메뉴 건너뛰기




Volumn 52, Issue 3, 2012, Pages 282-290

Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine production

Author keywords

3T3 L1 cells; aromatase; breast cancer; interleukins; melatonin; pineal gland; tumor necrosis factor

Indexed keywords

AROMATASE; INTERLEUKIN 11; INTERLEUKIN 6; MELATONIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84858751360     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00940.x     Document Type: Article
Times cited : (54)

References (64)
  • 2
    • 33750975372 scopus 로고    scopus 로고
    • The role of estrogen in the initiation of breast cancer
    • DOI 10.1016/j.jsbmb.2006.09.004, PII S0960076006002457
    • Russo J, Russo IH,. The role of estrogen in the initiation of breast cancer. J Steroid Biochem Mol Biol 2006; 102: 89-96. (Pubitemid 44750629)
    • (2006) Journal of Steroid Biochemistry and Molecular Biology , vol.102 , pp. 89-96
    • Russo, J.1    Russo, I.H.2
  • 3
    • 78649735494 scopus 로고    scopus 로고
    • Molecularly targeted endocrine therapies for breast cancer
    • Orlando L, Schiavone P, Fedele P, et al., Molecularly targeted endocrine therapies for breast cancer. Cancer Treat Rev 2010; 36S (3): S67-S71.
    • (2010) Cancer Treat Rev , vol.36 S , Issue.3
    • Orlando, L.1    Schiavone, P.2    Fedele, P.3
  • 4
    • 0021931084 scopus 로고
    • Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue
    • Landeghem AA, Poortman J, Nabuurs M, et al., Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res 1985; 45: 2900-2906. (Pubitemid 15232767)
    • (1985) Cancer Research , vol.45 , Issue.6 , pp. 2900-2906
    • Van Landeghem, A.A.J.1    Poortman, J.2    Nabuurs, M.3    Thijssen, J.H.H.4
  • 5
    • 0032031754 scopus 로고    scopus 로고
    • In situ aromatization enhances breast tumor estradiol levels and cellular proliferation
    • Yue W, Wang JP, Hamilton CJ, et al., In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res 1998; 58: 927-932. (Pubitemid 28182460)
    • (1998) Cancer Research , vol.58 , Issue.5 , pp. 927-932
    • Yue, W.1    Wang, J.-P.2    Hamilton, C.J.3    Demers, L.M.4    Santen, R.J.5
  • 6
    • 0033771003 scopus 로고    scopus 로고
    • Role of aromatase in sex steroid action
    • Simpson ER,. Role of aromatase in sex steroid action. J Mol Endocrinol 2000; 25: 149-156.
    • (2000) J Mol Endocrinol , vol.25 , pp. 149-156
    • Simpson, E.R.1
  • 7
    • 0342804465 scopus 로고    scopus 로고
    • Melatonin and mammary pathological growth
    • DOI 10.1006/frne.1999.0194
    • Cos S, Sánchez-Barceló EJ,. Melatonin and mammary pathological growth. Front Neuroendocrinol 2000; 21: 133-170. (Pubitemid 30228502)
    • (2000) Frontiers in Neuroendocrinology , vol.21 , Issue.2 , pp. 133-170
    • Cos, S.1    Sanchez-Barcelo, E.J.2
  • 8
    • 0343130501 scopus 로고    scopus 로고
    • Melatonin, experimental basis for a possible application in breast cancer prevention and treatment
    • Cos S, Sánchez-Barceló EJ,. Melatonin, experimental basis for a possible application in breast cancer prevention and treatment. Histol Histopathol 2000; 15: 637.
    • (2000) Histol Histopathol , vol.15 , pp. 637
    • Cos, S.1    Sánchez-Barceló, E.J.2
  • 10
    • 0036479749 scopus 로고    scopus 로고
    • Melatonin as a chronobiotic/anticancer agent: Cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy
    • Blask DE, Sauer LA, Dauchy RT,. Melatonin as a chronobiotic/anticancer agent: cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Topics Med Chem 2002; 2: 113-132.
    • (2002) Curr Topics Med Chem , vol.2 , pp. 113-132
    • Blask, D.E.1    Sauer, L.A.2    Dauchy, R.T.3
  • 11
    • 0023698530 scopus 로고
    • Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture
    • Hill SM, Blask DE,. Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res 1988; 48: 6121-6126. (Pubitemid 18266811)
    • (1988) Cancer Research , vol.48 , Issue.21 , pp. 6121-6126
    • Hill, S.M.1    Blask, D.E.2
  • 12
    • 78650672113 scopus 로고    scopus 로고
    • Basic mechanisms involved in the anti-cancer effects of melatonin
    • Mediavilla MD, Sánchez-Barceló EJ, Tan DX, et al., Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem 2010; 17: 4462-4481.
    • (2010) Curr Med Chem , vol.17 , pp. 4462-4481
    • Mediavilla, M.D.1    Sánchez-Barceló, E.J.2    Tan, D.X.3
  • 13
    • 77954322791 scopus 로고    scopus 로고
    • Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells
    • Jung-Hynes B, Huang W, Reiter RJ, et al., Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells. J Pineal Res 2010; 49: 60-68.
    • (2010) J Pineal Res , vol.49 , pp. 60-68
    • Jung-Hynes, B.1    Huang, W.2    Reiter, R.J.3
  • 14
    • 77956301403 scopus 로고    scopus 로고
    • Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)
    • Leja-Szpak A, Jaworek J, Pierzchalski P, et al., Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). J Pineal Res 2010; 99: 248-255.
    • (2010) J Pineal Res , vol.99 , pp. 248-255
    • Leja-Szpak, A.1    Jaworek, J.2    Pierzchalski, P.3
  • 15
    • 79952561418 scopus 로고    scopus 로고
    • Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients
    • Casado-Zapico S, Martín V, García-Santos G, et al., Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients. J Pineal Res 2011; 50: 345-355.
    • (2011) J Pineal Res , vol.50 , pp. 345-355
    • Casado-Zapico, S.1    Martín, V.2    García-Santos, G.3
  • 21
    • 14644440522 scopus 로고    scopus 로고
    • Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line
    • DOI 10.1016/j.jsbmb.2004.11.005
    • Sonne-Hansen K, Lykkesfeldt AE,. Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line. J Steroid Biochem Mol Biol 2005; 93: 25-34. (Pubitemid 40312730)
    • (2005) Journal of Steroid Biochemistry and Molecular Biology , vol.93 , Issue.1 , pp. 25-34
    • Sonne-Hansen, K.1    Lykkesfeldt, A.E.2
  • 22
    • 0032565919 scopus 로고    scopus 로고
    • Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors
    • DOI 10.1016/S0303-7207(98)00095-1, PII S0303720798000951
    • Ram PT, Kiefer T, Silverman M, et al., Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. Mol Cell Endocrinol 1998; 141: 53-64. (Pubitemid 28393379)
    • (1998) Molecular and Cellular Endocrinology , vol.141 , Issue.1-2 , pp. 53-64
    • Ram, P.T.1    Kiefer, T.2    Silverman, M.3    Song, Y.4    Brown, G.M.5    Hill, S.M.6
  • 23
    • 0037188428 scopus 로고    scopus 로고
    • Involvement of the mt1 melatonin receptor in human breast cancer
    • DOI 10.1016/S0304-3835(01)00873-4, PII S0304383501008734
    • Ram PT, Dai J, Yuan L, et al., Involvement of the MT-1 melatonin receptor in human breast cancer. Cancer Lett 2002; 179: 141-150. (Pubitemid 34215105)
    • (2002) Cancer Letters , vol.179 , Issue.2 , pp. 141-150
    • Ram, P.T.1    Dai, J.2    Yuan, L.3    Dong, C.4    Kiefer, T.L.5    Lai, L.6    Hill, S.M.7
  • 25
    • 70350646913 scopus 로고    scopus 로고
    • Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cáncer cells
    • Martínez-Campa C, González A, Mediavilla MD, et al., Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cáncer cells. Br J Cancer 2009; 101: 1613-1619.
    • (2009) Br J Cancer , vol.101 , pp. 1613-1619
    • Martínez-Campa, C.1    González, A.2    Mediavilla, M.D.3
  • 29
    • 0035266474 scopus 로고    scopus 로고
    • Tumor necrosis factor α and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein α and peroxisome proliferator-activated receptor γ: Mechanism of desmoplastic reaction
    • Meng LI, Zhou J, Sasano H, et al., Tumor necrosis factor α and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein α and peroxisome proliferator-activated receptor γ: mechanism of desmoplastic reaction. Cancer Res 2001; 61: 2250-2255. (Pubitemid 32692055)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 2250-2255
    • Meng, L.1    Zhou, J.2    Sasano, H.3    Suzuki, T.4    Zeitoun, K.M.5    Bulun, S.E.6
  • 30
    • 0026793195 scopus 로고
    • Quantitation of adipose conversión and triglycerides by staining intracytoplasmic lipids with Oil red O
    • Ramírez-Zacarias JL, Castro-Muñozledo F, Kuri-Harcuch W,. Quantitation of adipose conversión and triglycerides by staining intracytoplasmic lipids with Oil red O. Histochemistry 1992; 97: 493-497.
    • (1992) Histochemistry , vol.97 , pp. 493-497
    • Ramírez-Zacarias, J.L.1    Castro-Muñozledo, F.2    Kuri-Harcuch, W.3
  • 31
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T,. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63. (Pubitemid 14203433)
    • (1983) Journal of Immunological Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 33
    • 45549093658 scopus 로고    scopus 로고
    • Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells
    • Hollingshead BD, Beischlag TV, Dinatale BC, et al., Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res 2008; 68: 3609-3617.
    • (2008) Cancer Res , vol.68 , pp. 3609-3617
    • Hollingshead, B.D.1    Beischlag, T.V.2    Dinatale, B.C.3
  • 34
    • 2542492928 scopus 로고    scopus 로고
    • The selective estrogen enzyme modulators in breast cancer: A review
    • DOI 10.1016/j.bbcan.2004.03.001, PII S0304419X04000186
    • Pasqualini JR,. The selective estrogen enzyme modulators in breast cancer: a review. Biochim Biophys Acta 2004; 1654: 123-143. (Pubitemid 38681205)
    • (2004) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1654 , Issue.2 , pp. 123-143
    • Pasqualini, J.R.1
  • 35
    • 18044372636 scopus 로고    scopus 로고
    • Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer
    • DOI 10.1016/j.jsbmb.2005.02.007, Proceedings of the 16th Internatioanl Symposium of the Journal of Steroid Biochemistry and Molecular Biology
    • Pasqualini JR, Chetrite GS,. Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer. J Steroid Biochem Mol Biol 2005; 93: 221-236. (Pubitemid 40602495)
    • (2005) Journal of Steroid Biochemistry and Molecular Biology , vol.93 , Issue.2-5 , pp. 221-236
    • Pasqualini, J.R.1    Chetrite, G.S.2
  • 38
    • 0036130293 scopus 로고    scopus 로고
    • The role of cytokines in regulating estrogen synthesis: Implications for the etiology of breast cancer
    • DOI 10.1186/bcr425
    • Purohit A, Newman SP, Reed MJ,. The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer. Breast Cancer Res 2002; 4: 65-69. (Pubitemid 34248122)
    • (2002) Breast Cancer Research , vol.4 , Issue.2 , pp. 65-69
    • Purohit, A.1    Newman, S.P.2    Reed, M.J.3
  • 39
    • 74849140072 scopus 로고    scopus 로고
    • Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α
    • Guerrero J, Tobar N, Caceres M, et al., Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α. Breast Cancer Res Treat 2010; 119: 497-508.
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 497-508
    • Guerrero, J.1    Tobar, N.2    Caceres, M.3
  • 40
    • 0028572548 scopus 로고
    • Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells
    • Molis TM, Spriggs LI, Hill SM,. Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol Endocrinol 1994; 8: 1681-1690.
    • (1994) Mol Endocrinol , vol.8 , pp. 1681-1690
    • Molis, T.M.1    Spriggs, L.I.2    Hill, S.M.3
  • 41
    • 0026769322 scopus 로고
    • The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system
    • Hill SM, Spriggs LL, Simon MA, et al., The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system. Cancer Lett 1992; 64: 249-256.
    • (1992) Cancer Lett , vol.64 , pp. 249-256
    • Hill, S.M.1    Spriggs, L.L.2    Simon, M.A.3
  • 43
    • 0034535853 scopus 로고    scopus 로고
    • Adipocyte differentiation and gene expression
    • Ntambi JM, Kim YC,. Adipocyte differentiation and gene expression. J Nutr 2000; 130: 3122S-3126S. (Pubitemid 32005353)
    • (2000) Journal of Nutrition , vol.130 , Issue.12
    • Ntambi, J.M.1    Kim, Y.-C.2
  • 44
    • 0025367046 scopus 로고
    • Expression of estrogen synthetase (P-450 aromatase) during adipose differentiation of 3T3-L1 cells
    • DOI 10.1016/0006-291X(90)90363-R
    • Yamada K, Harada N,. Expression of estrogen synthetase (P-450 aromatase) during adipose differentiation of 3T3-L1 cells. Biochem Biophys Res Commun 1990; 169: 531-536. (Pubitemid 20216140)
    • (1990) Biochemical and Biophysical Research Communications , vol.169 , Issue.2 , pp. 531-536
    • Yamada, K.1    Harada, N.2
  • 45
    • 0030604007 scopus 로고    scopus 로고
    • Effects of melatonin on the proliferation and differentiation of human neuroblastoma cells in culture
    • DOI 10.1016/S0304-3940(96)13035-4
    • Cos S, Verduga R, Fernández-Viadero C, et al., Effects of melatonin on the proliferation and differentiation of human neuroblastoma cells in culture. Neurosci Lett 1996; 216: 113-116. (Pubitemid 26327037)
    • (1996) Neuroscience Letters , vol.216 , Issue.2 , pp. 113-116
    • Cos, S.1    Verduga, R.2    Fernandez-Viadero, C.3    Megias, M.4    Crespo, D.5
  • 46
    • 0028441269 scopus 로고
    • Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells
    • Crespo D, Fernández-Viadero C, Verduga R, et al., Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells. J Pineal Res 1994; 16: 215-222.
    • (1994) J Pineal Res , vol.16 , pp. 215-222
    • Crespo, D.1    Fernández-Viadero, C.2    Verduga, R.3
  • 47
    • 0033820053 scopus 로고    scopus 로고
    • Melatonin effects on intercellular junctional communication in MCF-7 human breast cancer cells
    • Cos S, Fernández R,. Melatonin effects on intercellular junctional communication in MCF-7 human breast cancer cells. J Pineal Res 2000; 29: 166-171.
    • (2000) J Pineal Res , vol.29 , pp. 166-171
    • Cos, S.1    Fernández, R.2
  • 48
    • 14944362307 scopus 로고    scopus 로고
    • Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism
    • DOI 10.1002/pros.20155
    • Sainz RM, Mayo JC, Tan DX, et al., Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism. Prostate 2005; 63: 29-43. (Pubitemid 40365388)
    • (2005) Prostate , vol.63 , Issue.1 , pp. 29-43
    • Sainz, R.M.1    Mayo, J.C.2    Tan, D.-X.3    Leon, J.4    Manchester, L.5    Reiter, R.J.6
  • 49
    • 33645473088 scopus 로고    scopus 로고
    • Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade
    • Radio NM, Doctor JS, Witt-Enderby PA,. Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. J Pineal Res 2006; 42: 332-342.
    • (2006) J Pineal Res , vol.42 , pp. 332-342
    • Radio, N.M.1    Doctor, J.S.2    Witt-Enderby, P.A.3
  • 50
    • 78349247846 scopus 로고    scopus 로고
    • Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression
    • Zhang L, Su P, Xu C, et al., Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression. J Pineal Res 2010; 49: 364-372.
    • (2010) J Pineal Res , vol.49 , pp. 364-372
    • Zhang, L.1    Su, P.2    Xu, C.3
  • 51
    • 34147213579 scopus 로고    scopus 로고
    • Melatonin influences the proliferative and differentiative activity of neural stem cells
    • DOI 10.1111/j.1600-079X.2007.00435.x
    • Moriya Y, Horie N, Mitome M, et al., Melatonin influences the proliferative and differentiative activity of neural stem cells. J Pineal Res 2007; 42: 411-418. (Pubitemid 46581666)
    • (2007) Journal of Pineal Research , vol.42 , Issue.4 , pp. 411-418
    • Moriya, T.1    Horie, N.2    Mitome, M.3    Shinohara, K.4
  • 54
  • 56
    • 0024566348 scopus 로고
    • Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta
    • DOI 10.1083/jcb.108.3.1105
    • Torti FM, Torti SV, Larrick JW, et al., Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor β. J Cell Biol 1989; 108: 1105-1113. (Pubitemid 19083754)
    • (1989) Journal of Cell Biology , vol.108 , Issue.3 , pp. 1105-1113
    • Torti, F.M.1    Torti, S.V.2    Larrick, J.W.3    Ringold, G.M.4
  • 57
    • 0027247823 scopus 로고
    • Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures
    • Keller DC, Du XX, Srour EF, et al., Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures. Blood 1993; 82: 1428-1435. (Pubitemid 23263958)
    • (1993) Blood , vol.82 , Issue.5 , pp. 1428-1435
    • Keller, D.C.1    Du, X.X.2    Srour, E.F.3    Hoffman, R.4    Williams, D.A.5
  • 58
    • 0034654120 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands inhibit estrogen biosynthesis in human breast adipose tissue: Possible implications for breast cancer therapy
    • Rubin GL, Zhao Y, Kalus AM, et al., Peroxisome proliferator-activated receptor γ ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. Cancer Res 2000; 60: 1604-1608. (Pubitemid 30183431)
    • (2000) Cancer Research , vol.60 , Issue.6 , pp. 1604-1608
    • Rubin, G.L.1    Zhao, Y.2    Kalus, A.M.3    Simpson, E.R.4
  • 59
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan NJ, Sasser AK, Axel AE, et al., Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 2009; 28: 2940-2947.
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3
  • 60
    • 0032188888 scopus 로고    scopus 로고
    • Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
    • Cos S, Fernández R, Güezmes A, et al., Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 1998; 58: 4383-4390. (Pubitemid 28450041)
    • (1998) Cancer Research , vol.58 , Issue.19 , pp. 4383-4390
    • Cos, S.1    Fernandez, R.2    Guezmes, A.3    Sanchez-Barcelo, E.J.4
  • 61
    • 77950644583 scopus 로고    scopus 로고
    • Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines
    • Tocharus J, Khontun C, Chongthammakun S, et al., Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines. J Pineal Res 2010; 48: 347-352.
    • (2010) J Pineal Res , vol.48 , pp. 347-352
    • Tocharus, J.1    Khontun, C.2    Chongthammakun, S.3
  • 62
    • 79951645465 scopus 로고    scopus 로고
    • Melatonin inhibits prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-B and STAT1 activity
    • Choi EY, Jin JY, Lee JY, et al., Melatonin inhibits prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-B and STAT1 activity. J Pineal Res 2011; 50: 197-206.
    • (2011) J Pineal Res , vol.50 , pp. 197-206
    • Choi, E.Y.1    Jin, J.Y.2    Lee, J.Y.3
  • 63
    • 79952540106 scopus 로고    scopus 로고
    • Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: The impact of circulating estrogen on its hermetic dose-response
    • Tai SH, Hung YC, Lee EJ, et al., Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hermetic dose-response. J Pineal Res 2011; 50: 292-303.
    • (2011) J Pineal Res , vol.50 , pp. 292-303
    • Tai, S.H.1    Hung, Y.C.2    Lee, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.