Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo

Journal of Controlled Release

Volumn 176, Issue 1, 2014, Pages 64-75

  Kowalski, Piotr S ^a   Zwiers, Peter J ^a   Morselt, Henrieandtte W M ^a   Kuldo, Joanna M ^a   Leus, Niek G J ^a   Ruiters, Marcel H J ^a,b   Molema, Grietje ^a   Kamps, Jan A A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Synvolux Therapeutics   (Netherlands)

Author keywords

Inflammation; Microvascular endothelial cells; NF kappa B p65; siRNA delivery; Targeted liposomes; Vascular cell adhesion molecule 1

Indexed keywords

INFLAMMATION; MICROVASCULAR ENDOTHELIAL CELLS; NF KAPPA B P65; SIRNA DELIVERY; VASCULAR CELL ADHESION MOLECULE-1;

BLOOD VESSELS; CELL ADHESION; CHLORINE COMPOUNDS; GENE EXPRESSION; LIPOSOMES; MAMMALS; PATHOLOGY; RNA;

ENDOTHELIAL CELLS;

1 METHYL 4 (CIS 9 DIOLEYL)METHYL PYRIDINIUM CHLORIDE; AMPHOPHILE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LIPOSOME; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN ANTIBODY; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1 ANTIBODY; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCULATION TIME; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BLOOD VESSEL; LASER MICRODISSECTION; LIPOSOMAL GENE DELIVERY SYSTEM; LIVER TOXICITY; MALE; MICROVASCULATURE; MOUSE; NEPHROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SINGLE DRUG DOSE; STEADY STATE; TISSUE DISTRIBUTION; UMBILICAL VEIN ENDOTHELIAL CELL;

INFLAMMATION; MICROVASCULAR ENDOTHELIAL CELLS; NF KAPPA B P65; SIRNA DELIVERY; TARGETED LIPOSOMES; VASCULAR CELL ADHESION MOLECULE-1;

ANIMALS; ANTIBODIES; ANTIGENS, CD; BRAIN; CADHERINS; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; KIDNEY; LIPOSOMES; LIVER; LUNG; MALE; MICE; MYOCARDIUM; PYRIDINIUM COMPOUNDS; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84892583287     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.12.029     Document Type: Article

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