-
1
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
-
8878485 10.1038/383728a0 1:CAS:528:DyaK28XmsVGns78%3D
-
Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996;383(6602):728-31.
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
2
-
-
0013199471
-
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
-
9630215 10.1016/S0092-8674(00)81432-4 1:CAS:528:DyaK1cXjsl2ksb4%3D
-
Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998;93(5):693-704.
-
(1998)
Cell
, vol.93
, Issue.5
, pp. 693-704
-
-
Peet, D.J.1
Turley, S.D.2
Ma, W.3
Janowski, B.A.4
Lobaccaro, J.M.5
Hammer, R.E.6
-
3
-
-
17744376173
-
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
-
11172721 10.1016/S1097-2765(01)00164-2 1:CAS:528:DC%2BD3MXis1KisbY%3D
-
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, et al. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001;7(1):161-71.
-
(2001)
Mol Cell
, vol.7
, Issue.1
, pp. 161-171
-
-
Chawla, A.1
Boisvert, W.A.2
Lee, C.H.3
Laffitte, B.A.4
Barak, Y.5
Joseph, S.B.6
-
4
-
-
0037188553
-
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
-
12032330 10.1073/pnas.112059299 1:CAS:528:DC%2BD38XktlCrsr8%3D
-
Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002;99(11):7604-9.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.11
, pp. 7604-7609
-
-
Joseph, S.B.1
McKilligin, E.2
Pei, L.3
Watson, M.A.4
Collins, A.R.5
Laffitte, B.A.6
-
5
-
-
0345461478
-
Putative metabolic effects of the liver X receptor (LXR)
-
14749264 10.2337/diabetes.53.2007.S36 1:CAS:528:DC%2BD2cXhtlGqsLc%3D
-
Steffensen KR, Gustafsson JA. Putative metabolic effects of the liver X receptor (LXR). Diabetes. 2004;53 Suppl 1:S36-42.
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 1
-
-
Steffensen, K.R.1
Gustafsson, J.A.2
-
6
-
-
33846208252
-
The nuclear receptor LXR is a glucose sensor
-
17187055 10.1038/nature05449 1:CAS:528:DC%2BD2sXjtFKjtg%3D%3D
-
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, et al. The nuclear receptor LXR is a glucose sensor. Nature. 2007;445(7124):219-23.
-
(2007)
Nature
, vol.445
, Issue.7124
, pp. 219-223
-
-
Mitro, N.1
Mak, P.A.2
Vargas, L.3
Godio, C.4
Hampton, E.5
Molteni, V.6
-
7
-
-
0037428442
-
Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis
-
12414791 10.1074/jbc.M210208200 1:CAS:528:DC%2BD3sXnsl2k
-
Cao GQ, Liang Y, Broderick CL, Oldham BA, Beyer TP, Schmidt RJ, et al. Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem. 2003;278(2):1131-6.
-
(2003)
J Biol Chem
, vol.278
, Issue.2
, pp. 1131-1136
-
-
Cao, G.Q.1
Liang, Y.2
Broderick, C.L.3
Oldham, B.A.4
Beyer, T.P.5
Schmidt, R.J.6
-
8
-
-
33751210100
-
Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
-
16873540 10.1210/en.2006-0243 1:CAS:528:DC%2BD28XhtFCgsLzP
-
Liu YJ, Yan CY, Wang Y, Nakagawa Y, Nerio N, Anghel A, et al. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006;147(11):5061-8.
-
(2006)
Endocrinology
, vol.147
, Issue.11
, pp. 5061-5068
-
-
Liu, Y.J.1
Yan, C.Y.2
Wang, Y.3
Nakagawa, Y.4
Nerio, N.5
Anghel, A.6
-
9
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
11090131 10.1101/gad.850400 1:CAS:528:DC%2BD3cXos1ehsLg%3D
-
Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li LP, et al. Role of LXRs in control of lipogenesis. Gene Dev. 2000;14(22):2831-8.
-
(2000)
Gene Dev
, vol.14
, Issue.22
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.P.6
-
10
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
-
11090130 10.1101/gad.844900 1:CAS:528:DC%2BD3cXos1ehsLs%3D
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14(22):2819-30.
-
(2000)
Genes Dev
, vol.14
, Issue.22
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
Shimomura, I.6
-
11
-
-
33847006599
-
The liver X receptor (LXR) and hepatic lipogenesis - The carbohydrate-response element-binding protein is a target gene of LXR
-
17107947 10.1074/jbc.M605023200 1:CAS:528:DC%2BD2sXkslCi
-
Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis - the carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282(1):743-51.
-
(2007)
J Biol Chem
, vol.282
, Issue.1
, pp. 743-751
-
-
Cha, J.Y.1
Repa, J.J.2
-
12
-
-
53349153430
-
Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
-
18684130 10.1111/j.1872-034X.2008.00382.x 1:CAS:528:DC%2BD1cXhsVWju7zL
-
Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, et al. Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res. 2008;38(11):1122-9.
-
(2008)
Hepatol Res
, vol.38
, Issue.11
, pp. 1122-1129
-
-
Higuchi, N.1
Kato, M.2
Shundo, Y.3
Tajiri, H.4
Tanaka, M.5
Yamashita, N.6
-
13
-
-
0036087776
-
Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
-
12015362 1:CAS:528:DC%2BD38Xks1aisr4%3D
-
Park SH, Gammon SR, Knippers JD, Paulsen SR, Rubink DS, Winder WW. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol. 2002;92(6):2475-82.
-
(2002)
J Appl Physiol
, vol.92
, Issue.6
, pp. 2475-2482
-
-
Park, S.H.1
Gammon, S.R.2
Knippers, J.D.3
Paulsen, S.R.4
Rubink, D.S.5
Winder, W.W.6
-
14
-
-
60549098942
-
Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
-
19285015 10.1016/j.bbrc.2009.01.163 1:CAS:528:DC%2BD1MXis1Grsrs%3D
-
Wang GL, Fu YC, Xu WC, Feng YQ, Fang SR, Zhou XH. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway. Biochem Biophys Res Commun. 2009;380(3):644-9.
-
(2009)
Biochem Biophys Res Commun
, vol.380
, Issue.3
, pp. 644-649
-
-
Wang, G.L.1
Fu, Y.C.2
Xu, W.C.3
Feng, Y.Q.4
Fang, S.R.5
Zhou, X.H.6
-
15
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
16732220 10.1038/nrd2060 1:CAS:528:DC%2BD28XlsV2jur8%3D
-
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506.
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.6
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
16
-
-
30844472024
-
An improved synthesis of resveratrol
-
16401555 10.1080/14786410500059532 1:CAS:528:DC%2BD28Xks1WrsA%3D%3D
-
Farina A, Ferranti C, Marra C. An improved synthesis of resveratrol. Nat Prod Res. 2006;20(3):247-52.
-
(2006)
Nat Prod Res
, vol.20
, Issue.3
, pp. 247-252
-
-
Farina, A.1
Ferranti, C.2
Marra, C.3
-
17
-
-
34547486917
-
Biotransformation of piceid in Polygonum cuspidatum to resveratrol by Aspergillus oryzae
-
17333175 10.1007/s00253-007-0874-3 1:CAS:528:DC%2BD2sXlslCksL4%3D
-
Wang H, Liu L, Guo YX, Dong YS, Zhang DJ, Xiu ZL. Biotransformation of piceid in Polygonum cuspidatum to resveratrol by Aspergillus oryzae. Appl Microbiol Biotechnol. 2007;75(4):763-8.
-
(2007)
Appl Microbiol Biotechnol
, vol.75
, Issue.4
, pp. 763-768
-
-
Wang, H.1
Liu, L.2
Guo, Y.X.3
Dong, Y.S.4
Zhang, D.J.5
Xiu, Z.L.6
-
18
-
-
33947325505
-
Effects of resveratrol in inflammatory arthritis
-
17115116 10.1007/s10753-006-9012-0 1:CAS:528:DC%2BD2sXjt1Wls7o%3D
-
Elmali N, Baysal O, Harma A, Esenkaya I, Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation. 2007;30(1-2):1-6.
-
(2007)
Inflammation
, vol.30
, Issue.1-2
, pp. 1-6
-
-
Elmali, N.1
Baysal, O.2
Harma, A.3
Esenkaya, I.4
Mizrak, B.5
-
19
-
-
21444437046
-
Cardiology patient pages. Red wine and your heart
-
15657377 10.1161/01.CIR.0000151608.29217.62
-
Szmitko PE, Verma S. Cardiology patient pages. Red wine and your heart. Circulation. 2005;111(2):e10-1.
-
(2005)
Circulation
, vol.111
, Issue.2
-
-
Szmitko, P.E.1
Verma, S.2
-
20
-
-
41949118209
-
Sirtuins: Novel targets for metabolic disease
-
18393104 1:CAS:528:DC%2BD1cXmtFygsbs%3D
-
Elliott PJ, Jirousek M. Sirtuins: novel targets for metabolic disease. Curr Opin Investig Drugs. 2008;9(4):371-8.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, Issue.4
, pp. 371-378
-
-
Elliott, P.J.1
Jirousek, M.2
-
21
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
-
18599363 10.1016/j.cmet.2008.06.011 1:CAS:528:DC%2BD1cXpvVKrs74%3D
-
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8(2):157-68.
-
(2008)
Cell Metab
, vol.8
, Issue.2
, pp. 157-168
-
-
Pearson, K.J.1
Baur, J.A.2
Lewis, K.N.3
Peshkin, L.4
Price, N.L.5
Labinskyy, N.6
-
22
-
-
84863011114
-
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
-
22304913 10.1016/j.cell.2012.01.017 1:CAS:528:DC%2BC38XhvFakurc%3D
-
Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo HB, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012;148(3):421-33.
-
(2012)
Cell
, vol.148
, Issue.3
, pp. 421-433
-
-
Park, S.J.1
Ahmad, F.2
Philp, A.3
Baar, K.4
Williams, T.5
Luo, H.B.6
-
23
-
-
0018128226
-
Lipid extraction of tissues with a low-toxicity solvent
-
727482 10.1016/0003-2697(78)90046-5 1:CAS:528:DyaE1cXmtFWmsL0%3D
-
Hara A, Radin NS. Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem. 1978;90(1):420-6.
-
(1978)
Anal Biochem
, vol.90
, Issue.1
, pp. 420-426
-
-
Hara, A.1
Radin, N.S.2
-
24
-
-
21244464299
-
Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice
-
10.1038/sj.ijo.0802943 1:CAS:528:DC%2BD2MXkvV2ntr4%3D
-
Carmona MC, Louche K, Nibbelink M, Prunet B, Bross A, Desbazeille M, et al. Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice. Int J Obes. 2005;29(7):864-71.
-
(2005)
Int J Obes
, vol.29
, Issue.7
, pp. 864-871
-
-
Carmona, M.C.1
Louche, K.2
Nibbelink, M.3
Prunet, B.4
Bross, A.5
Desbazeille, M.6
-
25
-
-
0036295401
-
LXR alpha is the dominant regulator of CYP7A1 transcription
-
12054605 10.1016/S0006-291X(02)00229-2 1:CAS:528:DC%2BD38XksVGiur0%3D
-
Gupta S, Pandak WM, Hylemon PB. LXR alpha is the dominant regulator of CYP7A1 transcription. Biochem Biophys Res Commun. 2002;293(1):338-43.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, Issue.1
, pp. 338-343
-
-
Gupta, S.1
Pandak, W.M.2
Hylemon, P.B.3
-
26
-
-
14544289119
-
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver
-
15733741 10.1016/j.biochi.2004.11.008 1:CAS:528:DC%2BD2MXhslCntLo%3D
-
Dentin R, Girard J, Postic C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie. 2005;87(1):81-6.
-
(2005)
Biochimie
, vol.87
, Issue.1
, pp. 81-86
-
-
Dentin, R.1
Girard, J.2
Postic, C.3
-
27
-
-
0141839103
-
Novel concepts in insulin regulation of hepatic gluconeogenesis
-
12959935 1:CAS:528:DC%2BD3sXosV2rur8%3D
-
Barthel A, Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab. 2003;285(4):E685-92.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
, Issue.4
-
-
Barthel, A.1
Schmoll, D.2
-
28
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
-
11557972 10.1038/35093050 1:CAS:528:DC%2BD3MXntVOrtLs%3D
-
Yoon JC, Puigserver P, Chen GX, Donovan J, Wu ZD, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001;413(6852):131-8.
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.X.3
Donovan, J.4
Wu, Z.D.5
Rhee, J.6
-
29
-
-
84871990404
-
The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance
-
23180161 10.1208/s12248-012-9429-3 1:CAS:528:DC%2BC3sXktFWisA%3D%3D
-
Gao M, Liu D. The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance. AAPS J. 2013;15(1):258-66.
-
(2013)
AAPS J
, vol.15
, Issue.1
, pp. 258-266
-
-
Gao, M.1
Liu, D.2
-
30
-
-
0037965630
-
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
-
12697904 10.1073/pnas.0830671100 1:CAS:528:DC%2BD3sXjs1yitb4%3D
-
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, et al. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA. 2003;100(9):5419-24.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.9
, pp. 5419-5424
-
-
Laffitte, B.A.1
Chao, L.C.2
Li, J.3
Walczak, R.4
Hummasti, S.5
Joseph, S.B.6
-
31
-
-
57349114641
-
Resveratrol alleviates alcoholic fatty liver in mice
-
10.1152/ajpgi.90358.2008 1:CAS:528:DC%2BD1cXht1ymtbvE
-
Ajmo JM, Liang XM, Rogers CQ, Pennock B, You M. Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver. 2008;295(4):G833-42.
-
(2008)
Am J Physiol Gastrointest Liver
, vol.295
, Issue.4
-
-
Ajmo, J.M.1
Liang, X.M.2
Rogers, C.Q.3
Pennock, B.4
You, M.5
-
32
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
15749705 10.1074/jbc.M501250200 1:CAS:528:DC%2BD2MXjsFOgtb8%3D
-
Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-95.
-
(2005)
J Biol Chem
, vol.280
, Issue.17
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
33
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
15684413 10.1074/jbc.M500655200 1:CAS:528:DC%2BD2MXjsFOgt7w%3D
-
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005;280(17):17038-45.
-
(2005)
J Biol Chem
, vol.280
, Issue.17
, pp. 17038-17045
-
-
Kaeberlein, M.1
McDonagh, T.2
Heltweg, B.3
Hixon, J.4
Westman, E.A.5
Caldwell, S.D.6
-
34
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
17086191 10.1038/nature05354 1:CAS:528:DC%2BD28Xht1Sgtb3I
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337-42.
-
(2006)
Nature
, vol.444
, Issue.7117
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
-
35
-
-
50649112638
-
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
-
18482975 10.1074/jbc.M802187200 1:CAS:528:DC%2BD1cXotlOitL0%3D
-
Hou XY, Xu SQ, Maitland-Toolan KA, Sato K, Jiang BB, Ido YS, et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008;283(29):20015-26.
-
(2008)
J Biol Chem
, vol.283
, Issue.29
, pp. 20015-20026
-
-
Hou, X.Y.1
Xu, S.Q.2
Maitland-Toolan, K.A.3
Sato, K.4
Jiang, B.B.5
Ido, Y.S.6
-
36
-
-
84860477354
-
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
-
22560220 10.1016/j.cmet.2012.04.003 1:CAS:528:DC%2BC38XmsVCit7w%3D
-
Price NL, Gomes AP, Ling AJY, Duarte FV, Martin-Montalvo A, North BJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012;15(5):675-90.
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 675-690
-
-
Price, N.L.1
Gomes, A.P.2
Ling, A.J.Y.3
Duarte, F.V.4
Martin-Montalvo, A.5
North, B.J.6
|