Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease

Journal of Controlled Release

Volumn 165, Issue 3, 2013, Pages 216-225

  Tlaxca, José L ^a   Rychak, Joshua J ^b   Ernst, Peter B ^c   Konkalmatt, Prasad R ^a   Shevchenko, Talent I ^d   Pizzaro, Theresa T ^e   Rivera Nieves, Jesús ^c   Klibanov, Alexander L ^a,d   Lawrence, Michael B ^a  

^a University of Virginia   (United States)

^b Targeson Inc   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Contrast agents; Gene delivery; MAdCAM 1; Sonoporation; Ultrasound; VCAM 1

Indexed keywords

CONTRAST AGENT; GENE DELIVERY; MADCAM-1; SONOPORATION; VCAM-1;

BIOLUMINESCENCE; DNA; ENDOTHELIAL CELLS; GENE TRANSFER; MAMMALS; MICROCIRCULATION; MOLECULAR IMAGING; PHOSPHORESCENCE; ULTRASONICS;

DISEASES;

LIGAND; LUCIFERASE; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; AU RICH ELEMENT; BIOLUMINESCENCE; CONTROLLED STUDY; CROHN DISEASE; ENDOTHELIUM; FEMALE; GENE TARGETING; GENETIC TRANSFECTION; ILEOCECAL VALVE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MESENTERY BLOOD VESSEL; MICROBUBBLE; MICROCIRCULATION; MIDGUT; MOLECULAR IMAGING; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; ULTRASOUND; VASCULARIZATION;

ANIMALS; CELL ADHESION MOLECULES; CROHN DISEASE; DISEASE MODELS, ANIMAL; DNA; ENDOTHELIUM, VASCULAR; FEMALE; GENE TRANSFER TECHNIQUES; LUCIFERASES, FIREFLY; MESENTERY; MICE; MICE, TRANSGENIC; MICROBUBBLES; MOLECULAR IMAGING; PLASMIDS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84871555406     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.021     Document Type: Article

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