 28:492-499.
    • (2009) Oncogene , vol.28 , pp. 492-499
    • Yue, S.1    Chen, Y.2    Cheng, S.Y.3
  • 63
    • 0033789068 scopus 로고    scopus 로고
    • Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
    • Methot N, Basler K. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 2000; 127:4001-4010.
    • (2000) Development , vol.127 , pp. 4001-4010
    • Methot, N.1    Basler, K.2
  • 64
    • 2442529664 scopus 로고    scopus 로고
    • Cullin-based ubiquitin li-gases: Cul3-BTB complexes join the family
    • Pintard L, Willems A, Peter M. Cullin-based ubiquitin li-gases: Cul3-BTB complexes join the family. EMBO J 2004; 23:1681-1687.
    • (2004) EMBO J , vol.23 , pp. 1681-1687
    • Pintard, L.1    Willems, A.2    Peter, M.3
  • 65
    • 27144525246 scopus 로고    scopus 로고
    • Neddylation and dened-dylation regulate Cul1 and Cul3 protein accumulation
    • Wu JT, Lin HC, Hu YC, Chien CT. Neddylation and dened-dylation regulate Cul1 and Cul3 protein accumulation. Nat Cell Biol 2005; 7:1014-1020.
    • (2005) Nat Cell Biol , vol.7 , pp. 1014-1020
    • Wu, J.T.1    Lin, H.C.2    Hu, Y.C.3    Chien, C.T.4
  • 66
    • 70349769327 scopus 로고    scopus 로고
    • Structures of SPOP-substrate complexes: Insights into molecular architectures of BTB-Cul3 ubiquitin ligases
    • Zhuang M, Calabrese MF, Liu J, et al. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell 2009; 36:39-50.
    • (2009) Mol Cell , vol.36 , pp. 39-50
    • Zhuang, M.1    Calabrese, M.F.2    Liu, J.3
  • 67
    • 77953050811 scopus 로고    scopus 로고
    • Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
    • Wang C, Pan Y, Wang B. Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 2010; 137:2001-2009.
    • (2010) Development , vol.137 , pp. 2001-2009
    • Wang, C.1    Pan, Y.2    Wang, B.3
  • 68
    • 28444451148 scopus 로고    scopus 로고
    • A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
    • Nybakken K, Vokes SA, Lin TY, McMahon AP, Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet 2005; 37:1323-1332.
    • (2005) Nat Genet , vol.37 , pp. 1323-1332
    • Nybakken, K.1    Vokes, S.A.2    Lin, T.Y.3    McMahon, A.P.4    Perrimon, N.5
  • 69
    • 0033761448 scopus 로고    scopus 로고
    • Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
    • Aza-Blanc P, Lin HY, Ruiz i Altaba A, Kornberg TB. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 2000; 127:4293-4301.
    • (2000) Development , vol.127 , pp. 4293-4301
    • Aza-Blanc, P.1    Lin, H.Y.2    Ruiz I Altaba, A.3    Kornberg, T.B.4
  • 70
    • 0032728958 scopus 로고    scopus 로고
    • Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
    • Wang G, Wang B, Jiang J. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev 1999; 13:2828-2837.
    • (1999) Genes Dev , vol.13 , pp. 2828-2837
    • Wang, G.1    Wang, B.2    Jiang, J.3
  • 71
    • 0028918468 scopus 로고
    • Protein kinase A and hedgehog signaling in Drosophila limb development
    • Jiang J, Struhl G. Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 1995; 80:563-572.
    • (1995) Cell , vol.80 , pp. 563-572
    • Jiang, J.1    Struhl, G.2
  • 72
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    • Zhang W, Zhao Y, Tong C, et al. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell 2005; 8:267-278.
    • (2005) Dev Cell , vol.8 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3


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