Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs

Molecular Cell

Volumn 5, Issue 1, 2000, Pages 59-71

  Tanimoto, Hiromu ^a   Itoh, Susumu ^b,c   Ten Dijke, Peter ^b,c   Tabata, Tetsuya ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOGEN;

ARTICLE; CYTOPLASM; DROSOPHILA; GENETIC TRANSCRIPTION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RECEPTOR GENE; SIGNAL TRANSDUCTION; TRANSDUCER;

ERINACEIDAE;

EID: 0343967010     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80403-7     Document Type: Article

References (67)

1. Alcedo, J., and Noll, M. (1997). Hedgehog and its patched-smoothened receptor complex: a novel signaling mechanism at the cell surface. Biol. Chem. 378, 583-590.
2. Alcedo, J., Ayzenzon, M., Von, O.T., Noll, M., and Hooper, J.E. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232.
3. Basler, K., and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
4. Brook, W.J., and Cohen, S.M. (1996). Antagonistic interactions between Wingless and Decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg. Science 273, 1373-1377.
5. Brummel, T.J., Twombly, V., Marques, G., Wrana, J.L., Newfeld, S.J., Attisano, L., Massagué, J., O'Connor, M.B., and Gelbart, W.M. (1994). Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell 78, 251-261.
6. Brummel, T., Abdollah, S., Haerry, T.E., Shimell, M.J., Merriam, J., Raftery, L., Wrana, J.L., and O'Connor, M.B. (1999). The Drosophila activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13, 98-111.
7. Burke, R., and Basler, K. (1996). Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269.
8. Cadigan, K.M., Fish, M.P., Rulifson, E.J., and Nusse, R. (1998). Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell 93, 767-777.
9. Campbell, G., and Tomlinson, A. (1999). Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker. Cell 96, 553-562.
10. Capdevila, J., and Guerrero, I. (1994). Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468.
11. Chen, Y., and Struhl, G. (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87, 553-563.
12. Chen, Y., and Struhl, G. (1998). In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125, 4943-4948.
13. Das, P., Inoue, H., Baker, J.C., Beppu, H., Kawabata, M., Harland, R.M., Miyazono, K., and Padgett, R.W. (1999). Drosophila dSmad2 and Atr-I transmit activin/TGFβ signals. Genes Cells 4, 123-134.
14. de Celis, J.F. (1997). Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing. Development 124, 1007-1018.
15. de Celis, J.F., Barrio, R., and Kafatos, F.C. (1996). A gene complex acting downstream of dpp in Drosophila wing morphogenesis. Nature 381, 421-424.
16. Golic, K.G. (1991). Site-specific recombination between homologous chromosomes in Drosophila. Science 252, 958-961.
17. Grimm, S., and Pflugfelder, G.O. (1996). Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless. Science 271, 1601-1604.
18. Gurdon, J.B., Dyson, S., and St Johnston, D. (1998). Cells' perception of position in a concentration gradient. Cell 95, 159-162.
19. Haerry, T.E., Khalsa, O., O'Connor, M.B., and Wharton, K.A. (1998). Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila. Development 125, 3977-3987.
20. Heldin, C.-H., Miyazono, K., and ten Dijke, P. (1997). TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
21. Ingham, P.W. (1998). Transducing Hedgehog: the story so far. EMBO J. 17, 3505-3511.
22. Inoue, H., Imamura, T., Ishidou, Y., Takase, M., Udagawa, Y., Oka, Y., Tsuneizumi, K., Tabata, T., Miyazono, K., and Kawabata, M. (1998). Interplay of signal mediators of Decapentaplegic (Dpp): molecular characterization of Mothers against dpp, Medea, and Daughters against dpp. Mol. Biol. Cell. 9, 2145-2156.
23. Ito, K., Awano, W., Suzuki, K., Hiromi, Y., and Yamamoto, D. (1997). The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. Development 124, 761-771.
24. Jazwinska, A., Kirov, N., Wieschaus, E., Roth, S., and Rushlow, C. (1999). The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell 96, 563-573.
25. Jiang, J., and Struhl, G. (1995). Protein kinase A and Hedgehog signaling in Drosophila limb development. Cell 80, 563-572.
26. Jiang, J., and Struhl, G. (1996). Complementary and mutually exclusive activities of Decapentaplegic and Wingless organize axial patterning during Drosophila leg development. Cell 86, 401-409.
27. Jiang, J., and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.
28. Kim, J., Johnson, K., Chen, H.J., Carroll, S., and Laughon, A. (1997). Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304-308.
29. Kojima, T., Michiue, T., Orihara, M., and Saigo, K. (1994). Induction of a mirror-image duplication of anterior wing structures by localized hedgehog expression in the anterior compartment of Drosophila melanogaster wing imaginal discs. Gene 148, 211-217.
30. Lawrence, P.A., and Struhl, G. (1996). Morphogens, compartments, and pattern: lessons from Drosophila? Cell 85, 951-961.
31. Lecuit, T., and Cohen, S.M. (1998). Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc. Development 125, 4901-4907.
32. Lecuit, T., Brook, W.J., Ng, M., Calleja, M., Sun, H., and Cohen, S.M. (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393.
33. Lepage, T., Cohen, S.M., Diaz, B.F., and Parkhurst, S.M. (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715.
34. Li, W., Ohlmeyer, J.T., Lane, M.E., and Kalderon, D. (1995). Function of protein kinase A in Hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.
35. Massagué, J. (1998). TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791.
36. Méthot, N., and Basler, K. (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-831.
37. Minami, M., Kinoshita, N., Kamoshida, Y., Tanimoto, H., and Tabata, T. (1999). brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes. Nature 398, 242-246.
38. Morimura, S., Maves, L., Chen, Y., and Hoffmann, F.M. (1996). decapentaplegic overexpression affects Drosophila wing and leg imaginal disc development and wingless expression. Dev. Biol. 177, 136-151.
39. Motzny, C.K., and Holmgren, R. (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137-150.
40. Mullor, J.L., Calleja, M., Capdevila, J., and Guerrero, I. (1997). Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning. Development 124, 1227-1237.
41. Nellen, D., Affolter, M., and Basler, K. (1994). Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78, 225-237.
42. Nellen, D., Burke, R., Struhl, G., and Basler, K. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368.
43. Neumann, C., and Cohen, S (1997a). Morphogens and pattern formation. Bioessays 19, 721-729.
44. Neumann, C.J., and Cohen, S.M. (1997b). Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124, 871-880.
45. Newfeld, S.J., Mehra, A., Singer, M.A., Wrana, J.L., Attisano, L., and Gelbart, W.M. (1997). Mothers against dpp participates in a DDP/ TGF-β responsive serine-threonine kinase signal transduction cascade. Development 124, 3167-3176.
46. Ohlmeyer, J.T., and Kalderon, D. (1998). Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-753.
47. Pan, D., and Rubin, G.M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.
48. Penton, A., Chen, Y., Staehling-Hampton, K., Wrana, J.L., Attisano, L., Szidonya, J., Cassill, J.A., Massagué, J., and Hoffmann, F.M. (1994). Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 78, 239-250.
49. Persson, U., Izumi, H., Souchelnytskyi, S., Itoh, S., Grimsby, S., Engstrom, U., Heldin, C.-H., Funa, K., and ten Dijke, P. (1998). The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation. FEBS Lett. 434, 83-87.
50. Posakony, L.G., Raftery, L.A., and Gelbart, W.M. (1990). Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary. Mech. Dev. 33, 69-82.
51. Raftery, L.A., and Sutherland, D.J. (1999). TGF-β family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210, 251-268.
52. Sanicola, M., Sekelsky, J., Elson, S., and Gelbart, W.M. (1995). Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745-756.
53. Sanson, B., Alexandre, C., Fascetti, N., and Vincent, J.-P. (1999). Engrailed and Hedgehog make the range of Wingless asymmetric in Drosophila embryos. Cell 98, 207-216.
54. Shimizu, K., and Gurdon, J.B. (1999). A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation. Proc. Natl. Acad. Sci. USA 96, 6791-6796.
55. Singer, M.A., Penton, A., Twombly, V., Hoffmann, F.M., and Gelbart, W.M. (1997). Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing. Development 124, 79-89.
56. Strigini, M., and Cohen, S.M. (1997). A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-4705.
57. Strutt, D.I., Wiersdorff, V., and Mlodzik, M. (1995). Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373, 705-709.
58. Tabata, T., and Kornberg, T.B. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.
59. Tabata, T., Schwartz, C., Gustavson, E., Ali, Z., and Kornberg, T.B. (1995). Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. Development 121, 3359-3369.
60. Theisen, H., Haerry, T.E., O'Connor, M.B., and Marsh, J.L. (1996). Developmental territories created by mutual antagonism between Wingless and Decapentaplegic. Development 122, 3939-3948.
61. Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T.B., Christian, J.L., and Tabata, T. (1997). Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389, 627-631.
62. van den Heuvel, M., and Ingham, P.W. (1996). smoothened encodes a receptor-like serpentine protein required for Hedgehog signaling. Nature 382, 547-551.
63. Wieser, R., Wrana, J.L., and Massagué, J. (1995). GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14, 2199-2208.
64. Wolpert, L. (1969). Positional information and the spatial pattern of cellular differentiation. J. Theor. Biol. 25, 1-47.
65. Xu, T., and Rubin, G.M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.
66. Zecca, M., Basler, K., and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.
67. Zecca, M., Basler, K., and Struhl, G. (1996). Direct and long-range action of a Wingless morphogen gradient. Cell 87, 833-844.