Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes - a comparative study

Biotechnology Journal

Volumn 7, Issue 11, 2012, Pages 1346-1358

  Geier, Martina ^a   Braun, Andreas ^a   Emmerstorfer, Anita ^b   Pichler, Harald ^a,b   Glieder, Anton ^b  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

Author keywords

Host comparison; Human cytochrome P450 2D6; Membrane protein expression; Pichia pastoris; Whole cell biotransformation

Indexed keywords

HOST COMPARISON; HUMAN CYTOCHROME; MEMBRANE PROTEINS; PICHIA PASTORIS; WHOLE-CELL BIOTRANSFORMATIONS;

BIOLOGICAL MEMBRANES; ENZYMES; ESCHERICHIA COLI; METABOLITES; MICROORGANISMS; YEAST;

BIOMOLECULES;

BUFURALOL; CHAPERONE; CYTOCHROME P450 2D6; CYTOCHROME P450 REDUCTASE; DRUG METABOLITE; RNA POLYMERASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BACTERIAL STRAIN; BIOTRANSFORMATION; CATALYST; COMPARATIVE STUDY; CONTROLLED STUDY; COPY NUMBER VARIATION; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE DOSAGE; GENE EXPRESSION SYSTEM; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; TEMPERATURE DEPENDENCE; YARROWIA LIPOLYTICA;

BIOREACTORS; BIOTECHNOLOGY; BIOTRANSFORMATION; CELL MEMBRANE; CLONING, MOLECULAR; CYTOCHROME P-450 CYP2D6; ESCHERICHIA COLI; ETHANOLAMINES; GLUCOSE; HUMANS; NADPH-FERRIHEMOPROTEIN REDUCTASE; PLASMIDS; RECOMBINANT PROTEINS; SACCHAROMYCETALES; TEMPERATURE;

ESCHERICHIA COLI; PICHIA PASTORIS;

EID: 84868633712     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200187     Document Type: Article

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