Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes

International Journal of Pharmaceutics

Volumn 459, Issue 1-2, 2014, Pages 40-50

  Leus, Niek G J ^a   Talman, Eduard G ^b   Ramana, Pranov ^a   Kowalski, Piotr S ^a   Woudenberg Vrenken, Titia E ^a   Ruiters, Marcel H J ^a,b   Molema, Grietje ^a   Kamps, Jan A A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Synvolux Therapeutics   (Netherlands)

Author keywords

Adhesion molecules; Antibody; Cationic lipid; Primary endothelial cells; siRNA delivery; Targeting

Indexed keywords

ANTIBODY; ANTIBODY SAINTPEGARG; E SELECTIN ANTIBODY; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; LIPOPLEX; MACROGOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VCAM 1 ANTIBODY;

ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CELL SPECIFICITY; CONTROLLED STUDY; DOWN REGULATION; DRUG FORMULATION; ENDOTHELIUM CELL; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; INFLAMMATION; LIPOSOMAL GENE DELIVERY SYSTEM; NANOENCAPSULATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA STABILITY; ZETA POTENTIAL;

ADHESION MOLECULES; ANTIBODY; CATIONIC LIPID; PRIMARY ENDOTHELIAL CELLS; SIRNA DELIVERY; TARGETING;

CAPILLARIES; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; E-SELECTIN; ELECTROCHEMISTRY; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; LIPIDS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; PYRIDINIUM COMPOUNDS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84892438208     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.008     Document Type: Article

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