VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression

International Journal of Pharmaceutics

Volumn 469, Issue 1, 2014, Pages 121-131

  Leus, Niek G J ^a   Morselt, Henriëtte W M ^a   Zwiers, Peter J ^a   Kowalski, Piotr S ^a   Ruiters, Marcel H J ^a,b   Molema, Grietje ^a   Kamps, Jan A A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Synvolux Therapeutics   (Netherlands)

Author keywords

Cationic lipid; Endothelial cells; Inflammation; siRNA; Targeted delivery; Vascular cell adhesion molecule 1

Indexed keywords

ALKALINE PHOSPHATASE; ANTI VCAM 1 SAINTPEGARG PEG2; ASPARTATE AMINOTRANSFERASE; CREATININE; LIPOPLEX; MACROGOL 2000; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN; 1-METHYL-4-(9-DIOLEYL)METHYLPYRIDINIUM; ANTIBODY; CADHERIN; LEUKOCYTE ANTIGEN; LIPID; MACROGOL DERIVATIVE; PYRIDINIUM DERIVATIVE; TUMOR NECROSIS FACTOR;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL HOMING; CELL MIGRATION; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOWN REGULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; ENDOTHELIUM; ENDOTHELIUM CELL; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTERNALIZATION; KIDNEY FUNCTION; LASER MICRODISSECTION; LIVER; LIVER FUNCTION; LUNG PARENCHYMA; MALE; MOLECULAR MECHANICS; MOUSE; NEPHROTOXICITY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; UREA BLOOD LEVEL; VENULE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; CONFOCAL MICROSCOPY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; PROCEDURES; RNA INTERFERENCE; TIME FACTOR; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; ANTIBODIES; ANTIGENS, CD; CADHERINS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; INFLAMMATION; LIPIDS; LUNG; MALE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; POLYETHYLENE GLYCOLS; PYRIDINIUM COMPOUNDS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS; TISSUE DISTRIBUTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1; VENULES;

EID: 84899856773     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.04.041     Document Type: Article

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