Melatonin receptor type 1 signals to extracellular signal-regulated kinase 1 and 2 via Gi and Gs dually coupled pathways in HEK-293 Cells

Biochemistry

Volumn 53, Issue 17, 2014, Pages 2827-2839

  Chen, Linjie ^a   He, Xiaobai ^a   Zhang, Yaping ^b   Chen, Xiaopan ^a,c   Lai, Xiangru ^a   Shao, Jiajie ^a   Shi, Ying ^a   Zhou, Naiming ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; PHYSIOLOGICAL MODELS; PHYSIOLOGY; PROTEINS;

CONCENTRATION-DEPENDENT; EXTRACELLULAR SIGNAL-REGULATED KINASE; G PROTEIN COUPLED RECEPTORS; MOLECULAR MECHANISM; PATHOLOGICAL RESPONSE; PHARMACOLOGICAL EFFECTS; PHOSPHOINOSITIDE 3-KINASE; PHYSIOLOGICAL FUNCTIONS;

HORMONES;

CALCIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MELATONIN; MELATONIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE C; RETINA S ANTIGEN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CAMP ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

CYCLIC AMP; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEK293 CELLS; HUMANS; MELATONIN; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84899829773     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500092e     Document Type: Article

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