The implementation of a design of experiments strategy to increase recombinant protein yields in yeast (Review)

Methods in Molecular Biology

Volumn 866, Issue , 2012, Pages 115-127

  Bora, Nagamani ^a   Bawa, Zharain ^a   Bill, Roslyn M ^a   Wilks, Martin D B ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b Smallpeice Enterprises Ltd   (United Kingdom)

Author keywords

Design of experiments; Process characterisation; Process development; Process optimisation

Indexed keywords

RECOMBINANT PROTEIN;

ARTICLE; GENETICS; METABOLISM; YEAST;

RECOMBINANT PROTEINS; YEASTS;

EID: 84859853677     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-770-5_11     Document Type: Article

References (20)

1. Anthony J (2003) Design of experiments for engineers and scientists. Butterworth-Heinemann, Oxford
2. Holmes WJ, Darby RAJ, Wilks MDB, Smith R, Bill RM (2009) Developing a scalable model of recombinant protein yield from Pichia pastoris : the infl uence of culture conditions, biomass and induction regime. Microb Cell Fact 8:35
3. Czitrom V (1999) One-factor-at-a-time versus designed experiments. Amer Statistician 53:2
4. Fisher RA (1971) The design of experiments, 9th edn. Macmillan, London
5. Rao RS, Kumar CG, Prakasham RS, Hobbs PJ (2008) The Taguchi methodology as a statistical tool for biotechnological applications: a critical appraisal. Biotechnol J 3:510-523 (Pubitemid 351618736)
6. Knospel F, Schindler RK, Lubberstedt M, Petzolt S, Gerlach JC, Zeilinger K (2010) Optimization of a serum-free culture medium for mouse embryonic stem cells using design of experiments (DoE) methodology. Cytotechnology 62:557-571
7. Bisgaard S, Fuller HT (1994-1995) Analysis of factorial experiments with defects or defectives as a response. Quality Eng 7:429-443
8. Yuan L-L, Li Y-Q, Wang Y, Zhang X-H, Xu Y-Q (2008) Optimization of critical medium components using response surface methodology for phenazine-1-carboxylic acid production by Pseudomonas sp. M-18Q. J Biosci Bioeng 105:232-237 (Pubitemid 351467191)
9. de Aguiar PF, Bourguignon B, Khots MS, Massart DL, Phan-Than-Luu R (1995) D-optimal designs. Chemometrics Internat Lab Sys 30:199-210
10. Luo W, Pla-Roca M, Juncker D (2011) Taguchi design-based optimization of sandwich immunoassay microarrays for detecting breast cancer biomarkers. Anal Chem 83:5767-5774
11. Myers RH, Montgomery DC (1995) Response surface methodology: process and product optimization using designed experiments, 1st edn. Wiley, New York
12. Einsfeldt K, Severo Junior JB, Correa Argondizzo AP, Medeiros MA, Alves TL, Almeida RV, Larentis AL (2011) Cloning and expression of protease ClpP from Streptococcus pneumoniae in Escherichia coli : Study of the infl uence of kanamycin and IPTG concentration on cell growth, recombinant protein production and plasmid stability. Vaccine. doi: 10.1016/j. vaccine.2011.05.073
13. Ferreira SL, Bruns RE, Ferreira HS, Matos GD, David JM, Brandao GC, da Silva EG, Portugal LA, dos Reis PS, Souza AS, dos Santos WN (2007) Box-Behnken design: an alternative for the optimization of analytical methods. Anal Chim Acta 597:179-186 (Pubitemid 47187836)
14. Montgomery DC, Peck EA (1982) Introduction to linear regression analysis. Wiley, New York
15. Mandenius CF, Brundin A (2008) Bioprocess optimization using design-of-experiments methodology. Biotechnol Prog 24:1191-1203
16. Shi F, Xu Z, Cen P (2006) Effi cient production of poly-gamma-glutamic acid by Bacillus subtilis ZJU-7. Appl Biochem Biotechnol 133: 271-282
17. Garcia-Arrazola R, Dawson P, Buchanan I, Doyle B, Fearn T, Titchener-Hooker N, Baganz F (2005) Evaluation of the effects and interactions of mixing and oxygen transfer on the production of Fab' antibody fragments in Escherichia coli fermentation with gas blending. Bioprocess Biosyst Eng 27:365-374 (Pubitemid 41709376)
18. Wang Y-H, Yang B, Ren J, Dong M-L, Liang D, Xu AL (2005) Optimization of medium composition for the production of clavulanic acid by Streptomyces clavuligerus . Process Biochem 40:1161-1166 (Pubitemid 39568347)
19. Pritchett J, Baldwin SA (2004) The effect of nitrogen source on yield and glycosylation of a human cystatin C mutant expressed in Pichia pastoris . J Ind Microbiol Biotechnol 31: 553-558 (Pubitemid 40175017)
20. Adinarayana K, Ellaiah P, Srinivasulu B, Bhavani Devi R, Adinarayana G (2003) Response surface methodological approach to optimize the nutritional parameters for neomycin production by Streptomyces marinensis under solid-state fermentation. Process Biochem 38:1565-1572 (Pubitemid 36821289)