L-threo-C 6 -pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells

Cellular Physiology and Biochemistry

Volumn 30, Issue 4, 2012, Pages 1051-1058

  Syed, Ismail ^a,c,d   Szulc, Zdzislaw M ^b   Ogretmen, Besim ^b   Kowluru, Anjaneyulu ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c Diabetes and Metabolism   (Israel)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cationic ceramide; Ceramide; Islet beta cell; Mitochondrial dysfunction; NADPH oxidase

Indexed keywords

CASPASE 3; CERAMIDE DERIVATIVE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; THREO C6 PYRIDINIUM CERAMIDE BROMIDE; UNCLASSIFIED DRUG; 2 N (6' (1'' PYRIDINIUM)HEXANOYL)SPHINGOSINE; 2-N-(6'-(1''-PYRIDINIUM)HEXANOYL)SPHINGOSINE; BROMIDE; CERAMIDE; CYBB PROTEIN, RAT; MEMBRANE PROTEIN; PYRIDINIUM DERIVATIVE;

ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; ENZYME ACTIVATION; METABOLISM; OXIDATIVE STRESS; RAT;

ANIMALS; BROMIDES; CASPASE 3; CELL LINE; CELL SURVIVAL; CERAMIDES; ENZYME ACTIVATION; INSULIN-SECRETING CELLS; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NADPH OXIDASE; OXIDATIVE STRESS; PYRIDINIUM COMPOUNDS; RATS; REACTIVE OXYGEN SPECIES;

MLCS; MLOWN;

EID: 84867210725     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000341481     Document Type: Article

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