Brain ischemia activates β- And γ-secretase cleavage of amyloid precursor protein: Significance in sporadic Alzheimer's disease

Molecular Neurobiology

Volumn 47, Issue 1, 2013, Pages 425-434

  Pluta, Ryszard ^a   Furmaga Jabłońska, Wanda ^b   MacIejewski, Ryszard ^b   Ułamek Kozioł, Marzena ^a   Jabłoński, Mirosław ^b  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Brain ischemia; Neuronal death; Oxidative stress; Secretase; Amyloid peptide; Secretase; Secretase

Indexed keywords

ADENYLATE CYCLASE; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BETA SECRETASE; BETA SECRETASE 1; CATHEPSIN B; ESTROGEN; GAMMA SECRETASE; GLUTAMINYL CYCLASE; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NICASTRIN; NOTCH RECEPTOR; PRESENILIN; PRESENILIN 1; PRESENILIN 2; PROTEIN KINASE B; SERINE PROTEINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOIDOSIS; APOPTOSIS; BRAIN CORTEX; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; DRUG EFFICACY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE OVEREXPRESSION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; MICROGLIA; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NERVE CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REPERFUSION INJURY; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; TRANSIENT ISCHEMIC ATTACK;

EID: 84872487799     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8360-z     Document Type: Review

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