Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins

Molecular Endocrinology

Volumn 13, Issue 12, 1999, Pages 2025-2038

  Brydon, Lena ^a,d   Roka, Florian ^b   Petit, Laurence ^a   De Coppet, Pierre ^a   Tissot, Michèle ^c   Barrett, Perry ^d   Morgan, Peter J ^d   Nanoff, Christian ^b   Strosberg, A Donny ^a   Jockers, Ralf ^a,c  

^a CNRS   (France)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c INSTITUT COCHIN   (France)

^d ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; MELATONIN 1A RECEPTOR; MELATONIN RECEPTOR; PERTUSSIS TOXIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPOPHYSIS PARS TUBERALIS; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SHEEP; SIGNAL TRANSDUCTION;

EID: 0033346394     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.12.0390     Document Type: Article

References (56)

1. Melatonin receptors: Localization, molecular pharmacology and physiological significance
2. Melatonin receptors
3. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
4. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock
5. The melatonin receptor in the human brain: Cloning experiments and distribution studies
6. Melatonin receptor subtype expression in human cerebellum
7. 125I]Iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes
8. Melatonin receptors step into the light: Cloning and classification of subtypes
9. Melatonin receptors activate heteromeric G-protein coupled Kir3 channels
10. Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: Activation of protein kinase C at dusk and dawn
11. The Mel1a melatonin receptor is coupled to parallel signal transduction pathways
12. Regulation of the Mel 1a melatonin receptor mRNA and protein levels in the ovine pars tuberalis: Evidence for a cyclic adenosine 3',5'-monophosphate-independent Mel 1a receptor coupling and an autoregulatory mechanism of expression
13. Signal transduction for melatonin in human lymphocytes. Involvement of a pertussis toxin-sensitive G protein
14. Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels
15. Coupling specificity between somatostatin receptor sst2A and G proteins: Isolation of the receptor-G protein complex with a receptor antibody
16. Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gsα
17. Human prostate muscarinic receptor subtypes
18. Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins
19. Rapid, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C
20. Antibodies for the immunochemistry of the human β3-adrenergic receptor
21. Evidence for multiple forms of melatonin receptor-G-protein complexes by solubilization and gel electrophoresis
22. Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain
23. Structural elements of G alpha subunits that interact with Gβγ, receptors, and effectors
24. Signalling functions and bio-chemical properties of pertussis toxin-resistant G-proteins
25. Recombinant Gqα. Mutational activation and coupling to receptors and phospholipase C
26. Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells
27. Role of phospholipase Cβ3 phosphorylation in the desensitization of cellular responses to platelet-activating factor
28. Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes
29. 2+ signalling in a human neuroblastoma
30. Mel 1a melatonin receptor expression is regulated by protein kinase C and an additional pathway addressed by the protein kinase C inhibitor Ro 31-8220 in ovine pars tuberalis cells
31. Development of polyclonal anti-D2 dopamine receptor antibodies using sequence-specific peptides
32. Studies of the renal action of melatonin: Evidence that the effects are mediated by 37 kDa receptors of the Mel1a subtype localized primarily to the basolateral membrane of the proximal tubule
33. Production of specific anti-rat 5-HT1A receptor antibodies in rabbits injected with a synthetic peptide
34. Antisera specific for D2 dopamine receptors
35. Both pertussis toxin-sensitive and insensitive G-proteins link melatonin receptor to inhibition of adenylyl cyclase in the ovine pars tuberalis
36. Intracellular signalling in the ovine pars tuberalis: An investigation using aluminium fluoride and melatonin
37. Membrane organization in G-protein mechanisms
38. Ultrastructure of melatonin-responsive cells in the ovine pars tuberalis
39. Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor
40. Molecular characterization of the melanin-concentrating-hormone receptor
41. G α q family members couple parathyroid hormone (PTH)/ PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells
42. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases
43. Direct stimulation of Bruton's tyrosine kinase by G(q)-protein α-sub-unit
44. Melatonin activates an outward current and inhibits lh in rat suprachiasmatic nucleus neurons
45. Direct activation of trpl cation channels by G α11 subunits
46. Differential expression of the melatonin receptor in human monocytes
47. Identification of the critical domains of the δ-opioid receptor involved in G protein coupling using site-specific synthetic peptides
48. Close association of the alpha subunits of Gq and G11 G proteins with actin filaments in WRK1 cells: Relation to G protein-mediated phospholipase C activation
49. 2+ currents in rat anterior pituitary cells
50. G protein diversity: A distinct class of α subunits is present in vertebrates and invertebrates
51. Topography of the active site of staphylococcal nuclease. Affinity labeling with diazonium substrate analogues
52. The derivatization of cross-linked polyacrylamide beads. Controlled introduction of functional groups for the preparation of special-purpose, biochemical adsorbents
53. Use of eukaryotic expression technology in the functional analysis of cloned genes
54. New molecular and structural determinants involved in β2-adrenergic receptor desensitization and sequestration. Delineation using chimeric β 3/β 2-adrenergic receptors
55. Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes
56. 2+ indicators with greatly improved fluorescence properties