Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastoris

Metabolic Engineering

Volumn 24, Issue , 2014, Pages 18-29

  Wriessnegger, Tamara ^a   Augustin, Peter ^a   Engleder, Matthias ^b   Leitner, Erich ^b   Müller, Monika ^c   Kaluzna, Iwona ^c   Schürmann, Martin ^c   Mink, Daniel ^c   Zellnig, Günther ^d   Schwab, Helmut ^a,b   Pichler, Harald ^a,b  

^a AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^c DSM RESOLVE   (Netherlands)

^d UNIVERSITY OF GRAZ   (Austria)

Author keywords

Cytochrome P450; Membrane protein; Metabolic engineering; Nootkatone; Pichia pastoris; Terpenoid

Indexed keywords

CELL CULTURE; CELLS; CITRUS FRUITS; METABOLISM; ODORS; YEAST;

CYTOCHROME P450; MEMBRANE PROTEINS; NOOTKATONE; PICHIA PASTORIS; TERPENOIDS;

METABOLIC ENGINEERING;

ALCOHOL DEHYDROGENASE; CYTOCHROME P450 REDUCTASE; DODECANE; FLAVORING AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; NOOTKATONE; OXYGENASE; SESQUITERPENOID; UNCLASSIFIED DRUG; VALENCENE; ARABIDOPSIS PROTEIN; SESQUITERPENE;

ARABIDOPSIS THALIANA; ARTICLE; BIOCATALYST; BIOTRANSFORMATION; CALLITROPSIS NOOTKATENSIS; CARBON SOURCE; CELL CULTURE; CELL LYSATE; CONTROLLED STUDY; HYDROXYLATION; HYOSCYAMUS; HYOSCYAMUS MUTICUS; IMMUNOBLOTTING; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; ORANGE (FRUIT); OXIDATION; PICHIA PASTORIS; PRIORITY JOURNAL; WESTERN BLOTTING; WHOLE CELL; YEAST; ARABIDOPSIS; BIOSYNTHESIS; CUPRESSUS; ENZYMOLOGY; GENETICS; METABOLISM; PICHIA;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; CUPRESSUS; HYOSCYAMUS; METABOLIC ENGINEERING; PICHIA; SESQUITERPENES;

EID: 84899802037     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.04.001     Document Type: Article

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