Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis

Biotechnology and Bioengineering

Volumn 101, Issue 2, 2008, Pages 400-407

  Deosarkar, Sudhir P ^a   Malgor, Ramiro ^b   Fu, Jie ^c   Kohn, Leonard D ^b   Hanes, Justin ^c   Goetz, Douglas J ^a  

^a Ohio University   (United States)

^b OHIO UNIVERSITY   (United States)

^c Johns Hopkins University   (United States)

Author keywords

Adhesion; Atherosclerosis; Drug delivery; VCAM 1

Indexed keywords

ATHEROSCLEROSIS; DRUG DELIVERY; FOCAL ADHESION; NEGATIVE CONTROL; POLYMERIC DRUG CARRIERS; POLYMERIC PARTICLES; SEBACIC ACID; VCAM-1;

ABS RESINS; ACIDS; ADHESION; ETHYLENE GLYCOL; GLYCOLS; LIGANDS; POLYETHYLENE GLYCOLS; POLYSTYRENES;

BIODEGRADABLE POLYMERS;

APOLIPOPROTEIN E; COPOLYMER; DRUG CARRIER; IMMUNOGLOBULIN G; LIGAND; POLY(SEBASIC ACID CO ETHYLENE GLYCOL); POLYMER; POLYSTYRENE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ACID ANHYDRIDE; MACROGOL DERIVATIVE; MONOCLONAL ANTIBODY; POLY(SEBACIC ANHYDRIDE) B POLYETHYLENE GLYCOL; POLY(SEBACIC ANHYDRIDE)-B-POLYETHYLENE GLYCOL; POLYSTYRENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BIODEGRADABILITY; CONJUGATION; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; FOCAL ADHESION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE; ANALYSIS OF VARIANCE; ANIMAL; AORTA; ENZYME SPECIFICITY; METABOLISM;

MURINAE; MUS;

ANALYSIS OF VARIANCE; ANHYDRIDES; ANIMALS; ANTIBODIES, MONOCLONAL; AORTA; ATHEROSCLEROSIS; DRUG CARRIERS; FOCAL ADHESIONS; LIGANDS; MICE; POLYETHYLENE GLYCOLS; POLYSTYRENES; SUBSTRATE SPECIFICITY; VASCULAR CELL ADHESION MOLECULE-1;

EID: 51649085622     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21885     Document Type: Article

References (38)

1. Burch EE, Shinde Patil VR, Camphausen RT, Kiani MF, Goetz DJ. 2002. The N-terminal peptide of PSGL-1 can mediate adhesion to trauma-activated endothelium via P-selectin in vivo. Blood 100(2):531-538.
2. Cybulsky MI, Gimbrone MA, Jr. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251(4995):788-791.
3. Dickerson JB, Blackwell JE, Ou JJ, Shinde Patil VR, Goetz DJ. 2001. Limited adhesion of biodegradable microspheres to E- and P-selectin under flow. Biotechnol Bioeng 73(6):500-509.
4. Dong ZM, Wagner DD. 1998. Leukocyte-endothelium adhesion molecules in atherosclerosis. J Lab Clin Med 132(5):369-375.
5. Eniola AO, Hammer DA. 2005. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: Effect of degradation on targeting activity. Biomaterials 26(6):661-670.
6. Eniola AO, Rodgers SD, Hammer DA. 2002. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes. Biomaterials 23(10):2167-2177.
7. Fu J, Fiegel J, Krauland E, Hanes J. 2002. New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials 23(22):4425-4433.
8. Fu J, Fiegel J, Hanes J. 2004. Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for controlled drug delivery. Macromolecules 37(19):7174-7180.
9. Galkina E, Ley K. 2007. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 27(11):2292-2301.
10. Goldsmith HL, Turitto VT. 1986. Rheological aspects of thrombosis and haemostasis: Basic principles and applications. ICTH-Report - Subcommittee on Rheology of the International Committee on Thrombosis and Haemostasis. Thromb Haemost 55(3):415-435.
11. Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R. 1994. Biodegradable long-circulating polymeric nanospheres. Science 263(5153):1600-1603.
12. Hammer DA, Tempelman LA, Apte SM. 1993. Statistics of cell adhesion under hydrodynamic flow: Simulation and experiment. Blood Cells 19(2):261-275, discussion 275-277.
13. Hanes J, Fu J. 2006. Functionalized poly(ether-anhydride) block copolymers, biodegradable polymers, composition including microspheres and nanospheres, and their use. PCT Int Appl, Patent WO 2006063249.
14. Iiyama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD, Cybulsky MI. 1999. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 85(2):199-207.
15. Kaufmann BA, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ, Lindner JR. 2007. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule. Circulation 116(3):276-284.
16. Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. 2005. Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res 96(3):327-336.
17. Kelly KA, Nahrendorf M, Yu AM, Reynolds F, Weissleder R. 2006. In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging. Mol Imaging Biol 8(4):201-207.
18. Kevil CG, Bullard DC. 2001. In vitro culture and characterization of gene targeted mouse endothelium. Acta Physiol Scand 173(1):151-157.
19. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. 2007. Getting to the site of inflammation: The leukocyte adhesion cascade updated. Nat Rev Immunol 7(9):678-689.
20. Libby P, Ridker PM, Maseri A. 2002. Inflammation and atherosclerosis. Circulation 105(9):1135-1143.
21. Luscinskas FW, Gimbrone MA, Jr. 1996. Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment. Annu Rev Med 47:413-421.
22. Lusis AJ. 2000. Atherosclerosis. Nature 407(6801):233-241.
23. McEver RP. 2001. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost 86(3):746-756.
24. Muro S, Dziubla T, Qiu W, Leferovich J, Cui X, Berk E, Muzykantov VR. 2006a. Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to intercellular adhesion molecule. J Pharmacol Exp Ther 317(3):1161-1169.
25. Muro S, Schuchman EH, Muzykantov VR. 2006b. Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation-and clathrin-dependent endocytosis. Mol Ther 13( 1):135-141.
26. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. 2006. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 114(14):1504-1511.
27. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. 1994. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 14(1):133-140.
28. Nakashima Y, Raines EW, Plump AS, Breslow JL, Ross R. 1998. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol 18(5):842-851.
29. Ross R. 1999. Atherosclerosis - An inflammatory disease. N Engl J Med 340(2):115-126.
30. Sakhalkar HS, Dalai MK, Salem AK, Ansari R, Fu J, Kiani MF, Kurjiaka DT, Hanes J, Shakesheff KM, Goetz DJ. 2003. Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proc Natl Acad Sci USA 100(26):15895-15900.
31. Sakhalkar HS, Hanes J, Fu J, Benavides U, Malgor R, Borruso CL, Kohn LD, Kurjiaka DT, Goetz DJ. 2005. Enhanced adhesion of ligand-conjugated biodegradable particles to colitic venules. FASEB J 19(7):792-794.
32. Scott RC, Wang B, Nallamothu R, Pattillo CB, Perez-Liz G, Issekutz A, Valle LD, Wood GC, Kiani MF. 2007. Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction. Biotechnol Bioeng 96(4):795-802.
33. Shinde Patil VR, Campbell CJ, Yun YH, Slack SM, Goetz DJ. 2001. Particle diameter influences adhesion under flow. Biophys J 80(4):1733-1743.
34. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. 2001. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 70(l-2):l-20.
35. Spragg DD, Alford DR, Greferath R, Larsen CE, Lee KD, Gurtner GC, Cybulsky MI, Tosi PF, Nicolau C, Gimbrone MA, Jr. 1997. Immuno-targeting of liposomes to activated vascular endothelial cells: A strategy for site-selective delivery in the cardiovascular system. Proc Natl Acad Sci USA 94(16):8795-8800.
36. Springer TA. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76(2):301-314.
37. Stahn R, Grittner C, Zeisig R, Karsten U, Felix SB, Wenzel K. 2001. Sialyl Lewis(x)-liposomes as vehicles for site-directed, E-selectin-mediated drug transfer into activated endothelial cells. Cell Mol Life Sci 58(1):141-147.
38. Tempelman LA, Park S, Hammer DA. 1994. Motion of model leukocytes near a wall in simple shear flow. Biotechnol Prog 10(1):97-108.