Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet

Journal of Controlled Release

Volumn 185, Issue 1, 2014, Pages 1-11

  Gao, Mingming ^a   Ma, Yongjie ^a   Cui, Ran ^a   Liu, Dexi ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Diabetes; Fatty liver; FGF21; Hydrodynamic gene delivery; Obesity; Thermogenesis

Indexed keywords

GENE TRANSFER; GLUCOSE; HYDRODYNAMICS; MAMMALS; MEDICAL PROBLEMS; METABOLISM; NUTRITION; PHYSIOLOGY; PROTEINS; TISSUE;

FATTY LIVER; FGF21; GENE DELIVERY; OBESITY; THERMOGENESIS;

GENE EXPRESSION;

DIO 2 PROTEIN; F4 80 PROTEIN; FIBROBLAST GROWTH FACTOR 21; MGAT 1 PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; DNA; FIBROBLAST GROWTH FACTOR; GLUCOSE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; ATTENUATION; BLOOD; BODY COMPOSITION; BROWN ADIPOSE TISSUE; CHRONIC INFLAMMATION; CONTROLLED STUDY; FATTY LIVER; FOOD INTAKE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYDRODYNAMICS BASED TRANSFECTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPOGENESIS; LIVER; MALE; METABOLISM; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; THERMOGENESIS; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANIMAL; BODY WEIGHT; C57BL MOUSE; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GENETICS; HYDRODYNAMICS; MOUSE MUTANT; PATHOLOGY;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; DIET, HIGH-FAT; DNA; FATTY LIVER; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GLUCOSE; HYDRODYNAMICS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; THERMOGENESIS;

EID: 84899846107     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.047     Document Type: Article

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