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Volumn 15, Issue 3, 2013, Pages 744-752

Resveratrol suppresses T0901317-induced hepatic fat accumulation in mice

Author keywords

AMPK; fatty liver; gluconeogenesis; lipogenesis; liver X receptor; resveratrol; T0901317

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ACETYL COENZYME A CARBOXYLASE; CHOLESTEROL; COMPOUND C; CYTOCHROME P450 1A1; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RESVERATROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84879795568     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-013-9473-7     Document Type: Article
Times cited : (29)

References (36)
  • 1
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • 8878485 10.1038/383728a0 1:CAS:528:DyaK28XmsVGns78%3D
    • Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996;383(6602):728-31.
    • (1996) Nature , vol.383 , Issue.6602 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 2
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • 9630215 10.1016/S0092-8674(00)81432-4 1:CAS:528:DyaK1cXjsl2ksb4%3D
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998;93(5):693-704.
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6
  • 3
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • 11172721 10.1016/S1097-2765(01)00164-2 1:CAS:528:DC%2BD3MXis1KisbY%3D
    • Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, et al. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001;7(1):161-71.
    • (2001) Mol Cell , vol.7 , Issue.1 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.H.3    Laffitte, B.A.4    Barak, Y.5    Joseph, S.B.6
  • 4
    • 0037188553 scopus 로고    scopus 로고
    • Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    • 12032330 10.1073/pnas.112059299 1:CAS:528:DC%2BD38XktlCrsr8%3D
    • Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002;99(11):7604-9.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.11 , pp. 7604-7609
    • Joseph, S.B.1    McKilligin, E.2    Pei, L.3    Watson, M.A.4    Collins, A.R.5    Laffitte, B.A.6
  • 5
    • 0345461478 scopus 로고    scopus 로고
    • Putative metabolic effects of the liver X receptor (LXR)
    • 14749264 10.2337/diabetes.53.2007.S36 1:CAS:528:DC%2BD2cXhtlGqsLc%3D
    • Steffensen KR, Gustafsson JA. Putative metabolic effects of the liver X receptor (LXR). Diabetes. 2004;53 Suppl 1:S36-42.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Steffensen, K.R.1    Gustafsson, J.A.2
  • 6
    • 33846208252 scopus 로고    scopus 로고
    • The nuclear receptor LXR is a glucose sensor
    • 17187055 10.1038/nature05449 1:CAS:528:DC%2BD2sXjtFKjtg%3D%3D
    • Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, et al. The nuclear receptor LXR is a glucose sensor. Nature. 2007;445(7124):219-23.
    • (2007) Nature , vol.445 , Issue.7124 , pp. 219-223
    • Mitro, N.1    Mak, P.A.2    Vargas, L.3    Godio, C.4    Hampton, E.5    Molteni, V.6
  • 7
    • 0037428442 scopus 로고    scopus 로고
    • Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis
    • 12414791 10.1074/jbc.M210208200 1:CAS:528:DC%2BD3sXnsl2k
    • Cao GQ, Liang Y, Broderick CL, Oldham BA, Beyer TP, Schmidt RJ, et al. Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem. 2003;278(2):1131-6.
    • (2003) J Biol Chem , vol.278 , Issue.2 , pp. 1131-1136
    • Cao, G.Q.1    Liang, Y.2    Broderick, C.L.3    Oldham, B.A.4    Beyer, T.P.5    Schmidt, R.J.6
  • 8
    • 33751210100 scopus 로고    scopus 로고
    • Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
    • 16873540 10.1210/en.2006-0243 1:CAS:528:DC%2BD28XhtFCgsLzP
    • Liu YJ, Yan CY, Wang Y, Nakagawa Y, Nerio N, Anghel A, et al. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006;147(11):5061-8.
    • (2006) Endocrinology , vol.147 , Issue.11 , pp. 5061-5068
    • Liu, Y.J.1    Yan, C.Y.2    Wang, Y.3    Nakagawa, Y.4    Nerio, N.5    Anghel, A.6
  • 9
    • 0034669171 scopus 로고    scopus 로고
    • Role of LXRs in control of lipogenesis
    • 11090131 10.1101/gad.850400 1:CAS:528:DC%2BD3cXos1ehsLg%3D
    • Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li LP, et al. Role of LXRs in control of lipogenesis. Gene Dev. 2000;14(22):2831-8.
    • (2000) Gene Dev , vol.14 , Issue.22 , pp. 2831-2838
    • Schultz, J.R.1    Tu, H.2    Luk, A.3    Repa, J.J.4    Medina, J.C.5    Li, L.P.6
  • 10
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • 11090130 10.1101/gad.844900 1:CAS:528:DC%2BD3cXos1ehsLs%3D
    • Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14(22):2819-30.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3    Bashmakov, Y.4    Lobaccaro, J.M.5    Shimomura, I.6
  • 11
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis - The carbohydrate-response element-binding protein is a target gene of LXR
    • 17107947 10.1074/jbc.M605023200 1:CAS:528:DC%2BD2sXkslCi
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis - the carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282(1):743-51.
    • (2007) J Biol Chem , vol.282 , Issue.1 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 12
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • 18684130 10.1111/j.1872-034X.2008.00382.x 1:CAS:528:DC%2BD1cXhsVWju7zL
    • Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, et al. Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res. 2008;38(11):1122-9.
    • (2008) Hepatol Res , vol.38 , Issue.11 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3    Tajiri, H.4    Tanaka, M.5    Yamashita, N.6
  • 13
    • 0036087776 scopus 로고    scopus 로고
    • Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
    • 12015362 1:CAS:528:DC%2BD38Xks1aisr4%3D
    • Park SH, Gammon SR, Knippers JD, Paulsen SR, Rubink DS, Winder WW. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol. 2002;92(6):2475-82.
    • (2002) J Appl Physiol , vol.92 , Issue.6 , pp. 2475-2482
    • Park, S.H.1    Gammon, S.R.2    Knippers, J.D.3    Paulsen, S.R.4    Rubink, D.S.5    Winder, W.W.6
  • 14
    • 60549098942 scopus 로고    scopus 로고
    • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
    • 19285015 10.1016/j.bbrc.2009.01.163 1:CAS:528:DC%2BD1MXis1Grsrs%3D
    • Wang GL, Fu YC, Xu WC, Feng YQ, Fang SR, Zhou XH. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway. Biochem Biophys Res Commun. 2009;380(3):644-9.
    • (2009) Biochem Biophys Res Commun , vol.380 , Issue.3 , pp. 644-649
    • Wang, G.L.1    Fu, Y.C.2    Xu, W.C.3    Feng, Y.Q.4    Fang, S.R.5    Zhou, X.H.6
  • 15
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • 16732220 10.1038/nrd2060 1:CAS:528:DC%2BD28XlsV2jur8%3D
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.6 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 16
    • 30844472024 scopus 로고    scopus 로고
    • An improved synthesis of resveratrol
    • 16401555 10.1080/14786410500059532 1:CAS:528:DC%2BD28Xks1WrsA%3D%3D
    • Farina A, Ferranti C, Marra C. An improved synthesis of resveratrol. Nat Prod Res. 2006;20(3):247-52.
    • (2006) Nat Prod Res , vol.20 , Issue.3 , pp. 247-252
    • Farina, A.1    Ferranti, C.2    Marra, C.3
  • 17
    • 34547486917 scopus 로고    scopus 로고
    • Biotransformation of piceid in Polygonum cuspidatum to resveratrol by Aspergillus oryzae
    • 17333175 10.1007/s00253-007-0874-3 1:CAS:528:DC%2BD2sXlslCksL4%3D
    • Wang H, Liu L, Guo YX, Dong YS, Zhang DJ, Xiu ZL. Biotransformation of piceid in Polygonum cuspidatum to resveratrol by Aspergillus oryzae. Appl Microbiol Biotechnol. 2007;75(4):763-8.
    • (2007) Appl Microbiol Biotechnol , vol.75 , Issue.4 , pp. 763-768
    • Wang, H.1    Liu, L.2    Guo, Y.X.3    Dong, Y.S.4    Zhang, D.J.5    Xiu, Z.L.6
  • 18
    • 33947325505 scopus 로고    scopus 로고
    • Effects of resveratrol in inflammatory arthritis
    • 17115116 10.1007/s10753-006-9012-0 1:CAS:528:DC%2BD2sXjt1Wls7o%3D
    • Elmali N, Baysal O, Harma A, Esenkaya I, Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation. 2007;30(1-2):1-6.
    • (2007) Inflammation , vol.30 , Issue.1-2 , pp. 1-6
    • Elmali, N.1    Baysal, O.2    Harma, A.3    Esenkaya, I.4    Mizrak, B.5
  • 19
    • 21444437046 scopus 로고    scopus 로고
    • Cardiology patient pages. Red wine and your heart
    • 15657377 10.1161/01.CIR.0000151608.29217.62
    • Szmitko PE, Verma S. Cardiology patient pages. Red wine and your heart. Circulation. 2005;111(2):e10-1.
    • (2005) Circulation , vol.111 , Issue.2
    • Szmitko, P.E.1    Verma, S.2
  • 20
    • 41949118209 scopus 로고    scopus 로고
    • Sirtuins: Novel targets for metabolic disease
    • 18393104 1:CAS:528:DC%2BD1cXmtFygsbs%3D
    • Elliott PJ, Jirousek M. Sirtuins: novel targets for metabolic disease. Curr Opin Investig Drugs. 2008;9(4):371-8.
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.4 , pp. 371-378
    • Elliott, P.J.1    Jirousek, M.2
  • 21
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • 18599363 10.1016/j.cmet.2008.06.011 1:CAS:528:DC%2BD1cXpvVKrs74%3D
    • Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8(2):157-68.
    • (2008) Cell Metab , vol.8 , Issue.2 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3    Peshkin, L.4    Price, N.L.5    Labinskyy, N.6
  • 22
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • 22304913 10.1016/j.cell.2012.01.017 1:CAS:528:DC%2BC38XhvFakurc%3D
    • Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo HB, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012;148(3):421-33.
    • (2012) Cell , vol.148 , Issue.3 , pp. 421-433
    • Park, S.J.1    Ahmad, F.2    Philp, A.3    Baar, K.4    Williams, T.5    Luo, H.B.6
  • 23
    • 0018128226 scopus 로고
    • Lipid extraction of tissues with a low-toxicity solvent
    • 727482 10.1016/0003-2697(78)90046-5 1:CAS:528:DyaE1cXmtFWmsL0%3D
    • Hara A, Radin NS. Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem. 1978;90(1):420-6.
    • (1978) Anal Biochem , vol.90 , Issue.1 , pp. 420-426
    • Hara, A.1    Radin, N.S.2
  • 24
    • 21244464299 scopus 로고    scopus 로고
    • Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice
    • 10.1038/sj.ijo.0802943 1:CAS:528:DC%2BD2MXkvV2ntr4%3D
    • Carmona MC, Louche K, Nibbelink M, Prunet B, Bross A, Desbazeille M, et al. Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice. Int J Obes. 2005;29(7):864-71.
    • (2005) Int J Obes , vol.29 , Issue.7 , pp. 864-871
    • Carmona, M.C.1    Louche, K.2    Nibbelink, M.3    Prunet, B.4    Bross, A.5    Desbazeille, M.6
  • 25
    • 0036295401 scopus 로고    scopus 로고
    • LXR alpha is the dominant regulator of CYP7A1 transcription
    • 12054605 10.1016/S0006-291X(02)00229-2 1:CAS:528:DC%2BD38XksVGiur0%3D
    • Gupta S, Pandak WM, Hylemon PB. LXR alpha is the dominant regulator of CYP7A1 transcription. Biochem Biophys Res Commun. 2002;293(1):338-43.
    • (2002) Biochem Biophys Res Commun , vol.293 , Issue.1 , pp. 338-343
    • Gupta, S.1    Pandak, W.M.2    Hylemon, P.B.3
  • 26
    • 14544289119 scopus 로고    scopus 로고
    • Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver
    • 15733741 10.1016/j.biochi.2004.11.008 1:CAS:528:DC%2BD2MXhslCntLo%3D
    • Dentin R, Girard J, Postic C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie. 2005;87(1):81-6.
    • (2005) Biochimie , vol.87 , Issue.1 , pp. 81-86
    • Dentin, R.1    Girard, J.2    Postic, C.3
  • 27
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • 12959935 1:CAS:528:DC%2BD3sXosV2rur8%3D
    • Barthel A, Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab. 2003;285(4):E685-92.
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , Issue.4
    • Barthel, A.1    Schmoll, D.2
  • 28
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • 11557972 10.1038/35093050 1:CAS:528:DC%2BD3MXntVOrtLs%3D
    • Yoon JC, Puigserver P, Chen GX, Donovan J, Wu ZD, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001;413(6852):131-8.
    • (2001) Nature , vol.413 , Issue.6852 , pp. 131-138
    • Yoon, J.C.1    Puigserver, P.2    Chen, G.X.3    Donovan, J.4    Wu, Z.D.5    Rhee, J.6
  • 29
    • 84871990404 scopus 로고    scopus 로고
    • The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance
    • 23180161 10.1208/s12248-012-9429-3 1:CAS:528:DC%2BC3sXktFWisA%3D%3D
    • Gao M, Liu D. The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance. AAPS J. 2013;15(1):258-66.
    • (2013) AAPS J , vol.15 , Issue.1 , pp. 258-266
    • Gao, M.1    Liu, D.2
  • 30
    • 0037965630 scopus 로고    scopus 로고
    • Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
    • 12697904 10.1073/pnas.0830671100 1:CAS:528:DC%2BD3sXjs1yitb4%3D
    • Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, et al. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA. 2003;100(9):5419-24.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.9 , pp. 5419-5424
    • Laffitte, B.A.1    Chao, L.C.2    Li, J.3    Walczak, R.4    Hummasti, S.5    Joseph, S.B.6
  • 32
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • 15749705 10.1074/jbc.M501250200 1:CAS:528:DC%2BD2MXjsFOgtb8%3D
    • Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-95.
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 33
    • 20444431507 scopus 로고    scopus 로고
    • Substrate-specific activation of sirtuins by resveratrol
    • 15684413 10.1074/jbc.M500655200 1:CAS:528:DC%2BD2MXjsFOgt7w%3D
    • Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005;280(17):17038-45.
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 17038-17045
    • Kaeberlein, M.1    McDonagh, T.2    Heltweg, B.3    Hixon, J.4    Westman, E.A.5    Caldwell, S.D.6
  • 34
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • 17086191 10.1038/nature05354 1:CAS:528:DC%2BD28Xht1Sgtb3I
    • Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337-42.
    • (2006) Nature , vol.444 , Issue.7117 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3    Jamieson, H.A.4    Lerin, C.5    Kalra, A.6
  • 35
    • 50649112638 scopus 로고    scopus 로고
    • SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    • 18482975 10.1074/jbc.M802187200 1:CAS:528:DC%2BD1cXotlOitL0%3D
    • Hou XY, Xu SQ, Maitland-Toolan KA, Sato K, Jiang BB, Ido YS, et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008;283(29):20015-26.
    • (2008) J Biol Chem , vol.283 , Issue.29 , pp. 20015-20026
    • Hou, X.Y.1    Xu, S.Q.2    Maitland-Toolan, K.A.3    Sato, K.4    Jiang, B.B.5    Ido, Y.S.6
  • 36
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • 22560220 10.1016/j.cmet.2012.04.003 1:CAS:528:DC%2BC38XmsVCit7w%3D
    • Price NL, Gomes AP, Ling AJY, Duarte FV, Martin-Montalvo A, North BJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012;15(5):675-90.
    • (2012) Cell Metab , vol.15 , Issue.5 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.Y.3    Duarte, F.V.4    Martin-Montalvo, A.5    North, B.J.6


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