Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid Saint-2

Journal of Controlled Release

Volumn 123, Issue 3, 2007, Pages 228-238

  van der Gun, Bernardina T F ^a,b   Monami, Amélie ^c   Laarmann, Sven ^d   Raskó, Tamás ^e   Ślaska Kiss, Krystyna ^e   Weinhold, Elmar ^c   Wasserkort, Reinhold ^f   de Leij, Lou F M H ^a,b   Ruiters, Marcel H J ^a,b   Kiss, Antal ^e   McLaughlin, Pamela M J ^a,b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d EUREGIO Biotech Center   (Germany)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^f EPIGENOMICS AG   (Germany)

Author keywords

Cationic liposome; DNA methyltransferase; Gene silencing; Intracellular protein delivery

Indexed keywords

AMPHIPHILIC LIPID SAINT-2:DOPE; CATIONIC LIPOSOMAL COMPOUNDS; CONTROLLED RELEASE; GALACTOSIDASE; GENE SILENCING; INTRACELLULAR PROTEIN DELIVERY; SERUM;

AMPHIPHILES; CELLS; DNA; GENES; LIPIDS; METHYLATION; NUCLEOTIDES; POSITIVE IONS; RNA;

PROTEINS;

BETA GALACTOSIDASE; CATIONIC LIPID; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DNA METHYLTRANSFERASE; LIPOSOME; N METHYL 4 (DIOLEYL)METHYLPYRIDINIUM; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; CELL LABELING; COMPLEX FORMATION; CONTROLLED STUDY; DNA METHYLATION; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUSPENSION CELL CULTURE; ZETA POTENTIAL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIBODIES; BETA-GALACTOSIDASE; CADHERINS; CATIONS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CHEMISTRY, PHARMACEUTICAL; COS CELLS; DNA; DNA METHYLATION; DRUG CARRIERS; DRUG COMPOUNDING; GENE SILENCING; HUMANS; JURKAT CELLS; MOLECULAR STRUCTURE; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; PROTEIN CONFORMATION; PROTEINS; PYRIDINIUM COMPOUNDS; RNA, SMALL INTERFERING; SERUM; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); TIME FACTORS; TRANSFECTION;

EID: 35548994599     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.08.014     Document Type: Article

References (29)

1. Jarver P., and Langel U. Cell-penetrating peptides-a brief introduction. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 260-263
2. Schwarze S., and Dowdy S. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol. Sci. 21 (2000) 45-48
3. Ye D., Xu D., Singer A.U., and Juliano R.L. Evaluation of strategies for the intracellular delivery of proteins. Pharm. Res. 19 (2002) 1302-1309
4. Zelphati O., Wang Y., Kitada S., Reed J., Felgner P., and Corbeil J. Intracellular delivery of proteins with a new lipid-mediated delivery system. J. Biol. Chem. 276 (2001) 35103-35110
5. Dalkara D., Chandrashekhar C., and Zuber G. Intracellular protein delivery with a dimerizable amphiphile for improved complex stability and prolonged protein release in the cytoplasm of adherent cell lines. J. Control. Release 116 (2006) 353-359
6. Zassler B., Blasig I.E., and Humpel C. Protein delivery of caspase-3 induces cell death in malignant C6 glioma, primary astrocytes and immortalized and primary brain capillary endothelial cells. J. Neuro-oncol. 71 (2005) 127-134
7. van der Woude I., Wagenaar A., Meekel A., ter Beest M., Ruiters M., Engberts J., and Hoekstra D. Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 1160-1165
8. Zuhorn I., Oberle V., Visser W., Engberts J., Bakowsky U., Polushkin E., and Hoekstra D. Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency. Biophys. J. 83 (2002) 2096-2108
9. Audouy S., and Hoekstra D. Cationic lipid-mediated transfection in vitro and in vivo. Mol. Membr. Biol. 18 (2001) 129-143
10. Audouy S.A.L., de Leij L.F.M.H., Hoekstra D., and Molema G. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm. Res. 19 (2002) 1599-1605
11. Nur I., Szyf M., Razin A., Glaser G., Rottem S., and Razin S. Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas). J. Bacteriol. 164 (1985) 19-24
12. Turker M.S. Gene silencing in mammalian cells and the spread of DNA methylation. Oncogene 21 (2002) 5388-5393
13. Rathert P., Rasko T., Roth M., Slaska-Kiss K., Pingoud A., Kiss A., and Jeltsch A. Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. Chem. Biochem. 8 (2007) 202-207
14. Laarmann S., and Schmidt M.A. The Escherichia coli AIDA autotransporter adhesin recognizes an integral membrane glycoprotein as receptor. Microbiology 149 (2003) 1871-1882
15. Tetzner R., Dietrich D., and Distler J. Control of carry-over contamination for PCR-based DNA methylation quantification using bisulfite treated DNA. Nucl. Acids Res. 35 (2007) e4
16. Lewin J., Schmitt A., Adorjan P., Hildmann T., and Piepenbrock C. Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates. Bioinformatics 20 (2004) 3005-3012
17. Audouy S., Molema G., de Leij L., and Hoekstra D. Serum as a modulator of lipoplex-mediated gene transfection: dependence of amphiphile, cell type and complex stability. J. Gene Med. 2 (2000) 465-476
18. Zuhorn I., Visser W., Bakowsky U., Engberts J., and Hoekstra D. Interference of serum with lipoplex-cell interaction: modulation of intracellular processing. Biochim. Biophys. Acta, Biomembr. 1560 (2002) 25-36
19. Chen C.-L., Liu S.S., Ip S.-M., Wong L.C., Ng T.Y., and Ngan H.Y.S. E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours. Eur. J. Cancer 39 (2003) 517-523
20. Chen Q., Lipkina G., Song Q., and Kramer R. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem. Biophys. Res. Commun. 315 (2004) 850-856
21. Corn P., Heath E., Heitmiller R., Fogt F., Forastiere A., Herman J., and Wu T. Frequent hypermethylation of the 5′ CpG island of E-cadherin in esophageal adenocarcinoma. Clin. Cancer Res. 7 (2001) 2765-2769
22. Dalkara D., Zuber G., and Behr J.P. Intracytoplasmic delivery of anionic proteins. Molec. Ther. 9 (2004) 964-969
23. Tinsley J., Hawker J., and Yuan Y. Efficient protein transfection of cultured coronary venular endothelial cells. Am. J. Physiol., Heart Circ. Physiol. 275 (1998) H1873-H1878
24. Rejman J., Oberle V., Zuhorn I., and Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochem. J. 377 (2004) 159-169
25. Rejman J., Bragonzi A., and Conese M. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. Molec. Ther. 12 (2005) 468-474
26. Plass C. Cancer epigenomics. Hum. Mol. Genet. 11 (2002) 2479-2488
27. Robertson K. DNA methylation and human disease. Nat. Rev., Genet. 6 (2005) 597-610
28. Xu G., and Bestor T. Cytosine methylation targetted to pre-determined sequences. Nat. Genet. 17 (1997) 376-378
29. Zheng X., Lundberg M., Karlsson A., and Johansson M. Lipid-mediated protein delivery of suicide nucleoside kinases. Cancer Res. 63 (2003) 6909-6913